{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T11:15:25Z","timestamp":1772450125271,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Transcatheter edge-to-edge repair (TEER) has emerged as an established treatment option for patients with severe mitral (MR) and tricuspid regurgitation (TR) who are at high surgical risk. Patients referred for TEER frequently present with advanced comorbidities, including cirrhosis or chronic liver disease (CLD). Hepatic dysfunction, driven by chronic venous congestion and impaired cardiac output, represents a key yet underrecognized determinant of prognosis in this population. The impact of TEER on hepatic function and outcomes in patients with advanced liver disease remains incompletely defined. Methods: This systematic review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO. A comprehensive literature search of PubMed, Scopus, Web of Science, and the Cochrane Library was performed up to 16 January 2026, without language restrictions. Studies evaluating mitral or tricuspid TEER in adult patients with cirrhosis, chronic or advanced liver disease, congestive hepatopathy, or cardiohepatic syndrome were included. Hepatic function was assessed using biochemical markers, clinical diagnoses, or composite scores such as Model for End-Stage Liver Disease (MELD) score and Model for End-Stage Liver Disease Excluding INR (MELD-XI). A qualitative synthesis was performed due to heterogeneity in study design and outcome reporting. Results: Twelve studies were included, comprising prospective and retrospective cohorts, registry-based analyses, mechanistic studies, and one illustrative case report. Six studies evaluated mitral TEER (M-TEER) and six tricuspid (T-TEER). Across both valve interventions, impaired baseline hepatic function was consistently associated with increased mortality and adverse clinical outcomes. MELD and MELD-XI scores emerged as robust prognostic markers following both M-TEER and T-TEER. Successful reduction in valvular regurgitation was associated with stabilization or improvement of hepatic parameters in selected patients, particularly after T-TEER. However, advanced cardiohepatic syndrome and limited hepatic reserve were linked to poor outcomes despite procedural success. Conclusions: Hepatic dysfunction is a powerful determinant of prognosis in patients undergoing M-TEER and T-TEER. While TEER may improve hepatic congestion and liver-related parameters in selected patients, outcomes are highly dependent on baseline hepatic reserve and global hemodynamic status. A personalized approach integrating hepatic assessment into patient selection and risk stratification is essential to optimize outcomes in this complex and growing population.<\/jats:p>","DOI":"10.3390\/jcm15051883","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T10:24:34Z","timestamp":1772447074000},"page":"1883","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Transcatheter Mitral and Tricuspid Valve Repair on Hepatic Function and Outcomes in Patients with Cirrhosis or Advanced Liver Disease\u2014A Personalized Approach"],"prefix":"10.3390","volume":"15","author":[{"given":"Tina","family":"Be\u010di\u0107","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-666X","authenticated-orcid":false,"given":"Ivana","family":"Juki\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital of Split, 21000 Split, Croatia"},{"name":"Faculty of Health Sciences, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-2345","authenticated-orcid":false,"given":"Petra \u0160imac","family":"Pri\u017emi\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Allergology and Clinical Immunology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivona","family":"Matuli\u0107","sequence":"additional","affiliation":[{"name":"Private Clinic Matulic, Osjecka Ulica 24a, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-0006","authenticated-orcid":false,"given":"Hana","family":"\u0110oga\u0161","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-6800","authenticated-orcid":false,"given":"Mislav","family":"Radi\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Allergology and Clinical Immunology, University Hospital of Split, 21000 Split, Croatia"},{"name":"Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2645-7597","authenticated-orcid":false,"given":"Josipa","family":"Radi\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia"},{"name":"Department of Internal Medicine, Division of Nephrology, Dialysis and Arterial Hypertension, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-7988","authenticated-orcid":false,"given":"Jonatan","family":"Vukovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, University Hospital of Split, 21000 Split, Croatia"},{"name":"Department of Internal Medicine, School of Medicine, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-3905","authenticated-orcid":false,"given":"Damir","family":"Fabijani\u0107","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Diseases, University Hospital of Split, 21000 Split, Croatia"},{"name":"Department of Clinical Propedeutics, School of Medicine, University of Split, 21000 Split, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1056\/NEJMoa1009355","article-title":"Percutaneous Repair or Surgery for Mitral Regurgitation","volume":"364","author":"Feldman","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.1016\/j.jacc.2015.10.018","article-title":"Randomized Comparison of Percutaneous Repair and Surgery for Mitral Regurgitation: 5-Year Results of EVEREST II","volume":"66","author":"Feldman","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1056\/NEJMoa1806640","article-title":"Transcatheter Mitral-Valve Repair in Patients with Heart Failure","volume":"379","author":"Stone","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1056\/NEJMoa1805374","article-title":"Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation","volume":"379","author":"Obadia","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1056\/NEJMoa2300213","article-title":"Five-Year Follow-up after Transcatheter Repair of Secondary Mitral Regurgitation","volume":"388","author":"Stone","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/eurjhf\/hfs079","article-title":"MitraClip Therapy in Daily Clinical Practice: Initial Results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry","volume":"14","author":"Baldus","year":"2012","journal-title":"Eur. J. Heart Fail."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/eurheartj\/ehv627","article-title":"One-Year Outcomes and Predictors of Mortality after MitraClip Therapy in Contemporary Clinical Practice: Results from the German Transcatheter Mitral Valve Interventions Registry","volume":"37","author":"Puls","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.jacc.2017.09.015","article-title":"Outcomes with Transcatheter Mitral Valve Repair in the United States: An STS\/ACC TVT Registry Report","volume":"70","author":"Sorajja","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1016\/j.jacc.2013.03.042","article-title":"Cardiohepatic Interactions in Heart Failure: An Overview and Clinical Implications","volume":"61","author":"Samsky","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jchf.2018.10.007","article-title":"Heart Failure and Liver Disease: Cardiohepatic Interactions","volume":"7","author":"Xanthopoulos","year":"2019","journal-title":"JACC Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Aspromonte, N., Fumarulo, I., Petrucci, L., Biferali, B., Liguori, A., Gasbarrini, A., Massetti, M., and Miele, L. (2023). The Liver in Heart Failure: From Biomarkers to Clinical Risk. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242115665"},{"key":"ref_12","first-page":"e58766","article-title":"Congestive Hepatopathy: A Review of the Literature","volume":"16","author":"Haddadin","year":"2024","journal-title":"Cureus"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1053\/jhep.2001.22172","article-title":"A Model to Predict Survival in Patients with End-Stage Liver Disease","volume":"33","author":"Kamath","year":"2001","journal-title":"Hepatology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.healun.2012.02.027","article-title":"Liver Dysfunction as a Predictor of Outcomes in Patients with Advanced Heart Failure Requiring Ventricular Assist Device Support: Use of the Model of End-Stage Liver Disease (MELD) and MELD eXcluding INR (MELD-XI) Scoring System","volume":"31","author":"Yang","year":"2012","journal-title":"J. Heart Lung Transplant."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wernly, B., Lichtenauer, M., Franz, M., Kabisch, B., Muessig, J., Masyuk, M., Hoppe, U.C., Kelm, M., and Jung, C. (2017). Model for End-Stage Liver Disease Excluding INR (MELD-XI) Score in Critically Ill Patients: Easily Available and of Prognostic Relevance. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0170987"},{"key":"ref_16","first-page":"1413","article-title":"Impact of Transcatheter Tricuspid Valve Repair for Severe Tricuspid Regurgitation on Kidney and Liver Function","volume":"12","author":"Karam","year":"2019","journal-title":"J. Am. Coll. Cardiol. Cardiovasc. Interv."},{"key":"ref_17","first-page":"699","article-title":"Prognostic Value of Impaired Hepato-Renal Function Assessed by the MELD-XI Score in Patients Undergoing Percutaneous Mitral Valve Repair","volume":"93","author":"Spieker","year":"2019","journal-title":"Catheter Cardiovasc. Interv."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1007\/s00392-021-01908-w","article-title":"Prognostic Value of Hepatorenal Function Following Transcatheter Edge-to-Edge Mitral Valve Repair","volume":"110","author":"Tanaka","year":"2021","journal-title":"Clin. Res. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcin.2021.10.033","article-title":"Cardiohepatic Syndrome Is Associated with Poor Prognosis in Patients Undergoing Tricuspid Transcatheter Edge-to-Edge Valve Repair","volume":"15","author":"Stolz","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1016\/j.jacc.2024.08.044","article-title":"Impact of Renal and Liver Function on Clinical Outcomes Following Tricuspid Valve Transcatheter Edge-to-Edge Repair","volume":"84","author":"Jorde","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/ejhf.2875","article-title":"Transcatheter Edge-to-Edge Repair: Fix the Heart, Heal the Liver","volume":"25","author":"Scotti","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4254\/wjh.v7.i5.753","article-title":"Influence of Cirrhosis in Cardiac Surgery Outcomes","volume":"7","author":"Esteve","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.athoracsur.2020.06.110","article-title":"Cardiac Surgery in Patients with Liver Cirrhosis (CASTER) Study: Early and Long-Term Outcomes","volume":"111","author":"Garatti","year":"2021","journal-title":"Ann. Thorac. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.carrev.2020.08.014","article-title":"Outcomes of MitraClip Placement in Patients with Liver Cirrhosis","volume":"29","author":"Sawalha","year":"2021","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1002\/ejhf.2842","article-title":"Cardio-hepatic syndrome in patients undergoing mitral valve transcatheter edge-to-edge repair","volume":"25","author":"Stolz","year":"2023","journal-title":"Eur. J. Heart Fail."},{"key":"ref_27","first-page":"344","article-title":"Transcatheter mitral valve repair in patients with chronic liver disease: Insights from the National Inpatient Sample","volume":"97","author":"Khan","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carrev.2024.08.001","article-title":"Risk factors for early mortality following transcatheter edge-to-edge repair of mitral regurgitation","volume":"74","author":"Yeo","year":"2025","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1111\/echo.15494","article-title":"Transcatheter mitral valve repair in a liver transplant candidate","volume":"39","author":"Ates","year":"2022","journal-title":"Echocardiography"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/ejhf.2307","article-title":"Cardiac output states in patients with severe functional tricuspid regurgitation: Impact on treatment success and prognosis","volume":"23","author":"Unterhuber","year":"2021","journal-title":"Eur. J. Heart Fail."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1016\/j.jcin.2023.07.040","article-title":"Stressed blood volume in severe tricuspid regurgitation: Implications for transcatheter treatment","volume":"16","author":"Rommel","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_32","first-page":"100414","article-title":"In-hospital outcomes of transcatheter tricuspid valve repair: An analysis from the National Inpatient Sample","volume":"1","author":"Torres","year":"2022","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jacc.2013.04.030","article-title":"4-Year Results of a Randomized Controlled Trial of Percutaneous Repair versus Surgery for Mitral Regurgitation","volume":"62","author":"Mauri","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1161\/CIRCULATIONAHA.116.024848","article-title":"Transcatheter Treatment of Severe Tricuspid Regurgitation with the Edge-to-Edge MitraClip Technique","volume":"135","author":"Nickenig","year":"2017","journal-title":"Circulation"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.jacc.2020.11.038","article-title":"Transcatheter Edge-to-Edge Repair for Treatment of Tricuspid Regurgitation","volume":"77","author":"Lurz","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1056\/NEJMoa2300525","article-title":"Transcatheter Repair for Patients with Tricuspid Regurgitation","volume":"388","author":"Sorajja","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1161\/CIRCULATIONAHA.125.074536","article-title":"Two-Year Outcomes of Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation: The TRILUMINATE Pivotal Randomized Controlled Trial","volume":"151","author":"Kar","year":"2025","journal-title":"Circulation"},{"key":"ref_38","first-page":"975","article-title":"Cardiac Syndromes in Liver Disease: A Clinical Conundrum","volume":"11","author":"Brankovic","year":"2023","journal-title":"J. Clin. Transl. Hepatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e043895","DOI":"10.1161\/JAHA.125.043895","article-title":"Noninvasive Hemodynamic Characterization of Cardiohepatic Syndrome in the Cardiac Intensive Care Unit","volume":"14","author":"Butt","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1053\/he.2000.5852","article-title":"A Model to Predict Poor Survival in Patients Undergoing Transjugular Intrahepatic Portosystemic Shunts","volume":"31","author":"Malinchoc","year":"2000","journal-title":"Hepatology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jacc.2013.02.094","article-title":"Percutaneous Mitral Valve Interventions in the Real World: Early and 1-Year Results from the ACCESS-EU, a Prospective, Multicenter, Nonrandomized Post-Approval Study of the MitraClip Therapy in Europe","volume":"62","author":"Maisano","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_42","first-page":"155","article-title":"Outcomes after Current Transcatheter Tricuspid Valve Intervention: Mid-Term Results from the International TriValve Registry","volume":"12","author":"Taramasso","year":"2019","journal-title":"J. Am. Coll. Cardiol. Cardiovasc. Interv."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"e343","DOI":"10.4244\/EIJ-D-21-00191","article-title":"Outcomes of Transcatheter Tricuspid Valve Intervention by Right Ventricular Function: A Multicentre Propensity-Matched Analysis","volume":"17","author":"Schlotter","year":"2021","journal-title":"EuroIntervention"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the Management of Valvular Heart Disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_45","first-page":"447","article-title":"10 Issues for the Clinician in Tricuspid Regurgitation Evaluation and Management: 2025 ACC Expert Consensus Decision Pathway: A Report of the American College of Cardiology Solution Set Oversight Committee","volume":"87","author":"Lindenfeld","year":"2025","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS Guidelines for the Management of Valvular Heart Disease","volume":"46","author":"Praz","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.xjon.2023.07.001","article-title":"Outcomes of Patients with Advanced Liver Disease Undergoing Cardiac Surgery","volume":"16","author":"Amabile","year":"2023","journal-title":"JTCVS Open"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"21800","DOI":"10.1038\/s41598-021-01322-2","article-title":"Renal and Hepatic Function of Patients with Severe Tricuspid Regurgitation Undergoing Inferior Caval Valve Implantation","volume":"11","author":"Hewing","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_49","first-page":"101714","article-title":"Effects of Transcatheter Tricuspid Valve Replacement on Hepatic and Renal Function in Severe Tricuspid Regurgitation","volume":"59","author":"Li","year":"2025","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"104353","DOI":"10.1016\/j.jaccas.2025.104353","article-title":"Transcatheter Tricuspid Valve Replacement Beyond Boundaries","volume":"30","author":"George","year":"2025","journal-title":"JACC Case Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jjcc.2025.03.009","article-title":"Tricuspid Regurgitation: Innovation, Current Landscape, and Future Perspective of Transcatheter Tricuspid Valve Interventions","volume":"86","author":"Sugiura","year":"2025","journal-title":"J. Cardiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jamacardio.2019.4428","article-title":"Association of Pulmonary Hypertension with Clinical Outcomes of Transcatheter Mitral Valve Repair","volume":"5","author":"Vemulapalli","year":"2020","journal-title":"JAMA Cardiol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1136\/heartjnl-2023-323473","article-title":"Association of Pulmonary Hypertension with the Outcome in Patients Undergoing Edge-to-Edge Mitral Valve Repair","volume":"110","author":"Ubben","year":"2024","journal-title":"Heart"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/ejhf.2637","article-title":"Evolution of Tricuspid Regurgitation after Transcatheter Edge-to-Edge Mitral Valve Repair for Secondary Mitral Regurgitation and Its Impact on Mortality","volume":"24","author":"Adamo","year":"2022","journal-title":"Eur. J. Heart Fail."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.4244\/EIJ-D-19-00718","article-title":"Impact of Mitral Regurgitation Aetiology on MitraClip Outcomes: The MitraSwiss Registry","volume":"16","author":"Klersy","year":"2020","journal-title":"EuroIntervention"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1161\/CIRCULATIONAHA.117.031733","article-title":"One-Year Outcomes After MitraClip for Functional Mitral Regurgitation","volume":"139","author":"Ailawadi","year":"2019","journal-title":"Circulation"},{"key":"ref_57","first-page":"2600","article-title":"1-Year Outcomes with Fourth-Generation Mitral Valve Transcatheter Edge-to-Edge Repair from the EXPAND G4 Study","volume":"16","author":"Mahoney","year":"2023","journal-title":"J. Am. Coll. Cardiol. Cardiovasc. Interv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jcin.2021.11.014","article-title":"Tricuspid Transcatheter Edge-to-Edge Valve Repair: Sooner Rather Than Later","volume":"15","author":"Burwash","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_59","first-page":"102644","article-title":"Inpatient Outcomes of Tricuspid Transcatheter Edge-to-Edge Repair in the United States Based on Sex","volume":"4","author":"Nguyen","year":"2025","journal-title":"J. Soc. Cardiovasc. Angiogr. Interv."},{"key":"ref_60","first-page":"E14","article-title":"Significantly Elevated Alkaline Phosphatase Caused by Congestive Hepatopathy in the Setting of Heart Failure with Preserved Ejection Fraction","volume":"121","author":"Wu","year":"2022","journal-title":"WMJ"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"European Association for the Study of the Liver (EASL) (2022). EASL Clinical Practice Guidelines on Prevention Management of Bleeding Thrombosis in Patients with Cirrhosis. J. Hepatol., 76, 1151\u20131184.","DOI":"10.1016\/j.jhep.2021.09.003"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Khandait, H., Jaiswal, V., Hanif, M., Shrestha, A.B., Iturburu, A., Shah, M., Ishak, A., Garimella, V., Ang, S.P., and Mathew, M. (2023). Percutaneous Coronary Intervention Outcomes in Patients with Liver Cirrhosis: A Systematic Review and Meta-Analysis. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10030092"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Sah, A.K., Afzal, M., Elshaikh, R.H., Abbas, A.M., Shalabi, M.G., Prabhakar, P.K., Babker, A.M.A., Khalimova, F.T., Sabrievna, V.A., and Choudhary, R.K. (2025). Innovative Strategies in the Diagnosis and Treatment of Liver Cirrhosis and Associated Syndromes. Life, 15.","DOI":"10.3390\/life15050779"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Russo, G., Maisano, F., Massaro, G., Terlizzese, G., Mariano, E., Bonanni, M., Matteucci, A., Bezzeccheri, A., Benedetto, D., and Chiricolo, G. (2022). Challenges and Open Issues in Transcatheter Mitral Valve Implantation: Smooth Seas Do Not Make Skillful Sailors. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.738756"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.carrev.2025.06.029","article-title":"Transcatheter Treatment of Tricuspid Regurgitation: A State-of-the-Art Review","volume":"82","author":"Sanfilippo","year":"2026","journal-title":"Cardiovasc. Revasc. 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