{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:20:32Z","timestamp":1790886032987,"version":"4.1.0"},"reference-count":54,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: This study assessed the relationship between serum calcium (Ca) and parathyroid hormone (PTH) levels, the size and weight of the enlarged parathyroid gland (PG), and the results of technetium-99m-metoxyisobutylisonitrile (MIBI) parathyroid scintigraphy with single-photon emission computed tomography\/computed tomography. Methods: Among 252 patients who underwent surgery for hyperparathyroidism between October 2022 and March 2025 at the Department of Endocrine Surgery of the University Hospital in Krakow, 212 patients with primary hyperparathyroidism (PHPT) were selected and divided into the MIBI(\u2212) (n = 49) and MIBI(+) (n = 163) groups. Results: MIBI was positive in 76.9% and negative in 23.1% patients with PHPT. Mean PTH in the MIBI(+) and MIBI(\u2212) groups was 177.3 \u00b1 144.7 and 127.7 \u00b1 59.4 pg\/mL, respectively. Significant differences were found in PTH (p &lt; 0.01), maximum excised PG size (p &lt; 0.01), and weight (p &lt; 0.01). PTH predicted positive scintigraphy in univariate analysis (OR = 2.65; 95% CI: 1.19\u20135.89; p = 0.02) and showed a borderline association in the multivariate model (OR = 2.47; 95% CI: 0.95\u20136.41; p = 0.06). Optimal cut-offs for predicting MIBI positivity were 135.0 pg\/mL for PTH (AUC = 0.64), 0.73 g for PG weight (AUC = 0.81), and 18.0 mm for PG maximum size (AUC = 0.78). The Wisconsin index (Ca \u00d7 PTH) was associated with positive MIBI (OR = 2.58; 95% CI: 1.15\u20135.78; p = 0.02), with an optimal cut-off of 256.0. Serum total Ca levels showed no significant association with positive MIBI (p = 0.60). Conclusions: Serum PTH levels, Wisconsin index, and enlarged PG size and weight may help predict parathyroid scintigraphy outcomes.<\/jats:p>","DOI":"10.3390\/jcm15051973","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T16:17:31Z","timestamp":1772641051000},"page":"1973","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Biochemical Parameters, Parathyroid Gland Morphometry, and Dual-Phase MIBI SPECT\/CT Findings in Primary Hyperparathyroidism"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9953-7198","authenticated-orcid":false,"given":"Anna","family":"Krzentowska","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Andrzej Frycz Modrzewski Krakow University Medical College, 30-705 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-4082","authenticated-orcid":false,"given":"Aleksander J\u00f3zef","family":"Konturek","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8157","authenticated-orcid":false,"given":"Filip","family":"Go\u0142kowski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Internal Medicine, Andrzej Frycz Modrzewski Krakow University Medical College, 30-705 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-6945","authenticated-orcid":false,"given":"Anna","family":"Merklinger-Grucha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics and Public Health, Andrzej Frycz Modrzewski Krakow University Medical College, 30-705 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-1851","authenticated-orcid":false,"given":"Marcin","family":"Barczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101247","DOI":"10.1016\/j.beem.2018.09.013","article-title":"Primary hyperparathyroidism","volume":"38","author":"Silva","year":"2024","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R56","DOI":"10.1530\/EC-17-0283","article-title":"Diagnosis, management, histology and genetics of sporadic primary hyperparathyroidism: Old knowledge with new tricks","volume":"7","author":"Mizamtsidi","year":"2018","journal-title":"Endocr. Connect."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000491034","article-title":"Primary Hyperparathyroidism","volume":"Volume 51","author":"Masi","year":"2019","journal-title":"Parathyroid Disorders: Focusing on Unmet Needs; Frontiers of Hormone Research"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12022-022-09709-1","article-title":"Overview of the 2022 WHO Classification of Parathyroid Tumors","volume":"33","author":"Erickson","year":"2022","journal-title":"Endocr. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3580","DOI":"10.1210\/jc.2014-1415","article-title":"Current issues in the presentation of asymptomatic primary hyperparathyroidism: Proceedings of the Fourth International Workshop","volume":"99","author":"Silverberg","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"zrae037","DOI":"10.1093\/bjsopen\/zrae037","article-title":"Operative management of primary hyperparathyroidism in Europe","volume":"8","author":"Bergenfelz","year":"2024","journal-title":"BJS Open"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2478\/raon-2020-0010","article-title":"Surgical options in treating patients with primary hyperparathyroidism","volume":"54","author":"Majcen","year":"2020","journal-title":"Radiol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.soc.2015.08.012","article-title":"Minimally Invasive Parathyroidectomy Versus Bilateral Neck Exploration for Primary Hyperparathyroidism","volume":"25","author":"Laird","year":"2016","journal-title":"Surg. Oncol. Clin. N. Am."},{"key":"ref_9","first-page":"127","article-title":"Comparison of SPET\/CT, SPET and planar imaging using Tc-MIBI as independent techniques to support minimally invasive parathyroidectomy in primary hyperparathyroidism: A meta-analysis","volume":"18","author":"Wei","year":"2015","journal-title":"Hell. J. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1210\/jc.2014-1413","article-title":"Guidelines for the management of asymptomatic primary hyperparathyroidism: Summary statement from the Fourth International Workshop","volume":"99","author":"Bilezikian","year":"2014","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Morris, M.A., Saboury, B., Ahlman, M., Malayeri, A.A., Jones, E.C., Chen, C.C., and Millo, C. (2022). Parathyroid Imaging: Past, Present, and Future. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.760419"},{"key":"ref_12","first-page":"152","article-title":"Radio-guided procedure in minimally invasive surgery for primary hyperparathyroidism","volume":"101","year":"2023","journal-title":"Cir. Esp."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijsu.2017.02.009","article-title":"Feasibility and safety of minimally invasive radioguided parathyroidectomy using very low intraoperative dose of Tc-99m MIBI","volume":"39","author":"Mehrabibahar","year":"2017","journal-title":"Int. J. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/07435800.2018.1437747","article-title":"MIBI scintigraphy of parathyroid adenomas: Correlation with biochemical and histological markers","volume":"43","author":"Cordes","year":"2018","journal-title":"Endocr. Res."},{"key":"ref_15","first-page":"208","article-title":"Interrelation between preoperative tests, intraoperative findings and outcomes of 99m-technetium-sestamibi scan in primary hyperparathyroidism","volume":"19","author":"Kostek","year":"2023","journal-title":"Acta Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1475-097X.2011.01048.x","article-title":"Correlation between serum calcium levels and dual-phase (99m)Tc-sestamibi parathyroid scintigraphy in primary hyperparathyroidism","volume":"32","author":"Mshelia","year":"2012","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/MNM.0000000000000803","article-title":"The relationship between semiquantitative parameters derived from technetium-99m metoxyisobutylisonitrile dual-phase parathyroid single-photon emission computed tomography images and disease severity in primary hyperparathyroidism","volume":"39","author":"Araz","year":"2018","journal-title":"Nucl. Med. Commun."},{"key":"ref_18","first-page":"148","article-title":"Diagnostic value of clinical parameters and parathyroid scintigraphy for asymptomatic primary hyperparathyroidism","volume":"23","author":"Ning","year":"2020","journal-title":"Hell. J. Nucl. Med."},{"key":"ref_19","first-page":"207","article-title":"Influence of medication and PTH levels on detection of parathyroid adenomas with dual isotope parathyroid scintigraphy","volume":"11","author":"Geysen","year":"2021","journal-title":"Am. J. Nucl. Med. Mol. Imaging"},{"key":"ref_20","first-page":"222","article-title":"Factors associated with negative 99mTc-MIBI scanning in patients with primary hyperparathyroidism","volume":"40","author":"Carral","year":"2021","journal-title":"Rev. Esp. Med. Nucl. Imagen Mol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3803\/EnM.2020.823","article-title":"Radioactive Parathyroid Adenomas on Sestamibi Scans: Low Parathyroid Hormone Secretory Potential and Large Volume","volume":"36","author":"Kong","year":"2021","journal-title":"Endocrinol. Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1001\/archsurg.142.4.381","article-title":"Predictors of an accurate preoperative sestamibi scan for single-gland parathyroid adenomas","volume":"142","author":"Stephen","year":"2007","journal-title":"Arch. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"101967","DOI":"10.1016\/j.beem.2024.101967","article-title":"Localization in primary hyperparathyroidism","volume":"39","author":"Aggarwal","year":"2025","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00259-014-2837-0","article-title":"18F-Fluorocholine PET\/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: A pilot study","volume":"41","author":"Lezaic","year":"2014","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2967\/jnumed.119.229914","article-title":"18F-Fluorocholine PET\/CT in Primary Hyperparathyroidism: Superior Diagnostic Performance to Conventional Scintigraphic Imaging for Localization of Hyperfunctioning Parathyroid Glands","volume":"61","author":"Cuderman","year":"2020","journal-title":"J. Nucl. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.2967\/jnumed.120.257303","article-title":"Assessment and Comparison of 18F-Fluorocholine PET and 99mTc-Sestamibi Scans in Identifying Parathyroid Adenomas: A Metaanalysis","volume":"62","author":"Whitman","year":"2021","journal-title":"J. Nucl. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s13304-025-02090-8","article-title":"How has the diagnostic approach to parathyroid localization techniques evolved in the past decade? Insights from a single-center experience","volume":"77","author":"Cacciatore","year":"2025","journal-title":"Updates Surg."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Chiu, W.Y., Chen, K.Y., Shun, C.T., Wu, M.H., Tsai, K.S., Chiu, C.H., Yang, W.S., and Yen, R.F. (2025). Conventional imaging techniques plus 18F-Fluorocholine PET\/CT: A comparative study of diagnostic accuracy in localizing parathyroid adenomas in primary hyperparathyroidism. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1595461"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.5603\/ep.103003","article-title":"Contemporary localization diagnostics in primary hyperparathyroidism. Review of visualization techniques including ultrasonography, PTH washout, 99mTc-MIBI scintigraphy, and 18F-choline PET","volume":"76","author":"Witowska","year":"2025","journal-title":"Endokrynol. Pol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s11845-022-03215-3","article-title":"Analysis of intraoperative laboratory measurements and imaging techniques such as Tc-99 m-MIBI SPECT\/CT, 18F-fluorocholine PET\/CT and ultrasound in patients operated with prediagnosis of parathyroid adenoma","volume":"192","author":"Bilen","year":"2023","journal-title":"Ir. J. Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1097\/MNM.0000000000000921","article-title":"Comparison between technetium-99m methoxyisobutylisonitrile scintigraphy and ultrasound in the diagnosis of parathyroid adenoma and parathyroid hyperplasia","volume":"39","author":"Xue","year":"2018","journal-title":"Nucl. Med. Commun."},{"key":"ref_32","unstructured":"(2025, July 21). Eurocrine. Available online: https:\/\/eurocrine.eu."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12149-021-01681-w","article-title":"Clinicopathological variables that correlate with sestamibi positivity in uniglandular parathyroid disease: A retrospective analysis of 378 parathyroid adenomas","volume":"36","author":"Atmaca","year":"2022","journal-title":"Ann. Nucl. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s13139-011-0103-y","article-title":"Differential findings of tc-99m sestamibi dual-phase parathyroid scintigraphy between benign and malignant parathyroid lesions in patients with primary hyperparathyroidism","volume":"45","author":"Cheon","year":"2011","journal-title":"Nucl. Med. Mol. Imaging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1067\/msy.2001.118371","article-title":"In vitro accumulation of technetium-99m-sestamibi in human parathyroid mitochondria","volume":"130","author":"Hetrakul","year":"2001","journal-title":"Surgery"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/01.rlu.0000242212.23936.a7","article-title":"Parameters in the prediction of the sensitivity of parathyroid scanning","volume":"31","author":"Siegel","year":"2006","journal-title":"Clin. Nucl. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1177\/000313480306900507","article-title":"Impact of hypercalcemia and parathyroid hormone level on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism","volume":"69","author":"Parikshak","year":"2003","journal-title":"Am. Surg."},{"key":"ref_38","first-page":"2639","article-title":"Effective factors on the sensitivity of preoperative sestamibi scanning for primary hyperparathyroidism","volume":"7","author":"Khorasani","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"104315","DOI":"10.1016\/j.amjoto.2024.104315","article-title":"Clinical predictors of negative\/equivocal SPECT imaging outcomes in primary hyperparathyroidism: Factors calling for 18F-choline-PET","volume":"45","author":"Ferrari","year":"2024","journal-title":"Am. J. Otolaryngol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"666","DOI":"10.20945\/2359-3997000000556","article-title":"Normocalcemic primary hyperparathyroidism","volume":"66","author":"Cusano","year":"2022","journal-title":"Arch. Endocrinol. Metab."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/SLA.0b013e31825ffbe1","article-title":"Creation of a \u201cWisconsin index\u201d nomogram to predict the likelihood of additional hyperfunctioning parathyroid glands during parathyroidectomy","volume":"257","author":"Mazeh","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"861","DOI":"10.21037\/gs-20-857","article-title":"Usefulness of the Wisconsin and CaPTHUS indices for predicting multiglandular disease in patients with primary hyperparathyroidism in a southern European population","volume":"10","year":"2021","journal-title":"Gland Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archsurg.141.8.777","article-title":"Predictors of single-gland vs multigland parathyroid disease in primary hyperparathyroidism: A simple and accurate scoring model","volume":"141","author":"Kebebew","year":"2006","journal-title":"Arch. Surg."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12020-023-03376-w","article-title":"Parathyroid carcinoma: Molecular therapeutic targets","volume":"81","author":"Marini","year":"2023","journal-title":"Endocrine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1053\/j.seminoncol.2010.10.013","article-title":"Parathyroid cancer","volume":"37","author":"Sharretts","year":"2010","journal-title":"Semin. Oncol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.suronc.2014.03.005","article-title":"Parathyroid carcinoma","volume":"23","author":"Mekel","year":"2014","journal-title":"Surg. Oncol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Zhu, Y., Wang, L., You, J., Deng, S., Shi, Y., Liu, Z., and Hong, Z. (2024). Diagnostic value of Tc-99m-MIBI SPECT\/CT in parathyroid carcinoma with lung metastasis: A case report and literature review. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1501447"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.remn.2010.08.006","article-title":"Falso negativo de la gammagraf\u00eda con 99mTc-sestamibi en un carcinoma paratiroideo con tumores pardos asociados. Aportaciones de la PET\/TAC-18F-FDG [False negative of the scintigraphy with 99mTc-sestamibi in parathyroid carcinoma with associated brown tumors. Contributions of the 18F-FDG-PET\/CT]","volume":"30","year":"2011","journal-title":"Rev. Esp. Med. Nucl."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00423-010-0724-0","article-title":"Results of surgery for sporadic primary hyperparathyroidism in patients with preoperatively negative sestamibi scintigraphy and ultrasound","volume":"396","author":"Bergenfelz","year":"2011","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.surg.2019.05.057","article-title":"Discordant findings on preoperative imaging for primary hyperparathyroidism and thyroid disease: Choosing the path to follow","volume":"166","author":"Beck","year":"2019","journal-title":"Surgery"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s13139-016-0438-5","article-title":"Usefulness of SPECT\/CT in Parathyroid Lesion Detection in Patients with Thyroid Parenchymal 99mTc-Sestamibi Retention","volume":"51","author":"Hwang","year":"2017","journal-title":"Nucl. Med. Mol. Imaging"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12149-020-01507-1","article-title":"18F-choline PET\/CT and PET\/MRI in primary and recurrent hyperparathyroidism: A systematic review of the literature","volume":"34","author":"Evangelista","year":"2020","journal-title":"Ann. Nucl. Med."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Kang, S., Cho, H., Kim, E., Kim, J.K., Kang, S.W., Jeong, J.J., Nam, K.H., and Chung, W. (2025). Comparison of 18F-Choline PET\/CT and 99mTc-Sestamibi SPECT\/CT in the Localization of Hyperactive Parathyroid Glands in Primary Hyperparathyroidism: Diagnostic Performance in Discordant Cases. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1677278"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/MNM.0000000000000899","article-title":"The efficacy of fluorine-18-choline PET\/CT in comparison with 99mTc-MIBI SPECT\/CT in the localization of a hyperfunctioning parathyroid gland in primary hyperparathyroidism","volume":"39","author":"Araz","year":"2018","journal-title":"Nucl. Med. Commun."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/5\/1973\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:00:05Z","timestamp":1772708405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/5\/1973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,4]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["jcm15051973"],"URL":"https:\/\/doi.org\/10.3390\/jcm15051973","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,4]]}}}