{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:25:51Z","timestamp":1781731551866,"version":"3.54.5"},"reference-count":84,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Platelet-rich plasma (PRP) is an autologous blood-derived biologic enriched in platelets and bioactive mediators. In urology and sexual medicine, PRP has been promoted for erectile dysfunction (ED) and a growing range of urogenital disorders on the premise that it may support angiogenesis, neuroregeneration, immune modulation, and tissue remodeling. However, clinical uptake has outpaced high-quality evidence, while heterogeneity in PRP preparation, characterization, and delivery limits interpretability and reproducibility. This structured narrative review aims to critically integrate mechanistic, preclinical, and clinical evidence regarding PRP use in ED, Peyronie\u2019s disease (PD), stress urinary incontinence (SUI), interstitial cystitis\/bladder pain syndrome (IC\/BPS), and selected emerging indications. We further aim to identify sources of heterogeneity and propose an actionable minimum reporting framework (PRP-Uro Checklist) to guide future research. Methods: A structured search of PubMed\/MEDLINE was conducted for studies published between 2021 and 2025. The relevant literature on PRP use in ED, PD, SUI, IC\/BPS, and related indications was included for critical narrative synthesis. Emphasis was placed on PRP classification and preparation variables, outcome measure validity, and sources of heterogeneity across studies. Results: Mechanistic and preclinical evidence supports PRP\u2019s potential to modulate nerve repair, angiogenesis, extracellular matrix remodeling, and immune polarization through a complex secretome of growth factors, cytokines, and extracellular vesicles (EVs). Clinical evidence suggests that intracavernosal PRP may improve erectile function in selected populations, but effect size, durability, and superiority over placebo remain uncertain due to small trials, substantial placebo effects, short follow-up, and incomplete biologic characterization. Evidence for PRP in PD, SUI, and IC\/BPS remains preliminary and is derived largely from small cohorts, proof-of-concept studies, or uncontrolled designs, although early findings suggest potential symptom benefit and acceptable short-term tolerability. Across indications, inconsistent PRP reporting, particularly the absence of absolute platelet dose, leukocyte quantification, activation method, and standardized treatment protocols, represents a major barrier to reproducibility and evidence synthesis. Conclusions: PRP is biologically plausible and appears broadly safe, but its role in urology and sexual medicine remains investigational and is not yet supported by guideline-level evidence. To enhance reproducibility and interpretation, we propose a Minimum PRP Reporting Checklist for Urology and Sexual Medicine Trials (PRP-Uro Checklist). Future progress requires rigorous standardized reporting, indication-specific biologic characterization, rigorously designed sham-controlled trials, clinically meaningful endpoints, and longer-term follow-up.<\/jats:p>","DOI":"10.3390\/jcm15082949","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:19:14Z","timestamp":1776075554000},"page":"2949","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["From Regenerative Mechanisms to Clinical Practice: Current Status, Controversies, and Future Perspectives of Platelet-Rich Plasma in Urology and Sexual Medicine"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1722-9835","authenticated-orcid":false,"given":"Rui","family":"Qu","sequence":"first","affiliation":[{"name":"Department of Urology and Pelvic Surgery and Andrology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4334-3662","authenticated-orcid":false,"given":"Jiaqi","family":"Gu","sequence":"additional","affiliation":[{"name":"West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Urology and Pelvic Surgery and Andrology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luo","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology and Pelvic Surgery and Andrology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Urology and Pelvic Surgery and Andrology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Anastasiadis, E., Ahmed, R., Khoja, A.K., and Yap, T. (2022). Erectile dysfunction: Is platelet-rich plasma the new frontier for treatment in patients with erectile dysfunction? A review of the existing evidence. Front. Reprod. Health, 4.","DOI":"10.3389\/frph.2022.944765"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.euf.2022.11.009","article-title":"The Current Role and Implications of Stem Cell Therapy in Erectile Dysfunction: A Transformation from Caterpillar to Butterfly Is Required","volume":"9","author":"Castiglione","year":"2023","journal-title":"Eur. Urol. Focus"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cytogfr.2021.11.003","article-title":"Applications of the regenerative capacity of platelets in modern medicine","volume":"64","author":"Goszka","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100317","DOI":"10.1016\/j.esxm.2020.100317","article-title":"Intracavernous injection of autologous platelet-rich plasma ameliorates hyperlipidemia-associated erectile dysfunction in a rat model","volume":"9","author":"Huang","year":"2021","journal-title":"Sex. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.arthro.2024.03.021","article-title":"Most orthopaedic platelet-rich plasma investigations don\u2019t report protocols and composition: An updated systematic review","volume":"41","author":"Lim","year":"2025","journal-title":"Arthroscopy"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rahman, E., Rao, P., Abu-Farsakh, H.N., Thonse, C., Ali, I., Upton, A.E., Baratikkae, S.Y., Carruthers, J.D.A., Mosahebi, A., and Heidari, N. (2024). Systematic review of platelet-rich plasma in medical and surgical specialties: Quality, evaluation, evidence, and enforcement. J. Clin. Med., 13.","DOI":"10.3390\/jcm13154571"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jisako.2023.07.010","article-title":"Review of Dohan Ehrenfest et al. (2009) on \u201cClassification of platelet concentrates: From pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)\u201d","volume":"9","author":"Calcei","year":"2024","journal-title":"J. ISAKOS"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"634","DOI":"10.12669\/pjms.39.3.7264","article-title":"Comparison of single and double centrifugation methods for preparation of platelet-rich plasma (PRP)","volume":"39","author":"Saqlain","year":"2023","journal-title":"Pak. J. Med. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Turajane, T., Cheeva-Akrapan, V., Saengsirinavin, P., and Lappaiwong, W. (2023). Composition of platelet-rich plasma prepared from knee osteoarthritic patients: Platelets, leukocytes, and subtypes of leukocyte. Cureus, 15.","DOI":"10.7759\/cureus.36399"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Gentile, P., Calabrese, C., De Angelis, B., Dionisi, L., Pizzicannella, J., Kothari, A., De Fazio, D., and Garcovich, S. (2020). Impact of the different preparation methods to obtain autologous non-activated platelet-rich plasma (A-PRP) and activated platelet-rich plasma (AA-PRP) in plastic surgery: Wound healing and hair regrowth evaluation. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21020431"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"54","DOI":"10.17691\/stm2020.12.6.07","article-title":"Effect of cryo-processing on platelet-rich autoplasma preparations","volume":"12","author":"Melnikov","year":"2021","journal-title":"Sovrem. Tehnol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Mercader Ruiz, J., Beitia, M., Delgado, D., S\u00e1nchez, P., S\u00e1nchez, M.B., Oraa, J., Benito-Lopez, F., Basabe-Desmonts, L., and S\u00e1nchez, M. (2024). Method to obtain a plasma rich in platelet- and plasma-growth factors based on water evaporation. PLoS ONE, 19.","DOI":"10.1371\/journal.pone.0297001"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Wu, W.S., Chen, L.R., and Chen, K.H. (2025). Platelet-rich plasma (PRP): Molecular mechanisms, actions and clinical applications in human body. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms262110804"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Del Amo, C., Perez-Valle, A., Atilano, L., and Andia, I. (2022). Unraveling the signaling secretome of platelet-rich plasma: Towards a better understanding of its therapeutic potential in knee osteoarthritis. J. Clin. Med., 11.","DOI":"10.3390\/jcm11030473"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Fidan, B.B., Ko\u00e7, E., \u00d6zotuk, E.\u00c7., Kaplan, O., \u00c7elebier, M., and Korkusuz, F. (2025). Do preparation techniques transform the metabolite profile of platelet-rich plasma?. Bioengineering, 12.","DOI":"10.3390\/bioengineering12070774"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"026111","DOI":"10.1063\/5.0196553","article-title":"Proteomics of human platelet lysates and insight from animal studies on platelet protein diffusion to hippocampus upon intranasal administration","volume":"8","author":"Le","year":"2024","journal-title":"APL Bioeng."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4103\/1673-5374.346461","article-title":"Platelet-rich plasma promotes peripheral nerve regeneration after sciatic nerve injury","volume":"18","author":"Wang","year":"2023","journal-title":"Neural Regen. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41536-022-00239-2","article-title":"Platelet-rich plasma loaded nerve guidance conduit as implantable biocompatible materials for recurrent laryngeal nerve regeneration","volume":"7","author":"Kim","year":"2022","journal-title":"NPJ Regen. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0043-1761194","article-title":"BDNF and Krox20 as indicators of platelet-rich plasma-induced nerve regeneration in a neuropathic orofacial pain model","volume":"18","author":"Winias","year":"2024","journal-title":"Eur. J. Dent."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jconrel.2024.01.043","article-title":"Platelet-rich plasma-derived exosomes boost mesenchymal stem cells to promote peripheral nerve regeneration","volume":"367","author":"Zhang","year":"2024","journal-title":"J. Control. Release"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"149496","DOI":"10.1016\/j.bbrc.2024.149496","article-title":"Platelet-rich plasma-derived exosomes enhance mesenchymal stem cell paracrine function and nerve regeneration potential","volume":"699","author":"Zhang","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ismy, J., Khalilullah, S.A., Maulana, R., and Hidayatullah, F. (2024). A potential treatment for erectile dysfunction: Effect of platelet-rich plasma administration on axon and collagen regeneration in cavernous nerve injury. Narra J, 4.","DOI":"10.52225\/narra.v4i2.880"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1055\/a-2317-4520","article-title":"Preconditioning local injection of activated platelet-rich plasma increases angiogenesis, VEGF levels, and viability of modified McFarlane flap in diabetes-induced rats","volume":"51","author":"Kamayana","year":"2024","journal-title":"Arch. Plast. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Chen, T., Song, P., He, M., Rui, S., Duan, X., Ma, Y., Armstrong, D.G., and Deng, W. (2023). Sphingosine-1-phosphate derived from PRP-Exos promotes angiogenesis in diabetic wound healing via the S1PR1\/AKT\/FN1 signalling pathway. Burn. Trauma, 11.","DOI":"10.1093\/burnst\/tkad003"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/JU.0000000000003481","article-title":"Platelet-rich plasma for the treatment of erectile dysfunction: A prospective, randomized, double-blind, placebo-controlled clinical trial","volume":"210","author":"Masterson","year":"2023","journal-title":"J. Urol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12610-024-00232-3","article-title":"Safety and efficacy of platelet-rich plasma injection for treatment of erectile dysfunction: A prospective randomized controlled study","volume":"34","author":"Ragheb","year":"2024","journal-title":"Basic Clin. Androl."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00345-024-05065-3","article-title":"Platelet-rich plasma therapy in erectile dysfunction and Peyronie\u2019s disease: A systematic review of the literature","volume":"42","author":"Asmundo","year":"2024","journal-title":"World J. Urol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Berndt, S., Carpentier, G., Turzi, A., Borlat, F., Cuendet, M., and Modarressi, A. (2021). Angiogenesis is differentially modulated by platelet-derived products. Biomedicines, 9.","DOI":"10.3390\/biomedicines9030251"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/SAP.0000000000003579","article-title":"Platelet-rich plasma combined fat transplantation for the treatment of bleomycin-induced murine scleroderma","volume":"90","author":"Wang","year":"2023","journal-title":"Ann. Plast. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"119934","DOI":"10.1016\/j.lfs.2021.119934","article-title":"Regenerative effect of platelet-rich plasma in the murine ischemic limbs","volume":"284","author":"Stilhano","year":"2021","journal-title":"Life Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Yadav, A., Ramasamy, T.S., Lin, S.C., Chen, S.H., Lu, J., Liu, Y.H., Lu, F.I., Hsueh, Y.Y., Lin, S.P., and Wu, C.C. (2022). Autologous platelet-rich growth factor reduces M1 macrophages and modulates inflammatory microenvironments to promote sciatic nerve regeneration. Biomedicines, 10.","DOI":"10.3390\/biomedicines10081991"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"24120","DOI":"10.1021\/acsami.3c02548","article-title":"Composite hydrogel conduit incorporated with platelet-rich plasma improved the regenerative microenvironment for peripheral nerve repair","volume":"15","author":"Dong","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Dai, P., Wu, Y., Gao, Y., Li, M., Zhu, M., Xu, H., Feng, X., Jin, Y., and Zhang, X. (2024). Multiomics analysis of platelet-rich plasma promoting biological performance of mesenchymal stem cells. BMC Genom., 25.","DOI":"10.1186\/s12864-024-10329-8"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/09537104.2021.1961717","article-title":"Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming","volume":"33","author":"Chen","year":"2022","journal-title":"Platelets"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.jsxm.2022.06.003","article-title":"Platelet rich plasma (PRP) growth factor concentration varies in men with erectile dysfunction","volume":"19","author":"Khodamoradi","year":"2022","journal-title":"J. Sex. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.urology.2023.01.028","article-title":"Is platelet rich plasma safe and effective in treatment of erectile dysfunction? Randomized controlled study","volume":"175","author":"Shaher","year":"2023","journal-title":"Urology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"970","DOI":"10.21037\/tau-24-30","article-title":"Efficacy and safety of platelet-rich plasma (PRP) in erectile dysfunction (ED): A systematic review and meta-analysis","volume":"13","author":"Huang","year":"2024","journal-title":"Transl. Androl. Urol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/j.jsxm.2021.03.008","article-title":"Platelet-rich plasma (PRP) improves erectile function: A double-blind, randomized, placebo-controlled clinical trial","volume":"18","author":"Poulios","year":"2021","journal-title":"J. Sex. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.23736\/S2724-6507.23.04060-5","article-title":"Regenerative treatment with platelet-rich plasma in patients with refractory erectile dysfunction: Short-term outcomes and predictive value of mean platelet volume","volume":"50","author":"Francomano","year":"2025","journal-title":"Minerva Endocrinol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ajur.2024.01.001","article-title":"Efficacy and safety of platelet-rich plasma intracavernous injection for patients with erectile dysfunction: A systematic review, meta-analysis, and meta-regression","volume":"11","author":"Suharyani","year":"2024","journal-title":"Asian J. Urol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100313","DOI":"10.1016\/j.esxm.2020.100313","article-title":"Early clinical results of the tolerability, safety, and efficacy of autologous platelet-rich plasma administration in erectile dysfunction","volume":"9","author":"Arda","year":"2021","journal-title":"Sex. Med."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zaghloul, A.S., El-Nashaar, A.M., Said, S.Z., Osman, I.A., and Mostafa, T. (2022). Assessment of the intracavernosal injection platelet-rich plasma in addition to daily oral tadalafil intake in diabetic patients with erectile dysfunction non-responding to on-demand oral PDE5 inhibitors. Andrologia, 54.","DOI":"10.1111\/and.14421"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Zaghloul, A.S., Mahmoud ElNashar, A.E.R., GamalEl Din, S.F., Zaki Said, S., Saad, H.M., Refaat Eldebs, H., and Abdel Latif Osman, I. (2021). Smoking status and the baseline international index of erectile function score can predict satisfactory response to platelet-rich plasma in patients with erectile dysfunction: A prospective pilot study. Andrologia, 53.","DOI":"10.1111\/and.14162"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2472786","DOI":"10.1080\/13685538.2025.2472786","article-title":"The efficacy of platelet-rich plasma (PRP) alone or in combination with low intensity shock wave therapy (Li-SWT) in treating erectile dysfunction: A systematic review and meta-analysis of seven randomized controlled trials","volume":"28","author":"Zhou","year":"2025","journal-title":"Aging Male"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s00345-025-05691-5","article-title":"Platelet-rich plasma intra-plaque injections rapidly reduce penile curvature and improve sexual function in Peyronie\u2019s disease patients: Results from a prospective large-cohort study","volume":"43","author":"Dachille","year":"2025","journal-title":"World J. Urol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.sxmr.2020.07.001","article-title":"Platelet-rich plasma and cellular therapies for sexual medicine and beyond","volume":"10","author":"Matz","year":"2022","journal-title":"Sex. Med. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/sxmrev\/qead027","article-title":"Platelet-rich plasma for the treatment of erectile dysfunction: A systematic review of preclinical and clinical studies","volume":"11","author":"Poulios","year":"2023","journal-title":"Sex. Med. Rev."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.purol.2020.05.002","article-title":"Biotherapies for erectile dysfunction and Peyronie\u2019s disease: Where are we now?","volume":"30","author":"Akakpo","year":"2020","journal-title":"Prog. Urol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Yang, W., Qiu, C., Zhai, J., Zhang, W., Huang, C., Shao, J., Zhang, J., Chen, S., Miao, X., and Chen, P. (2023). Ultrasound-targeted microbubble destruction mediates PDE5i\/NO integration for cavernosum remodeling and penile rehabilitation. Bioeng. Transl. Med., 8.","DOI":"10.1002\/btm2.10568"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/andr.12873","article-title":"Neutralizing antibody to proNGF rescues erectile function by regulating the expression of neurotrophic and angiogenic factors in a mouse model of cavernous nerve injury","volume":"9","author":"Chung","year":"2021","journal-title":"Andrology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jsxm.2019.12.002","article-title":"Dynamic changes in erectile function and histological architecture after intracorporal injection of human placental stem cells in a pelvic neurovascular injury rat model","volume":"17","author":"Gu","year":"2020","journal-title":"J. Sex. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"508","DOI":"10.4103\/aja2024115","article-title":"Effects of human umbilical cord-derived mesenchymal stem cell therapy for cavernous nerve injury-induced erectile dysfunction in the rat model","volume":"27","author":"Wang","year":"2025","journal-title":"Asian J. Androl."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Shao, J., Nie, P., Yang, W., Guo, R., Ding, D., Liang, R., Wei, B., and Wei, H. (2022). An EPO-loaded multifunctional hydrogel synergizing with adipose-derived stem cells restores neurogenic erectile function via enhancing nerve regeneration and penile rehabilitation. Bioeng. Transl. Med., 7.","DOI":"10.1002\/btm2.10319"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1007\/s11033-021-06332-x","article-title":"Improvement of damaged cavernosa followed by neuron-like differentiation at injured cavernous nerve after transplantation of stem cells seeded on the PLA nanofiber in rats with cavernous nerve injury","volume":"48","author":"Kim","year":"2021","journal-title":"Mol. Biol. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1111\/andr.13065","article-title":"A novel flavonoid derivative of icariside II improves erectile dysfunction in a rat model of cavernous nerve injury","volume":"9","author":"Gu","year":"2021","journal-title":"Andrology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.jsxm.2020.12.016","article-title":"CXCL5 cytokine is a major factor in platelet-rich plasma\u2019s preservation of erectile function in rats after bilateral cavernous nerve injury","volume":"18","author":"Wu","year":"2021","journal-title":"J. Sex. Med."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Liao, C.H., Lee, K.H., Chung, S.D., Chen, K.C., Praveen Rajneesh, C., Chen, B.H., Cheng, J.H., Lin, W.Y., Chiang, H.S., and Wu, Y.N. (2022). Intracavernous injection of platelet-rich plasma therapy enhances erectile function and decreases the mortality rate in streptozotocin-induced diabetic rats. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms23063017"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.21037\/tau-22-791","article-title":"The use of low-intensity extracorporeal shockwave therapy in management of erectile dysfunction following prostate cancer treatment: A review of the current literature","volume":"12","author":"Matthew","year":"2023","journal-title":"Transl. Androl. Urol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.56434\/j.arch.esp.urol.20257808.135","article-title":"Erectile function recovery using shockwave and platelet-rich plasma: A single-centre prospective comparative study","volume":"78","author":"Dogan","year":"2025","journal-title":"Arch. Esp. Urol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"164","DOI":"10.56434\/j.arch.esp.urol.20257802.23","article-title":"Low-intensity extracorporeal shock wave therapy and platelet-rich plasma: Effective combination treatment of chronic-phase Peyronie\u2019s disease","volume":"78","year":"2025","journal-title":"Arch. Esp. Urol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"367","DOI":"10.23736\/S2724-6051.23.05458-7","article-title":"A new alternative approach to management of acute phase Peyronie\u2019s disease: Low intensity extracorporeal shockwave therapy and platelet-rich plasma","volume":"76","author":"Karakose","year":"2024","journal-title":"Minerva Urol. Nephrol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s41443-024-00844-3","article-title":"A phase 2 randomized, placebo-controlled crossover trial to evaluate safety and efficacy of platelet-rich plasma injections for Peyronie\u2019s disease: Clinical trial update","volume":"36","author":"Ledesma","year":"2024","journal-title":"Int. J. Impot. Res."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Jhang, J.F., Jiang, Y.H., Lin, T.Y., and Kuo, H.C. (2023). The tumor necrosis factor-\u03b1 level in platelet-rich plasma might be associated with treatment outcome in patients with interstitial cystitis\/bladder pain syndrome or recurrent urinary tract infection. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25010163"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/s00192-025-06324-6","article-title":"Efficacy and safety of submucosal intravesical injection of platelet-rich plasma in the treatment of interstitial cystitis\/painful bladder syndrome","volume":"37","author":"Mourad","year":"2026","journal-title":"Int. Urogynecol. J."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Zheng, Q., Zhang, P., Guo, W., Zhang, J., Zhang, F., Ma, C., Yang, Y., Cui, L., Wu, Y., and Zhang, L. (2025). A standardized protocol for modified platelet-rich plasma collection for the treatment of interstitial cystitis\/bladder pain syndrome. Bladder, 12.","DOI":"10.14440\/bladder.2024.0052"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1097\/AOG.0000000000006081","article-title":"Platelet-rich plasma for genitourinary syndrome of menopause in breast cancer survivors","volume":"146","author":"Chen","year":"2025","journal-title":"Obstet. Gynecol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Sacarin, G., Abu-Awwad, A., Razvan, N., Craina, M., Hogea, B., Sorop, B., Abu-Awwad, S.A., Diaconu, M., Pilut, N.C., and Suba, M.I. (2025). Sexual quality of life in postmenopausal women: A comparative randomized controlled trial of intravaginal PRP therapy versus local hormonal treatments. Medicina, 61.","DOI":"10.3390\/medicina61071140"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s00192-022-05112-w","article-title":"Treatment with platelet-rich plasma attenuates proprioceptor abnormalities in a rat model of postpartum stress urinary incontinence","volume":"33","author":"Liu","year":"2022","journal-title":"Int. Urogynecol. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/s41598-020-80598-2","article-title":"A pilot study: Effectiveness of local injection of autologous platelet-rich plasma in treating women with stress urinary incontinence","volume":"11","author":"Long","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5213\/inj.2040272.136","article-title":"Therapeutic efficacy of urethral sphincter injections of platelet-rich plasma for the treatment of stress urinary incontinence due to intrinsic sphincter deficiency: A proof-of-concept clinical trial","volume":"25","author":"Jiang","year":"2021","journal-title":"Int. Neurourol. J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e668","DOI":"10.1097\/SPV.0000000000001100","article-title":"The Use of Platelet-rich Plasma as a Novel Nonsurgical Treatment of the Female Stress Urinary Incontinence: A Prospective Pilot Study","volume":"27","author":"Athanasiou","year":"2021","journal-title":"Female Pelvic Med. Reconstr. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/SPV.0000000000001378","article-title":"Platelet-Rich Plasma for the Treatment of Stress Urinary Incontinence\u2014A Randomized Trial","volume":"30","author":"Grigoriadis","year":"2024","journal-title":"Urogynecology"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.urology.2024.06.047","article-title":"A Single Injection of Platelet-rich Plasma Injection for the Treatment of Stress Urinary Incontinence in Females: A Randomized Placebo-controlled Trial","volume":"193","author":"Ashton","year":"2024","journal-title":"Urology"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/15533506211014848","article-title":"The emerging role on the use of platelet-rich plasma products in the management of urogynaecological disorders","volume":"29","author":"Prodromidou","year":"2022","journal-title":"Surg. Innov."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"qdaf307","DOI":"10.1093\/jsxmed\/qdaf307","article-title":"Platelet-rich plasma in the management of vulvovaginal disorders: A systematic review","volume":"23","author":"Cabrera","year":"2026","journal-title":"J. Sex. Med."},{"key":"ref_76","first-page":"63","article-title":"Platelet-rich plasma for the treatment of lichen sclerosus","volume":"8","author":"Villalpando","year":"2021","journal-title":"Plast. Aesthetic Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Paganelli, A., Contu, L., Condorelli, A., Ficarelli, E., Motolese, A., Paganelli, R., and Motolese, A. (2023). Platelet-rich plasma (PRP) and adipose-derived stem cell (ADSC) therapy in the treatment of genital lichen sclerosus: A comprehensive review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms242216107"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Dankova, I., Pyrgidis, N., Tishukov, M., Georgiadou, E., Nigdelis, M.P., Solomayer, E.F., Marcon, J., Stief, C.G., and Hatzichristou, D. (2023). Efficacy and safety of platelet-rich plasma injections for the treatment of female sexual dysfunction and stress urinary incontinence: A systematic review. Biomedicines, 11.","DOI":"10.3390\/biomedicines11112919"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"151627","DOI":"10.1016\/j.acthis.2020.151627","article-title":"Application of platelet-rich plasma (PRP) improves self-renewal of human spermatogonial stem cells in two-dimensional and three-dimensional culture systems","volume":"122","author":"Khadivi","year":"2020","journal-title":"Acta Histochem."},{"key":"ref_80","first-page":"21","article-title":"Laws and regulations on platelet-rich plasma use for musculoskeletal pathologies in South America: A narrative review","volume":"50","author":"Nakamura","year":"2025","journal-title":"Int. Orthop."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Colomer-Selva, R., Tvarijonavciute, A., Franco-Mart\u00ednez, L., Hern\u00e1ndez-Guerra, \u00c1.M., Carrillo, J.M., Rubio, M., Sopena, J.J., and Satu\u00e9, K. (2025). Physiological factors affecting platelet-rich plasma variability in human and veterinary medicine. Front. Vet. Sci., 12.","DOI":"10.3389\/fvets.2025.1571373"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Mochizuki, T., Ushiki, T., Suzuki, K., Sato, M., Ishiguro, H., Suwabe, T., Edama, M., Omori, G., Yamamoto, N., and Kawase, T. (2023). Characterization of leukocyte- and platelet-rich plasma derived from female college athletes: Growth factor, inflammatory cytokines, and anti-inflammatory cytokine levels. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713592"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Qin, H., Yang, H., Wang, J., Jiang, D., Chen, Y., Wang, W., and Wang, A. (2025). Progress in the clinical application of allogeneic platelet-rich plasma for diabetic foot treatment. Front. Endocrinol., 16.","DOI":"10.3389\/fendo.2025.1694691"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Koller, D., Beam, A., Manrai, A., Ashley, E., Liu, X., Gichoya, J., Holmes, C., Zou, J., Dagan, N., and Wong, T.Y. (2024). Why We Support and Encourage the Use of Large Language Models in NEJM AI Submissions. NEJM AI, 1.","DOI":"10.1056\/AIe2300128"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/2949\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:10:25Z","timestamp":1777263025000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/2949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,13]]},"references-count":84,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jcm15082949"],"URL":"https:\/\/doi.org\/10.3390\/jcm15082949","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,13]]}}}