{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:59:23Z","timestamp":1773219563697,"version":"3.50.1"},"reference-count":18,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This proof-of-concept study examined the association between CT-derived sarcopenia indices and achievement of Patient Acceptable Symptom State (PASS) in a metabolically homogeneous subgroup of patients with psoriatic arthritis (PsA) receiving biologic therapy. Methods: We retrospectively analyzed 26 PsA patients without diabetes, hypertension, or thyroid disorders who were treated with TNF or IL-17 inhibitors and underwent opportunistic CT imaging at the L2 vertebral level. Body composition parameters included total abdominal muscle area (TAMA), subcutaneous adipose tissue (SAT), and sarcopenia index (SI = TAMA\/height2). PASS achievement at 12 weeks was assessed retrospectively. Receiver operating characteristic (ROC) analysis was performed. Results: Fourteen patients achieved PASS. Compared with non-achievers, these patients had significantly higher TAMA, SAT, and SI values (all p &lt; 0.05). ROC analysis identified an SI threshold of 4657.5 cm2\/m2 (sensitivity 78.6%, specificity 83.3%, p = 0.003). Conclusions: In this metabolically homogeneous PsA subgroup, higher CT-derived muscle mass measures were associated with PASS achievement at 12 weeks. These findings are hypothesis-generating and require validation in larger prospective cohorts.<\/jats:p>","DOI":"10.3390\/jcm15062105","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:53:31Z","timestamp":1773140011000},"page":"2105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Relationship Between CT-Derived Sarcopenia Index and Patient Acceptable Symptom State (PASS) in Psoriatic Arthritis: A Preliminary Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Sibel","family":"Bakirci","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Antalya Training and Research Hospital, Antalya 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulperi Ates","family":"Cetinkaya","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Antalya Training and Research Hospital, Antalya 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gokhan","family":"Sargin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Adnan Menderes University Hospital, Aydin 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazmi","family":"Kastan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Antalya Training and Research Hospital, Antalya 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0821-3632","authenticated-orcid":false,"given":"Mustafa","family":"Sagan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Antalya Training and Research Hospital, Antalya 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iclal Erdem","family":"Toslak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Antalya Training and Research Hospital, Antalya 07070, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"990S","DOI":"10.1093\/jn\/127.5.990S","article-title":"Sarcopenia: Origins and clinical relevance","volume":"127","author":"Rosenberg","year":"1997","journal-title":"J. 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