{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:57:03Z","timestamp":1776333423164,"version":"3.51.2"},"reference-count":21,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Wrist osteomyelitis caused by Scedosporium apiospermum is exceedingly rare. Its indolent course and destructive potential may result in extensive bone loss and pose substantial diagnostic and therapeutic challenges. Methods: We report a case of chronic wrist osteomyelitis caused by Scedosporium apiospermum in a 68-year-old kidney\u2013pancreas transplant recipient. Results: Following diagnosis, systemic antifungal therapy with voriconazole was initiated, and multiple surgical debridements were performed to achieve local disease control, resulting in a large defect of the carpus and distal forearm. Hand salvage was attempted using an osteocutaneous triple-barrel fibula flap. The postoperative course was complicated by congestion of the fibula skin island, which was managed with leech therapy. Subsequent infection with a multi-resistant Aeromonas spp. and Morganella morganii led to flap necrosis, ultimately requiring transradial forearm amputation. Conclusions: Destructive Scedosporium apiospermum osteomyelitis in immunocompromised patients is a major challenge for reconstructive surgeons. Interdisciplinary management is essential as mold eradication is only achievable through a combined surgical and antimicrobial approach. In advanced destructive osteomyelitis, the choice between limb salvage and amputation should be individualized, considering patient comorbidities, reconstructive risk, and patients\u2019 preferences. This case highlights the importance of balancing careful indication and patient counseling in complex clinical scenarios.<\/jats:p>","DOI":"10.3390\/jcm15083035","type":"journal-article","created":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:04:42Z","timestamp":1776330282000},"page":"3035","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Destructive Mold Osteomyelitis of the Wrist Caused by Scedosporium apiospermum\u2014A Case Report"],"prefix":"10.3390","volume":"15","author":[{"given":"Camilla","family":"Bo","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-4109","authenticated-orcid":false,"given":"Anna","family":"Conen","sequence":"additional","affiliation":[{"name":"Clinic for Infectious Diseases and Infection Prevention, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Giacalone","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, Kantonsspital Aarau, 5001 Aarau, Switzerland"},{"name":"Plastic and Reconstructive Surgery, Department of Surgical Sciences, Tor Vergata University of Rome, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regula","family":"Marti","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-7967","authenticated-orcid":false,"given":"Rainer","family":"Grobholz","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Zurich, 8032 Zurich, Switzerland"},{"name":"Institute of Pathology, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1552-7983","authenticated-orcid":false,"given":"Harald","family":"Seeger","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kantonsspital Baden, 5404 Baden, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger J.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A.","family":"Plock","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-9591","authenticated-orcid":false,"given":"Florian S.","family":"Frueh","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Hand Surgery, Kantonsspital Aarau, 5001 Aarau, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Asperges, E., Albi, G., Truffelli, F., Salvaderi, A., Puci, F., Sangani, A., Zuccaro, V., Scotti, V., Orsolini, P., and Brunetti, E. 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