{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:51:45Z","timestamp":1770817905306,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Ministry of Health of the Czech Republic","doi-asserted-by":"publisher","award":["NU23-10-00413"],"award-info":[{"award-number":["NU23-10-00413"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: This study aimed to compare the clinical and radiological outcomes of treating unstable osteoporotic vertebral fractures using hybrid fixation with uncemented transpedicular screws (Group A) versus polymethylmethacrylate (PMMA) cement-augmented screws (Group B). Methods: A retrospective comparative study of 55 patients treated between 01\/2017 and 03\/2024. Group A included 35 patients (mean age 71.22 \u00b1 6.12 years); Group B included 20 patients (mean age 72.9 \u00b1 7.75 years). Clinical outcomes were compared preoperatively, 6 weeks and 1 year after surgery. For clinical evaluation, the ODI and VAS for back pain were used. Restoration of the sagittal spinal profile was evaluated using the sagittal Cobb angle and the height of the fractured vertebral body. Results: Both groups showed significant clinical improvement in ODI and VAS scores at 6 weeks and 1 year postoperatively (p &lt; 0.001), without significant between-group differences. The ODI changed from a preoperative value of 75.07 \u00b1 21.13 to 50.72 \u00b1 17.7 at 6 weeks postoperatively, and to 28.83 \u00b1 20.9 at 1 year postoperatively in Group A. In Group B, the preoperative ODI value of 66.8 \u00b1 14.56 changed to 47.00 \u00b1 11.72 at 6 weeks and to 19.8 \u00b1 9.15 at 1 year postoperatively The VAS decreased from 7.55 \u00b1 1.43 preoperatively to 3.50 \u00b1 1.17 at 6 weeks and to 1.52 \u00b1 1.18 at 1 year postoperatively in Group A, and from 7.53 \u00b1 1.39 preoperatively to 2.53 \u00b1 1.02 at 6 weeks and to 1.52 \u00b1 1.18 at 1 year postoperatively in Group B. In Group A, preoperative Cobb angle values of 11.01 \u00b1 13.85 improved to 7.33 \u00b1 16.17 at 6 weeks, with subsequent loss to 12.96 \u00b1 14.75 degrees at 1 year postoperatively. In Group B, preoperative values were 11.44 \u00b1 17.84, corrected to 5.16 \u00b1 8.33 at 6 weeks, and to 7.37 \u00b1 9.28 degrees at 1 year postoperatively. Conclusions: Good clinical outcomes were achieved in both evaluated groups using uncemented or cement-augmented screws, without a statistically significant difference. Differences were noted in the radiological evaluation of the success of sagittal profile correction. While both groups showed initial radiological improvement, the uncemented screw group experienced a statistically significant loss of correction at the 1-year follow-up.<\/jats:p>","DOI":"10.3390\/jcm15041414","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:13:15Z","timestamp":1770808395000},"page":"1414","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Clinical and Radiological Outcomes Between Uncemented and Cement Augmented Screws in Short Segment Hybrid Fixation of Unstable Osteoporotic Vertebral Fractures"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9753-8840","authenticated-orcid":false,"given":"Josef","family":"Vcelak","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, First Faculty of Medicine, Charles University and Bulovka University Hospital, 180 81 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Kral","sequence":"additional","affiliation":[{"name":"Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General Teaching Hospital, 128 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Sedova","sequence":"additional","affiliation":[{"name":"Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General Teaching Hospital, 128 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9622-9528","authenticated-orcid":false,"given":"Jan","family":"Lesenky","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, First Faculty of Medicine, Charles University and Bulovka University Hospital, 180 81 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8498-5895","authenticated-orcid":false,"given":"Ondrej","family":"Seda","sequence":"additional","affiliation":[{"name":"Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General Teaching Hospital, 128 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s00586-022-07519-x","article-title":"Georg Schmorl prize of the German spine society (DWG) 2022: Current treatment for inpatients with osteoporotic thoracolumbar fractures-results of the EOFTT study","volume":"32","author":"Ullrich","year":"2023","journal-title":"Eur. Spine J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1177\/2192568217717972","article-title":"Classification of Osteoporotic Thoracolumbar Spine Fractures: Recommendations of the Spine for Orthopaedics and Trauma (DGOU)","volume":"8","author":"Schnake","year":"2018","journal-title":"Glob. Spine J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"176","DOI":"10.5435\/00124635-201103000-00007","article-title":"The treatment of symptomatic osteoporotic spinal compression fractures","volume":"19","author":"Esses","year":"2011","journal-title":"J. Am. Acad. Orthop. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.clinbiomech.2019.06.008","article-title":"Influence of additional cement augmentation on endplate stability in circumferential stabilisation of osteoporotic spine fractures","volume":"68","author":"Herren","year":"2019","journal-title":"Clin. Biomech."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s13018-020-01938-6","article-title":"Analysis of two minimally invasive procedures for osteoporotic vertebral compression fractures with intravertebral cleft: A systematic review and meta-analysis","volume":"15","author":"Wei","year":"2020","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.31616\/asj.2022.0441","article-title":"Management of Osteoporotic Fracture: Review Update 2022","volume":"16","author":"Jang","year":"2022","journal-title":"Asian Spine J."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Spiegl, U.J., Ahrberg, A.B., Anemuller, C., Jarvers, J.-S., Glasmacher, S., Hoh, N., Josten, C., and Heyde, C.-E. (2020). Which anatomic structures are responsible for the reduction loss after hybrid stabilisation of osteoporotic fractures of the thoracolumbar spine. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-3065-3"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1007\/s00068-024-02645-1","article-title":"Satisfactory 2-year outcome of minimal invasive hybrid stabilisation with double treated screws for unstable osteoporotic spinal fractures","volume":"50","author":"Mahmoud","year":"2024","journal-title":"Eur. J. Trauma. Emerg. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s00586-019-05957-8","article-title":"Hybrid stabilisation of unstable osteoporotic thoracolumbar vertebral body fractures: Clinical and radiological outcome after a mean of 4 years","volume":"28","author":"Spiegl","year":"2019","journal-title":"Eur. Spine J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1302\/0301-620X.98B8.37413","article-title":"Cement augmentation versus extended dorsal instrumentation in the treatment of osteoporotic vertebral fractures","volume":"98","author":"Weiser","year":"2016","journal-title":"Bone Joint J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s00586-009-1073-y","article-title":"Management of pulmonary cement embolism after percutaneous vertebroplasty and kyphoplasty: A systematic review of the literature","volume":"18","author":"Krueger","year":"2009","journal-title":"Eur. Spine J."},{"key":"ref_12","first-page":"135","article-title":"Vertebroplasty combined with image-guided percutaneous cement augmented transpedicular fixation for the treatment of complex vertebral fractures in osteoporotic patients","volume":"54","author":"Vougioukas","year":"2010","journal-title":"J. Neurosurg. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"600","DOI":"10.22603\/ssrr.2023-0296","article-title":"Short Fixation Using Upward\/Downward Penetrating Endplate Screws and Percutaneous Vertebral Augmentation for Unstable Osteoporotic Vertebral Fractures","volume":"8","author":"Fujii","year":"2024","journal-title":"Spine Surg. Relat. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jss.2010.09.009","article-title":"Surgical Treatment of Osteoporotic Thoracolumbar Compressive Fractures with Open Vertebral Cement Augmentation of Expandable Pedicle Screw Fixation: A Biomechanical Study and a 2-Year Follow-up of 20 Patients","volume":"173","author":"Wu","year":"2012","journal-title":"J. Surg. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.spinee.2017.01.009","article-title":"Risk of cement leakage and pulmonary embolism by bone cement-augmented pedicle screw fixation of the thoracolumbar spine","volume":"17","author":"Janssen","year":"2017","journal-title":"Spine J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3171\/2015.10.SPINE15511","article-title":"Cement leakage in pedicle screw augmentation: A prospective analysis of 98 patients and 474 augmented pedicle screws","volume":"25","author":"Mueller","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref_17","first-page":"457","article-title":"The significance of radiolucent zones surrounding pedicle screws. Definition of screw loosening in spinal instrumentation","volume":"86","author":"Olerud","year":"2004","journal-title":"J. Bone Joint Surg. Br."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e247","DOI":"10.1016\/j.wneu.2018.08.045","article-title":"Application of Cement-Injectable Cannulated Pedicle Screw in Treatment of Osteoporotic Thoracolumbar Vertebral Compression Fracture (AO Type A): A retrospective Study of 28 Cases","volume":"120","author":"Rong","year":"2018","journal-title":"World Neurosurg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00586-011-1824-4","article-title":"Polymethylmethacrylate augmentation of the pedicle screw: The cement distribution in the vertebral body","volume":"20","author":"Hu","year":"2011","journal-title":"Eur. Spine J."},{"key":"ref_20","first-page":"924","article-title":"Kyphoplasty with Posterior Dynamic Stabilisation in the Surgical Treatment of Unstable Thoracolumbar Osteoporotic Vertebral Compression Fractures","volume":"31","author":"Octenoglu","year":"2021","journal-title":"Turk. Neurosurg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/jcvjs.JCVJS_188_20","article-title":"Effectiveness and reliability of cannulated fenestrated screws augmented with polymethylmethacrylate cement in the surgical treatment of osteoporotic vertebral fractures","volume":"12","author":"Coniglio","year":"2021","journal-title":"J. Craniovert. Junction Spine"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"E541","DOI":"10.1016\/j.wneu.2020.08.002","article-title":"Comparison of Long Segmental Dorsal Stabilisation with Complete Versus Restricted Pedicle Screw Cement Augmentation in Unstable Osteoporotic Midthoracic Vertebral Body Fractures: A Biomechanical Study","volume":"143","author":"Spiegl","year":"2020","journal-title":"World Neurosurg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1007\/s00586-008-0769-8","article-title":"Assessment of different screw augmentation techniques and screw designs in osteoporotic spines","volume":"17","author":"Becker","year":"2008","journal-title":"Eur. Spine J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.6061\/clinics\/2015(02)08","article-title":"Surgical treatment of the osteoporotic spine with bone cement-injectable cannulated pedicle screw fixation: Technical description and preliminary application in 43 patients","volume":"70","author":"Dai","year":"2015","journal-title":"Clinics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.14444\/8474","article-title":"Surgical Site Infection After Polymethyl Methacrylate Pedicle Screw Augmentation in Osteoporotic Spinal Vertebrae: A Series of 537 cases","volume":"17","year":"2023","journal-title":"Int. J. Spine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1007\/s00402-022-04434-0","article-title":"Occurrence of adjacent segment fractures after surgical treatment of an osteoporotic vertebral fracture: A retrospective comparison between two different treatment methods","volume":"143","author":"Aboud","year":"2023","journal-title":"Arch. Orthop. Trauma. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"102779","DOI":"10.1016\/j.otsr.2020.102779","article-title":"Treatment of osteoporotic vertebral fractures","volume":"107","author":"Prost","year":"2021","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.spinee.2019.02.013","article-title":"Development of a scoring system for predicting adjacent vertebral fracture after balloon kyphoplasty","volume":"19","author":"Takahashi","year":"2019","journal-title":"Spine J."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"De Simone, M., Choucha, A., Ciaglia, E., Conti, V., Pecoraro, G., Santurro, A., Puca, A.A., Cascella, M., and Iaconetta, G. (2024). Discogenic Low Back Pain: Anatomic and Pathophysiologic Characterization, Clinical Evaluation, Biomarkers, AI, and Treatment Options. J. Clin. Med., 13.","DOI":"10.3390\/jcm13195915"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/4\/1414\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:42:50Z","timestamp":1770810170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/4\/1414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,11]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15041414"],"URL":"https:\/\/doi.org\/10.3390\/jcm15041414","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,11]]}}}