{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T14:44:42Z","timestamp":1776696282109,"version":"3.51.2"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T00:00:00Z","timestamp":1776643200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Open Research Fund of the State Key Laboratory of Complex, Severe, and Rare Diseases","award":["2025-O-PY-004"],"award-info":[{"award-number":["2025-O-PY-004"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: To evaluate changes in corneal topography and densitometry (CD) 3 months after accelerated corneal collagen crosslinking (CXL) for keratoconus and to investigate influencing factors. Methods: Twenty-one (41 eyes) patients with KC who underwent accelerated epithelium-off CXL were included in this retrospective observational study; preoperative and 3-month postoperative CD and corneal topographic parameters measured by Pentacam HR were collected. The changes in corneal topographic parameters and CD before and after CXL were subsequently compared, and the correlation between age, corneal topographic parameters and CD changes was analysed. Results: Except for TCT (p = 0.026), no significant changes were observed in topographic parameters (p &gt; 0.05). There was a significant increase in total CD (tCD), CD 0\u20132 mm and CD 2\u20136 mm from the whole, anterior and central corneal layers after CXL compared to pre-operation (p &lt; 0.05). The results of the correlating factors showed that age was positively associated with changes in tCD, CD 0\u20132 mm, and CD 2\u20136 mm from the whole, anterior and central corneal layer (p &lt; 0.05), which was fully consistent with the regions treated by CXL. Other factors showed only marginal associations and were not consistent with the regions treated by CXL. Conclusions: An increase in CD can be observed in patients with KC at 3 months after undergoing accelerated CXL, and this is particularly focused on the 0\u20132 mm and 2\u20136 mm regions of the anterior and central corneal layers. The degree of change in CD was influenced by age, which may suggest differences in corneal response to CXL in KC of different ages.<\/jats:p>","DOI":"10.3390\/jcm15083137","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:22:47Z","timestamp":1776691367000},"page":"3137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Corneal Densitometry and Relationship to Corneal Topographical Parameters in Accelerated Corneal Crosslinking for the Treatment of Keratoconus"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-2719","authenticated-orcid":false,"given":"Yifan","family":"Du","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"},{"name":"Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"},{"name":"Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"},{"name":"Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"},{"name":"Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/bjophthalmol-2015-307059","article-title":"Management of advanced corneal ectasias","volume":"100","author":"Maharana","year":"2016","journal-title":"Br. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ajo.2004.04.031","article-title":"Collaborative Longitudinal Evaluation of Keratoconus study group. Quality of life in keratoconus","volume":"138","author":"Kymes","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"6390","DOI":"10.1167\/iovs.13-12547","article-title":"The corneal epithelial basement membrane: Structure, function, and disease","volume":"54","author":"Torricelli","year":"2013","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ophtha.2017.01.040","article-title":"Randomized Controlled Trial Comparing Transepithelial Corneal crosslinking Using Iontophoresis with the Dresden Protocol in Progressive Keratoconus","volume":"124","author":"Lombardo","year":"2017","journal-title":"Ophthalmology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joco.2017.07.003","article-title":"Updates on corneal collagen crosslinking: Indications, techniques and clinical outcomes","volume":"29","author":"Mohammadpour","year":"2017","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"406850","DOI":"10.1155\/2012\/406850","article-title":"Collagen crosslinking: Current status and future directions","volume":"2012","author":"Hovakimyan","year":"2012","journal-title":"J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/ICO.0000000000002092","article-title":"Accelerated Versus Standard Corneal crosslinking for Progressive Keratoconus: A Meta-Analysis of Randomized Controlled Trials","volume":"39","author":"Kobashi","year":"2020","journal-title":"Cornea"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ophtha.2011.08.024","article-title":"Corneal densitometry as an indicator of corneal health","volume":"119","author":"Otri","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Dong, J., Zhang, Y., Zhang, H., Jia, Z., Zhang, S., Sun, B., Han, Y., and Wang, X. (2018). Corneal densitometry in high myopia. BMC Ophthalmol., 18.","DOI":"10.1186\/s12886-018-0851-x"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3341\/kjo.2010.24.5.284","article-title":"Anterior segment parameters using Pentacam and prediction of corneal endothelial cell loss after cataract surgery","volume":"24","author":"Cho","year":"2010","journal-title":"Korean J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1097\/ICO.0000000000000266","article-title":"Corneal densitometry in keratoconus","volume":"33","author":"Lopes","year":"2014","journal-title":"Cornea"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"8747013","DOI":"10.1155\/2017\/8747013","article-title":"Corneal Backscatters as an Objective Index for Assessing Fuchs\u2019 Endothelial Corneal Dystrophy: A Pilot Study","volume":"2017","author":"Chu","year":"2017","journal-title":"J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4103\/joco.joco_145_21","article-title":"Corneal Haze and Densitometry in Keratoconus after Collagen crosslinking by Three Different Protocols","volume":"33","author":"Badawi","year":"2022","journal-title":"J. Curr. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/ICO.0000000000002334","article-title":"Corneal Haze After Transepithelial Collagen crosslinking for Keratoconus: A Scheimpflug Densitometry Analysis","volume":"39","author":"Lai","year":"2020","journal-title":"Cornea"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chen, X., Shen, Y., Xu, H., Wang, X., and Zhou, X. (2020). One-year natural course of corneal densitometry in high myopic patients after implantation of an implantable collamer lens (model V4c). BMC Ophthalmol., 20.","DOI":"10.1186\/s12886-020-1320-x"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ajo.2018.10.002","article-title":"Corneal Densitometry as a Predictive Diagnostic Tool for Visual Acuity Results After Descemet Membrane Endothelial Keratoplasty","volume":"198","author":"Schaub","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1167\/iovs.13-13236","article-title":"Normative values for corneal densitometry analysis by Scheimpflug optical assessment","volume":"55","author":"Rozema","year":"2014","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10792-018-0876-4","article-title":"Corneal densitometry after accelerated corneal collagen crosslinking in progressive keratoconus","volume":"39","author":"Shajari","year":"2019","journal-title":"Int. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1007\/s10792-022-02572-3","article-title":"One-year non-comparative observational study to evaluate corneal tomographic, densitometric, and aberrometric features following accelerated corneal crosslinking in progressive keratoconus","volume":"43","author":"Mohebbi","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jcrs.2014.07.043","article-title":"Changes in straylight and densitometry values after corneal collagen crosslinking","volume":"41","author":"Pircher","year":"2015","journal-title":"J. Cataract Refract Surg."},{"key":"ref_21","first-page":"184","article-title":"Corneal Collagen crosslinking in the Stabilization of Keratoconus","volume":"116","author":"Maier","year":"2019","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/APO.0b013e3182729df0","article-title":"Changes in Forward and Backward Light Scatter in Keratoconus Resulting From Corneal crosslinking","volume":"2","author":"Rozema","year":"2013","journal-title":"Asia Pac. J. Ophthalmol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/01.icl.0000189038.74139.4a","article-title":"In vivo confocal microscopy findings in keratoconus","volume":"32","author":"Kanpolat","year":"2006","journal-title":"Eye Contact Lens"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/bjophthalmol-2012-302913","article-title":"Measuring corneal clouding in patients suffering from mucopolysaccharidosis with the Pentacam densitometry programme","volume":"97","author":"Elflein","year":"2013","journal-title":"Br. J. Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2147\/OPTO.S226000","article-title":"Corneal Imaging and Densitometry Measurements in Juvenile and Adult Keratoconus Patients to Evaluate Disease Progression and Treatment Effects After Corneal crosslinking","volume":"11","author":"Alzahrani","year":"2019","journal-title":"Clin. Optom."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jcrs.2016.04.019","article-title":"Natural history of corneal haze after corneal collagen crosslinking in keratoconus using Scheimpflug analysis","volume":"42","author":"Kim","year":"2016","journal-title":"J. Cataract Refract Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/ICO.0000000000000017","article-title":"Corneal collagen fibril changes after ultraviolet a\/riboflavin corneal crosslinking","volume":"33","author":"Xia","year":"2014","journal-title":"Cornea"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Li, W., and Wang, B. (2017). Efficacy and safety of transepithelial corneal collagen crosslinking surgery versus standard corneal collagen crosslinking surgery for keratoconus: A meta-analysis of randomized controlled trials. BMC Ophthalmol., 17.","DOI":"10.1186\/s12886-017-0657-2"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jcrs.2010.10.052","article-title":"Corneal thickness changes after corneal collagen crosslinking for keratoconus and corneal ectasia: One-year results","volume":"37","author":"Greenstein","year":"2011","journal-title":"J. Cataract Refract Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"8285649","DOI":"10.1155\/2019\/8285649","article-title":"10-Year Results of Standard crosslinking in Patients with Progressive Keratoconus in Romania","volume":"2019","author":"Nicula","year":"2019","journal-title":"J. Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1177\/1120672120944798","article-title":"Corneal biomechanical outcome of collagen crosslinking in keratoconic patients evaluated by Corvis ST","volume":"31","author":"Jabbarvand","year":"2021","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s10792-016-0397-y","article-title":"Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction","volume":"37","author":"Poyales","year":"2017","journal-title":"Int. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s10792-022-02491-3","article-title":"Corneal densitometry in bilateral keratoconus patients with unilateral corneal Vogt\u2019s striae: A contralateral eye study","volume":"43","author":"Wei","year":"2023","journal-title":"Int. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/opo.12009","article-title":"Statistical guidelines for the analysis of data obtained from one or both eyes","volume":"33","author":"Armstrong","year":"2013","journal-title":"Ophthalmic Physiol. Opt."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/3137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T13:53:17Z","timestamp":1776693197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/8\/3137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,20]]},"references-count":34,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["jcm15083137"],"URL":"https:\/\/doi.org\/10.3390\/jcm15083137","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,20]]}}}