{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:55:28Z","timestamp":1791881728488,"version":"4.3.4"},"reference-count":21,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Colorectal liver metastases remain a fascinating field in the area of hepatobiliary diseases and surgery, with diagnosis, prognosis, management, and surgical treatment in an area of focus for the latest advancements [...]<\/jats:p>","DOI":"10.3390\/jcm15093315","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:55:39Z","timestamp":1777370139000},"page":"3315","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Advances in Hepatobiliary Surgery: Diagnosis, Prognosis, Management and Surgery for Colorectal Liver Metastases"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3786-4609","authenticated-orcid":false,"given":"Alexandros","family":"Giakoustidis","sequence":"first","affiliation":[{"name":"First Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1009-1685","authenticated-orcid":false,"given":"Vasileios","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"First Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6023-4744","authenticated-orcid":false,"given":"Dimitrios","family":"Giakoustidis","sequence":"additional","affiliation":[{"name":"First Department of Surgery, General Hospital Papageorgiou, Aristotle University of Thessaloniki, 56429 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0296-7648","authenticated-orcid":false,"given":"Matteo","family":"Donadon","sequence":"additional","affiliation":[{"name":"Surgical Oncology Program, University Maggiore Hospital, University of Piemonte Orientale, 28100 Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-5021","authenticated-orcid":false,"given":"Guido","family":"Torzilli","sequence":"additional","affiliation":[{"name":"Division of Hepatobiliary Surgery & General Surgery, Humanitas Research Hospital, 20089 Rozzano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Papakonstantinou, M., Fantakis, A., Torzilli, G., Donadon, M., Chatzikomnitsa, P., Giakoustidis, D., Papadopoulos, V.N., and Giakoustidis, A. (2025). A Systematic Review of Disappearing Colorectal Liver Metastases: Resection or No Resection?. J. Clin. Med., 14.","DOI":"10.3390\/jcm14041147"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1200\/JCO.2006.05.8727","article-title":"Complete response of colorectal liver metastases after chemotherapy: Does it mean cure?","volume":"24","author":"Benoist","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Boraschi, P., Moretto, R., Donati, F., Borelli, B., Mercogliano, G., Giugliano, L., Boccaccino, A., Della Pina, M.C., Colombatto, P., and Signori, S. (2023). Exploring the Outcome of Disappearance or Small Remnants of Colorectal Liver Metastases during First-Line Chemotherapy on Hepatobiliary Contrast-Enhanced and Diffusion-Weighted MR Imaging. Cancers, 15.","DOI":"10.3390\/cancers15082200"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hess, G.F., Aegerter, N.L.E., Zeindler, J., Vosbeck, J., Neusch\u00fctz, K.J., M\u00fcller, P.C., Muenst, S., D\u00e4ster, S., Bolli, M., and Kollmar, O. (2024). Impact of Positive Lymph Nodes after Systematic Perihilar Lymphadenectomy in Colorectal Liver Metastases. J. Clin. Med., 13.","DOI":"10.3390\/jcm13175301"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/01.sla.0000109154.00020.e0","article-title":"The role of lymphadenectomy for liver tumors: Further considerations on the appropriateness of treatment strategy","volume":"239","author":"Ercolani","year":"2004","journal-title":"Ann. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.annonc.2022.10.003","article-title":"Metastatic colorectal cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up","volume":"34","author":"Cervantes","year":"2023","journal-title":"Ann. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Paramythiotis, D., Karlafti, E., Tsavdaris, D., Kiouti, F.A., Haidich, A.B., Ioannidis, A., Panidis, S., and Michalopoulos, A. (2024). The Effect of Hepatic Surgical Margins of Colorectal Liver Metastases on Prognosis: A Systematic Review and Meta-Analysis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13247776"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Zhao, W., Dai, S., Yue, L., Xu, F., Gu, J., Dai, X., and Qian, X. (2022). Emerging mechanisms progress of colorectal cancer liver metastasis. Front. Endocrinol., 13.","DOI":"10.3389\/fendo.2022.1081585"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3892\/ol.2011.432","article-title":"Mechanisms regulating colorectal cancer cell metastasis into liver","volume":"3","author":"Jin","year":"2012","journal-title":"Oncol. Lett."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ags3.12071","article-title":"Recent advances in treatment for colorectal liver metastasis","volume":"2","author":"Oki","year":"2018","journal-title":"Ann. Gastroenterol. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/hepr.14058","article-title":"Current status and future perspectives of robotic liver surgery","volume":"54","author":"Soyama","year":"2024","journal-title":"Hepatol. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archsurg.138.7.777","article-title":"Robotics in general surgery: Personal experience in a large community hospital","volume":"138","author":"Giulianotti","year":"2003","journal-title":"Arch. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1055\/a-1329-3067","article-title":"Robotic Liver Surgery\u2014Current Standards and Future Perspectives","volume":"59","author":"Becker","year":"2021","journal-title":"Z. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Schiavone, V., Carannante, F., Capolupo, G.T., Miacci, V., Costa, G., Caricato, M., and Mascian\u00e0, G. (2025). Liver Robotic Surgery: A Review of Current Use and Future Perspectives. J. Clin. Med., 14.","DOI":"10.20944\/preprints202509.0204.v1"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Paramythiotis, D., Tsavdaris, D., Tsavdaris, G., Hatzidakis, A., Psarras, K., Mekras, A., Georgiades, C., and Michalopoulos, A. (2025). Surgery Without Scalpel: Histotripsy as a Non-Invasive and Non-Thermal Modality for Liver Tumor Ablation. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186391"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Uysal, M., Wehrle, C.J., Satish, S., Knott, E., Hong, H., Allkushi, E., Schlegel, A., Berber, E., Aucejo, F., and Kim, J. (2025). Histotripsy of Liver Tumors: Patient Selection, Ethical Discussions, and How We Do It. Cancers, 17.","DOI":"10.20944\/preprints202501.1472.v1"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-bioeng-073123-022334","article-title":"Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound","volume":"26","author":"Xu","year":"2024","journal-title":"Annu. Rev. Biomed. Eng."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/02656736.2021.1905189","article-title":"Histotripsy: The first noninvasive, non-ionizing, non-thermal ablation technique based on ultrasound","volume":"38","author":"Xu","year":"2021","journal-title":"Int. J. Hyperth."},{"key":"ref_19","unstructured":"(2026, March 01). CIRS Inc.\u2014Computerized Imaging Reference Systems, Tissue Simulation & Phantom Technology (2021): Triple Modality 3D Abdominal Phantom\u2014Model 057A. Available online: https:\/\/www.cirsinc.com\/products\/ultrasound\/zerdine-hydrogel\/triple-modality-3d-abdominal-phantom."},{"key":"ref_20","unstructured":"Kyoto Kagaku Co., Ltd. (2026, March 01). Abdominal Intraoperative & Laparoscopic Ultrasound Phantom\u2014IOUSFAN, Update 7 August 2020. Available online: https:\/\/www.kyotokagaku.com\/en\/products_data\/us-3\/."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Elisei, R.C., Graur, F., Szold, A., Melzer, A., Moldovan, S.C., Motrescu, M., Moi\u015f, E., Popa, C., P\u00eesla, D., and Vaida, C. (2024). Gelatin-Based Liver Phantoms for Training Purposes: A Cookbook Approach. J. Clin. Med., 13.","DOI":"10.3390\/jcm13123440"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3315\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:38:35Z","timestamp":1791880715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":21,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15093315"],"URL":"https:\/\/doi.org\/10.3390\/jcm15093315","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}