{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:56:58Z","timestamp":1785427018549,"version":"3.56.0"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["143549"],"award-info":[{"award-number":["143549"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["134863"],"award-info":[{"award-number":["134863"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"award":["143549"],"award-info":[{"award-number":["143549"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"publisher"}]},{"award":["134863"],"award-info":[{"award-number":["134863"]}],"id":[{"id":"https:\/\/ror.org\/03g2am276","id-type":"ROR","asserted-by":"publisher"}]},{"name":"New National Excellence Program of the Ministry of Human Capacities","award":["EK\u00d6P-339-SZTE"],"award-info":[{"award-number":["EK\u00d6P-339-SZTE"]}]},{"name":"New National Excellence Program of the Ministry of Human Capacities","award":["EK\u00d6P-342-SZTE"],"award-info":[{"award-number":["EK\u00d6P-342-SZTE"]}]},{"award":["EK\u00d6P-339-SZTE"],"award-info":[{"award-number":["EK\u00d6P-339-SZTE"]}],"id":[{"id":"https:\/\/ror.org\/00rb16m44","id-type":"ROR","asserted-by":"publisher"}]},{"award":["EK\u00d6P-342-SZTE"],"award-info":[{"award-number":["EK\u00d6P-342-SZTE"]}],"id":[{"id":"https:\/\/ror.org\/00rb16m44","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023322","name":"Faculty of Medicine, University of Szeged","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100023322","id-type":"DOI","asserted-by":"crossref"}]},{"id":[{"id":"https:\/\/ror.org\/01pnej532","id-type":"ROR","asserted-by":"publisher"}]},{"name":"EU\u2019s Horizon 2020 research and innovation program","award":["2024-1.2.3-HU-RIZONT-2024-00035"],"award-info":[{"award-number":["2024-1.2.3-HU-RIZONT-2024-00035"]}]},{"award":["2024-1.2.3-HU-RIZONT-2024-00035"],"award-info":[{"award-number":["2024-1.2.3-HU-RIZONT-2024-00035"]}],"id":[{"id":"https:\/\/ror.org\/019w4f821","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Crohn\u2019s disease complicated by intra-abdominal abscesses often requires surgery. Percutaneous drainage may prevent surgery, but optimal post-drainage management is unclear. We aimed to analyze the long-term outcomes of Crohn\u2019s disease with intra-abdominal abscesses after intervention. Methods: Patients with penetrating Crohn\u2019s disease and a single intra-abdominal abscess were enrolled in this multicenter, international, retrospective study after the detection of the abscess (baseline), with a minimum follow-up of 12 months. Those requiring urgent bowel resection were excluded. Patients were grouped by elective surgical need after successful (catheter insertion with effective drainage) percutaneous drainage (controls: no pre-resection drainage). The primary outcome was abscess recurrence. We also assessed stoma rate, post-procedural complications, hospitalizations, advanced treatment need, postoperative luminal recurrence, and need for re-drainage. Results: We studied 157 patients with Crohn\u2019s disease (9 countries; males: 58%, median age: 32.4 [interquartile range: 25\u201339 years]); 89\/157 underwent percutaneous drainage (median follow-up: 95.9 weeks [interquartile range: 58\u2013104]). Abscess recurrence did not differ by drainage (p = 0.221). Abscess size was associated with advanced-treatment initiation (Odds ratio: 0.978; 95% confidence interval: 0.960\u20130.997, p = 0.023) and postoperative luminal recurrence (Odds ratio: 1.044, 95% confidence interval: 1.012\u20131.078, p = 0.007). Time to resection was longer after drainage, and ROC analysis raised predictive value for re-drainage (16.6 weeks post-drainage; AUC = 0.82, 95% confidence interval: 0.73\u20130.92). Patients without drainage had more post-procedural complications. Conclusions: Abscess size should guide management. Delayed resection may increase re-drainage odds, whereas surgery alone may have higher complication rates. Percutaneous drainage can safely postpone resection.<\/jats:p>","DOI":"10.3390\/jcm15072724","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T02:06:21Z","timestamp":1775441181000},"page":"2724","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Long-Term Outcomes of Crohn\u2019s Disease Complicated by Intra-Abdominal Abscess: A Retrospective International Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0068","authenticated-orcid":false,"given":"P\u00e9ter","family":"Bacsur","sequence":"first","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, K\u00e1lv\u00e1ria Ave. 57, H-6725 Szeged, Hungary"},{"name":"Translational Colorectal Research Group, Hungarian Centre of Excellence for Molecular Medicine (HCEMM), University of Szeged (USZ), H-6728 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylwia","family":"Nemeczek","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Diseases Unit, Department of Gastroenterology, Clinical Hospital No. 2, 35-301 Rzeszow, Poland"},{"name":"Institute of Medicine, Medical College, Rzeszow University, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5954-151X","authenticated-orcid":false,"given":"Rafa\u0142","family":"Filip","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Diseases Unit, Department of Gastroenterology, Clinical Hospital No. 2, 35-301 Rzeszow, Poland"},{"name":"Institute of Medicine, Medical College, Rzeszow University, 35-959 Rzeszow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7621-8100","authenticated-orcid":false,"given":"Fotios","family":"Fousekis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Mpakogiannis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3818-6205","authenticated-orcid":false,"given":"Anna","family":"Kagramanova","sequence":"additional","affiliation":[{"name":"Moscow Clinical Scientific Center Named After A.S. Loginov, 111123 Moscow, Russia"},{"name":"Research Institute of Health Organization and Medical Management, 115088 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2026-9678","authenticated-orcid":false,"given":"Konstantinos","family":"Argyriou","sequence":"additional","affiliation":[{"name":"Inflammatory Bowel Diseases Unit, Department of Gastroenterology, University Hospital of Larissa, 41110 Larissa, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7790-7845","authenticated-orcid":false,"given":"Ploutarchos","family":"Pastras","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3094-8209","authenticated-orcid":false,"given":"Christos","family":"Triantos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, University Hospital of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Miheller","sequence":"additional","affiliation":[{"name":"Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, H-1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8233-9638","authenticated-orcid":false,"given":"Mar\u00eda Jos\u00e9","family":"Casanova","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto de Investigaci\u00f3n Sanitaria del Hospital de La Princesa, Hospital Universitario de La Princesa, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Universidad Aut\u00f3noma de Madrid (UAM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Instituto de Investigaci\u00f3n Sanitaria del Hospital de La Princesa, Hospital Universitario de La Princesa, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBEREHD), Universidad Aut\u00f3noma de Madrid (UAM), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9338-4140","authenticated-orcid":false,"given":"Andreas","family":"Blesl","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1859-7146","authenticated-orcid":false,"given":"Sophie","family":"Vieujean","sequence":"additional","affiliation":[{"name":"Hepato-Gastroenterology and Digestive Oncology, University Hospital CHU of Li\u00e8ge, B-4000 Li\u00e8ge, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Ili\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, H-1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00f3r\u00e1nt","family":"G\u00f6nczi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncology, Semmelweis University, H-1083 Budapest, 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Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3190-7330","authenticated-orcid":false,"given":"No\u00e9mi","family":"G\u00e1lfalvi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, K\u00e1lv\u00e1ria Ave. 57, H-6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6339-9679","authenticated-orcid":false,"given":"M\u00e1t\u00e9","family":"P\u00e1pista","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Szent-Gy\u00f6rgyi Medical School, University of Szeged, K\u00e1lv\u00e1ria Ave. 57, H-6725 Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3948-6488","authenticated-orcid":false,"given":"Peter L.","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 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Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/gutjnl-2017-315568","article-title":"Natural disease course of Crohn\u2019s disease during the first 5 years after diagnosis in a European population-based inception cohort: An Epi-IBD study","volume":"68","author":"Burisch","year":"2019","journal-title":"Gut"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000367859","article-title":"Abdominal abscess in Crohn\u2019s disease: Multidisciplinary management","volume":"32","author":"Carbonnel","year":"2014","journal-title":"Dig. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00247-015-3533-3","article-title":"Role of percutaneous abscess drainage in the management of young patients with Crohn disease","volume":"46","author":"Pugmire","year":"2016","journal-title":"Pediatr. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/ecco-jcc\/jjv198","article-title":"A meta-analysis of percutaneous drainage versus surgery as the initial treatment of Crohn\u2019s disease-related intra-abdominal abscess","volume":"10","author":"Clancy","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/ecco-jcc\/jjz187","article-title":"ECCO Guidelines on Therapeutics in Crohn\u2019s Disease: Surgical Treatment","volume":"14","author":"Adamina","year":"2020","journal-title":"J. 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Gastroenterol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/7\/2724\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T04:10:57Z","timestamp":1775448657000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/7\/2724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":20,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jcm15072724"],"URL":"https:\/\/doi.org\/10.3390\/jcm15072724","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,3]]}}}