{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:36:34Z","timestamp":1793230594074,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Daiichi-Sankyo, Tokyo, Japan"},{"name":"Galician Cardiology Society"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Atrial fibrillation (AF) is the most common sustained arrhythmia in adults, with a prevalence that increases with age. In older patients, its clinical impact is particularly relevant due to higher mortality and greater comorbidity burden. This study aimed to compare patients aged \u226580 years with younger patients in a large AF cohort. Methods: The REGUEIFA registry is an observational, prospective, multicentre study including consecutive patients with AF managed by cardiologists. Baseline clinical characteristics, comorbidities, complementary test findings, AF type, therapeutic strategies, anticoagulation patterns, and patient-reported outcomes were compared. Results: A total of 1007 patients were included, of whom 18.2% were aged \u226580 years. Older patients showed a higher prevalence of hypertension, renal dysfunction, conduction disorders, chronic obstructive pulmonary disease, and neoplastic disease, along with higher thromboembolic (CHA2DS2-VASc 3.7 \u00b1 1.04 vs. 2.1 \u00b1 1.49; p &lt; 0.001) and haemorrhagic risk (HAS-BLED 1.3 \u00b1 0.8 vs. 0.6 \u00b1 0.7; p &lt; 0.001). Permanent AF was more frequent, whereas rhythm control strategies and antiarrhythmic drug use were less common, and quality of life was poorer. Anticoagulation rates were high in both groups (\u224890%), with greater use of vitamin K antagonists (VKAs) in older patients, although anticoagulation control was similar. Patients treated with direct-acting oral anticoagulants reported a lower treatment burden and greater perceived benefit than those receiving VKAs. Conclusions: Patients aged \u226580 years with AF exhibit greater comorbidity, poorer perceived health status, and higher thromboembolic and haemorrhagic risk. Their management is more often oriented towards rate control strategies and VKA use, while rhythm control approaches are more common in younger patients.<\/jats:p>","DOI":"10.3390\/jcm15051955","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T13:11:36Z","timestamp":1772629896000},"page":"1955","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age-Related Differences in the Clinical Profile and Management of Atrial Fibrillation: Results from the Multicentre REGUEIFA Registry"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6478-262X","authenticated-orcid":false,"given":"Alejandro Manuel","family":"L\u00f3pez-Pena","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"},{"name":"CardioHULA Research Group, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela FIDIS, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Elices-Teja","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"},{"name":"CardioHULA Research Group, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela FIDIS, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Dur\u00e1n-Bob\u00edn","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"},{"name":"CardioHULA Research Group, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela FIDIS, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-221X","authenticated-orcid":false,"given":"Laila","family":"Gonz\u00e1lez-Melchor","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"},{"name":"CardioHULA Research Group, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela FIDIS, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0625-6555","authenticated-orcid":false,"given":"Mar\u00eda","family":"V\u00e1zquez-Caama\u00f1o","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital San Rafael, 15006 La Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Fern\u00e1ndez-Obanza","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital \u00c1lvaro Cunqueiro and Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IISGS), 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gonz\u00e1lez-Babarro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Montecelo, 36071 Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Cabanas-Grand\u00edo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital \u00c1lvaro Cunqueiro and Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IISGS), 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Pi\u00f1eiro-Portela","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complexo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Prada-Delgado","sequence":"additional","affiliation":[{"name":"Cardiology Department, Complexo Hospitalario Universitario de A Coru\u00f1a, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Guti\u00e9rrez-Feijoo","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de Ourense, 32005 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evaristo","family":"Freire","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital de Ourense, 32005 Ourense, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"D\u00edaz-Castro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital \u00c1lvaro Cunqueiro and Instituto de Investigaci\u00f3n Sanitaria Galicia Sur (IISGS), 36312 Vigo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3087-2067","authenticated-orcid":false,"given":"Javier","family":"Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n Cardiovascular, Departamento de Ciencias de la Salud and Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Universidade da Coru\u00f1a, CIBERCV, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7903-9490","authenticated-orcid":false,"given":"Javier","family":"Garc\u00eda-Seara","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Cl\u00ednico de Santiago de Compostela, CIBERCV, 15706 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-9778","authenticated-orcid":false,"given":"Carlos","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitario Lucus Augusti, 27003 Lugo, Spain"},{"name":"CardioHULA Research Group, Fundaci\u00f3n Instituto de Investigaci\u00f3n Sanitaria de Santiago de Compostela FIDIS, 27003 Lugo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Rienstra","year":"2024","journal-title":"Eur. 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