{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T09:30:34Z","timestamp":1775813434175,"version":"3.50.1"},"reference-count":49,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Laryngeal cancer remains a global health burden, particularly in regions with high tobacco and alcohol consumption. This study aimed to provide a comprehensive epidemiological overview of laryngeal cancer in Western Greece and to assess overall survival (OS), disease-specific survival (DSS), and key prognostic factors over a 21-year period. Methods: A retrospective cohort study was conducted, including patients diagnosed and treated for laryngeal cancer at the Otorhinolaryngology Department of the University General Hospital of Patras between 1997 and 2017. Demographic, clinical, histopathological, and treatment data were collected. Survival outcomes were estimated using Kaplan\u2013Meier analysis and compared using the log-rank test. Multivariable Cox proportional hazards regression was performed to identify independent prognostic factors. Significance was set at p \u2264 0.05. Results: A total of 211 patients were included (mean age 62.7 years; 95.3% male). Active smoking was reported in 97.6% of cases. Most patients (88.6%) were diagnosed at advanced stages (III\u2013IV), with glottic tumors being the most common (61.1%). The 5-year OS and DSS rates were 47.0% and 55.6%, respectively. Larger tumor size, nodal involvement, and advanced stage were significantly associated with reduced DSS in univariable analysis (p &lt; 0.001). Cox regression confirmed tumor size (HR = 1.665, 95% CI: 1.187\u20132.336) and nodal status (HR = 1.546, 95% CI: 1.176\u20132.031) as independent predictors of DSS. Conclusions: The findings highlight the impact of advanced disease at diagnosis and the central prognostic role of tumor burden in laryngeal cancer in Western Greece. Early detection and timely management remain essential to improve patient outcomes.<\/jats:p>","DOI":"10.3390\/jcm15082868","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:55:12Z","timestamp":1775807712000},"page":"2868","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Profile and Survival Outcomes of Laryngeal Cancer in Western Greece: A 21-Year Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7789-7130","authenticated-orcid":false,"given":"Christos S.","family":"Avdulla","sequence":"first","affiliation":[{"name":"Department of Public Health, Epidemiology and Quality of Life, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Mastronikolis","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ntaniela","family":"Tachirai","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, University General Hospital \u201cAttikon\u201d, 12462 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7499-4034","authenticated-orcid":false,"given":"Eleni","family":"Jelastopulu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Epidemiology and Quality of Life, University of Patras, 26504 Patras, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.nic.2022.07.011","article-title":"Anatomy of the Larynx and Cervical Trachea","volume":"32","author":"McCullagh","year":"2022","journal-title":"Neuroimaging Clin. 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