{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:31:32Z","timestamp":1777444292692,"version":"3.51.4"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Portal vein thrombosis (PVT) is prevalent among candidates for liver transplantation (LT) and may serve as a contraindication to transplantation when extensive. Given the rising prevalence of metabolic syndrome, this study aimed to identify clinical factors associated with PVT and evaluate its impact on access to the LT waiting list and the likelihood of undergoing transplantation. Methods: A retrospective cohort of 711 consecutive patients assessed for LT between 2008 and 2020 was included. Data on PVT and various clinical variables were collected, including reasons for exclusion from the waiting list and dropout rates. Multivariable logistic regression models with forward selection and bootstrap were constructed to assess factors associated with PVT, access to the waiting list, and LT. Results: PVT was identified in 11.6% of patients (n = 83), with advanced thrombosis observed in 21% of cases. Obesity emerged as the only independent factor significantly associated with the presence of PVT (p = 0.001, OR 2.619, 95% CI 1.577\u20134.352). Patients with PVT were more frequently excluded from the waiting list due to clinical contraindications compared to those without PVT (26% vs. 14%, p = 0.04). However, multivariable analysis did not demonstrate an independent association between PVT and access to the waiting list or LT. No significant differences were observed in the reasons for dropout from the waiting list between patients with and without PVT. Conclusions: PVT appears to be associated with the metabolic profile of LT candidates, particularly obesity; however, it does not significantly limit access to LT.<\/jats:p>","DOI":"10.3390\/jcm15093358","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:33:37Z","timestamp":1777376017000},"page":"3358","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Portal Vein Thrombosis in Cirrhotic Candidates for Liver Transplantation and Its Impact on the Transplant Accessibility"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-009X","authenticated-orcid":false,"given":"Simona","family":"Parisse","sequence":"first","affiliation":[{"name":"Wellbeing, Health and Environmental Sustainability, Sapienza University of Rome, Via della Fontanelle, 02100 Rieti, Italy"},{"name":"AOU Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8553-5589","authenticated-orcid":false,"given":"Flaminia","family":"Ferri","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7338-9203","authenticated-orcid":false,"given":"Adriano","family":"De Santis","sequence":"additional","affiliation":[{"name":"Wellbeing, Health and Environmental Sustainability, Sapienza University of Rome, Via della Fontanelle, 02100 Rieti, Italy"},{"name":"AOU Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4056-9245","authenticated-orcid":false,"given":"Fabio","family":"Melandro","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, Department of General and Specialty Surgery, Sapienza University of Rome, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Corona","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Unit, Department of Radiological Oncological and Anatomo-Pathological Sciences, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quirino","family":"Lai","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, Department of General and Specialty Surgery, Sapienza University of Rome, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7448-1404","authenticated-orcid":false,"given":"Pierleone","family":"Lucatelli","sequence":"additional","affiliation":[{"name":"Vascular and Interventional Radiology Unit, Department of Radiological Oncological and Anatomo-Pathological Sciences, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-6863","authenticated-orcid":false,"given":"Gianluca","family":"Mennini","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, Department of General and Specialty Surgery, Sapienza University of Rome, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5105-4656","authenticated-orcid":false,"given":"Massimo","family":"Rossi","sequence":"additional","affiliation":[{"name":"General Surgery and Organ Transplantation Unit, Department of General and Specialty Surgery, Sapienza University of Rome, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-1961","authenticated-orcid":false,"given":"Stefano","family":"Ginanni Corradini","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, AOU Policlinico Umberto I, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Prakash, S., Bies, J., Hassan, M., Mares, A., and Didia, S.C. 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