{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:31:11Z","timestamp":1792794671781,"version":"4.5.0"},"reference-count":41,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Diabetes Center Berne"},{"id":[{"id":"https:\/\/ror.org\/02a9khs93","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Older patients with fractures often present with a complex interplay of factors associated with frailty and functional decline. The emerging concept of Orthogeriatric Fracture Syndrome (OFS) aims to characterize these distinct relationships of pathologies and outcomes. Despite increasing recognition of OFS in clinical practice, due to the distributed nature of fragility factors across medical disciplines, it remains poorly defined in the literature. Methods: We used large-scale text mining of 26 million PubMed abstracts to quantify the occurrence and interrelationship of OFS-related concepts across all disciplines in biomedical research. Results: OFS terms were more prevalent in fragility fractures than in other fracture types, particularly osteoporosis (0.52 vs. 0.09, p &lt; 0.05). In pairwise keyword correlation (Pearson \u03c6), the correlations presented between OFS keywords are comparable to the ones in the more established metabolic syndrome (e.g., \u03c6 = 0.07 between stroke and hypertension, p &lt; 0.05). For OFS, osteoporosis emerged as the central node linking OFS outcomes and pathologies, correlating with fragility fracture (\u03c6 = 0.176, p &lt; 0.05) and sarcopenia (\u03c6 = 0.03, p &lt; 0.05). Sarcopenia in turn correlated with gait (\u03c6 = 0.04, p &lt; 0.05), malnutrition (\u03c6 = 0.05, p &lt; 0.05), and frailty (\u03c6 = 0.032, p &lt; 0.05). Old age keywords showed substantially higher association with OFS keywords (e.g., \u03c6 = 0.06 for elderl* and hip fracture, p &lt; 0.05) than with metabolic syndrome terms (elderl* and insulin resistance, p &gt; 0.05). Conclusions: Overall, the analysis showed statistically significant associations between keywords representing OFS outcomes, pathologies and old age. The combined occurrence of osteoporosis, sarcopenia, frailty and risk of falls may help conceptually identify older adults at risk and inform preventive measures. This large-scale bibliometric analysis supports OFS as a conceptually coherent, proposed theoretical framework for cross-disciplinary awareness and coordinated care, with a literature-level organizational pattern comparable to metabolic syndrome, however, pending prospective clinical validation. This study reframes fragility fractures as the endpoint of a broader, potentially modifiable risk constellation and underscores the need for further clinical and epidemiological validation.<\/jats:p>","DOI":"10.3390\/jcm15083105","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T08:24:23Z","timestamp":1776673463000},"page":"3105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Orthogeriatric Fracture Syndrome: A Large-Scale Bibliometric Analysis of a Proposed Concept for Cross-Disciplinary Awareness and Coordinated Care"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2293-6160","authenticated-orcid":false,"given":"Alceu","family":"Bissoto","sequence":"first","affiliation":[{"name":"Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"},{"name":"Department of Digital Medicine, University of Bern, 3012 Bern, Switzerland"},{"name":"Diabetes Center Berne, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike Annette","family":"Bischoff-Ferrari","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, University of Basel, 4002 Basel, Switzerland"},{"name":"Department of Aging Medicine, FELIX Platter Basel, University of Basel, 4002 Basel, Switzerland"},{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Blum","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"City Hospital Zurich, 8063 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Brunner","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"City Hospital Zurich, 8063 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-3368","authenticated-orcid":false,"given":"Michael","family":"Dietrich","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"City Hospital Zurich, 8063 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"Division of Bone Diseases, Geneva University Hospital, 1211 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Goetz","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"St. Katharinental Clinic, Diessenhofen, Spital Thurgau AG, Thurmed AG, 8253 Diessenhofen, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0865-2575","authenticated-orcid":false,"given":"Slavko","family":"Rogan","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"Department of Health Professions, Bern University of Applied Sciences, 3008 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Scheel-Sailer","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"Centre for Rehabilitation and Sports Medicine, Inselspital, University Hospital Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4377-7074","authenticated-orcid":false,"given":"Lisa Margret","family":"Koch","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"},{"name":"Department of Digital Medicine, University of Bern, 3012 Bern, Switzerland"},{"name":"Diabetes Center Berne, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0708-4097","authenticated-orcid":false,"given":"Johannes Dominik","family":"Bastian","sequence":"additional","affiliation":[{"name":"Fragility Fracture Network, 3010 Bern, Switzerland"},{"name":"Department of Orthopaedic Surgery and Traumatology, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.amjms.2023.03.001","article-title":"When should clinicians use the term syndrome?","volume":"365","author":"Nugent","year":"2023","journal-title":"Am. 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