{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:21:10Z","timestamp":1773307270500,"version":"3.50.1"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2014Ricerca Corrente"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Complex Regional Pain Syndrome (CRPS) is a debilitating pain condition with complex pathophysiology and limited treatment efficacy. Whole-body cryostimulation (WBC) has shown promising results in other chronic pain syndromes, but no studies to date have examined its use in CRPS. To evaluate the safety, feasibility, and potential benefits of WBC in a female patient with CRPS of the ankle. Methods: A 65-year-old female outpatient with type I CRPS at the right ankle underwent 15 WBC sessions (3 min at \u2212110 \u00b0C) over two weeks, without any concurrent pharmacological or rehabilitative interventions. Assessments at baseline and post-intervention included standardized measures of pain (VAS, SF-MPQ), disability (PDI), catastrophizing (PCS), mobility (TUG, Chair Stand Test), strength and ROM (goniometry, MRC), psychosocial status (SF-36, WHO-5, PSQI, BDI, STAI), and MRI of the right knee and ankle. Results: Post-treatment, the patient showed substantial improvements in pain (VAS \u221266.7%, SF-MPQ \u221251.7%), function (TUG \u221231.8%), muscle strength, psychological well-being, and quality of life. MRI and edema measurements indicated stabilization or regression of inflammatory features. No adverse effects were reported. Conclusions: This case suggests that WBC may represent a safe, well-tolerated, non-pharmacological intervention for CRPS, with potential to improve pain, function, and well-being.<\/jats:p>","DOI":"10.3390\/jcm15062142","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:43:18Z","timestamp":1773240198000},"page":"2142","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-Body Cryostimulation in Complex Regional Pain Syndrome: A Case Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9637-0940","authenticated-orcid":false,"given":"Paolo","family":"Piter\u00e0","sequence":"first","affiliation":[{"name":"Department of Neurosciences \u201cRita Levi Montalcini\u201d, University of Turin, 10126 Turin, Italy"},{"name":"Laboratory of Clinical Neurobiology, IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital, 28824 Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Camedda","sequence":"additional","affiliation":[{"name":"Division of Neurology and Neurorehabilitation, IRCCS Istituto Auxologico Italiano, 28824 Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6487-4810","authenticated-orcid":false,"given":"Elisa","family":"Prina","sequence":"additional","affiliation":[{"name":"Department of Neurosciences \u201cRita Levi Montalcini\u201d, University of Turin, 10126 Turin, Italy"},{"name":"Laboratory of Clinical Neurobiology, IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital, 28824 Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora Franzini","family":"Tibaldeo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Physical and Rehabilitation Medicine, University of Torino, 10121 Torino, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Baccalaro","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomechanics, Rehabilitation and Ergonomics, IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital, Piancavallo, 28824 Verbania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3719-8789","authenticated-orcid":false,"given":"Paolo","family":"Capodaglio","sequence":"additional","affiliation":[{"name":"Research Laboratory in Biomechanics, Rehabilitation and Ergonomics, IRCCS Istituto Auxologico Italiano, San Giuseppe Hospital, Piancavallo, 28824 Verbania, Italy"},{"name":"Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"ref_1","unstructured":"Guthmiller, K.B., Dua, A., Dey, S., and Varacallo, M.A. (2025). 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