{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:57:01Z","timestamp":1776689821443,"version":"3.51.2"},"reference-count":24,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Twin pregnancies carry substantially elevated perinatal risks, yet tools for first-trimester risk stratification remain limited. This retrospective cohort study evaluated the predictive value of crown\u2013rump length (CRL) and nuchal translucency (NT) discordance for adverse perinatal outcomes in 184 twin pregnancies at Ankara Etlik City Hospital, Turkey (October 2022\u2013January 2024). Methods: CRL discordance \u2265 10% and NT discordance \u2265 20% were assessed for a birth-weight-based proxy of fetal growth restriction (FGR), preeclampsia, and neonatal outcomes using multivariable logistic regression adjusted for chorionicity, body mass index (BMI), and conception mode. Results: CRL discordance \u2265 10% was independently associated with the birth-weight-based FGR proxy (adjusted odds ratio [OR] 7.79, 95% confidence interval [CI] 3.95\u201320.12, p &lt; 0.001; area under the curve [AUC] 0.736). NT discordance \u2265 20% was also independently associated with the birth-weight-based FGR proxy (OR 3.74, 95% CI 1.91\u20138.39, p &lt; 0.001; AUC 0.612). Both parameters were associated with lower Apgar scores. IVF conception was independently associated with preeclampsia in an exploratory analysis (OR 5.31, 95% CI 1.41\u201328.66, p = 0.016). Continuous modelling confirmed a dose\u2013response relationship for CRL discordance (OR per 1% increase = 1.20, 95% CI 1.13\u20131.32). Conclusions: These findings suggest that first-trimester CRL discordance may provide useful early prognostic information for birth-weight-based adverse growth outcome in twin pregnancies, pending prospective validation in cohorts with Doppler-based FGR ascertainment.<\/jats:p>","DOI":"10.3390\/jcm15083129","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:01:22Z","timestamp":1776686482000},"page":"3129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Predictive Value of First-Trimester Crown\u2013Rump Length and Nuchal Translucency Discordance for Fetal Growth Restriction in Twin Pregnancies: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Cans\u0131n","family":"Ero\u011flu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, 06010 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9861-6767","authenticated-orcid":false,"given":"\u00d6mer Osman","family":"Ero\u011flu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, 06010 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7022-3029","authenticated-orcid":false,"given":"Ali Turhan","family":"\u00c7a\u011flar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Ankara Etlik City Hospital, 06010 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Smits, J., and Monden, C. 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