{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:01:30Z","timestamp":1773655290461,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: This study aimed to evaluate the impact of postoperative immunonutrition on vaginal cuff healing in well-nourished patients undergoing laparoscopic surgery for endometrial cancer. The secondary objective was to assess postoperative complications occurring within 30 days. Methods: This prospective observational cohort study included patients who underwent laparoscopic surgery for endometrial cancer. Patients receiving postoperative oral immune-modulating diets were compared with those managed with a standard postoperative diet. Vaginal cuff healing assessed at postoperative 4th and 6th weeks. Postoperative complications within 30 days were recorded prospectively. Results: A total of 131 patients were included [immunonutrition group, n = 69; control group, n = 62]. At the 4th postoperative week, complete vaginal cuff healing was observed in 84.1% of the immunonutrition group and 75.8% of the control group [p = 0.24]. By the 6th postoperative week, complete healing rates were comparable [96.6% vs. 93.1%, p = 0.43]. In multivariable analysis, vaginal cuff closure time was independently associated with delayed cuff healing [p = 0.02]. Postoperative morbidity did not differ between groups. Conclusions: Vaginal cuff healing after laparoscopic surgery for endometrial cancer was primarily influenced by surgical factors, particularly vaginal cuff closure time, rather than postoperative immunonutrition.<\/jats:p>","DOI":"10.3390\/jcm15062248","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T08:41:26Z","timestamp":1773650486000},"page":"2248","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative Vaginal Cuff Healing After Minimally Invasive Surgery for Endometrial Cancer: The Role of Postoperative Immunonutrition"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6454-6470","authenticated-orcid":false,"given":"Sevda","family":"Bas","sequence":"first","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"},{"name":"Department of Translational Medicine, Institute of Health Sciences, Cukurova University, Adana 01330, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9604-6852","authenticated-orcid":false,"given":"B\u00fc\u015fra Asena","family":"Torun","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7602-7396","authenticated-orcid":false,"given":"Eda","family":"Koyuncuo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8040-339X","authenticated-orcid":false,"given":"O\u011fuz","family":"Uyar","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba","family":"Yar","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda Y\u00fcksel","family":"\u015eim\u015fek","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8607-6628","authenticated-orcid":false,"given":"Sevtap","family":"Seyfettino\u011flu","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9053","authenticated-orcid":false,"given":"Mehmet Ali","family":"Narin","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Adana City Training and Research Hospital, University of Health Sciences, Adana 01120, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"ref_1","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1200\/JCO.2009.22.3248","article-title":"Laparoscopy compared with laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study","volume":"27","author":"Walker","year":"2009","journal-title":"J. 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