{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:30:16Z","timestamp":1777444216700,"version":"3.51.4"},"reference-count":16,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Total knee arthroplasty (TKA) is a common procedure aimed at alleviating knee pain and restoring function in patients with degenerative joint diseases. Traditional implants are typically designed to restore mechanical knee alignment, but personalized implants have shown promise in improving clinical outcomes. The Origin\u00ae individualized TKA system provides a tailored approach to knee reconstruction by utilizing preoperative 3D planning to create individualized implants and cutting guides based on each patient\u2019s unique anatomy. Surgical Technique: The Origin\u00ae system employs a preoperative computed tomography (CT) scan and Knee-Plan\u00ae software to design individualized implants that optimize alignment and joint anatomy. The surgical technique involves the use of patient-specific cutting guides for precise bone resections and the insertion of either cruciate-retaining (CR) or posterior-stabilized (PS) implants, depending on individual patient needs. This process aims to replicate the pre-arthritic alignment and kinematics of the pre-arthritic knee. Postoperative Protocol: The postoperative protocol allows for immediate weight-bearing, and patients are guided through a structured rehabilitation program to ensure optimal recovery. Full range-of-motion exercises begin early to promote knee mobility and strength. Discussion: The individualized TKA system offers several advantages, including precise restoration of pre-arthritic anatomy, reduced bone resection, and improved implant fit. These benefits are particularly valuable in patients with unique anatomical challenges, such as deformities or previous surgeries. Despite the potential advantages, challenges remain, including the costs and time associated with individualized manufacturing, as well as increased radiation exposure from the required CT scans. Conclusions: The Origin\u00ae individualized TKA system represents a significant advancement in knee arthroplasty by providing a tailored approach to patient care. Future studies are needed to further evaluate the long-term outcomes and cost-effectiveness of this personalized system compared to conventional TKA approaches.<\/jats:p>","DOI":"10.3390\/jcm15093356","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:33:37Z","timestamp":1777376017000},"page":"3356","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Individualized Total Knee Arthroplasty Using the Origin\u00ae: A Step-by-Step Surgical Technique and Clinical Application"],"prefix":"10.3390","volume":"15","author":[{"given":"Mohammad","family":"Alajji","sequence":"first","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2774-1170","authenticated-orcid":false,"given":"Marc","family":"Barrera Uso","sequence":"additional","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-1824","authenticated-orcid":false,"given":"Thais Dutra","family":"Vieira","sequence":"additional","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarik","family":"Ait Si Selmi","sequence":"additional","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Bonnin","sequence":"additional","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Sappey-Marinier","sequence":"additional","affiliation":[{"name":"Centre Orthopedique Santy, Ramsay Sante, H\u00f4pital Prive Jean Mermoz, 69008 Lyon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s42836-023-00175-6","article-title":"Epidemiology of primary and revision total knee arthroplasty: Analysis of demographics, comorbidities and outcomes from the national inpatient sample","volume":"5","author":"Nham","year":"2023","journal-title":"Arthroplasty"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.arth.2023.01.060","article-title":"Current Concepts in Alignment in Total Knee Arthroplasty","volume":"38","author":"Karasavvidis","year":"2023","journal-title":"J. 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