{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T17:12:49Z","timestamp":1772212369730,"version":"3.50.1"},"reference-count":36,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: In this study, we aimed to evaluate whether neonatal ischemia-modified albumin (IMA) and umbilical venous cord blood gas parameters are associated with antenatal markers of fetal well-being, including the umbilical coiling index (UCI) and umbilical artery (UA) and middle cerebral artery (MCA) Doppler indices. Methods: For this prospective observational study, sixty-five low-risk term pregnancies (\u226537 weeks) were included. Prenatal ultrasound was used to measure the UCI and UA\/MCA Doppler indices. At delivery, umbilical venous cord blood gas and serum IMA analyses were performed. Maternal and neonatal data (birth weight, 5 min Apgar score, NICU admission, sex, and delivery mode) were recorded, and correlations and group comparisons were performed (p &lt; 0.05). Results: The UCI ranged from 0.210 to 0.471 coil\/cm (mean 0.337). The UA and MCA Doppler indices were within the reference ranges. The UCI showed no significant correlation with umbilical venous blood gas values, IMA, UA\/MCA Doppler indices, gestational age\/weeks, or 5 min Apgar score. The UA S\/D ratio and UA resistive index (RI) were negatively correlated with birth weight (p &lt; 0.05). Umbilical venous pH was positively correlated with the 5 min Apgar score, whereas venous pCO2 was negatively correlated with the 5 min Apgar score (both p &lt; 0.05). Newborns with venous pH &lt; 7.32 had higher cesarean delivery rates and higher rooming-in rates. Newborns admitted to the NICU had higher mean UA systolic velocity\/diastolic velocity (S\/D) and UA pulsatility index (PI) and lower venous pH. Conclusions: In low-risk term pregnancies, the UCI was not associated with cord blood gas parameters, IMA, or UA\/MCA Doppler indices. These results suggest that the UCI may have limited clinical utility as a predictor of early neonatal acidosis or oxidative stress in a strictly low-risk population.<\/jats:p>","DOI":"10.3390\/jcm15051810","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T15:52:38Z","timestamp":1772207558000},"page":"1810","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Umbilical Coiling Index, Doppler Parameters, and Cord Blood Gas Analysis: Lack of Correlation in Uncomplicated Term Pregnancies"],"prefix":"10.3390","volume":"15","author":[{"given":"Zeynep Begum","family":"Celik","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Turhal State Hospital, Tokat 60300, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulseren","family":"Dinc","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleyman Caner","family":"Karahan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumeyye Sura","family":"Ayan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-4525","authenticated-orcid":false,"given":"Suleyman","family":"Guven","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon 61080, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S6.e1","DOI":"10.1016\/j.ajog.2015.07.050","article-title":"What is the placenta?","volume":"213","author":"Burton","year":"2015","journal-title":"Am. 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