{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:12:13Z","timestamp":1776172333027,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To investigate the association between the uric acid-to-high-density lipoprotein cholesterol ratio (UAHDLr) and the risk of new-onset atrial fibrillation (NOAF) during hospitalization in patients with non-ST-elevation myocardial infarction (NSTEMI). Methods: This retrospective cohort study included NSTEMI patients without prior atrial fibrillation. UAHDLr was log2-transformed to evaluate the effect of doubling. Feature selection was performed using least absolute shrinkage and selection operator regression. Cox proportional hazards models with sequential adjustments were applied. Nonlinear associations were assessed using restricted cubic spline analysis, and discrimination was evaluated with time-dependent receiver operating characteristic analysis. Results: UAHDLr was independently associated with in-hospital NOAF across all models. Doubling (1-unit increase) UAHDLr significantly increased NOAF risk in unadjusted (HR: 5.97, 95% CI: 3.71\u20139.61) and clinically adjusted models (HR: 5.98, 95% CI: 3.58\u20139.99). The association was stronger in the LASSO-adjusted (HR: 8.19, 95% CI: 4.13\u201316.24) and fully adjusted models (HR: 13.40, 95% CI: 5.90\u201330.44). Spline analysis showed a progressive increase in NOAF risk with higher UAHDLr values. Discrimination was stable, with an area under the curve of approximately 0.76. Conclusions: UAHDLr is a strong, easily accessible biomarker for predicting in-hospital NOAF in NSTEMI patients and may support early risk stratification.<\/jats:p>","DOI":"10.3390\/jcm15082977","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:23:56Z","timestamp":1776169436000},"page":"2977","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Uric Acid-to-HDL Cholesterol Ratio as an Independent Predictor of In-Hospital New-Onset Atrial Fibrillation in Non-ST-Elevation Myocardial Infarction"],"prefix":"10.3390","volume":"15","author":[{"given":"Mehmet Nail","family":"Bilen","sequence":"first","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9097-5391","authenticated-orcid":false,"given":"\u00d6mer","family":"Gen\u00e7","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gazi","family":"\u00c7apar","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5820-1927","authenticated-orcid":false,"given":"Muhammed Mert","family":"G\u00f6ksu","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6744-1287","authenticated-orcid":false,"given":"H\u00fcseyin","family":"Akg\u00fcn","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9728-8475","authenticated-orcid":false,"given":"Gamze","family":"Acar","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ksenin Cansu","family":"\u00d6zdo\u011fan","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnseli","family":"\u00dcredi","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furkan","family":"\u015een","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2461-6795","authenticated-orcid":false,"given":"Ufuk Sali","family":"Halil","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-2455","authenticated-orcid":false,"given":"Yusuf","family":"\u0130nci","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deniz Dilan Naki","family":"Tekin","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahri","family":"Er","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1231-0933","authenticated-orcid":false,"given":"Ersin","family":"\u0130bi\u015fo\u011flu","sequence":"additional","affiliation":[{"name":"\u0130stanbul Ba\u015fak\u015fehir \u00c7am ve Sakura \u015eehir Hastanesi, 34480 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.jacc.2019.07.020","article-title":"Atrial Fibrillation and Diabetes Mellitus: JACC Review Topic of the Week","volume":"74","author":"Wang","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e027089","DOI":"10.1161\/JAHA.122.027089","article-title":"Elevated Uric Acid Is Associated with New-Onset Atrial Fibrillation: Results from the Swedish AMORIS Cohort","volume":"12","author":"Ding","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Wu, X., Zhang, Y., Yang, X., Xu, Z., and Feng, Y. (2023). Incorporating Uric Acid into the CHA2DS2-VASc Score Improves the Prediction of New-Onset Atrial Fibrillation in Patients with Acute Myocardial Infarction. BMC Cardiovasc. Disord., 23.","DOI":"10.1186\/s12872-023-03561-9"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Li, Z., Liu, Q., and Yao, Z. (2024). The Serum Uric Acid-to-High-Density Lipoprotein Cholesterol Ratio Is a Predictor for All-Cause and Cardiovascular Disease Mortality: A Cross-Sectional Study. Front. Endocrinol., 15.","DOI":"10.3389\/fendo.2024.1417485"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12944-025-02551-4","article-title":"Association between the Uric Acid-to-HDL-Cholesterol Ratio (UHR) and the Risk of Cardiovascular Disease and Dyslipidemia: A Population-Based Study","volume":"24","author":"Yi","year":"2025","journal-title":"Lipids Health Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the Management of Acute Coronary Syndromes","volume":"44","author":"Byrne","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC Guidelines for the Management of Atrial Fibrillation Developed in Collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Rienstra","year":"2024","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/ehjci\/jev014","article-title":"Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"16","author":"Lang","year":"2015","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S0894-7317(89)80014-8","article-title":"Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms","volume":"2","author":"Schiller","year":"1989","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/CIRCULATIONAHA.110.990192","article-title":"Atrial Fibrillation and Death after Myocardial Infarction: A Community Study","volume":"123","author":"Jabre","year":"2011","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/hrt.2007.134486","article-title":"Short- and Long-Term Outcomes Following Atrial Fibrillation in Patients with Acute Coronary Syndromes with or without ST-Segment Elevation","volume":"94","author":"Lopes","year":"2008","journal-title":"Heart"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1001\/jamainternmed.2013.11912","article-title":"Atrial Fibrillation and the Risk of Myocardial Infarction","volume":"174","author":"Soliman","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1161\/CIR.0000000000000665","article-title":"2019 AHA\/ACC\/HRS Focused Update of the 2014 AHA\/ACC\/HRS Guideline for the Management of Patients with Atrial Fibrillation: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration with the Society of Thoracic Surgeons","volume":"140","author":"January","year":"2019","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/01.CIR.89.2.724","article-title":"Echocardiographic Predictors of Nonrheumatic Atrial Fibrillation: The Framingham Heart Study","volume":"89","author":"Vaziri","year":"1994","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/TCRM.S5701","article-title":"The role of urate and xanthine oxidase in vascular oxidative stress: Future directions","volume":"5","author":"George","year":"2009","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.cca.2018.05.046","article-title":"Uric Acid and Cardiovascular Disease","volume":"484","author":"Ndrepepa","year":"2018","journal-title":"Clin. Chim. Acta"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1365-2796.2009.02133.x","article-title":"Uric Acid and Risk of Myocardial Infarction, Stroke and Congestive Heart Failure in 417,734 Men and Women in the Apolipoprotein Mortality Risk Study (AMORIS)","volume":"266","author":"Holme","year":"2009","journal-title":"J. Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1253\/circrep.CR-19-0088","article-title":"Hyperuricemia as a Risk Factor for Atrial Fibrillation Due to Soluble and Crystalized Uric Acid","volume":"1","author":"Taufiq","year":"2019","journal-title":"Circ. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/01.RES.0000146094.59640.13","article-title":"Antiinflammatory Properties of HDL","volume":"95","author":"Barter","year":"2004","journal-title":"Circ. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1056\/NEJM198911093211907","article-title":"High-density lipoprotein\u2014The clinical implications of recent studies","volume":"321","author":"Gordon","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12933-025-02837-y","article-title":"Impact of Glucometabolic Status on Type 4a Myocardial Infarction in Patients with Non-ST-Segment Elevation Myocardial Infarction: The Role of Stress Hyperglycemia Ratio","volume":"24","author":"Armillotta","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nrcardio.2015.2","article-title":"Inflammation and the pathogenesis of atrial fibrillation","volume":"12","author":"Hu","year":"2015","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_23","first-page":"277","article-title":"Serum Uric Acid to HDL Cholesterol Ratio Is Associated with Diabetic Control in New Onset Type 2 Diabetic Population","volume":"62","author":"Kosekli","year":"2023","journal-title":"Acta Clin. Croat."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1007\/s12012-025-10000-y","article-title":"Association Between the Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Residual Risk for Coronary Artery Disease","volume":"25","author":"Zhong","year":"2025","journal-title":"Cardiovasc. Toxicol."},{"key":"ref_25","first-page":"751","article-title":"Uric Acid to HDL-C Ratio as a Marker of Coronary Artery Disease Severity in Non-ST-Elevation Myocardial Infarction Patients","volume":"41","year":"2025","journal-title":"Acta Cardiol. Sin."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/2977\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T12:37:46Z","timestamp":1776170266000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/2977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,14]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jcm15082977"],"URL":"https:\/\/doi.org\/10.3390\/jcm15082977","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,14]]}}}