{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:15:37Z","timestamp":1773335737644,"version":"3.50.1"},"reference-count":13,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","award":["59266703"],"award-info":[{"award-number":["59266703"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100024075","name":"Region of Southern Denmark","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Louis-Hansen Foundation"},{"DOI":"10.13039\/501100007437","name":"Tryg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Danish Colitis Crohn\u2019s Foundation"},{"name":"Chief Physician Association at Odense University Hospital\u2013Region of Southern Denmark"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Exercise has been suggested as a supplementary modality for Inflammatory Bowel Disease (IBD), but supporting evidence remains scarce. We aimed to assess whether a 12-week physical exercise intervention improves quality of life (QOL) in adults with active IBD. Methods: An open-labeled randomized controlled trial examining the efficacy of a 12-week physical exercise intervention on QOL in adults (18\u201365 years) with active IBD. Participants were randomized 1:1 into either an intervention group, with two weekly supervised exercise sessions and one home session, or a control group with standard care. QOL by the Inflammatory Bowel Disease Questionnaire (IBDQ) was the primary outcome. Secondary outcomes were the European Quality of Life 5 Dimensions (EQ5D), waist circumference, blood pressure, disease activity, and lipid status. Explorative outcomes were C-reactive protein, fecal calprotectin, and cytokines (interleukin-6, -8, and -10 and tumor necrosis factor). Results: We screened 183 patients and included 44 participants, with 22 in each group. Eleven participants completed more than 50% of the exercise sessions. Among the participants, 17 were male, 27 were female, and the mean age was 37 years. The mean IBDQ scores at week 12 showed no statistically significant difference: 172 for the intervention group (95%CI: 158\u2013185) and 164 for the control group (95%CI: 151\u2013178). No clinically significant differences for secondary or exploratory outcomes were found. Conclusions: We did not find any difference in the QOL after a 12-week exercise intervention in patients with active IBD compared to standard care. Recruiting proved difficult, as did adherence to exercise sessions, mostly due to scheduling issues.<\/jats:p>","DOI":"10.3390\/jcm15062106","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:53:31Z","timestamp":1773140011000},"page":"2106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The IBD-FITT Study\u2014Moderate-Intensity Exercise for Patients with Active Inflammatory Bowel Disease: An Open-Label Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3959-2926","authenticated-orcid":false,"given":"Ken","family":"Lund","sequence":"first","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, 5000 Odense C, Denmark"},{"name":"Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-0115","authenticated-orcid":false,"given":"Torben","family":"Knudsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Hospital of Southwest Jutland, 6700 Esbjerg, Denmark"},{"name":"Department of Regional Health Science, Center Southwest Jutland, University of Southern Denmark, 6700 Esbjerg, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8148-6572","authenticated-orcid":false,"given":"Jens","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastrointestinal Diseases, Odense University Hospital, 5000 Odense C, Denmark"},{"name":"Research Unit of Medical Gastroenterology, Department of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-4902","authenticated-orcid":false,"given":"Kate Lykke","family":"Lambertsen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Odense University Hospital, 5000 Odense C, Denmark"},{"name":"Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, 5230 Odense M, Denmark"},{"name":"BRIDGE\u2013Brain Research\u2013Inter Disciplinary Guided Excellence, Department of Clinical Research, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasmus Gaardsk\u00e6r","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Hans Christian Andersen Children\u2019s Hospital, Odense University Hospital, 5000 Odense C, Denmark"},{"name":"Research Unit of Pediatrics, Department of Clinical Research, University of Southern Denmark, 5230 Odense M, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten Bogh","family":"Juhl","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, 5230 Odense M, Denmark"},{"name":"Department of Physiotherapy and Occupational Therapy, Herlev and Gentofte Hospital, Copenhagen University Hospital, 2730 Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9514-3033","authenticated-orcid":false,"given":"Bente Mertz","family":"N\u00f8rg\u00e5rd","sequence":"additional","affiliation":[{"name":"Center for Clinical Epidemiology, Odense University Hospital, 5000 Odense C, Denmark"},{"name":"Research Unit of Clinical Epidemiology, Department of Clinical Research, University of Southern Denmark, 5000 Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/ecco-jcc\/jjab178","article-title":"ECCO Guidelines on Therapeutics in Ulcerative Colitis: Medical Treatment","volume":"16","author":"Raine","year":"2022","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1093\/ecco-jcc\/jjae091","article-title":"ECCO Guidelines on Therapeutics in Crohn\u2019s Disease: Medical Treatment","volume":"18","author":"Gordon","year":"2024","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jones, K., Kimble, R., Baker, K., and Tew, G.A. (2022). Effects of structured exercise programmes on physiological and psychological outcomes in adults with inflammatory bowel disease (IBD): A systematic review and meta-analysis. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0278480"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00384-023-04437-2","article-title":"A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease","volume":"38","author":"Allen","year":"2023","journal-title":"Int. J. Color. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/2050640620936383","article-title":"Moderate endurance and muscle training is beneficial and safe in patients with quiescent or mildly active Crohn\u2019s disease","volume":"8","author":"Seeger","year":"2020","journal-title":"United Eur. Gastroenterol. 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