{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T09:04:49Z","timestamp":1784019889668,"version":"3.55.0"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Permanent pacemaker (PM) implantation is a well-recognized complication of transcatheter aortic valve implantation (TAVI), but its long-term prognostic impact remains uncertain. To evaluate the association between PM implantation and all-cause mortality in TAVI recipients. Methods: We performed a post hoc analysis of a prospective single-center TAVI registry (2016\u20132020). The primary endpoint was all-cause mortality at 1 and 5 years. Cox regression and Kaplan\u2013Meier analyses were applied. Validation was performed using the nationwide AUTHEARTVISIT claims database. Results: Among 1114 consecutive TAVI patients (mean age 81\u2009 \u00b1 \u20095.8 years; 49.8% female), 120 (10.8%) had a pre-existing PM (Pre-PM), and 153 (13.7%) received a new PM within 30 days post-TAVI (Post-PM). Post-PM patients were older (p = 0.006), more often male (p &lt; 0.001), had higher Troponin T levels (p = 0.002), more pre-existing right bundle branch block (p &lt; 0.001), and longer QRS duration (p &lt; 0.001) compared to patients without PM. In multivariate analysis, one-year mortality was associated with Troponin T (p = 0.002) and NT-proBNP (p = 0.002) serum levels. Pre- or Post-PM status was not associated with 1-year mortality (p = 0.455, p = 975). However, Pre-PM status was independently associated with 5-year mortality (HR 1.4, 95% CI: 1.0\u20131.9, p = 0.03), whereas Post-PM status was not (HR 1.2, 95% CI: 0.8\u20131.6, p = 0.22). Findings were confirmed in the nationwide AUTHEARTVISIT cohort. Conclusions: In this large, real-world TAVI cohort with national validation, Post-PM status was not associated with mortality at 1 or 5 years. By contrast, Pre-PM identified patients at higher long-term risk, possibly reflecting underlying cardiac disease.<\/jats:p>","DOI":"10.3390\/jcm15062288","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:42:16Z","timestamp":1773751336000},"page":"2288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Permanent Pacemaker Implantation After TAVI and Its Association with Survival: Single-Center Cohort and Nationwide Validation"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0628-7028","authenticated-orcid":false,"given":"Gudrun","family":"Lamm","sequence":"first","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Veraar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"H\u00f6bart","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Granner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Will","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0141-7639","authenticated-orcid":false,"given":"Christian","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roya A.","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Mount Sinai Fuster Heart Hospital, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-7661","authenticated-orcid":false,"given":"Johann","family":"Auer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I with Cardiology and Intensive Care, St. Josef Hospital Braunau, 5280 Braunau am Inn, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik J.","family":"Ankersmit","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Surgery, Medical University of Vienna, 1090 Vienna, Austria"},{"name":"Laboratory for Cardiac and Thoracic Diagnosis, Regeneration and Applied Immunology, Medical University of Vienna, 1090 Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Hammerer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta C.","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Mascherbauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, University Hospital St. P\u00f6lten-NOE LGA, Karl Landsteiner University, 3100 St. P\u00f6lten, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1016\/j.jacc.2022.08.787","article-title":"National Trends in TAVR and SAVR for Patients with Severe Isolated Aortic Stenosis","volume":"80","author":"Sharma","year":"2022","journal-title":"J. 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