{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:42:48Z","timestamp":1784122968399,"version":"3.55.0"},"reference-count":107,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Breast cancer-related lymphedema (BCRL) affects quality of life (QoL) and increases healthcare costs. Resistance training (RT) is proposed as a preventive strategy, although its safety and effectiveness remain uncertain. Objective: To evaluate the effectiveness and safety of RT in preventing BCRL in women at risk. Methods: MEDLINE, Embase, CENTRAL, PEDro, and LILACS databases were searched from their inception to January 2025, along with the gray literature, trial registries, and preprints. Risk of bias was assessed using RoB 2, and certainty of the evidence (CoE) was assessed using GRADE. Primary outcomes were the occurrence of lymphedema and overall QoL; secondary outcomes included pain, upper limb function, range of motion (ROM), grip strength, and adverse events. Results: Eight RCTs (n = 1131) were included. The effects of RT on lymphedema and arm volume are very uncertain (very low CoE). For QoL, pain, ROM, and grip strength, the findings were inconsistent and uncertain (low to very low CoE). Adverse events were mild and transient, with no serious complications. Conclusion: RT is probably safe in women at risk of developing BCRL. Its preventive effectiveness is highly uncertain. Well-designed RCTs with standardized diagnostic criteria, patient-centered outcomes, and long-term follow-up are needed to establish their role in BCRL prevention with greater certainty. Ethics and dissemination: This study did not require ethical approval. The results will be disseminated through publications in peer-reviewed journals and academic presentations. Registration: PROSPERO (CRD42023455720).<\/jats:p>","DOI":"10.3390\/jcm15093297","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:55:39Z","timestamp":1777370139000},"page":"3297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Can Resistance Training Prevent Breast Cancer-Related Lymphedema? A Systematic Review with Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4123-4255","authenticated-orcid":false,"given":"Ra\u00fal Alberto","family":"Aguilera-Egu\u00eda","sequence":"first","affiliation":[{"name":"Departamento de Salud P\u00fablica, Facultad de Medicina, Universidad Cat\u00f3lica de la Sant\u00edsima Concepci\u00f3n, Concepci\u00f3n 4090541, Chile"},{"name":"Doctorado en Metodolog\u00eda de la Investigaci\u00f3n Biom\u00e9dica y Salud P\u00fablica, Universidad Aut\u00f3noma de Barcelona, 08193 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6942-6956","authenticated-orcid":false,"given":"Carlos","family":"Zaror","sequence":"additional","affiliation":[{"name":"Departamento de Odontopediatr\u00eda y Ortodoncia, Facultad de Odontolog\u00eda, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Center for Research in Epidemiology, Economics and Oral Public Health (CIEESPO), Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Centro de Excelencia CIGES, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-9316","authenticated-orcid":false,"given":"Ruvistay","family":"Guti\u00e9rrez-Arias","sequence":"additional","affiliation":[{"name":"Departamento de Apoyo en Rehabilitaci\u00f3n Cardiopulmonar Integral, Instituto Nacional del T\u00f3rax, Santiago 7500921, Chile"},{"name":"Exercise and Rehabilitation Sciences Laboratory, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile"},{"name":"INTRehab Research Group, Instituto Nacional del T\u00f3rax, Santiago 8580745, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga Patricia","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Salud Oral, Facultad de Salud, Universidad Aut\u00f3noma de Manizales, Pereira 660003, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-0848","authenticated-orcid":false,"given":"H\u00e9ctor","family":"Fuentes-Barria","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CEIMA), Universidad Arturo Prat, Iquique 1110939, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3100-5491","authenticated-orcid":false,"given":"Barbara Burgos","family":"Mansilla","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias de la Rehabilitaci\u00f3n, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8850-1018","authenticated-orcid":false,"given":"\u00c1ngel","family":"Roco-Videla","sequence":"additional","affiliation":[{"name":"Direcci\u00f3n de Desarrollo y Postgrados, Universidad Aut\u00f3noma de Chile, Santiago 7500912, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naira Figueiredo","family":"Deana","sequence":"additional","affiliation":[{"name":"Departamento de Odontopediatr\u00eda y Ortodoncia, Facultad de Odontolog\u00eda, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Doctoral Program in Sciences in Applied Cellular and Molecular Biology, Universidad de La Frontera, Temuco 4811230, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Melo-Lonconao","sequence":"additional","affiliation":[{"name":"Departamento Nacional de Salud P\u00fablica, Facultad de Medicina, Universidad San Sebasti\u00e1n, Sede Concepci\u00f3n 4081339, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bonfill","sequence":"additional","affiliation":[{"name":"Center for Research in Epidemiology, Economics and Oral Public Health (CIEESPO), Faculty of Dentistry, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Clinical Epidemiology and Public Health, Biomedical Research Institut Sant Pau, 08025 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-8988","authenticated-orcid":false,"given":"Pamela","family":"Ser\u00f3n","sequence":"additional","affiliation":[{"name":"Centro de Excelencia CIGES, Universidad de La Frontera, Temuco 4811230, Chile"},{"name":"Centro de Investigaci\u00f3n en Medicina de Altura (CEIMA), Universidad Arturo Prat, Iquique 1110939, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Lian, Y., Sandhu, S., Asefa, Y., and Gupta, A. (2024). The effect of exercise on reducing lymphedema severity in breast cancer survivors. Cancers, 16.","DOI":"10.3390\/cancers16071367"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e2456142","DOI":"10.1001\/jamanetworkopen.2024.56142","article-title":"Incidence rate trends of breast cancer overall and by molecular subtype by race and ethnicity and age","volume":"8","author":"Li","year":"2025","journal-title":"JAMA Netw. Open"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Tomi\u0107, S., Malenkovi\u0107, G., Muji\u010di\u0107, E., \u0160ljivo, A., and Tomi\u0107, S.D. (2024). Impact of risk factors, early rehabilitation and management of lymphedema associated with breast cancer: A retrospective study of breast cancer survivors over 5 years. BMC Womens Health, 24.","DOI":"10.1186\/s12905-024-03062-7"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e35650","DOI":"10.1002\/cncr.35650","article-title":"Patient-reported persistent lymphedema and peripheral neuropathy among long-term breast cancer survivors in the Carolina Breast Cancer Study","volume":"131","author":"Yarosh","year":"2025","journal-title":"Cancer"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Alcaraz, M.N., P\u00e9rula-de Torres, L.A., Jim\u00e9nez-V\u00edlchez, A.J., Rodr\u00edguez-Fern\u00e1ndez, P., Olmo-Carmona, M.V., Mu\u00f1oz-Garc\u00eda, M.T., Jorge-Guti\u00e9rrez, P., Serrano-Merino, J., Romero-Rodr\u00edguez, E., and Rodr\u00edguez-Elena, L. (2022). Impact of activity-oriented propioceptive antiedema therapy on the health-related quality of life of women with upper-limb lymphedema secondary to breast cancer\u2014A randomized clinical trial. J. Clin. Med., 11.","DOI":"10.3390\/jcm11071884"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15347354211046192","DOI":"10.1177\/15347354211046192","article-title":"Evaluating the quality of life and sleep quality in Saudi women with breast cancer-related lymphedema: A cross-sectional correlational study","volume":"20","author":"Tamam","year":"2021","journal-title":"Integr. Cancer Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00595-024-02960-5","article-title":"Database study of risk factors for breast cancer-related lymphedema: A statistical analysis of 2359 cases over 10 years","volume":"55","author":"Matsumoto","year":"2025","journal-title":"Surg. Today"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.21037\/gs-24-123","article-title":"Efficacy of intermittent pneumatic compression on breast cancer-related upper limb lymphedema: A systematic review and meta-analysis in clinical studies","volume":"13","author":"Hou","year":"2024","journal-title":"Gland Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4274\/ejbh.galenos.2024.2023-12-8","article-title":"Comparison of volume measurements and bioimpedance spectroscopy using a stand-on device for assessment of unilateral breast cancer-related lymphedema","volume":"20","author":"Ward","year":"2024","journal-title":"Eur. J. Breast Health"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3250143","DOI":"10.1155\/2024\/3250143","article-title":"Supraclavicular irradiation induces lymphedema in breast cancer patients treated with axillary lymph node dissection and taxane-containing chemotherapy","volume":"2024","author":"Horisawa","year":"2024","journal-title":"Breast J."},{"key":"ref_12","first-page":"248","article-title":"Factors affecting the formation of lymphedema due to breast cancer (Is primary systemic treatment an independent factor in the formation of breast cancer related lymphedema?)","volume":"41","year":"2025","journal-title":"Turk. J. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.32768\/abc.202182119-126","article-title":"Quality of life for women with breast cancer-related lymphedema: The importance of collaboration between physical medicine and rehabilitation and general surgery clinics","volume":"8","author":"Turgay","year":"2021","journal-title":"Arch. Breast Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ram\u00edrez-Parada, K., Lopez-Garzon, M., Sanchez-Rojel, C., Petric-Guajardo, M., Alfaro-Barra, M., Fern\u00e1ndez-Verdejo, R., Reyes-Ponce, A., Merino-Pereira, G., and Cantarero-Villanueva, I. (2022). Effect of supervised resistance training on arm volume, quality of life and physical performance among women at high risk for breast cancer-related lymphedema: A study protocol for a randomized controlled trial (STRONG-B). Front. Oncol., 12.","DOI":"10.3389\/fonc.2022.850564"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.22359\/cswhi_12_2_06","article-title":"Economic and social aspects of secondary lymphedema following treatment of breast cancer","volume":"12","author":"Pitr","year":"2021","journal-title":"Clin. Soc. Work Health Interv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/1096-9098(200006)74:2<95::AID-JSO3>3.0.CO;2-Q","article-title":"Challenging the myth of exercise-induced lymphedema following breast cancer: A series of case reports","volume":"74","author":"Harris","year":"2000","journal-title":"J. Surg. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/jnci\/93.2.96","article-title":"Arm edema in breast cancer patients","volume":"93","author":"Erickson","year":"2001","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-0038-1660832","article-title":"Effect of exercise on breast cancer-related lymphedema: What the lymphatic surgeon needs to know","volume":"35","author":"Panchik","year":"2019","journal-title":"J. Reconstr. Microsurg."},{"key":"ref_19","first-page":"3593","article-title":"Resistance exercise and breast cancer-related lymphedema\u2014A systematic review update and meta-analysis","volume":"28","author":"Hasenoehrl","year":"2020","journal-title":"Support. Care Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2165\/00007256-200535060-00001","article-title":"Exercise and the lymphatic system: Implications for breast-cancer survivors","volume":"35","author":"Lane","year":"2005","journal-title":"Sports Med."},{"key":"ref_21","first-page":"CD009765","article-title":"Conservative interventions for preventing clinically detectable upper-limb lymphoedema in patients who are at risk of developing lymphoedema after breast cancer therapy","volume":"2015","author":"Stuiver","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/ptj\/pzaa087","article-title":"Interventions for breast cancer-related lymphedema: Clinical practice guideline from the Academy of Oncologic Physical Therapy of APTA","volume":"100","author":"Davies","year":"2020","journal-title":"Phys. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1249\/MSS.0000000000002116","article-title":"Exercise guidelines for cancer survivors: Consensus statement from International Multidisciplinary Roundtable","volume":"51","author":"Campbell","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"4396","DOI":"10.1200\/JCO.2006.08.2024","article-title":"Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: A multicenter randomized controlled trial","volume":"25","author":"Courneya","year":"2007","journal-title":"J. Clin. Oncol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/0284186X.2016.1268266","article-title":"Progressive strength training to prevent lymphoedema in the first year after breast cancer\u2014The LYCA feasibility study","volume":"56","author":"Lanng","year":"2017","journal-title":"Acta Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1001\/jama.2010.1837","article-title":"Weight lifting for women at risk for breast cancer-related lymphedema: A randomized trial","volume":"304","author":"Schmitz","year":"2010","journal-title":"JAMA"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10549-012-2331-y","article-title":"Exercise for health: A randomized, controlled trial evaluating the impact of a pragmatic, translational exercise intervention on the quality of life, function and treatment-related side effects following breast cancer","volume":"137","author":"Hayes","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/01893697-200624020-00003","article-title":"Resistance and stretching shoulder exercises early following axillary surgery for breast cancer","volume":"24","author":"Kilbreath","year":"2006","journal-title":"Rehabil. Oncol."},{"key":"ref_29","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2022). Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. Version 6.3; Updated February 2022."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e080935","DOI":"10.1136\/bmjopen-2023-080935","article-title":"Can resistance exercise prevent breast cancer-related lymphoedema? A systematic review and metanalysis protocol","volume":"14","author":"Seron","year":"2024","journal-title":"BMJ Open"},{"key":"ref_32","first-page":"CD013307","article-title":"Educational and psychological interventions for managing atopic dermatitis (eczema)","volume":"2024","author":"Singleton","year":"2024","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan\u2014A web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jclinepi.2023.03.003","article-title":"GRADE guidance 36: Updates to GRADE\u2019s approach to addressing inconsistency","volume":"158","author":"Guyatt","year":"2023","journal-title":"J. Clin. Epidemiol."},{"key":"ref_37","unstructured":"Higgins, J.P.T., Thomas, J., Chandler, J., Cumpston, M., Li, T., Page, M.J., and Welch, V.A. (2023). Chapter 13: Assessing risk of bias due to missing results in a synthesis. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. Version 6.4; Updated August 2023."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1002\/sim.7588","article-title":"A comparison of seven random-effects models for meta-analyses that estimate the summary odds ratio","volume":"37","author":"Jackson","year":"2018","journal-title":"Stat. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13690-023-01215-y","article-title":"Methods for meta-analysis and meta-regression of binomial data: Concepts and tutorial with Stata command metapreg","volume":"82","author":"Nyaga","year":"2024","journal-title":"Arch. Public Health"},{"key":"ref_40","unstructured":"Deeks, J.J., Higgins, J.P.T., Altman, D.G., McKenzie, J.E., and Veroniki, A.A. (2024). Chapter 10: Analysing data and undertaking meta-analyses. Cochrane Handbook for Systematic Reviews of Interventions, Cochrane. Version 6.2."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","article-title":"GRADE guidelines: 7. Rating the quality of evidence: Inconsistency","volume":"64","author":"Guyatt","year":"2011","journal-title":"J. Clin. Epidemiol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: An emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/cncr.31962","article-title":"Progressive resistance training to prevent arm lymphedema in the first year after breast cancer surgery: Results of a randomized controlled trial","volume":"125","author":"Johansen","year":"2019","journal-title":"Cancer"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s11764-011-0208-4","article-title":"A randomized trial of exercise on well-being and function following breast cancer surgery: The RESTORE trial","volume":"6","author":"Anderson","year":"2012","journal-title":"J. Cancer Surviv."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1007\/s11764-022-01192-1","article-title":"Effects of a 12-week supervised resistance training program, combined with home-based physical activity, on physical fitness and quality of life in female breast cancer survivors: The EFICAN randomized controlled trial","volume":"17","author":"Bartholdy","year":"2023","journal-title":"J. Cancer Surviv."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s10549-012-1964-1","article-title":"Upper limb progressive resistance training and stretching exercises following surgery for early breast cancer: A randomized controlled trial","volume":"133","author":"Kilbreath","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2340\/16501977-2167","article-title":"Influence of arm crank ergometry on development of lymphoedema in breast cancer patients after axillary dissection: A randomized controlled trial","volume":"49","author":"Schmidt","year":"2017","journal-title":"J. Rehabil. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3109\/02841860903061683","article-title":"Physical activity for the affected limb and arm lymphedema after breast cancer surgery: A prospective, randomized controlled trial with two years follow-up","volume":"48","author":"Sagen","year":"2009","journal-title":"Acta Oncol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/0284186X.2018.1560497","article-title":"Adherence to a long-term progressive resistance training program, combining supervised and home-based exercise for breast cancer patients during adjuvant treatment","volume":"58","author":"Lund","year":"2019","journal-title":"Acta Oncol."},{"key":"ref_50","first-page":"44","article-title":"Upper extremity lymphedema after axillary lymph node dissection: Prospective lymphoscintigraphic evaluation","volume":"49","author":"Szuba","year":"2016","journal-title":"Lymphology"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ygyno.2013.07.101","article-title":"Intensive complete decongestive physiotherapy for cancer-related upper-limb lymphedema: 11 days achieved greater volume reduction than 4","volume":"131","author":"Vignes","year":"2013","journal-title":"Gynecol. Oncol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10549-024-07356-0","article-title":"BE-WEL trial (breast: Evaluation of weight and exercise for lymphoedema) testing weight control and exercise programmes for women with breast cancer related lymphoedema: A feasibility trial","volume":"207","author":"Harvie","year":"2024","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cct.2017.07.017","article-title":"The Women In Steady Exercise Research (WISER) survivor trial: The innovative transdisciplinary design of a randomized controlled trial of exercise and weight-loss interventions among breast cancer survivors with lymphedema","volume":"61","author":"Winkels","year":"2017","journal-title":"Contemp. Clin. Trials"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"pzac137","DOI":"10.1093\/ptj\/pzac137","article-title":"Does manual lymphatic drainage add value in reducing suprafascial fluid accumulation and skin elasticity in patients with breast cancer-related lymphedema?","volume":"102","author":"Gebruers","year":"2022","journal-title":"Phys. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1002\/cncr.34377","article-title":"Risk factors for breast cancer-related lymphedema in patients undergoing 3 years of prospective surveillance with intervention","volume":"128","author":"Koelmeyer","year":"2022","journal-title":"Cancer"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Alcaraz, M.N., P\u00e9rula-de-Torres, L.\u00c1., Serrano-Merino, J., Jim\u00e9nez-V\u00edlchez, A.J., Olmo-Carmona, M.V., Mu\u00f1oz-Garc\u00eda, M.T., Bartolom\u00e9-Moreno, C., Oliv\u00e1n-Bl\u00e1zquez, B., and Magall\u00f3n-Botaya, R. (2020). Efficacy and efficiency of a new therapeutic approach based on activity-oriented proprioceptive antiedema therapy (TAPA) for edema reduction and improved occupational performance in the rehabilitation of breast cancer-related arm lymphedema in women: A controlled, randomized clinical trial. BMC Cancer, 20.","DOI":"10.1186\/s12885-020-07558-x"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ejon.2017.09.004","article-title":"The effectiveness of a clinical and home-based physical activity program and simple lymphatic drainage in the prevention of breast cancer-related lymphedema: A prospective randomized controlled study","volume":"31","author":"Kapucu","year":"2017","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10549-017-4221-9","article-title":"Changes in arm tissue composition with slowly progressive weight-lifting among women with breast cancer-related lymphedema","volume":"164","author":"Zhang","year":"2017","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"3250","DOI":"10.1245\/s10434-019-07344-5","article-title":"A randomized trial evaluating bioimpedance spectroscopy versus tape measurement for the prevention of lymphedema following treatment for breast cancer: Interim analysis","volume":"26","author":"Ridner","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_60","first-page":"2047","article-title":"Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection","volume":"24","author":"Cho","year":"2016","journal-title":"Support. Care Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ejon.2019.02.006","article-title":"The effectiveness of lymphedema self-management in the prevention of breast cancer-related lymphedema and quality of life: A randomized controlled trial","volume":"40","author":"Temur","year":"2019","journal-title":"Eur. J. Oncol. Nurs."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"De Oliveira, M.M.F., Gurgel, M.S.C., Amorim, B.J., Ramos, C.D., Derchain, S., Furlan-Santos, N., Dos Santos, C.C., and Sarian, L.O. (2018). Long term effects of manual lymphatic drainage and active exercises on physical morbidities, lymphoscintigraphy parameters and lymphedema formation in patients operated due to breast cancer: A clinical trial. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0189176"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"b5396","DOI":"10.1136\/bmj.b5396","article-title":"Effectiveness of early physiotherapy to prevent lymphoedema after surgery for breast cancer: Randomised, single blinded, clinical trial","volume":"340","year":"2010","journal-title":"BMJ"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"S317","DOI":"10.1016\/j.pmrj.2017.05.010","article-title":"The underutilization of rehabilitation to treat physical impairments in breast cancer survivors","volume":"9","author":"Stubblefield","year":"2017","journal-title":"PM R"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1556\/650.2016.30390","article-title":"Daganatos betegekben kialakult m\u00e1sodlagos nyirok\u00f6d\u00e9ma ell\u00e1t\u00e1sa [Management of secondary lymphedema in patients with cancer]","volume":"157","author":"Wenczl","year":"2016","journal-title":"Orv. Hetil."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/SLA.0000000000003491","article-title":"Risk of lymphedema following contemporary treatment for breast cancer: An analysis of 7617 consecutive patients from a multidisciplinary perspective","volume":"274","author":"Byun","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/lrb.2016.0054","article-title":"Measurement of local tissue water in patients with breast cancer-related lymphedema","volume":"16","author":"Bakar","year":"2018","journal-title":"Lymphat. Res. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3109\/09593985.2013.876695","article-title":"Manual lymphatic drainage versus exercise in the early postoperative period for breast cancer","volume":"30","author":"Morais","year":"2014","journal-title":"Physiother. Theory Pract."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1249\/MSS.0b013e31818b98fb","article-title":"Exercise and secondary lymphedema: Safety, potential benefits, and research issues","volume":"41","author":"Hayes","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1245\/s10434-018-6601-8","article-title":"Reducing breast cancer-related lymphedema (BCRL) through prospective surveillance monitoring using bioimpedance spectroscopy (BIS) and patient directed self-interventions","volume":"25","author":"Kilgore","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s11764-015-0507-2","article-title":"Differences in limb volume trajectories after breast cancer treatment","volume":"10","author":"Smoot","year":"2016","journal-title":"J. Cancer Surviv."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1620\/tjem.247.139","article-title":"The 10-min holistic self-care for patients with breast cancer-related lymphedema: Pilot randomized controlled study","volume":"247","author":"Arinaga","year":"2019","journal-title":"Tohoku J. Exp. Med."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13014-016-0619-5","article-title":"Feasibility of a 12-month-exercise intervention during and after radiation and chemotherapy in cancer patients: Impact on quality of life, peak oxygen consumption, and body composition","volume":"11","author":"Grabenbauer","year":"2016","journal-title":"Radiat. Oncol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.breast.2014.11.012","article-title":"Health related quality of life improvement in breast cancer patients: Secondary outcome from a simple blinded, randomised clinical trial","volume":"24","author":"Lacomba","year":"2015","journal-title":"Breast"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1245\/s10434-014-3761-z","article-title":"Proactive approach to lymphedema risk reduction: A prospective study","volume":"21","author":"Fu","year":"2014","journal-title":"Ann. Surg. Oncol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1023\/A:1016591121762","article-title":"Physiotherapy after breast cancer surgery: Results of a randomised controlled study to minimise lymphoedema","volume":"75","author":"Box","year":"2002","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"105","DOI":"10.29289\/259453942020V30S1105","article-title":"Exercise protocol for shoulder movement with restricted amplitude movement for 15 or 30 days after breast-conserving surgery with oncoplastic technique: Randomized clinical trial","volume":"30","author":"Rizzi","year":"2020","journal-title":"Mastology"},{"key":"ref_78","first-page":"188","article-title":"Intermittent pneumatic compression acts synergistically with manual lymphatic drainage in complex decongestive physiotherapy for breast cancer treatment-related lymphedema","volume":"42","author":"Szolnoky","year":"2009","journal-title":"Lymphology"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"d5326","DOI":"10.1136\/bmj.d5326","article-title":"Effect of manual lymph drainage in addition to guidelines and exercise therapy on arm lymphoedema related to breast cancer: Randomised controlled trial","volume":"343","author":"Devoogdt","year":"2011","journal-title":"BMJ"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/S0104-42302006000100020","article-title":"Exerc\u00edcios livres versus direcionados nas complica\u00e7\u00f5es p\u00f3s-operat\u00f3rias de c\u00e2ncer de mama [Random clinical comparative trial between free and directed exercise in post-operative complications of breast cancer]","volume":"52","author":"Rezende","year":"2006","journal-title":"Rev. Assoc. Med. Bras."},{"key":"ref_81","first-page":"204","article-title":"Preventing lymphoedema after breast cancer surgery by elastic restraint orthotic and manual lymphatic drainage: A randomized clinical trial","volume":"137","year":"2011","journal-title":"Med. Clin."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1080\/0284186X.2019.1643916","article-title":"Heavy-load resistance exercise during chemotherapy in physically inactive breast cancer survivors at risk for lymphedema: A randomized trial","volume":"58","author":"Bloomquist","year":"2019","journal-title":"Acta Oncol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1200\/JCO.2005.03.6749","article-title":"Randomized controlled trial of weight training and lymphedema in breast cancer survivors","volume":"24","author":"Ahmed","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1080\/0284186X.2019.1670357","article-title":"Mounting evidence supports the safety of weight lifting after breast cancer","volume":"58","author":"Dalton","year":"2019","journal-title":"Acta Oncol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1089\/lrb.2015.0021","article-title":"Ultrasonographic evaluation of the effects of progressive resistive exercise in breast cancer-related lymphedema","volume":"14","author":"Bok","year":"2016","journal-title":"Lymphat. Res. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1249\/MSS.0000000000000988","article-title":"A randomized trial on the effect of exercise mode on breast cancer-related lymphedema","volume":"48","author":"Buchan","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_87","first-page":"184","article-title":"Effects of resistance exercises and complex decongestive therapy on arm function and muscular strength in breast cancer related lymphedema","volume":"48","author":"Do","year":"2015","journal-title":"Lymphology"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s11764-013-0284-8","article-title":"Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: A randomised controlled trial","volume":"7","author":"Cormie","year":"2013","journal-title":"J. Cancer Surviv."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1177\/1534735413477194","article-title":"Neither heavy nor light load resistance exercise acutely exacerbates lymphedema in breast cancer survivor","volume":"12","author":"Cormie","year":"2013","journal-title":"Integr. Cancer Ther."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1177\/1534735415617283","article-title":"Acute inflammatory response to low-, moderate-, and high-load resistance exercise in women with breast cancer-related lymphedema","volume":"15","author":"Cormie","year":"2016","journal-title":"Integr. Cancer Ther."},{"key":"ref_91","first-page":"80","article-title":"Effects of compression on lymphedema during resistance exercise in women with breast cancer-related lymphedema: A randomized, cross-over trial","volume":"48","author":"Singh","year":"2015","journal-title":"Lymphology"},{"key":"ref_92","first-page":"521","article-title":"Water versus land-based multimodal exercise program effects on body composition in breast cancer survivors: A controlled clinical trial","volume":"21","author":"Courtney","year":"2013","journal-title":"Support. Care Cancer"},{"key":"ref_93","first-page":"54996","article-title":"Ultrasonographic evaluation of breast cancer-related lymphedema","volume":"119","author":"Jeon","year":"2017","journal-title":"J. Vis. Exp."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/PHM.0b013e318278b0e8","article-title":"Water-based exercise for patients with chronic arm lymphedema: A randomized controlled pilot trial","volume":"92","author":"Johansson","year":"2013","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1016\/j.apmr.2010.09.008","article-title":"Effect of active resistive exercise on breast cancer-related lymphedema: A randomized controlled trial","volume":"91","author":"Kim","year":"2010","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/PHM.0000000000000089","article-title":"Breast cancer-related lymphedema: A randomized controlled pilot and feasibility study","volume":"93","author":"Letellier","year":"2014","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s12282-016-0747-7","article-title":"The effects of complex exercise on shoulder range of motion and pain for women with breast cancer-related lymphedema: A single-blind, randomized controlled trial","volume":"24","author":"Park","year":"2017","journal-title":"Breast Cancer"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1056\/NEJMoa0810118","article-title":"Weight lifting in women with breast-cancer-related lymphedema","volume":"361","author":"Schmitz","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3390\/healthcare3030695","article-title":"The effects of resistance training on physical function and quality of life in breast cancer survivors","volume":"3","author":"Simonavice","year":"2015","journal-title":"Healthcare"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1139\/apnm-2013-0281","article-title":"The effects of a 6-month resistance training and dried plum consumption intervention on strength, body composition, blood markers of bone turnover, and inflammation in breast cancer survivors","volume":"39","author":"Simonavice","year":"2014","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_101","first-page":"9","article-title":"Effects of resistance exercise in women with or at risk for breast cancer-related lymphedema","volume":"25","author":"Simonavice","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/ajco.12471","article-title":"Compression use during an exercise intervention and associated changes in breast cancer-related lymphedema","volume":"12","author":"Singh","year":"2016","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1089\/lrb.2015.0036","article-title":"Combining manual lymph drainage with physical exercise after modified radical mastectomy effectively prevents upper limb lymphedema","volume":"14","author":"Zhang","year":"2016","journal-title":"Lymphat. Res. Biol."},{"key":"ref_104","first-page":"103","article-title":"Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery","volume":"45","author":"Zimmermann","year":"2012","journal-title":"Lymphology"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1200\/JCO.2014.57.7395","article-title":"Weight lifting and physical function among survivors of breast cancer: A post hoc analysis of a randomized controlled trial","volume":"33","author":"Brown","year":"2015","journal-title":"J. Clin. Oncol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10549-015-3409-0","article-title":"Weight lifting and appendicular skeletal muscle mass among breast cancer survivors: A randomized controlled trial","volume":"151","author":"Brown","year":"2015","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/030089160609200109","article-title":"Two exercise schemes in postoperative breast cancer: Comparison of effects on shoulder movement and lymphatic disturbance","volume":"92","author":"Franco","year":"2006","journal-title":"Tumori"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3297\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:08:58Z","timestamp":1778576938000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3297"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,26]]},"references-count":107,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15093297"],"URL":"https:\/\/doi.org\/10.3390\/jcm15093297","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,26]]}}}