{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:59:52Z","timestamp":1776736792220,"version":"3.51.2"},"reference-count":97,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation programme","award":["101073533"],"award-info":[{"award-number":["101073533"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Charcot neuro-osteoarthropathy remains one of the most serious complications of diabetic neuropathy, with the potential for rapid progression to deformity, ulceration and limb-threatening outcomes. The earliest signs and symptoms are often subtle and easily missed, yet early recognition provides a narrow window of opportunity to prevent irreversible structural change. Contemporary diagnostic pathways are underpinned by close clinical observation and correlation of bedside findings with detailed imaging analysis, enabling earlier identification of active disease before collapse occurs. This article provides a comprehensive overview of the Charcot foot, integrating clinical presentation, differential diagnosis and current approaches to investigation and management. It also highlights the challenges of monitoring disease activity over time, including remission and relapse, and the importance of timely specialist referral and multidisciplinary management. By reinforcing structured assessment and targeted intervention, this review aims to support consistent, evidence-informed care for people affected by Charcot neuro-osteoarthropathy.<\/jats:p>","DOI":"10.3390\/jcm15051993","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:52:11Z","timestamp":1772711531000},"page":"1993","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Burning Issues\/Hot Topics: The Charcot Foot"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7416-956X","authenticated-orcid":false,"given":"Victoria E. L.","family":"Milbourn","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Amsterdam University Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"},{"name":"Amsterdam Movement Sciences, Rehabilitation and Development, Amsterdam University Medical Centre, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands"},{"name":"Mike Edmonds Foot Unit, King\u2019s College Hospital National Health Service Foundation Trust, London SE5 9RS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1849-4549","authenticated-orcid":false,"given":"Ava","family":"Khoshnaghsh","sequence":"additional","affiliation":[{"name":"Guy\u2019s, King\u2019s and St Thomas\u2019 School of Medicine, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE5 9RS, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-0069","authenticated-orcid":false,"given":"Michael E.","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Mike Edmonds Foot Unit, King\u2019s College Hospital National Health Service Foundation Trust, London SE5 9RS, UK"},{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina L.","family":"Petrova","sequence":"additional","affiliation":[{"name":"Mike Edmonds Foot Unit, King\u2019s College Hospital National Health Service Foundation Trust, London SE5 9RS, UK"},{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine, King\u2019s College London, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e3646","DOI":"10.1002\/dmrr.3646","article-title":"Guidelines on the diagnosis and treatment of active Charcot neuro-osteoarthropathy in persons with diabetes mellitus (IWGDF 2023)","volume":"40","author":"Wukich","year":"2024","journal-title":"Diabetes Metab. 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