{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:20:23Z","timestamp":1778934023394,"version":"3.51.4"},"reference-count":160,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hair loss, or alopecia, constitutes a significant and prevalent concern affecting individuals worldwide. Despite the availability of numerous commercial solutions, many individuals continue to experience substantial psychological distress, leading to adverse impact on personal relationships, social interactions, and occupational performance. The limitations of conventional treatments, such as oral medication with potential systemic side effects and topical applications with localized adverse events, have driven the exploration of alternative therapies. Emerging localized injectable treatments for hair regrowth (PRP, stem cells, exosomes) offer a promising avenue for addressing this persistent issue. These injectable therapies hold the potential to minimize the systemic side effects often associated with oral medications, while also mitigating the localized adverse events that can arise from topical applications. This narrative review provides a comprehensive overview of the medical state-of-the-art in off-label injectable hair regrowth treatments, delving into the diverse range of available options. A critical component of this narrative review involves a thorough evaluation of relevant clinical studies, assessing the efficacy and safety profiles of these emerging therapies. Furthermore, detailed attention is given to injection techniques and administration protocols, crucial factors in optimizing treatment outcomes. These evolving therapies represent a significant advancement in the field of scalp regenerative medicine. By stimulating hair follicle reactivation, these treatments aim to promote sustained and natural hair growth, providing individuals with more effective and durable solutions. The enhanced safety profiles of these injectable therapies, compared to conventional systemic pharmacological treatments (minoxidil, finasteride), offer a substantial improvement in patient care, addressing a widespread clinical need.<\/jats:p>","DOI":"10.3390\/jcm15051836","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:24:34Z","timestamp":1772447074000},"page":"1836","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Advances in Medicalized Hair Loss Solutions: A Review of Current Clinical Practices and Regenerative Medicine-Based Protocols with Focus on Off-Label Injectable Treatments"],"prefix":"10.3390","volume":"15","author":[{"given":"Angelica","family":"Ferro","sequence":"first","affiliation":[{"name":"Development Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alkhowailed","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Qassim University, Buraidah 52571, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-2704","authenticated-orcid":false,"given":"Alexandre","family":"Porcello","sequence":"additional","affiliation":[{"name":"Development Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0093-8826","authenticated-orcid":false,"given":"Marco","family":"Cerrano","sequence":"additional","affiliation":[{"name":"Aesthetic Surgery Department, Entourage Aesthetic Clinic, CH-1003 Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e8le","family":"Chemali","sequence":"additional","affiliation":[{"name":"Plastic and Aesthetic Surgery Service, Centre M\u00e9dical Lausanne Ouest, CH-1008 Prilly, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Louren\u00e7o","sequence":"additional","affiliation":[{"name":"Development Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00edntia","family":"Marques","sequence":"additional","affiliation":[{"name":"Development Department, LOUNA REGENERATIVE SA, CH-1207 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8916-9463","authenticated-orcid":false,"given":"Wassim","family":"Raffoul","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery, Ensemble Hospitalier de la C\u00f4te, CH-1110 Morges, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7346-9921","authenticated-orcid":false,"given":"Lee Ann","family":"Applegate","sequence":"additional","affiliation":[{"name":"Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland"},{"name":"Center for Applied Biotechnology and Molecular Medicine, University of Zurich, CH-8057 Zurich, Switzerland"},{"name":"Oxford OSCAR Suzhou Center, Oxford University, Suzhou 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-8702","authenticated-orcid":false,"given":"Alexis E.","family":"Laurent","sequence":"additional","affiliation":[{"name":"Manufacturing Department, LAM Biotechnologies SA, CH-1066 Epalinges, Switzerland"},{"name":"Manufacturing Department, TEC-PHARMA SA, CH-1038 Bercher, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/jdv.17079","article-title":"Common causes of hair loss\u2014Clinical manifestations, trichoscopy and therapy","volume":"35","author":"Alessandrini","year":"2021","journal-title":"J. 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