{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T11:24:45Z","timestamp":1773746685795,"version":"3.50.1"},"reference-count":17,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Parathyroid hormone (PTH) is closely linked to mineral metabolism, kidney function, inflammation, and cardiovascular disease. However, its clinical significance in unselected hospitalized populations remains insufficiently characterized. We aimed to evaluate the prevalence of elevated PTH and its association with long-term mortality in a real-world cohort of internal medicine inpatients. Methods: In this retrospective cohort study, electronic records of adults hospitalized in an internal medicine department in 2019 were reviewed. Patients with available in-hospital PTH measurements were included. Elevated PTH was defined as &gt;88 pg\/mL. Clinical characteristics and laboratory parameters were recorded. The primary outcome was all-cause mortality with a minimum follow-up of 2 years. Cox proportional hazards models adjusted for clinically relevant covariates were used to examine the association between PTH and mortality. Results: A total of 1595 patients were included, of whom 567 (35.5%) had elevated PTH levels. Patients with elevated PTH were older and had a higher burden of chronic kidney disease, cardiovascular disease, and inflammatory and nutritional abnormalities. During a mean follow-up of 22 \u00b1 13 months, mortality occurred more frequently in patients with elevated PTH than in those with normal levels (56.1% vs. 33.7%, p &lt; 0.001). After multivariable adjustment, elevated PTH remained independently associated with increased mortality risk-adjusted HR (1.36, 95% CI 1.15\u20131.62, p &lt; 0.001). Conclusions: Elevated PTH is common among hospitalized internal medicine patients and is associated with increased long-term mortality. PTH may represent an integrated biomarker reflecting disease burden, inflammation, and renal dysfunction and could contribute to risk stratification in hospitalized populations. Prospective studies are warranted to clarify underlying mechanisms and clinical implications.<\/jats:p>","DOI":"10.3390\/jcm15062272","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T10:21:41Z","timestamp":1773742901000},"page":"2272","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Parathyroid Hormone and Long-Term Mortality in Hospitalized Patients: A Real-World Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-4339","authenticated-orcid":false,"given":"H\u00fcseyin","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, \u0130stanbul 34480, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9223-4212","authenticated-orcid":false,"given":"Ece","family":"\u00c7ift\u00e7i \u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haseki Traning and Research Hospital, University of Health Science, \u0130stanbul 34275, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8147-7374","authenticated-orcid":false,"given":"\u00d6zge","family":"Yasun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, University of Health Science, \u0130stanbul 34480, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5695-3105","authenticated-orcid":false,"given":"Esra","family":"Kaplan Arat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Izmit Seka State Hospital, Kocaeli 41100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-8889","authenticated-orcid":false,"given":"Onur","family":"Arat","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Izmit Seka State Hospital, Kocaeli 41100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2325-7776","authenticated-orcid":false,"given":"Seher \u0130rem","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haseki Traning and Research Hospital, University of Health Science, \u0130stanbul 34275, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8584-395X","authenticated-orcid":false,"given":"B\u00fc\u015fra","family":"\u00c7etintulum Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haseki Traning and Research Hospital, University of Health Science, \u0130stanbul 34275, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-2575","authenticated-orcid":false,"given":"Hayriye Esra","family":"Atao\u011flu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Haseki Traning and Research Hospital, University of Health Science, \u0130stanbul 34275, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/j.2040-4603.2016.tb00690.x","article-title":"PTH and vitamin D","volume":"6","author":"Khundmiri","year":"2016","journal-title":"Compr. 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