{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T09:43:36Z","timestamp":1776159816304,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Endoscopic bariatric and metabolic therapies (EBMTs) offer minimally invasive treatment options for obesity and related metabolic disorders such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated steatotic liver disease (MASLD). These therapies are broadly categorized into gastric and small bowel interventions. Gastric EBMTs, including intragastric balloons and endoscopic sleeve gastroplasty, promote weight loss primarily through mechanical restriction and delayed gastric emptying, thereby improving metabolic outcomes. Small bowel therapies target the proximal intestine to modulate nutrient-sensing and hormonal pathways, providing metabolic benefits that may occur independently of weight loss. Techniques such as duodenal mucosal resurfacing, electroporation-based re-cellularization, and duodenal-jejunal bypass liners demonstrate promising effects on glycemic control, insulin sensitivity, and liver health. Emerging technologies utilizing thermal, vapor, and laser ablation further expand therapeutic possibilities. While these interventions show favorable safety profiles and potential as standalone or adjunctive treatments, further long-term studies and randomized trials are necessary to optimize patient selection and procedural protocols. Collectively, EBMTs represent an evolving paradigm in the management of obesity and metabolic diseases, bridging the gap between conservative medical therapies and bariatric surgery.<\/jats:p>","DOI":"10.3390\/jcm15082832","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:26:39Z","timestamp":1775661999000},"page":"2832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Endoscopy for Metabolic Diseases"],"prefix":"10.3390","volume":"15","author":[{"given":"Maria Valeria","family":"Matteo","sequence":"first","affiliation":[{"name":"Digestive Endoscopy Unit, Fondazione Policlinico Universitario A. 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Endosc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1177\/2050640620926837","article-title":"Metabolic endoscopy: Today\u2019s science\u2014tomorrow\u2019s treatment","volume":"8","author":"Hadefi","year":"2020","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.3350\/cmh.2024.0431","article-title":"Epidemiology of metabolic dysfunction-associated steatotic liver disease","volume":"31","author":"Younossi","year":"2025","journal-title":"Clin. Mol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Mauro, A., Lusetti, F., Scalvini, D., Bardone, M., De Grazia, F., Mazza, S., Pozzi, L., Ravetta, V., Rovedatti, L., and Sgarlata, C. (2023). A Comprehensive Review on Bariatric Endoscopy: Where We Are Now and Where We Are Going. 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Drug Pipeline for MASLD: What Can Be Learned from the Successful Story of Resmetirom. Curr. Issues Mol. Biol., 47.","DOI":"10.3390\/cimb47030154"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1055\/a-2630-2062","article-title":"Devices and techniques for bariatric and metabolic endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review","volume":"57","author":"Matteo","year":"2025","journal-title":"Endoscopy"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.jhep.2019.07.026","article-title":"Endoscopic bariatric and metabolic therapies for non-alcoholic fatty liver disease","volume":"71","author":"Bazerbachi","year":"2019","journal-title":"J. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.tem.2024.11.001","article-title":"Endoscopic management of obesity and metabolic diseases","volume":"36","author":"Walradt","year":"2025","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/0366-6999.221283","article-title":"Development of Bariatric and Metabolic Endoscopy","volume":"131","author":"Li","year":"2018","journal-title":"Chin. Med. J."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Ghusn, W., Zeineddine, J., Betancourt, R.S., Gajjar, A., Yang, W., Robertson, A.G., and Ghanem, O.M. (2025). Advances in Metabolic Bariatric Surgeries and Endoscopic Therapies: A Comprehensive Narrative Review of Diabetes Remission Outcomes. Medicina, 61.","DOI":"10.3390\/medicina61020350"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"26317745211019156","DOI":"10.1177\/26317745211019156","article-title":"Bariatric and metabolic endoscopy: Impact on obesity and related comorbidities","volume":"14","author":"Mehta","year":"2021","journal-title":"Clin. Med. Insights Gastroenterol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"711","DOI":"10.5946\/ce.2023.253","article-title":"The evolution and current state of bariatric endoscopy in Western countries","volume":"57","author":"Matteo","year":"2024","journal-title":"Clin. Endosc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.4239\/wjd.v15.i11.2255","article-title":"Bariatric and endo-bariatric interventions for diabetes: What is the current evidence?","volume":"15","author":"Mondal","year":"2024","journal-title":"World J. Diabetes"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.gie.2015.03.1964","article-title":"ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies","volume":"82","author":"Kumar","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.gie.2023.12.004","article-title":"American Society for Gastrointestinal Endoscopy\u2013European Society of Gastrointestinal Endoscopy guideline on primary endoscopic bariatric and metabolic therapies for adults with obesity","volume":"99","author":"Jirapinyo","year":"2024","journal-title":"Gastrointest. 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Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1007\/s11695-017-2636-3","article-title":"The Influence of the Orbera Intragastric Balloon Filling Volumes on Weight Loss, Tolerability, and Adverse Events: A Systematic Review and Meta-Analysis","volume":"27","author":"Kumar","year":"2017","journal-title":"Obes. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1007\/s11695-020-04985-4","article-title":"Intragastric Balloon: A Retrospective Evaluation of 5874 Patients on Tolerance, Complications, and Efficacy in Different Degrees of Overweight","volume":"30","author":"Diestel","year":"2020","journal-title":"Obes. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s11695-008-9593-9","article-title":"Evidence-based Review of the Bioenterics Intragastric Balloon for Weight Loss","volume":"18","author":"Dumonceau","year":"2008","journal-title":"Obes. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.soard.2017.09.528","article-title":"Brazilian Intragastric Balloon Consensus Statement (BIBC): Practical guidelines based on experience of over 40,000 cases","volume":"14","author":"Neto","year":"2018","journal-title":"Surg. Obes. Relat. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.cgh.2019.08.022","article-title":"Efficacy and Safety of Endoscopic Sleeve Gastroplasty: A Systematic Review and Meta-Analysis","volume":"18","author":"Hedjoudje","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0140-6736(22)01280-6","article-title":"Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT): A prospective, multicentre, randomised trial","volume":"400","author":"Bazerbachi","year":"2022","journal-title":"Lancet"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.cgh.2020.09.055","article-title":"Five-Year Outcomes of Endoscopic Sleeve Gastroplasty for the Treatment of Obesity","volume":"19","author":"Sharaiha","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.cgh.2016.12.012","article-title":"Endoscopic Sleeve Gastroplasty Significantly Reduces Body Mass Index and Metabolic Complications in Obese Patients","volume":"15","author":"Sharaiha","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.gie.2018.12.012","article-title":"Short-term outcomes of endoscopic sleeve gastroplasty in 1000 consecutive patients","volume":"89","author":"Alqahtani","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s12664-021-01202-7","article-title":"Endoscopic sleeve gastroplasty\u2014minimally invasive treatment for non-alcoholic fatty liver disease and obesity","volume":"40","author":"Jagtap","year":"2021","journal-title":"Indian J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1080\/17474124.2024.2387231","article-title":"Endoscopic sleeve gastroplasty for metabolic dysfunction-associated steatotic liver disease","volume":"18","author":"Matteo","year":"2024","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"983","DOI":"10.14309\/ajg.0000000000002087","article-title":"Regression of Hepatic Fibrosis After Endoscopic Gastric Plication in Nonalcoholic Fatty Liver Disease","volume":"118","author":"Jirapinyo","year":"2023","journal-title":"Am. J. Gastroenterol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1055\/a-2117-6274","article-title":"Improvements in hepatic steatosis, obesity, and insulin resistance in adults with nonalcoholic fatty liver disease after the primary obesity surgery endoluminal 2.0 procedure","volume":"55","author":"AlKhatry","year":"2023","journal-title":"Endoscopy"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.gie.2019.02.025","article-title":"Endoscopic sleeve gastroplasty for obesity: Defining the risk and reward after more than 1600 procedures","volume":"89","author":"Storm","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11894-020-00798-8","article-title":"Endobariatrics and Metabolic Endoscopy: Can We Solve the Obesity Epidemic with Our Scope?","volume":"22","author":"Farha","year":"2020","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.gie.2022.02.050","article-title":"Endoscopic gastroplasty versus laparoscopic sleeve gastrectomy: A noninferiority propensity score\u2013matched comparative study","volume":"96","author":"Alqahtani","year":"2022","journal-title":"Gastrointest. Endosc."},{"key":"ref_38","first-page":"S242","article-title":"Update data: A pilot study to evaluate the efficacy and safety of Gastric Mucosal Ablation (GMA) of the fundus with Hybrid Argon Plasma Coagulation (HybridAPC) combined with Endoscopic Sleeve Gastroplasty (ESG) in obese patients","volume":"57","author":"Angelini","year":"2025","journal-title":"Endoscopy"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"E141","DOI":"10.1055\/a-2767-0830","article-title":"Combined gastric mucosal ablation of the fundus using a new hybrid device with endoscopic sleeve gastroplasty for obesity","volume":"58","author":"Gualtieri","year":"2026","journal-title":"Endoscopy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1053\/j.gastro.2024.08.008","article-title":"Endoscopic Gastric Fundal Mucosal Ablation Induces Weight Loss in Adults With Obesity","volume":"167","author":"Maselli","year":"2024","journal-title":"Gastroenterology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s42000-023-00429-7","article-title":"The role of the gastric fundus in glycemic control","volume":"22","author":"Kehagias","year":"2023","journal-title":"Hormones"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1136\/gutjnl-2020-322073","article-title":"Small intestinal metabolism is central to whole-body insulin resistance","volume":"70","author":"Angelini","year":"2021","journal-title":"Gut"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1111\/dom.15533","article-title":"A look at duodenal mucosal resurfacing: Rationale for targeting the duodenum in type 2 diabetes","volume":"26","author":"Hoyt","year":"2024","journal-title":"Diabetes Obes. Metab."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/gutjnl-2019-318349","article-title":"Endoscopic duodenal mucosal resurfacing for the treatment of type 2 diabetes mellitus: One year results from the first international, open-label, prospective, multicentre study","volume":"69","author":"Holleman","year":"2020","journal-title":"Gut"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.giec.2024.06.002","article-title":"Small Bowel Therapies for Metabolic Disease and Obesity","volume":"34","author":"Gualtieri","year":"2024","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.medj.2024.03.014","article-title":"Endoscopic duodenal mucosa ablation techniques for diabetes and nonalcoholic fatty liver disease: A systematic review","volume":"5","author":"Musso","year":"2024","journal-title":"Med"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"E132","DOI":"10.1152\/ajpendo.00337.2021","article-title":"Duodenal mucosal resurfacing with a GLP-1 receptor agonist increases postprandial unconjugated bile acids in patients with insulin-dependent type 2 diabetes","volume":"322","author":"Meiring","year":"2022","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.2337\/dc16-0383","article-title":"Endoscopic Duodenal Mucosal Resurfacing for the Treatment of Type 2 Diabetes: 6-Month Interim Analysis From the First-in-Human Proof-of-Concept Study","volume":"39","author":"Rajagopalan","year":"2016","journal-title":"Diabetes Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e00364","DOI":"10.14309\/ctg.0000000000000364","article-title":"Bariatric and Metabolic Endoscopy: A New Paradigm","volume":"12","author":"Telese","year":"2021","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1007\/s11695-020-05170-3","article-title":"Metabolic Effects of Endoscopic Duodenal Mucosal Resurfacing: A Systematic Review and Meta-analysis","volume":"31","author":"Funari","year":"2021","journal-title":"Obes. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109194","DOI":"10.1016\/j.diabres.2022.109194","article-title":"Durable metabolic improvements 2 years after duodenal mucosal resurfacing (DMR) in patients with type 2 diabetes (REVITA-1 Study)","volume":"184","author":"Hopkins","year":"2022","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E1792","DOI":"10.1055\/a-1550-7668","article-title":"Endoscopic duodenal mucosal resurfacing for nonalcoholic steatohepatitis (NASH): A pilot study","volume":"9","author":"Hadefi","year":"2021","journal-title":"Endosc. Int. Open"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"154908","DOI":"10.1016\/j.metabol.2021.154908","article-title":"Mechanisms of action of duodenal mucosal resurfacing in insulin resistant women with polycystic ovary syndrome","volume":"125","author":"Kaur","year":"2021","journal-title":"Metabolism"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/gidisord6010013","article-title":"Metabolic Endoscopy: Should Gastroenterologists Be Treating Type 2 Diabetes?","volume":"6","author":"Norton","year":"2024","journal-title":"Gastrointest. Disord."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"AB11","DOI":"10.1016\/j.gie.2023.04.060","article-title":"Duodenal Mucosal Regeneration Induced by Endoscopic Pulsed Electric Field Treatment Improves Glycemic Control in Patients with Type II Diabetes\u2014Interim Results from a First-in-Human Study","volume":"97","author":"Sartoretto","year":"2023","journal-title":"Gastrointest. Endosc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.gie.2024.04.2904","article-title":"Recellularization via electroporation therapy of the duodenum combined with glucagon-like peptide-1 receptor agonist to replace insulin therapy in patients with type 2 diabetes: 12-month results of a first-in-human study","volume":"100","author":"Busch","year":"2024","journal-title":"Gastrointest. Endosc."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.igie.2025.03.012","article-title":"Durable insulin elimination after duodenal re-cellularization via electroporation therapy combined with glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes","volume":"4","author":"Busch","year":"2025","journal-title":"iGIE"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.igie.2025.03.008","article-title":"Radiofrequency vapor ablation for duodenal mucosal ablation in the treatment of type 2 diabetes: Results from the first-in-human pilot study","volume":"4","author":"Norton","year":"2025","journal-title":"iGIE"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/ueg2.12762","article-title":"Duodenal Laser Ablation for Treatment of Type 2 Diabetes: Results of First in Human Study","volume":"13","author":"Kovarova","year":"2025","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1089\/dia.2009.0063","article-title":"Pilot Clinical Study of an Endoscopic, Removable Duodenal-Jejunal Bypass Liner for the Treatment of Type 2 Diabetes","volume":"11","author":"Rodriguez","year":"2009","journal-title":"Diabetes Technol. Ther."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.2337\/dc17-1985","article-title":"Effect of the Duodenal-Jejunal Bypass Liner on Glycemic Control in Patients With Type 2 Diabetes With Obesity: A Meta-analysis With Secondary Analysis on Weight Loss and Hormonal Changes","volume":"41","author":"Jirapinyo","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"111806","DOI":"10.1016\/j.nut.2022.111806","article-title":"Impact of duodenal-jejunal bypass liner (DJBL) on NAFLD in patients with obesity and type 2 diabetes mellitus","volume":"103\u2013104","author":"Roehlen","year":"2022","journal-title":"Nutrition"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1055\/s-0042-118961","article-title":"EndoBarrier Gastrointestinal Liner in Type 2 Diabetic Patients Improves Liver Fibrosis as Assessed by Liver Elastography","volume":"125","author":"Gollisch","year":"2016","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/SLA.0000000000004339","article-title":"Efficacy and Safety of the Duodeno-Jejunal Bypass Liner in Patients With Metabolic Syndrome: A Multicenter Randomized Controlled Trial (ENDOMETAB)","volume":"272","author":"Caiazzo","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Thompson, C.C., Jirapinyo, P., McCarty, T.R., Brethauer, S., Shaheen, N., Sullivan, S.A., Koch, T., Reavis, K.M., Abu Dayyeh, B.K., and Wilson, E.B. (2025). A Multicenter Double-blind Randomized Sham-controlled Trial Assessing the EndoBarrier Duodenal-jejunal Bypass Liner for the Treatment of Poorly Controlled type 2 Diabetes Mellitus with Concomitant Obesity: The ENDO Trial. Ann. Surg.","DOI":"10.1097\/SLA.0000000000006974"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1007\/s11695-018-3441-3","article-title":"Adverse Events of the Duodenal-Jejunal Bypass Liner: A Systematic Review","volume":"28","author":"Betzel","year":"2018","journal-title":"Obes. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"555","DOI":"10.5056\/jnm20221","article-title":"Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study","volume":"27","author":"Oh","year":"2021","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.gie.2017.07.009","article-title":"Partial jejunal diversion using an incisionless magnetic anastomosis system: 1-year interim results in patients with obesity and diabetes","volume":"86","author":"Machytka","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Sangiorgi, G.M., Cereda, A., Porchetta, N., Benedetto, D., Matteucci, A., Bonanni, M., Chiricolo, G., and De Lorenzo, A. (2021). Endovascular Bariatric Surgery as Novel Minimally Invasive Technique for Weight Management in the Morbidly Obese: Review of the Literature. Nutrients, 13.","DOI":"10.3390\/nu13082541"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/2832\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T08:41:27Z","timestamp":1776156087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/2832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,8]]},"references-count":69,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jcm15082832"],"URL":"https:\/\/doi.org\/10.3390\/jcm15082832","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,8]]}}}