{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:53:19Z","timestamp":1774630399036,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T00:00:00Z","timestamp":1774569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Osteoporosis and osteoarthritis are age-related musculoskeletal disorders with a high socio-health burden, affecting both healthcare systems and individuals\u2019 quality of life. Both conditions are generally accompanied by a concomitant decline in muscle mass and strength, referred to as sarcopenia. In this context, tensiomyography emerges as a novel, non-invasive potential diagnostic strategy for assessing muscle quality, as this parameter influences the progression of both conditions. Methods: Histomorphometric and immunohistochemical analyses were performed on vastus lateralis muscle tissue obtained from patients undergoing surgery for femoral fracture affected by osteoporosis or osteopenia, patients operated for hip osteoarthritis, and patients undergoing hip arthroplasty for osteoarthritis, concomitantly affected by osteoporosis or osteopenia. In addition, muscle function was assessed in these patients using tensiomyographic analysis. Results: In osteoarthritic, osteoporotic, and osteopenic patients, a reduction in muscle quality and function was observed compared with the other two experimental groups, indicating an unfavorable effect of the coexistence of the two conditions on the muscular component. Furthermore, contraction time (Tc) measured by tensiomyography was negatively correlated with lumbar spine bone mineral density values and positively correlated with the percentage of type II muscle fibers. Conclusions: This study highlights how tensiomyography may represent a valuable non-invasive diagnostic strategy for assessing muscle status in osteoporotic and osteoarthritic patients, as it is able to detect muscle alterations that parallel the worsening of bone status and that cannot be inferred from simple biopsy analysis. Thus, tensiomyography could be considered a practical adjunct tool in the clinical assessment of musculoskeletal frailty.<\/jats:p>","DOI":"10.3390\/jcm15072583","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:45:42Z","timestamp":1774626342000},"page":"2583","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beyond Histology: Tensiomyography as an Integrated Measure of Muscle Function in Osteoporotic and Osteoarthritic Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-4030","authenticated-orcid":false,"given":"Chiara","family":"Greggi","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Traumatology, \u201cPoliclinico Tor Vergata\u201d Foundation, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Scaminaci","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Policlinico Paolo Giaccone, Viale Del Vespro, 129, 90127 Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8441-3731","authenticated-orcid":false,"given":"Manuela","family":"Montanaro","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Health and Health Professions, Link Campus University, Via del Casale di S. Pio V, 44, 00165 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Talarico","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, \u201cPoliclinico Tor Vergata\u201d Foundation, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Matticari","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, \u201cPoliclinico Tor Vergata\u201d Foundation, Viale Oxford 81, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Albanese","sequence":"additional","affiliation":[{"name":"Statistical and Actuarial Department in Italian Workers\u2019 Compensation Authority (INAIL), Via Stefano Gradi, 55, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jure","family":"Jemec","sequence":"additional","affiliation":[{"name":"TMG-BMC d.o.o., Stihova Ulica 24, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergej","family":"Rozman","sequence":"additional","affiliation":[{"name":"TMG-BMC d.o.o., Stihova Ulica 24, 1000 Ljubljana, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-5676","authenticated-orcid":false,"given":"Alessandro","family":"Mauriello","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1826-2880","authenticated-orcid":false,"given":"Riccardo","family":"Iundusi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, \u201cPoliclinico Tor Vergata\u201d Foundation, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Gasbarra","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, \u201cPoliclinico Tor Vergata\u201d Foundation, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Department of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-2189","authenticated-orcid":false,"given":"Umberto","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, \u201cPoliclinico Tor Vergata\u201d Foundation, Viale Oxford 81, 00133 Rome, Italy"},{"name":"Faculty of Medicine and Surgery, University \u201cOur Lady of Good Counsel\u201d, Rruga Dritan Hoxha, 1000 Tirana, Albania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1038\/s41598-025-91783-6","article-title":"Global, Regional, and National Epidemiology of Osteoarthritis in Working-Age Individuals: Insights from the Global Burden of Disease Study 1990\u20132021","volume":"15","author":"Ma","year":"2025","journal-title":"Sci. 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