{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:22:12Z","timestamp":1791883332416,"version":"4.3.4"},"reference-count":111,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Transcatheter aortic valve implantation (TAVI) has become the preferred treatment for patients with symptomatic severe aortic valve stenosis. Newer-generation devices, increased operator experience, and improved patient selection have contributed to a reduction in complication rates. However, the occurrence of new-onset left bundle branch block (LBBB) after TAVI remains high, and currently it is the most common complication associated with the procedure. This review discusses the current understanding of new-onset LBBB, including its causes, incidence, clinical outcomes, and management strategies.<\/jats:p>","DOI":"10.3390\/jcm15083016","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:02:33Z","timestamp":1776261753000},"page":"3016","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["New-Onset Left Bundle Branch Block After TAVI: An Updated Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4680-2194","authenticated-orcid":false,"given":"Juan Ignacio","family":"Mayol","sequence":"first","affiliation":[{"name":"Centro Cardiol\u00f3gico Americano, Sanatorio Americano, 11300 Montevideo, Uruguay"},{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillem","family":"Muntan\u00e9-Carol","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Gracida","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-5398","authenticated-orcid":false,"given":"Andrea","family":"Ruberti","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2146-3197","authenticated-orcid":false,"given":"Ana","family":"Marcano","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Roura","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neus","family":"Salvatella","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3792-8972","authenticated-orcid":false,"given":"Luis","family":"Teruel","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"G\u00f3mez-Lara","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Romaguera","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8780-720X","authenticated-orcid":false,"given":"Josep","family":"Com\u00edn-Colet","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-3095","authenticated-orcid":false,"given":"Joan Antoni","family":"G\u00f3mez-Hospital","sequence":"additional","affiliation":[{"name":"Cardiology Department, Bellvitge University Hospital, 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"},{"name":"Bio-Heart Cardiovascular, Respiratory and Systemic Diseases and Cellular Aging Program, Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Catalunya, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0140-6736(06)69208-8","article-title":"Burden of valvular heart diseases: A population-based study","volume":"368","author":"Nkomo","year":"2006","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1001\/jama.2024.16477","article-title":"Calcific aortic stenosis: A review","volume":"332","author":"Otto","year":"2024","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1161\/01.CIR.38.1S5.V-61","article-title":"Aortic stenosis","volume":"38","author":"Ross","year":"1968","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehab395","article-title":"2021 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"43","author":"Vahanian","year":"2022","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1093\/eurheartj\/ehaf194","article-title":"2025 ESC\/EACTS Guidelines for the management of valvular heart disease","volume":"46","author":"Praz","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/eurheartj\/ehac803","article-title":"ESC\/EACTS vs. ACC\/AHA guidelines for the management of severe aortic stenosis","volume":"44","author":"Lee","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1008232","article-title":"Transcatheter aortic-valve implantation for aortic stenosis in patients who cannot undergo surgery","volume":"363","author":"Leon","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa1103510","article-title":"Transcatheter versus surgical aortic-valve replacement in high-risk patients","volume":"364","author":"Smith","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1056\/NEJMoa1700456","article-title":"Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients","volume":"376","author":"Reardon","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa1814052","article-title":"Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients","volume":"380","author":"Mack","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients","volume":"380","author":"Popma","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1056\/NEJMoa2307447","article-title":"Transcatheter Aortic-Valve Replacement in Low-Risk Patients at Five Years","volume":"389","author":"Mack","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1161\/CIRCULATIONAHA.117.028352","article-title":"Conduction Disturbances After Transcatheter Aortic Valve Replacement: Current Status and Future Perspectives","volume":"136","author":"Auffret","year":"2017","journal-title":"Circulation"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jacc.2014.11.027","article-title":"Late Cardiac Death in Patients Undergoing Transcatheter Aortic Valve Replacement: Incidence and Predictors of Advanced Heart Failure and Sudden Cardiac Death","volume":"65","author":"Urena","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.jcin.2019.03.025","article-title":"Long-Term Outcomes in Patients with New-Onset Persistent Left Bundle Branch Block Following TAVR","volume":"12","author":"Chamandi","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jcin.2013.08.015","article-title":"Impact of new-onset persistent left bundle branch block on late clinical outcomes in patients undergoing transcatheter aortic valve implantation with a balloon-expandable valve","volume":"7","author":"Urena","year":"2014","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1093\/eurheartj\/ehz924","article-title":"Clinical impact of conduction disturbances in transcatheter aortic valve replacement recipients: A systematic review and meta-analysis","volume":"41","author":"Faroux","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.ijcard.2016.11.104","article-title":"Evaluation of current practices in transcatheter aortic valve implantation: The WRITTEN (WoRldwIde TAVI ExperieNce) survey","volume":"228","author":"Cerrato","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/europace\/euac027","article-title":"Management of conduction disorders after transcatheter aortic valve implantation: Results of the EHRA survey","volume":"24","author":"Badertscher","year":"2022","journal-title":"Europace"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Szotek, M., Dru\u017cbicki, \u0141., Sabatowski, K., Amoroso, G.R., De Schouwer, K., and Matusik, P.T. (2023). Transcatheter Aortic Valve Implantation and Cardiac Conduction Abnormalities: Prevalence, Risk Factors and Management. J. Clin. Med., 12.","DOI":"10.3390\/jcm12186056"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1080\/17434440.2019.1624161","article-title":"How does new-onset left bundle branch block affect the outcomes of transcatheter aortic valve repair?","volume":"16","author":"Guimaraes","year":"2019","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e015441","DOI":"10.1161\/CIRCINTERVENTIONS.125.015441","article-title":"Outcomes of Patients with New Left Bundle Branch Block After TAVR: TVT Registry Insights","volume":"19","author":"Singh","year":"2026","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.4244\/EIJV9I10A194","article-title":"Occurrence, fate and consequences of ventricular conduction abnormalities after transcatheter aortic valve implantation","volume":"9","author":"Houthuizen","year":"2014","journal-title":"EuroIntervention"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.jcin.2018.04.016","article-title":"Arrhythmic Burden as Determined by Ambulatory Continuous Cardiac Monitoring in Patients with New-Onset Persistent Left Bundle Branch Block Following Transcatheter Aortic Valve Replacement: The MARE Study","volume":"11","author":"Urena","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.amjcard.2019.11.025","article-title":"Late Electrocardiographic Changes in Patients with New-Onset Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation","volume":"125","author":"Faroux","year":"2020","journal-title":"Am. J. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.carrev.2015.11.005","article-title":"Mortality and major adverse cardiovascular events after transcatheter aortic valve replacement using Edwards valve versus CoreValve: A meta-analysis","volume":"17","author":"Panchal","year":"2016","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"308","DOI":"10.2459\/JCM.0000000000001459","article-title":"Acute expansion of nitinol-based self-expandable device in patients undergoing transfemoral aortic valve implantation","volume":"24","author":"Spaccarotella","year":"2023","journal-title":"J. Cardiovasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1093\/eurheartj\/ehaa036","article-title":"Comparison of newer generation self-expandable vs. balloon-expandable valves in transcatheter aortic valve implantation: The randomized SOLVE-TAVI trial","volume":"41","author":"Thiele","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e1077","DOI":"10.4244\/EIJ-D-22-00558","article-title":"Permanent pacemaker implantation and left bundle branch block with self-expanding valves\u2014A SCOPE 2 subanalysis","volume":"18","author":"Pellegrini","year":"2023","journal-title":"EuroIntervention"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"E326","DOI":"10.25270\/jic\/21.00203","article-title":"Generational Differences in Outcomes of Self-Expanding Valves for Transcatheter Aortic Valve Replacement","volume":"34","author":"Loewenstein","year":"2022","journal-title":"J. Invasive Cardiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.carrev.2024.05.002","article-title":"Conduction disorders following transcatheter aortic valve replacement using acurate Neo2 transcatheter heart valve: A propensity matched analysis","volume":"68","author":"Loewenstein","year":"2024","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.recesp.2015.06.027","article-title":"Conduction Abnormalities and Pacemaker Implantations After SAPIEN 3 Vs SAPIEN XT Prosthesis Aortic Valve Implantation","volume":"69","author":"Husser","year":"2016","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.jcin.2022.02.027","article-title":"Transcatheter Aortic Valve Replacement with Self-Expanding ACURATE neo2: Postprocedural Hemodynamic and Short-Term Clinical Outcomes","volume":"15","author":"Buono","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.carrev.2019.01.006","article-title":"Left Bundle Branch Block after Transcatheter Aortic Valve Implantation with Edwards Sapien 3 Valve: Influence of the Valve Depth Implantation","volume":"20","author":"Teijeiro","year":"2019","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.jcin.2023.05.004","article-title":"First-in-Human Multicenter Experience of the Newest Generation Supra-Annular Self-Expanding Evolut FX TAVR System","volume":"16","author":"Zaid","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/08998280.2020.1717906","article-title":"Effect of new and persistent left bundle branch block after transcatheter aortic valve replacement on long-term need for pacemaker implantation","volume":"33","author":"Hamandi","year":"2020","journal-title":"Bayl. Univ. Med. Cent. Proc."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Monizzi, G., Olivares, P., Makmur, G., Fabbiocchi, F., Grancini, L., Mastrangelo, A., Ferrari, C., Galli, S., Montorsi, P., and Bartorelli, A.L. (2022). Conduction disorders after transcatheter aortic valve implantation: A comparison between SAPIEN 3 and SAPIEN 3 Ultra balloon-expandable valves. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.922696"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1016\/S0140-6736(24)00821-3","article-title":"LANDMARK comparison of early outcomes of newer-generation Myval transcatheter heart valve series with contemporary valves (Sapien and Evolut) in real-world individuals with severe symptomatic native aortic stenosis: A randomised non-inferiority trial","volume":"403","author":"Baumbach","year":"2024","journal-title":"Lancet"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jcin.2022.08.057","article-title":"Transcatheter Aortic Valve Replacement with the Latest-Iteration Self-Expanding or Balloon-Expandable Valves: The Multicenter OPERA-TAVI Registry","volume":"15","author":"Costa","year":"2022","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.4244\/EIJ-D-22-01022","article-title":"One-year outcomes after transcatheter aortic valve implantation with the latest-generation SAPIEN balloon-expandable valve: The S3U registry","volume":"18","author":"Cannata","year":"2023","journal-title":"EuroIntervention"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.carrev.2024.12.008","article-title":"One-year hemodynamic and clinical outcomes in self-expanding valves: Comparison of ACURATE neo2 versus ACURATE neo","volume":"79","author":"Sugiyama","year":"2024","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.carrev.2024.01.016","article-title":"Safety and effectiveness of the novel Myval Octacor transcatheter heart valve in severe, symptomatic aortic valve stenosis\u2014A real-world Indian experience (The OCTACOR India Study)","volume":"63","author":"Jose","year":"2024","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijcard.2021.12.049","article-title":"Myval versus alternative balloon- and self-expandable transcatheter heart valves: A central core lab analysis of conduction disturbances","volume":"351","author":"Halim","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.carrev.2023.04.014","article-title":"Safety and performance parameters of the Myval transcatheter aortic valve bioprosthesis: The SAPPHIRE prospective registry","volume":"55","author":"Testa","year":"2023","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_45","first-page":"431","article-title":"Impact of implantation technique on conduction disturbances for TAVR with the self-expanding portico\/navitor valve","volume":"101","author":"Wang","year":"2023","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jacasi.2024.04.010","article-title":"Initial Results of Intra-Annular Self-Expandable Valves: Insights From the OCEAN-TAVI Registry","volume":"4","author":"Shirai","year":"2024","journal-title":"JACC Asia"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ijcard.2022.05.014","article-title":"Development of atrioventricular and intraventricular conduction disturbances in patients undergoing transcatheter aortic valve replacement with new generation self-expanding valves: A real world multicenter analysis","volume":"362","author":"Baz","year":"2022","journal-title":"Int. J. Cardiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.jcin.2015.05.010","article-title":"Inverse Relationship Between Membranous Septal Length and the Risk of Atrioventricular Block in Patients Undergoing Transcatheter Aortic Valve Implantation","volume":"8","author":"Hamdan","year":"2015","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jtcvs.2020.07.072","article-title":"Membranous septum length predicts conduction disturbances following transcatheter aortic valve replacement","volume":"164","author":"Chen","year":"2022","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.jcin.2019.05.056","article-title":"Minimizing Permanent Pacemaker Following Repositionable Self-Expanding Transcatheter Aortic Valve Replacement","volume":"12","author":"Jilaihawi","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jcct.2022.07.003","article-title":"Impact of membranous septum length on pacemaker need with different transcatheter aortic valve replacement systems: The INTERSECT registry","volume":"16","author":"Hokken","year":"2022","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.jacc.2012.07.035","article-title":"Predictive factors and long-term clinical consequences of persistent left bundle branch block following transcatheter aortic valve implantation with a balloon-expandable valve","volume":"60","author":"Urena","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_53","first-page":"538","article-title":"Long-term clinical outcome of persistent left bundle branch block after transfemoral aortic valve implantation","volume":"93","author":"Gonska","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.jacasi.2023.07.013","article-title":"Feasibility and Outcome of Transjugular Intracardiac Echocardiography-Guided Transcatheter Aortic Valve Replacement","volume":"3","author":"Murakami","year":"2023","journal-title":"JACC Asia"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e013094","DOI":"10.1161\/CIRCINTERVENTIONS.123.013094","article-title":"Impact of Transjugular Intracardiac Echocardiography-Guided Self-Expandable Transcatheter Aortic Valve Implantation on Reduction of Conduction Disturbances","volume":"17","author":"Ishizu","year":"2024","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"435","DOI":"10.23736\/S2724-5683.24.06477-9","article-title":"Acurate neo2 is associated with a reduced inflammatory response in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation","volume":"72","author":"Chiabrando","year":"2024","journal-title":"Minerva Cardiol. Angiol."},{"key":"ref_57","first-page":"E162","article-title":"Aortic annulus to left coronary distance as a predictor for persistent left bundle branch block after TAVI","volume":"89","author":"Jochheim","year":"2017","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.amjcard.2020.01.008","article-title":"Novel Anatomic Predictors of New Persistent Left Bundle Branch Block After Evolut Transcatheter Aortic Valve Implantation","volume":"125","author":"Zaid","year":"2020","journal-title":"Am. J. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1093\/eurheartj\/ehr110","article-title":"Timing and potential mechanisms of new conduction abnormalities during the implantation of the Medtronic CoreValve System in patients with aortic stenosis","volume":"32","author":"Nuis","year":"2011","journal-title":"Eur. Heart J."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.4244\/EIJ-D-17-00252","article-title":"Very low pacemaker rate following ACURATE neo transcatheter heart valve implantation","volume":"13","author":"Toggweiler","year":"2017","journal-title":"EuroIntervention"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/ehjci\/jev343","article-title":"Calcium distribution patterns of the aortic valve as a risk factor for the need of permanent pacemaker implantation after transcatheter aortic valve implantation","volume":"17","author":"Fujita","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e000972","DOI":"10.1136\/openhrt-2018-000972","article-title":"Anatomical predictors of conduction damage after transcatheter implantation of the aortic valve","volume":"6","author":"Tretter","year":"2019","journal-title":"Open Heart"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Yu, Q., Fu, Q., Xia, Y., and Wu, Y. (2024). Predictors, clinical impact, and management strategies for conduction abnormalities after transcatheter aortic valve replacement: An updated review. Front. Cardiovasc. Med., 11.","DOI":"10.3389\/fcvm.2024.1370244"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1093\/eurheartj\/ehz227","article-title":"New-onset left bundle branch block after transcatheter aortic valve replacement is associated with adverse long-term clinical outcomes in intermediate-risk patients: An analysis from the PARTNER II trial","volume":"40","author":"Nazif","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/ehjqcco\/qcaa089","article-title":"Predictors of pacemaker implantation after transcatheter aortic valve implantation according to kind of prosthesis and risk profile: A systematic review and contemporary meta-analysis","volume":"7","author":"Bruno","year":"2021","journal-title":"Eur. Heart J. Qual. Care Clin. Outcomes"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Wang, J., Liu, S., Han, X., Chen, Y., Chen, H., Wan, Z., and Song, B. (2022). Prognostic Outcome of New-Onset Left Bundle Branch Block After Transcatheter Aortic Valve Replacement in Patients with Aortic Stenosis: A Systematic Review and Meta-Analysis. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.842929"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"e003635","DOI":"10.1161\/CIRCINTERVENTIONS.115.003635","article-title":"Impact of New-Onset Left Bundle Branch Block and Periprocedural Permanent Pacemaker Implantation on Clinical Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement: A Systematic Review and Meta-Analysis","volume":"9","author":"Regueiro","year":"2016","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.1093\/eurheartj\/ehab364","article-title":"2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy","volume":"42","author":"Glikson","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.jacc.2019.07.014","article-title":"Management of Conduction Disturbances Associated with Transcatheter Aortic Valve Replacement: JACC Scientific Expert Panel","volume":"74","author":"Ellenbogen","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1016\/j.jacc.2020.08.050","article-title":"2020 ACC Expert Consensus Decision Pathway on Management of Conduction Disturbances in Patients Undergoing Transcatheter Aortic Valve Replacement: A Report of the American College of Cardiology Solution Set Oversight Committee","volume":"76","author":"Lilly","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.hrthm.2023.09.004","article-title":"ECG characteristics of \u201ctrue\u201d left bundle branch block: Insights from transcatheter aortic valve-related LBBB and His-Purkinje conduction system pacing-correctable LBBB","volume":"20","author":"Kawamura","year":"2023","journal-title":"Heart Rhythm."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ejheart.2006.04.011","article-title":"Left bundle branch block as a risk factor for progression to heart failure","volume":"9","author":"Zannad","year":"2007","journal-title":"Eur. J. Heart Fail."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1586\/14779072.6.6.843","article-title":"Impact of left bundle branch block and activation pattern on the heart","volume":"6","author":"Abdou","year":"2008","journal-title":"Expert Rev. Cardiovasc. Ther."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7326\/0003-4819-90-3-303","article-title":"Newly acquired left bundle-branch block: The Framingham study","volume":"90","author":"Schneider","year":"1979","journal-title":"Ann. Intern. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1161\/01.CIR.98.22.2494","article-title":"Bundle-branch block in a general male population: The study of men born 1913","volume":"98","author":"Eriksson","year":"1998","journal-title":"Circulation"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/S0002-9149(96)00160-9","article-title":"Natural history of isolated bundle branch block","volume":"77","author":"Fahy","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1067\/mhj.2002.121264","article-title":"Left bundle-branch block is associated with increased 1-year sudden and total mortality rate in 5517 outpatients with congestive heart failure: A report from the Italian network on congestive heart failure","volume":"143","author":"Baldasseroni","year":"2002","journal-title":"Am. Heart J."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Kim, K., Ko, Y.G., Shim, C.Y., Ryu, J., Lee, Y.J., Seo, J., Lee, S.J., Cho, I., Hong, S.J., and Ahn, C.M. (2022). Impact of New-Onset Persistent Left Bundle Branch Block on Reverse Cardiac Remodeling and Clinical Outcomes After Transcatheter Aortic Valve Replacement. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.893878"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1136\/heartjnl-2015-307666","article-title":"Chronic pacing and adverse outcomes after transcatheter aortic valve implantation","volume":"101","author":"Dizon","year":"2015","journal-title":"Heart"},{"key":"ref_80","first-page":"1386","article-title":"New-Onset Left Bundle Branch Block After TAVI has a Deleterious Impact on Left Ventricular Systolic Function","volume":"35","author":"Eschalier","year":"2019","journal-title":"Can. J. Cardiol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1093\/eurheartj\/eht376","article-title":"Clinical implications of new-onset left bundle branch block after transcatheter aortic valve replacement: Analysis of the PARTNER experience","volume":"35","author":"Nazif","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.amjcard.2022.03.053","article-title":"Risk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation","volume":"175","author":"Tsushima","year":"2022","journal-title":"Am. J. Cardiol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1161\/CIRCULATIONAHA.112.001099","article-title":"Clinical impact of persistent left bundle-branch block after transcatheter aortic valve implantation with CoreValve Revalving System","volume":"127","author":"Testa","year":"2013","journal-title":"Circulation"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.jcin.2021.07.043","article-title":"Outcomes Following Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement: SWEDEHEART Observational Study","volume":"14","author":"Saleh","year":"2021","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jcin.2018.10.053","article-title":"Mortality and Heart Failure Hospitalization in Patients with Conduction Abnormalities After Transcatheter Aortic Valve Replacement","volume":"12","author":"Gerds","year":"2019","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1016\/j.jacc.2018.10.044","article-title":"2018 ACC\/AHA\/HRS Guideline on the Evaluation and Management of Patients with Bradycardia and Cardiac Conduction Delay: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society","volume":"74","author":"Kusumoto","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.hrthm.2023.01.013","article-title":"Incidence and management of atrioventricular conduction disorders in new-onset left bundle branch block after TAVI: A prospective multicenter study","volume":"20","author":"Ploux","year":"2023","journal-title":"Heart Rhythm."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1016\/j.hrthm.2024.12.019","article-title":"Prospective validation of a prespecified algorithm for the management of conduction disturbances after transcatheter aortic valve replacement: The PROMOTE study","volume":"22","author":"Veiga","year":"2025","journal-title":"Heart Rhythm."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1016\/j.jcin.2024.07.032","article-title":"Conduction Disturbances After Transcatheter Aortic Valve Replacement: An Update on Epidemiology, Preventive Strategies, and Management","volume":"17","author":"Nuche","year":"2024","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jacc.2020.12.062","article-title":"Ambulatory Electrocardiogram Monitoring in Patients Undergoing Transcatheter Aortic Valve Replacement: JACC State-of-the-Art Review","volume":"77","author":"Philippon","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.hrthm.2021.11.020","article-title":"Bradyarrhythmias detected by extended rhythm recording in patients undergoing transcatheter aortic valve replacement (Brady-TAVR Study)","volume":"19","author":"Tarakji","year":"2022","journal-title":"Heart Rhythm."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1016\/j.jacc.2019.02.068","article-title":"Ambulatory Rhythm Monitoring to Detect Late High-Grade Atrioventricular Block Following Transcatheter Aortic Valve Replacement","volume":"73","author":"Ream","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Nozica, N., Siontis, G.C.M., Elchinova, E.G., Goulouti, E., Asami, M., Bartkowiak, J., Baldinger, S., Servatius, H., Seiler, J., and Tanner, H. (2022). Assessment of New Onset Arrhythmias After Transcatheter Aortic Valve Implantation Using an Implantable Cardiac Monitor. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.876546"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jcin.2018.04.011","article-title":"Immediate Post-Procedural 12-Lead Electrocardiography as Predictor of Late Conduction Defects After Transcatheter Aortic Valve Replacement","volume":"11","author":"Gerds","year":"2018","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1093\/europace\/euaa213","article-title":"Arrhythmic burden in patients with new-onset persistent left bundle branch block after transcatheter aortic valve replacement: 2-year results of the MARE study","volume":"23","author":"Urena","year":"2021","journal-title":"Europace"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e014446","DOI":"10.1161\/JAHA.119.014446","article-title":"Electrophysiology Testing to Stratify Patients with Left Bundle Branch Block After Transcatheter Aortic Valve Implantation","volume":"9","author":"Knecht","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Pagnoni, M., Meier, D., Luca, A., Fournier, S., Aminfar, F., Gentil, P., Haddad, C., Domenichini, G., Lebloa, M., and Herrera-Siklody, C. (2022). Yield of the electrophysiological study in patients with new-onset left bundle branch block after transcathether aortic valve replacement: The PR interval matters. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.1065221"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"20","DOI":"10.15420\/aer.2019.38.3","article-title":"Use of Electrophysiological Studies in Transcatheter Aortic Valve Implantation","volume":"9","author":"Michowitz","year":"2020","journal-title":"Arrhythm. Electrophysiol. Rev."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.hroo.2022.10.007","article-title":"Invasive electrophysiological testing to predict and guide permanent pacemaker implantation after transcatheter aortic valve implantation: A meta-analysis","volume":"4","author":"Siontis","year":"2023","journal-title":"Heart Rhythm O2"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jacep.2025.09.010","article-title":"Risk Stratification in Left Bundle Branch Block After Transcatheter Aortic Valve Implantation: A Multicenter ECG Algorithm Study","volume":"12","author":"Badertscher","year":"2025","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jcin.2016.03.024","article-title":"The Electrocardiogram After Transcatheter Aortic Valve Replacement Determines the Risk for Post-Procedural High-Degree AV Block and the Need for Telemetry Monitoring","volume":"9","author":"Toggweiler","year":"2016","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"676","DOI":"10.2459\/JCM.0000000000001516","article-title":"Effect of acute CORticosteroids on conduction defects after Transcatheter Aortic Valve Implantation: The CORTAVI study","volume":"24","author":"Barone","year":"2023","journal-title":"J. Cardiovasc. Med."},{"key":"ref_103","first-page":"e56824","article-title":"Intraoperative Corticosteroids and Pacemaker Implantation After Transcatheter Aortic Valve Replacement","volume":"16","author":"Tiago","year":"2024","journal-title":"Cureus"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"e043791","DOI":"10.1161\/JAHA.125.043791","article-title":"Preoperative Colchicine and Conduction Disturbances After Transcatheter Aortic Valve Implantation: A US Retrospective Cohort Analysis","volume":"14","author":"Abdelsayed","year":"2025","journal-title":"J. Am. Heart Assoc."},{"key":"ref_105","unstructured":"Kenneally, L.F. (2025, January 31). The GLUCO-TAVR trial. Presented at the European Society of Cardiology Congress, Madrid, Spain."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"6501","DOI":"10.1038\/s41467-025-61916-6","article-title":"Colchicine in patients with aortic stenosis undergoing transcatheter aortic valve replacement: A double-blind randomized trial","volume":"16","author":"Ryffel","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"875","DOI":"10.4244\/EIJ-D-18-01060","article-title":"Pacemaker dependency after transcatheter aortic valve implantation: Incidence, predictors and long-term outcomes","volume":"15","author":"Costa","year":"2019","journal-title":"EuroIntervention"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"e012594","DOI":"10.1161\/JAHA.119.012594","article-title":"Pacemaker Implantation and Dependency After Transcatheter Aortic Valve Replacement in the REPRISE III Trial","volume":"8","author":"Meduri","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"102603","DOI":"10.1016\/j.eclinm.2024.102603","article-title":"Permanent pacemaker reduction using temporary-permanent pacemaker as a 1-month bridge after transcatheter aortic valve replacement: A prospective, multicentre, single-arm, observational study","volume":"72","author":"Chang","year":"2024","journal-title":"eClinicalMedicine"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1016\/j.jacep.2025.07.028","article-title":"Prophylactic Permanent Pacemaker Implantation After Transcatheter Aortic Valve Replacement","volume":"11","author":"Fischer","year":"2025","journal-title":"JACC Clin. Electrophysiol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/j.jcin.2019.09.029","article-title":"Left Ventricular Rapid Pacing Via the Valve Delivery Guidewire in Transcatheter Aortic Valve Replacement","volume":"12","author":"Faurie","year":"2019","journal-title":"JACC Cardiovasc. Interv."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/3016\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:55:55Z","timestamp":1776934555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/3016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,15]]},"references-count":111,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jcm15083016"],"URL":"https:\/\/doi.org\/10.3390\/jcm15083016","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,15]]}}}