{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:49:41Z","timestamp":1775638181939,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T00:00:00Z","timestamp":1775260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Signet-ring cell colorectal cancer (SRCC) and colorectal cancer with a signet-ring cell component (SRC) are rare histological subtypes associated with poor prognosis. Although these entities are classified separately based on pathological criteria, it remains unclear whether they differ in clinical behavior and survival outcomes. This study aimed to compare the clinicopathological characteristics and survival of patients with SRCC and SRC. Methods: Patients who underwent surgery for colorectal cancer (CRC) between January 2012 and December 2019 and were diagnosed with SRCC or SRC on histopathological examination were retrospectively included. Demographic, clinical, and survival data were analyzed and compared between the two groups. Results: A total of 32 patients (22 males, 10 females) with SRCC or SRC were included, representing 2.6% (32\/1253) of all CRC cases operated at our center. Seven patients (five with SRCC and two with SRC) had synchronous distant metastases, including liver-only metastases (9%), diffuse intra-abdominal seeding (9%), and ovarian metastasis (3%). The mean disease-free survival was 19.2 \u00b1 3.3 months overall, and 17.18 \u00b1 3.61 months for SRCC and 19.3 \u00b1 9 months for SRC. The mean overall survival was 70.9 \u00b1 10.18 months overall, and 65.95 \u00b1 13.77 months for SRCC and 79.20 \u00b1 15.03 months for SRC. No statistically significant difference in overall survival was observed between the groups (p = 0.534). Conclusions: SRCC and SRC demonstrate broadly similar clinicopathological features, with younger age at diagnosis observed in SRCC patients. However, given the limited sample size, the absence of statistically significant differences in survival outcomes should be interpreted with caution and does not imply equivalence. Distant metastasis remains the most important prognostic factor in both groups.<\/jats:p>","DOI":"10.3390\/jcm15072736","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T02:06:21Z","timestamp":1775441181000},"page":"2736","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Signet-Ring Cell Colorectal Cancer and Signet-Ring Cell Component Colorectal Cancer: Do They Differ in Clinical Behavior?"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0917-9345","authenticated-orcid":false,"given":"Cebrail","family":"Akyuz","sequence":"first","affiliation":[{"name":"Department of General Surgery, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4588-0112","authenticated-orcid":false,"given":"Oguzhan","family":"Sunamak","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1271-1299","authenticated-orcid":false,"given":"Aytac","family":"Selman","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9903-6246","authenticated-orcid":false,"given":"Mehmet O.","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Gaziantep City Hospital, University of Health Sciences, Gaziantep 27500, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umut","family":"Kina Kilicaslan","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Martin Luther Hospital, 14193 Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-4798","authenticated-orcid":false,"given":"Kadir","family":"Corbaci","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Bilecik Seyh Edebali University, Bilecik 11100, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0472-8846","authenticated-orcid":false,"given":"Feza","family":"Ekiz","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Istanbul Medical Faculty, University of Istanbul, Istanbul 34093, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-2195","authenticated-orcid":false,"given":"Turgut","family":"Donmez","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Bakirkoy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul 34149, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3065-3585","authenticated-orcid":false,"given":"Evren","family":"Besler","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul 34668, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Liu, X., Huang, L., Liu, M., and Wang, Z. 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