{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:42:23Z","timestamp":1770903743809,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Post-extraction alveolar bone resorption complicates implant planning and compromises functional and aesthetic outcomes. High-power lasers, including surgically applied Er:YAG and Nd:YAG lasers, as well as Nd:YAG-based photobiomodulation (PBM), have been proposed as adjunctive approaches to decontaminate extraction sockets, modulate inflammation, and stimulate osteogenesis, potentially limiting post-extraction ridge collapse. Methods: This systematic review and meta-analysis included prospective and retrospective clinical studies evaluating changes in alveolar ridge height, width, volume, or density following tooth extraction treated with Er:YAG, surgically applied Nd:YAG, or Nd:YAG-based PBM. Outcomes were assessed using cone-beam computed tomography (CBCT) or calibrated mechanical or optical measurement methods. Study selection followed PRISMA guidelines. Quantitative synthesis was performed using random-effects meta-analysis, and certainty of evidence was assessed using the GRADE approach. Results: All laser modalities demonstrated statistically and clinically significant preservation of alveolar bone compared with standard care. Er:YAG laser therapy resulted in a mean ridge preservation of 1.12 mm (95% CI: 0.9\u20131.4), while surgically applied Nd:YAG achieved a comparable effect of 1.15 mm (95% CI: 0.88\u20131.4). Nd:YAG-based PBM showed the most consistent effect, with a mean difference of 1.20 mm (95% CI: 1.0\u20131.4) and the lowest heterogeneity (I2 = 22%). The largest effects were observed within the first month after extraction (mean difference 1.26 mm) and diminished with longer follow-up. CBCT-based assessments demonstrated the highest measurement precision, with an average effect of 1.32 mm. Overall certainty of evidence was rated as moderate due to risk of bias, incomplete methodological reporting, and possible publication bias. Conclusions: Er:YAG, Nd:YAG, and Nd:YAG-based PBM represent effective adjunctive approaches for alveolar ridge preservation following tooth extraction, particularly during the early healing phase. Their effects appear enhanced when combined with barrier membranes or osteoconductive grafting materials. CBCT should be preferred for outcome assessment in both clinical practice and research. These findings support the evidence-based integration of laser technologies into ridge preservation protocols in implant dentistry and oral surgery.<\/jats:p>","DOI":"10.3390\/jcm15041447","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:05:46Z","timestamp":1770897946000},"page":"1447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Laser-Assisted Strategies for Alveolar Bone Preservation After Tooth Extraction: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Magdalena","family":"Gryka-Deszczy\u0144ska","sequence":"first","affiliation":[{"name":"Dentalove Clinic Ltd., 19 Borzymowska Street, 03-565 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Dembicka-M\u0105czka","sequence":"additional","affiliation":[{"name":"Dental Office-Artistic Smile Studio, 61\/1 Krakowska Street, 33-100 Tarn\u00f3w, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3173-9389","authenticated-orcid":false,"given":"Jakub","family":"Fiegler-Rudol","sequence":"additional","affiliation":[{"name":"Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-251X","authenticated-orcid":false,"given":"Dariusz","family":"Skaba","sequence":"additional","affiliation":[{"name":"Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5673-7413","authenticated-orcid":false,"given":"Rafa\u0142","family":"Wiench","sequence":"additional","affiliation":[{"name":"Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"key":"ref_1","first-page":"238","article-title":"Er:YAG laser therapy on alveolar osteitis after mandibular third molar surgery: A randomized controlled clinical study","volume":"42","author":"Han","year":"2024","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/cid.12991","article-title":"The effect of post-extraction socket preservation laser treatment on bone density 4 months after extraction: Randomized controlled trial","volume":"23","author":"Pajk","year":"2021","journal-title":"Clin. Implant. Dent. Relat. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s10103-024-04215-8","article-title":"Impact of photobiomodulation in alveolar ridge preservation and implant stability after a dental extraction: A systematic review","volume":"39","author":"Mahintach","year":"2024","journal-title":"Lasers Med. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s10103-020-02962-y","article-title":"Photobiomodulation as an adjunctive therapy for alveolar socket preservation: A preliminary study in humans","volume":"35","author":"Rosero","year":"2020","journal-title":"Lasers Med. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jab\u0142o\u0144ski, P., Musia\u0142, M., Wiench, R., Stefanik, N., Olchowy, C., Matys, J., Skaba, D., and Grzech-Le\u015bniak, K. (2022). Photobiomodulation therapy in the treatment of oral mucositis: A case report. Medicina, 58.","DOI":"10.3390\/medicina58050618"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Michalak, F., Dominiak, M., Grzech-Le\u015bniak, Z., Kiryk, J., and Grzech-Le\u015bniak, K. (2025). Photobiomodulation in medication-related osteonecrosis of the jaw: Outcomes in stage I and its adjunctive role in advanced cases. Biomedicines, 13.","DOI":"10.3390\/biomedicines13051042"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Vescovi, P., De Francesco, P., Giovannacci, I., Le\u00e3o, J.C., and Barone, A. (2024). Piezoelectric surgery, Er:YAG laser surgery and Nd:YAG laser photobiomodulation: A combined approach to treat medication-related osteonecrosis of the jaws (MRONJ). Dent. J., 12.","DOI":"10.3390\/dj12080261"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"933","DOI":"10.17219\/dmp\/181532","article-title":"Advancements in alveolar bone reconstruction: A systematic review of bone block utilization in dental practice","volume":"61","author":"Hnitecka","year":"2024","journal-title":"Dent. Med. Probl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jcms.2020.11.010","article-title":"Postoperative evaluation of Er:YAG laser, piezosurgery, and rotary systems used for osteotomy in mandibular third-molar extractions","volume":"49","author":"Civak","year":"2021","journal-title":"J. Craniomaxillofac Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s10266-022-00734-4","article-title":"Immediate dental implant placement in post-extraction-infected sites decontaminated with Er,Cr:YSGG laser: A retrospective cohort study","volume":"111","author":"Crippa","year":"2023","journal-title":"Odontology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e20942","DOI":"10.1097\/MD.0000000000020942","article-title":"Clinical comparison between Er:YAG and CO2 laser in treatment of oral tumorous lesions: A meta-analysis","volume":"99","author":"Liu","year":"2020","journal-title":"Medicine"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Robijns, J., Nair, R.G., Lodewijckx, J., Arany, P., Barasch, A., Bjordal, J.M., Bossi, P., Chilles, A., Corby, P.M., and Epstein, J.B. (2022). Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Front Oncol., 12.","DOI":"10.3389\/fonc.2022.927685"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3329\/bjms.v22i3.65328","article-title":"To evaluate the effects of low-level laser therapy (LLLT) on wound healing of extraction socket: A systematic review","volume":"22","author":"Karim","year":"2023","journal-title":"Bangladesh J. Med. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.joms.2021.10.005","article-title":"Efficacy and Safety of Concentrated Growth Factor Fibrin on the Extraction of Mandibular Third Molars: A Prospective, Randomized, Double-Blind Controlled Clinical Study","volume":"80","author":"Fang","year":"2022","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_16","first-page":"235","article-title":"Laser treatment of hard tissue lesions","volume":"4","author":"Matsumoto","year":"2004","journal-title":"J. Oral. Laser Appl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/lsm.1900150407","article-title":"Erb:YAG and Hol:YAG laser osteotomy: The effect of laser ablation on bone healing","volume":"15","author":"Buchelt","year":"1994","journal-title":"Lasers Surg. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Parker, S., Cronshaw, M., Anagnostaki, E., Mylona, V., Lynch, E., and Grootveld, M. (2020). Current concepts of laser\u2013oral tissue interaction. Dent. J., 8.","DOI":"10.3390\/dj8030061"},{"key":"ref_19","first-page":"47","article-title":"Advances in bone surgery: The Er:YAG laser in oral surgery and implant dentistry","volume":"2","year":"2022","journal-title":"Clin. Cosmet. Investig. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"9654975","DOI":"10.1155\/2016\/9654975","article-title":"Assessment of temperature rise and time of alveolar ridge splitting by means of Er:YAG laser, piezosurgery, and surgical saw: An ex vivo study","volume":"2016","author":"Matys","year":"2016","journal-title":"BioMed Res. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.joms.2010.02.029","article-title":"Bone healing after bur and Er:YAG laser ostectomies","volume":"69","author":"Martins","year":"2011","journal-title":"J. Oral. Maxillofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/wrr.12678","article-title":"Does laser therapy improve the wound healing process after tooth extraction? A systematic review","volume":"27","author":"Lemes","year":"2019","journal-title":"Wound Repair. Regen."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/prd.12080","article-title":"Periodontal and peri-implant wound healing following laser therapy","volume":"68","author":"Aoki","year":"2015","journal-title":"Periodontol. 2000"},{"key":"ref_24","first-page":"343","article-title":"Laser decontamination and LED photobiomodulation promote bone regeneration and wound healing by secondary intention in alveolar ridge preservation: Clinical and radiographic evaluation","volume":"40","author":"Caccianiga","year":"2022","journal-title":"Photobiomodul. Photomed. Laser Surg."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Sun, F., Zhang, Z., Duan, X., Long, X., Liu, X., Zou, D., and He, J. (2023). Influence of Er:YAG laser irradiation on the outcomes of alveolar ridge preservation at the infected molar sites: A randomized controlled trial. BMC Oral. Health, 23.","DOI":"10.1186\/s12903-023-02996-y"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.11607\/prd.5067","article-title":"Er:YAG laser-assisted bone regenerative therapy for implant placement: A case series","volume":"41","author":"Taniguchi","year":"2021","journal-title":"Int. J. Periodontics Restor. Dent."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1563\/AAID-JOI-D-09-00120.1","article-title":"Platelet-derived growth factor secretion and bone healing after Er:YAG laser bone irradiation","volume":"37","author":"Kesler","year":"2011","journal-title":"J. Oral. Implantol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.joms.2021.10.006","article-title":"Is the Er:YAG laser effective in reducing pain, edema, and trismus after removal of impacted mandibular third molars? A meta-analysis","volume":"80","author":"Barros","year":"2022","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.adaj.2023.03.004","article-title":"Photobiomodulation in dental extraction therapy: Postsurgical pain reduction and wound healing","volume":"154","author":"Sourvanos","year":"2023","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/prd.12067","article-title":"Lasers in periodontal therapy","volume":"67","author":"Passanezi","year":"2015","journal-title":"Periodontol. 2000"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/jcpe.13390","article-title":"Post-extraction dimensional changes: A systematic review and meta-analysis","volume":"48","author":"Stuhr","year":"2021","journal-title":"J. Clin. Periodontol."},{"key":"ref_32","first-page":"1269","article-title":"Alveolus soft and bone tissue regeneration after laser biomodulation: A histological study","volume":"60","author":"Nica","year":"2019","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cap.10059","article-title":"Adjunctive Nd:YAG laser irradiation for ridge preservation and immediate implant procedures: A consecutive case series","volume":"9","author":"Choi","year":"2019","journal-title":"Clin. Adv. Periodontics"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Reynolds, M.A., Aichelmann-Reidy, M.E., and Rosen, P.S. (2020). Lasers in periodontal and peri-implant therapy: Challenges and opportunities. Emerging Therapies in Periodontics, Springer. Available online: https:\/\/link.springer.com\/chapter\/10.1007\/978-3-030-42990-4_15.","DOI":"10.1007\/978-3-030-42990-4_15"},{"key":"ref_35","first-page":"9","article-title":"All tissues dental laser Er:YAG laser: Review article","volume":"1","author":"Abdulsamee","year":"2017","journal-title":"Biomed. J. Sci. Tech. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"340","DOI":"10.5005\/jp-journals-10015-1186","article-title":"Application of Er:YAG and Er,Cr:YSGG lasers in cavity preparation for dental tissues: A literature review","volume":"3","author":"Santos","year":"2012","journal-title":"World J. Dent."},{"key":"ref_37","first-page":"e78279","article-title":"Erbium-doped yttrium aluminium garnet (Er:YAG) lasers in the treatment of peri-implantitis","volume":"17","author":"Almoharib","year":"2025","journal-title":"Cureus"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"111","DOI":"10.17219\/dmp\/100386","article-title":"Er:YAG and diode laser application in implant bed preparation and implant uncovering: A case report","volume":"56","author":"Dominiak","year":"2019","journal-title":"Dent. Med. Probl."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.cden.2004.06.001","article-title":"Erbium lasers in dentistry","volume":"48","year":"2004","journal-title":"Dent. Clin. N. Am."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/lsm.20528","article-title":"Er:YAG laser osteotomy for removal of impacted teeth: Clinical comparison of two techniques","volume":"39","author":"Zeilhofer","year":"2007","journal-title":"Lasers Surg. Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3109\/00016357.2010.517556","article-title":"Influence of carbon dioxide laser irradiation on the healing process of extraction sockets","volume":"69","author":"Fukuoka","year":"2011","journal-title":"Acta Odontol. Scand."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Tzanakakis, E.G.C., Skoulas, E., Pepelassi, E., Koidis, P., and Tzoutzas, I.G. (2021). The use of lasers in dental materials: A review. Materials, 14.","DOI":"10.3390\/ma14123370"},{"key":"ref_43","first-page":"936","article-title":"Lasers and their applications in the dental practice","volume":"7","author":"Pandarathodiyil","year":"2020","journal-title":"Int. J. Dent. Oral. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Daigo, Y., Daigo, E., Fukuoka, H., Fukuoka, N., Ishikawa, M., and Takahashi, K. (2020). Wound healing and cell dynamics including mesenchymal and dental pulp stem cells induced by photobiomodulation therapy: An example of socket-preserving effects after tooth extraction in rats and a literature review. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21186850"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Zisis, S., Zisis, V., and Braun, A. (2025). Evaluating the efficacy of various laser types in periodontal treatment: A narrative review. Oral, 5.","DOI":"10.3390\/oral5030049"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4236\/ojst.2022.1210027","article-title":"Laser and its application in periodontology: A review of literature","volume":"12","author":"Karameh","year":"2022","journal-title":"Open J. Stomatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e099","DOI":"10.1590\/1807-3107bor-2021.vol35.0099","article-title":"Laser in periodontal treatment: Is it an effective treatment or science fiction?","volume":"35","author":"Theodoro","year":"2021","journal-title":"Braz. Oral Res."},{"key":"ref_48","first-page":"178","article-title":"Indications and limitations of Er:YAG laser applications in dentistry","volume":"19","author":"Bader","year":"2006","journal-title":"Am. J. Dent."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/4\/1447\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:52:42Z","timestamp":1770900762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/4\/1447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":48,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,2]]}},"alternative-id":["jcm15041447"],"URL":"https:\/\/doi.org\/10.3390\/jcm15041447","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]}}}