{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T06:58:49Z","timestamp":1773212329687,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Knee arthrodesis markedly alters lower limb biomechanics and creates a challenging scenario when associated with end-stage ankle osteoarthritis. No prior reports have specifically described treatment with total ankle replacement (TAR) in the presence of an ipsilateral fused knee. This study evaluated the feasibility and mid-term outcomes of TAR in this rare condition. Methods: Two patients with post-traumatic end-stage ankle osteoarthritis and long-standing knee arthrodesis underwent TAR using a lateral transfibular approach with a Zimmer Trabecular Metal\u2122 implant. Surgical planning aimed to restore coronal and sagittal alignment. Postoperative management and rehabilitation were specifically adapted to the absence of knee motion, with emphasis on gait re-education. Clinical and radiographic follow-up was performed up to 36 months. Results: At final follow-up, both patients showed substantial pain reduction, improved ankle range of motion, and recovery of a stable, functional gait compatible with knee fusion. Imaging demonstrated well-aligned, stable components without loosening or subsidence. No major complications or reoperations occurred. Conclusions: Lateral transfibular TAR appears feasible and effective for end-stage ankle osteoarthritis in patients with ipsilateral knee arthrodesis, preserving ankle motion and supporting functional ambulation in this complex setting.<\/jats:p>","DOI":"10.3390\/jcm15062094","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T08:43:31Z","timestamp":1773132211000},"page":"2094","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Ankle Replacement Through a Lateral Transfibular Approach in Patients with Ipsilateral Knee Arthrodesis: Report of Two Cases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1729-5509","authenticated-orcid":false,"given":"Carla","family":"Carf\u00ec","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, 20090 Milan, Italy"},{"name":"IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0524-609X","authenticated-orcid":false,"given":"Serban-Andrei","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Ankle and Foot Unit, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-3373","authenticated-orcid":false,"given":"Cristian","family":"Indino","sequence":"additional","affiliation":[{"name":"Ankle and Foot Unit, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Della","family":"Rocca","sequence":"additional","affiliation":[{"name":"IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Maccario","sequence":"additional","affiliation":[{"name":"Ankle and Foot Unit, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico Giuseppe","family":"Usuelli","sequence":"additional","affiliation":[{"name":"Ankle and Foot Unit, Humanitas San Pio X Hospital, 20159 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref_1","first-page":"241","article-title":"Knee Fusion or Above-The-Knee Amputation after Failed Two-Stage Reimplantation Total Knee Arthroplasty","volume":"3","year":"2015","journal-title":"Arch. 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