{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:14:26Z","timestamp":1778058866127,"version":"3.51.4"},"reference-count":39,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Contrast-associated acute kidney injury (CA-AKI) is a frequent complication after coronary angiography (CAG) that may adversely affect outcomes in patients with acute coronary syndrome (ACS). We aimed to estimate the incidence of CA-AKI and evaluate its association with 30-day all-cause mortality in adults with ACS undergoing CAG. Methods: We conducted a retrospective cohort study; CA-AKI was defined as an increase in serum creatinine \u22650.5 mg\/dL or \u226525% from baseline within 72 h after contrast exposure, according to KDIGO criteria. The primary outcome was 30-day all-cause mortality. Survival analyses were performed using Kaplan\u2013Meier curves and Cox proportional hazards models. Results: Including 374 consecutive adults with ACS who underwent diagnostic or therapeutic CAG at a tertiary referral center. The mean age was 68.8 \u00b1 11.2 years, and 72.6% were male. CA-AKI occurred in 17.4% of patients, and 11.7% died within 30 days. In multivariable analysis, age (HR 1.04; 95% CI 1.00\u20131.07), CA-AKI (HR 2.81; 95% CI 1.48\u20135.33), stress hyperglycemia \u2265180 mg\/dL (HR 2.88; 95% CI 1.54\u20135.38), and delirium (HR 7.20; 95% CI 2.40\u201320.92) were independent predictors of mortality. Conclusions: age, CA-AKI, stress hyperglycemia, and delirium independently predict short-term mortality after CAG in ACS, supporting integrated risk-stratified peri-procedural management. These observations suggest that mortality in these patients may be related to an inflammatory process secondary to ischemia\/reperfusion, which is probably induced by dysregulation of the central autonomic network and activation of the hypothalamic\u2013pituitary\u2013adrenal axis which is currently underdiagnosed.<\/jats:p>","DOI":"10.3390\/jcm15093534","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:36:23Z","timestamp":1778052983000},"page":"3534","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Contrast-Associated Acute Kidney Injury and Mortality Risk After Coronary Angiography for Acute Coronary Syndromes: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Eva Maria","family":"Olivas-Flores","sequence":"first","affiliation":[{"name":"Departamento de Anestesiolog\u00eda, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"},{"name":"Departamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Guadalajara 46600, Ameca Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Daniel","family":"Rocha-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Salud-Enfermedad Como Proceso Individual, Centro Universitario de Tonal\u00e1, Universidad de Guadalajara, Guadalajara 44100, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelita del Socorro","family":"Valencia-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Departamento de Anestesiolog\u00eda, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Rojas-Castillo","sequence":"additional","affiliation":[{"name":"Departamento de Hemodin\u00e1mica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Guillermo","family":"Delgado-Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Departamento de Hemodin\u00e1mica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Patricia","family":"Pizarro-Gonzales","sequence":"additional","affiliation":[{"name":"Departamento de Hemodin\u00e1mica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario Alberto","family":"Mireles-Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Educaci\u00f3n e Investigaci\u00f3n en Salud, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Ahuixotl","family":"Guti\u00e9rrez-Aceves","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Educaci\u00f3n e Investigaci\u00f3n en Salud, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3471-5835","authenticated-orcid":false,"given":"Nicte Selene","family":"Fajardo-Robledo","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n y Desarrollo Farmac\u00e9utico, Centro Universitario de Ciencias Exactas e Ingenier\u00edas, Universidad de Guadalajara, Guadalajara 44430, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian Esau","family":"De La Cruz-Estrella","sequence":"additional","affiliation":[{"name":"Departamento de Hemodin\u00e1mica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Lorena","family":"Mariscal-Chavez","sequence":"additional","affiliation":[{"name":"Departamento de Hemodin\u00e1mica, Hospital de Especialidades, Centro M\u00e9dico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Vazquez-Villegas","sequence":"additional","affiliation":[{"name":"Instituto Regional de Investigaci\u00f3n en Salud, Departamento de Salud P\u00fablica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-6003","authenticated-orcid":false,"given":"Fabiola","family":"Gonzalez-Ponce","sequence":"additional","affiliation":[{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-667X","authenticated-orcid":false,"given":"Ernesto German","family":"Cardona-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9470-2489","authenticated-orcid":false,"given":"David","family":"Cardona-M\u00fcller","sequence":"additional","affiliation":[{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0001-3787","authenticated-orcid":false,"given":"Jorge Ivan","family":"Gamez-Nava","sequence":"additional","affiliation":[{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6517-6344","authenticated-orcid":false,"given":"Laura","family":"Gonzalez-Lopez","sequence":"additional","affiliation":[{"name":"Instituto de Terap\u00e9utica Experimental y Cl\u00ednica, Programa de Doctorado en Farmacolog\u00eda, Departamento de Fisiolog\u00eda, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1038\/s41591-023-02513-2","article-title":"A new clinical classification of acute myocardial infarction","volume":"29","author":"Lindahl","year":"2023","journal-title":"Nat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth Universal Definition of Myocardial Infarction (2018)","volume":"72","author":"Thygesen","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e771","DOI":"10.1161\/CIR.0000000000001328","article-title":"2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the Management of Patients with Acute Coronary Syndromes","volume":"151","author":"Rao","year":"2025","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1093\/eurheartj\/ehad191","article-title":"2023 ESC Guidelines for the management of acute coronary syndromes","volume":"44","author":"Rossello","year":"2023","journal-title":"Eur. Heart J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.carrev.2021.12.007","article-title":"Radial Artery Access Complications: Prevention, Diagnosis and Management","volume":"40","author":"Roy","year":"2022","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO Clinical Practice Guidelines for Acute Kidney Injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin. Prac."},{"key":"ref_7","first-page":"1883","article-title":"Acute Kidney Injury Requiring Dialysis Following Percutaneous Coronary Intervention: Insights From the PROGRESS-COMPLICATIONS Registry","volume":"106","author":"Mutlu","year":"2025","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_8","unstructured":"Modi, K., Padala, S.A., and Gupta, M. (2026). Contrast-Induced Nephropathy. StatPearls [Internet], StatPearls Publishing."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s40620-021-01021-1","article-title":"The global incidence and mortality of contrast-associated acute kidney injury following coronary angiography: A meta-analysis of 1.2 million patients","volume":"34","author":"Lun","year":"2021","journal-title":"J. Nephrol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1007\/s11255-022-03110-x","article-title":"Incidence and mortality of acute kidney disease following coronary angiography: A cohort study of 9223 patients","volume":"54","author":"Liu","year":"2022","journal-title":"Int. Urol. Nephrol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/heartjnl-2017-311975","article-title":"Contrast-induced acute kidney injury and mortality in ST elevation myocardial infarction treated with primary percutaneous coronary intervention","volume":"104","author":"Silvain","year":"2018","journal-title":"Heart"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ahj.2025.01.002","article-title":"Tailored hydration for prevention of contrast-induced acute kidney injury after coronary angiography or PCI: A systematic review and meta-analysis","volume":"282","author":"Cossette","year":"2025","journal-title":"Am. Heart J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/08998280.2024.2301903","article-title":"Patient characteristics associated with acute kidney injury following coronary angiography","volume":"37","author":"Knott","year":"2024","journal-title":"Proc. Bayl. Univ. Med. Cent."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Zhou, D., Lun, Z., Wang, B., Liu, J., Liu, L., Chen, G., Ying, M., Li, H., Chen, S., and Tan, N. (2022). Association Between Non-Recovered Contrast-Associated Acute Kidney Injury and Poor Prognosis in Patients Undergoing Coronary Angiography. Front. Cardiovasc. Med., 9.","DOI":"10.3389\/fcvm.2022.823829"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Sielski, J., Kazir\u00f3d-Wolski, K., Piotrowska, A.M., Jurczak, B., Klasa, A., Kozie\u0142, K., Ludew, M., Maj, F., Merchel, L., and Pytlak, K. (2025). Contrast-Induced Nephropathy After Invasive Coronary Angiography and Its Effect on Short- and Long-Term Outcomes in Acute Coronary Syndrome Patients. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113725"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/CIA.S452882","article-title":"A Comparison Between Two Different Definitions of Contrast-Associated Acute Kidney Injury for Long-Term Mortality in Patients with Chronic Kidney Disease Undergoing Coronary Angiography","volume":"19","author":"Feng","year":"2024","journal-title":"Clin. Interv. Aging"},{"key":"ref_17","unstructured":"Mexican Social Security Institute (IMSS) (2024). 2024 Annual Report: Coverage and Institutional Medical Care, IMSS."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Liu, J., Li, Q., Lai, D., Chen, G., Wang, B., Liu, L., Huang, H., Lun, Z., Ying, M., and Chen, G. (2021). Trends in incidence and long-term prognosis of acute kidney injury following coronary angiography in Chinese cohort with 11,943 patients from 2013 to 2017: An observational study. BMC Nephrol., 22.","DOI":"10.1186\/s12882-021-02427-6"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"15348","DOI":"10.1038\/s41598-021-94910-1","article-title":"Association of the classification and severity of heart failure with the incidence of contrast-induced acute kidney injury","volume":"11","author":"Xu","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6641887","DOI":"10.1155\/2021\/6641887","article-title":"Association of Early and Late Contrast-Associated Acute Kidney Injury and Long-Term Mortality in Patients Undergoing Coronary Angiography","volume":"2021","author":"Lun","year":"2021","journal-title":"J. Interv. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1159\/000546496","article-title":"Early versus Late Acute Kidney Injury in Patients Undergoing Primary Percutaneous Coronary Intervention","volume":"15","author":"Greenberg","year":"2025","journal-title":"Cardiorenal Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"108959","DOI":"10.1016\/j.diabres.2021.108959","article-title":"Does a strict glycemic control during acute coronary syndrome play a cardioprotective effect? Pathophysiology and clinical evidence","volume":"178","author":"Caturano","year":"2021","journal-title":"Diabetes Res. Clin. Prac."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Shan, Y., Lin, M., Gu, F., Ying, S., Bao, X., Zhu, Q., Tao, Y., Chen, Z., Li, D., and Zhang, W. (2023). Association between fasting stress hyperglycemia ratio and contrast-induced acute kidney injury in coronary angiography patients: A cross-sectional study. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1300373"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s13098-024-01345-5","article-title":"The impact of the stress hyperglycemia ratio on the risk of contrast-associated acute kidney injury in patients undergoing coronary angiography: A large real-world cohort study","volume":"16","author":"Li","year":"2024","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12933-023-01759-x","article-title":"Association between the stress hyperglycemia ratio and severity of coronary artery disease under different glucose metabolic states","volume":"22","author":"Zhang","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Zhao, Y., Zhao, Y., Wang, S., Fan, Z., Wang, Y., Liu, F., and Liu, Z. (2025). Association between stress hyperglycemia ratio and contrast-induced nephropathy in ACS patients undergoing PCI: A retrospective cohort study from the MIMIC-IV database. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-04573-3"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12933-024-02220-3","article-title":"Effects of the stress hyperglycemia ratio on long-term mortality in patients with triple-vessel disease and acute coronary syndrome","volume":"23","author":"Zhang","year":"2024","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1186\/s12933-025-02837-y","article-title":"Impact of glucometabolic status on type 4a myocardial infarction in patients with non\u2013ST-segment elevation myocardial infarction: The role of stress hyperglycemia ratio","volume":"24","author":"Armillotta","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13098-024-01575-7","article-title":"Relationship between stress hyperglycemia ratio and progression of non target coronary lesions: A retrospective cohort study","volume":"17","author":"Liu","year":"2025","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12933-026-03100-8","article-title":"Stress hyperglycemia ratio in coronary artery disease: A systematic review and meta-analysis of severity and prognosis","volume":"25","author":"Wang","year":"2026","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"784","DOI":"10.26599\/1671-5411.2025.09.003","article-title":"Delirium risk factors in patients \u2265 60 years of age with recent myocardial infarction","volume":"22","author":"Burchacka","year":"2025","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_32","first-page":"1072","article-title":"Incidence and predictors of delirium on the intensive care unit after acute myocardial infarction, insight from a retrospective registry","volume":"98","author":"Zotzmann","year":"2021","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1536\/ihj.25-289","article-title":"Delirium in Nonagenarians with Acute Coronary Syndrome Following Percutaneous Coronary Intervention","volume":"66","author":"Hayakawa","year":"2025","journal-title":"Int. Heart J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.carrev.2023.06.010","article-title":"Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes","volume":"57","author":"Park","year":"2023","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1007\/s00059-024-05250-5","article-title":"Clinical characteristics of delirium in older patients with first-ever acute myocardial infarction who underwent percutaneous coronary intervention","volume":"49","author":"Tan","year":"2024","journal-title":"Herz"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Wang, W.-H., Hong, Y.-C., Chen, H.-M., Chen, D., Wei, K.-C., and Lai, P.-C. (2022). Risk Factors and Outcome of Acute Kidney Injury following Acute Myocardial Infarction\u2014A Case Series Study from 2009 to 2019. J. Clin. Med., 11.","DOI":"10.3390\/jcm11206083"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"612032","DOI":"10.1155\/2013\/612032","article-title":"NGAL and metabolomics: The single biomarker to reveal the metabolome alterations in Kidney injury","volume":"2013","author":"Noto","year":"2013","journal-title":"BioMed Res. Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e025729","DOI":"10.1161\/JAHA.122.025729","article-title":"A Biomarker-Enhanced Model for Prediction of Acute Kidney Injury and Cardiovascular Risk Following Angiographic Procedures: CASABLANCA AKI Prediction Substudy","volume":"11","author":"Mohebi","year":"2022","journal-title":"J. Am. Heart Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.acvd.2018.11.006","article-title":"Evaluation of neutrophil gelatinase-associated lipocalin and cystatin C as biomarkers of acute kidney injury after ST-segment elevation myocardial infarction treated by percutaneous coronary intervention","volume":"112","author":"Nguyen","year":"2019","journal-title":"Arch. Cardiovasc. Dis."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3534\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:25:13Z","timestamp":1778055913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":39,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15093534"],"URL":"https:\/\/doi.org\/10.3390\/jcm15093534","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}