{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T12:07:07Z","timestamp":1784203627931,"version":"3.55.0"},"reference-count":92,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Over the past years, burn care has evolved from a discipline focused on survival to one centered on restoring long-term health, function, and quality of life. Significant advances in critical care, early excision and grafting, infection control, and metabolic support have transformed survival outcomes for even the most severe injuries. As a result, the field now faces a new frontier: understanding and managing the long-term physical, psychological, and systemic sequelae of survival. This review traces the evolution of burn care over the last century and outlines the challenges and priorities for the next 25 years. The first era of progress, defined by innovations in resuscitation, surgery, and critical care, has given rise to a growing cohort of long-term survivors. Research over the past decade has revealed that major burns induce chronic multisystem alterations, including metabolic, cardiovascular, neurocognitive, and immunological dysfunctions. Emerging concepts such as burn-associated heart failure exemplify this shift from acute to chronic disease understanding. Looking ahead, the future of burn medicine lies in personalized and lifelong care, supported by translational research, digital health, regenerative therapies, and interdisciplinary collaboration. Overall, burn care stands at a pivotal crossroads. By integrating precision medicine, rehabilitation science, and psychosocial care, we aim to move the field from survival toward sustained, holistic recovery over the next 25 years.<\/jats:p>","DOI":"10.3390\/jcm15083102","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:24:23Z","timestamp":1776673463000},"page":"3102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evolving Burn Care: The Transition from Life Preservation to Life Restoration\u2015A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Tobias","family":"Niederegger","sequence":"first","affiliation":[{"name":"Medical Faculty, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jule","family":"Brandt","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schaschinger","sequence":"additional","affiliation":[{"name":"Medical Faculty, University of Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alen","family":"Palackic","sequence":"additional","affiliation":[{"name":"Department of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-979X","authenticated-orcid":false,"given":"Valentin","family":"Haug","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Vivantes Hospital Friedrichshain, 10249 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Klimitz","sequence":"additional","affiliation":[{"name":"Department of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3402-2860","authenticated-orcid":false,"given":"Ulrich","family":"Kneser","sequence":"additional","affiliation":[{"name":"Department of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6112-8671","authenticated-orcid":false,"given":"Christoph","family":"Hirche","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand and Reconstructive Microsurgery, Hand Trauma and Replantation Center (FESSH), BG Unfallklinik Frankfurt, Affiliated Hospital of Goethe University Frankfurt, 60389 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ziegler","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Hand and Reconstructive Microsurgery, Hand Trauma and Replantation Center (FESSH), BG Unfallklinik Frankfurt, Affiliated Hospital of Goethe University Frankfurt, 60389 Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Aman","sequence":"additional","affiliation":[{"name":"Department of Hand-, Replantation- and Microsurgery, Department of Burns and Plastic Surgery, BG Klinikum Unfallkrankenhaus Berlin, Chair of Hand-, Replantation- and Microsurgery, Charit\u00e9 Universit\u00e4tsmedizin Berlin, 12683 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Harhaus-W\u00e4hner","sequence":"additional","affiliation":[{"name":"Department of Hand-, Replantation- and Microsurgery, Department of Burns and Plastic Surgery, BG Klinikum Unfallkrankenhaus Berlin, Chair of Hand-, Replantation- and Microsurgery, Charit\u00e9 Universit\u00e4tsmedizin Berlin, 12683 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6173-8602","authenticated-orcid":false,"given":"Gabriel","family":"Hundeshagen","sequence":"additional","affiliation":[{"name":"Department of Hand-, Plastic and Reconstructive Surgery, Microsurgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, 67071 Ludwigshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.4103\/2321-3868.143620","article-title":"History of burns: The past, present and the future","volume":"2","author":"Lee","year":"2014","journal-title":"Burn. 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