{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:02:36Z","timestamp":1771498956649,"version":"3.50.1"},"reference-count":15,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Relapsing polychondritis (RP) is a rare immune-mediated inflammatory disorder characterized by recurrent inflammation of cartilaginous structures. Although RP frequently coexists with other autoimmune disorders, its association with inflammatory bowel disease (IBD), particularly Crohn\u2019s disease, has been rarely described. We report the case of a 53-year-old man who presented with bilateral auricular inflammation sparing the earlobes and was diagnosed with RP based on clinical and histopathological findings. During treatment with systemic corticosteroids and methotrexate, he developed severe abdominal pain accompanied by inflammatory arthritis. These symptoms were initially considered related to treatment; however, subsequent endoscopic and histologic evaluation revealed Crohn\u2019s disease involving the terminal ileum. Therapeutic adjustment, including discontinuation of nonsteroidal anti-inflammatory drugs and optimization of immunosuppressive therapy, resulted in resolution of both gastrointestinal and musculoskeletal symptoms. This case emphasizes the importance of considering concomitant IBD in patients with RP who develop unexplained gastrointestinal manifestations. Recognizing this rare coexistence may facilitate earlier diagnosis and more appropriate therapeutic decision-making in patients with multisystem inflammatory disease.<\/jats:p>","DOI":"10.3390\/jcm15041609","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T09:55:31Z","timestamp":1771494931000},"page":"1609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of Relapsing Polychondritis and Crohn\u2019s Disease: Clinical Insights from a Rare Case"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-696X","authenticated-orcid":false,"given":"Sang Wan","family":"Chung","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul 02453, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00005792-197605000-00001","article-title":"Relapsing polychondritis: Prospective study of 23 patients and a review of the literature","volume":"55","author":"McAdam","year":"1976","journal-title":"Medicine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.7326\/0003-4819-104-1-74","article-title":"Relapsing polychondritis: Survival and predictive role of early disease manifestations","volume":"104","author":"Michet","year":"1986","journal-title":"Ann. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0196-0709(96)90079-4","article-title":"Relapsing polychondritis in association with Crohn\u2019s disease","volume":"17","author":"Touma","year":"1996","journal-title":"Am. J. Otolaryngol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.12701\/yujm.2020.00304","article-title":"Co-existence of relapsing polychondritis and Crohn disease treated successfully with infliximab","volume":"38","author":"Jung","year":"2021","journal-title":"Yeungnam Univ. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.2169\/internalmedicine.5024-24","article-title":"Coexistence of relapsing polychondritis, Crohn\u2019s disease, and pyoderma gangrenosum successfully treated with biologics","volume":"64","author":"Yamazaki","year":"2025","journal-title":"Intern. 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Rep., 18.","DOI":"10.1007\/s11926-015-0549-5"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"Danese","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.semarthrit.2011.08.006","article-title":"Biologics in relapsing polychondritis: A literature review","volume":"41","author":"Kraus","year":"2012","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Hutto, S.K., Maher, M.D., Miloslavsky, E.M., and Venna, N. (2021). Nodular Pachymeningitis Associated with Relapsing Polychondritis and Crohn Disease Responsive to Adalimumab and Prednisone. Neurol. Neuroimmunol. 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