{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T10:12:56Z","timestamp":1778148776278,"version":"3.51.4"},"reference-count":42,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004061","name":"Jubil\u00e4umsfond of the \u00d6sterreichische Nationalbank","doi-asserted-by":"publisher","award":["15656"],"award-info":[{"award-number":["15656"]}],"id":[{"id":"10.13039\/501100004061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cardiovascular disease remains the leading cause of mortality worldwide. In recent years, several non-invasive imaging techniques have been introduced to improve the assessment of atherosclerotic burden and cardiovascular risk, including computed tomography and vascular ultrasound. Three-dimensional ultrasound has emerged as a promising method for the non-invasive quantification of plaque volume in peripheral arteries. Methods: In this prospective single-centre study, 63 patients with low to moderate cardiovascular risk (6\u201320% according to the Framingham Risk Score) were included. All participants underwent baseline examinations, and 38 patients completed follow-up after a mean period of 2 years. The assessment included coronary artery calcium scoring (CACS) by computed tomography and three-dimensional ultrasound to measure peripheral plaque volume in carotid and femoral arteries. Baseline values and progression of coronary and peripheral atherosclerosis were analysed using Spearman\u2019s correlation. Results: Sixty-three patients were included in the final analysis. A significant correlation was observed between baseline CACS and peripheral plaque volume (r = 0.32; p = 0.010). In addition, the progression of coronary calcium scores was significantly associated with the progression of peripheral plaque volume (r = 0.34; p = 0.037). Conclusions: Coronary artery calcium is significantly associated with peripheral plaque burden, both at baseline and over time. The parallel progression of coronary and peripheral atherosclerosis suggests that peripheral plaque volume assessed by 3D ultrasound may serve as a surrogate marker for coronary disease progression.<\/jats:p>","DOI":"10.3390\/jcm15093546","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:03:37Z","timestamp":1778144617000},"page":"3546","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Atherosclerosis Progression Evaluation in Coronary Arteries by Computed Tomography Compared to Peripheral Vessels Using 3D Ultrasonography"],"prefix":"10.3390","volume":"15","author":[{"given":"Maria","family":"Noflatscher","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5251-6971","authenticated-orcid":false,"given":"Michael","family":"Schreinlechner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Sommer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Freiberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Plank","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4049-4494","authenticated-orcid":false,"given":"Pietro G.","family":"Lacaita","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3609-9730","authenticated-orcid":false,"given":"Markus","family":"Theurl","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Kirchmair","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6755-4399","authenticated-orcid":false,"given":"Gudrun","family":"Feuchtner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-3447","authenticated-orcid":false,"given":"Peter","family":"Marschang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III (Cardiology, Angiology), Medical University of Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria"},{"name":"Department of Internal Medicine, Central Hospital of Bolzano (SABES-ASDAA), Via Lorenz Boehler 5, 39100 Bolzano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: A systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atherosclerosis\u2014An inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_3","first-page":"377","article-title":"Modern risk stratification in coronary heart disease","volume":"4","author":"Ginghina","year":"2011","journal-title":"J. Med. Life"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.atherosclerosis.2012.04.007","article-title":"\u201cIn vivo\u201d imaging of atherosclerosis","volume":"224","author":"Gallino","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.amjmed.2005.10.062","article-title":"Prediction of mortality risk in the elderly","volume":"119","author":"Stork","year":"2006","journal-title":"Am. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1161\/STROKEAHA.110.589754","article-title":"Carotid plaque area and intima-media thickness in prediction of first-ever ischemic stroke: A 10-year follow-up of 6584 men and women: The Tromso Study","volume":"42","author":"Mathiesen","year":"2011","journal-title":"Stroke"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/1358863X11400936","article-title":"The development and potential of acoustic radiation force impulse (ARFI) imaging for carotid artery plaque characterization","volume":"16","author":"Allen","year":"2011","journal-title":"Vasc. Med."},{"key":"ref_8","first-page":"676","article-title":"Carotid artery atheroma: Comparison of preoperative B-mode ultrasound appearance with carotid endarterectomy specimen pathology","volume":"29","author":"Graham","year":"1988","journal-title":"J. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1001\/jama.2012.9630","article-title":"Common carotid intima-media thickness measurements in cardiovascular risk prediction: A meta-analysis","volume":"308","author":"Peters","year":"2012","journal-title":"JAMA"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.atherosclerosis.2012.05.007","article-title":"European Guidelines on cardiovascular disease prevention in clinical practice (version 2012): The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts)","volume":"223","author":"Perk","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0735-1097(00)01119-0","article-title":"Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: Results of 1764 patients","volume":"37","author":"Haberl","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_12","first-page":"e584","article-title":"2010 ACCF\/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines","volume":"122","author":"Greenland","year":"2010","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.jacc.2015.01.017","article-title":"Prevalence, impact, and predictive value of detecting subclinical coronary and carotid atherosclerosis in asymptomatic adults: The BioImage study","volume":"65","author":"Baber","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/eurheartj\/ehz455","article-title":"2019 ESC\/EAS Guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk","volume":"41","author":"Mach","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Noflatscher, M., Schreinlechner, M., Sommer, P., Kerschbaum, J., Berggren, K., Theurl, M., Kirchmair, R., and Marschang, P. (2018). Influence of Traditional Cardiovascular Risk Factors on Carotid and Femoral Atherosclerotic Plaque Volume as Measured by Three-Dimensional Ultrasound. J. Clin. Med., 8.","DOI":"10.3390\/jcm8010032"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5414\/CN110381","article-title":"Effect of chronic kidney disease and sex on carotid and femoral plaque volume as measured by three-dimensional ultrasound","volume":"96","author":"Noflatscher","year":"2021","journal-title":"Clin. Nephrol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Sommer, P., Schreinlechner, M., Noflatscher, M., Lener, D., Mair, F., Theurl, M., Kirchmair, R., and Marschang, P. (2023). Increasing Soluble P-Selectin Levels Predict Higher Peripheral Atherosclerotic Plaque Progression. J. Clin. Med., 12.","DOI":"10.3390\/jcm12206430"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343145","article-title":"Mannheim carotid intima-media thickness and plaque consensus (2004\u20132006\u20132011). An update on behalf of the advisory board of the 3rd, 4th and 5th watching the risk symposia, at the 13th, 15th and 20th European Stroke Conferences, Mannheim, Germany, 2004, Brussels, Belgium, 2006, and Hamburg, Germany, 2011","volume":"34","author":"Touboul","year":"2012","journal-title":"Cerebrovasc. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/01621459.1951.10500769","article-title":"The Kolmogorov-Smirnov Test for Goodness of Fit","volume":"46","author":"Massey","year":"1951","journal-title":"J. Am. Stat. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4065\/74.4.347","article-title":"Progression of coronary artery calcification: A pilot study","volume":"74","author":"Maher","year":"1999","journal-title":"Mayo Clin. Proc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1161\/01.ATV.21.3.421","article-title":"Natural history and topographic pattern of progression of coronary calcification in symptomatic patients: An electron-beam CT study","volume":"21","author":"Schmermund","year":"2001","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0002-9149(00)00820-1","article-title":"Rates of progression of coronary calcium by electron beam tomography","volume":"86","author":"Budoff","year":"2000","journal-title":"Am. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0002-9149(03)00892-0","article-title":"Progression of coronary calcium on serial electron beam tomographic scanning is greater in patients with future myocardial infarction","volume":"92","author":"Raggi","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.jcmg.2010.08.018","article-title":"Progression of Coronary Artery Calcium Predicts All-Cause Mortality","volume":"3","author":"Budoff","year":"2010","journal-title":"JACC-Cardiovasc. Imaging"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.jacc.2010.06.038","article-title":"Coronary Artery Calcium Progression: An Important Clinical Measurement? A Review of Published Reports","volume":"56","author":"McEvoy","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/j.jacc.2010.10.034","article-title":"Peripheral arterial disease and progression of coronary atherosclerosis","volume":"57","author":"Hussein","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Achim, A., Stanek, A., Homorodean, C., Spinu, M., Onea, H.L., Lazar, L., Marc, M., Ruzsa, Z., and Olinic, D.M. (2022). Approaches to Peripheral Artery Disease in Diabetes: Are There Any Differences?. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19169801"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/MCA.0000000000000531","article-title":"Differences in coronary plaque characteristics between patients with and those without peripheral arterial disease","volume":"28","author":"Bryniarski","year":"2017","journal-title":"Coron. Artery Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/1358863X13493825","article-title":"Peripheral artery disease and risk of cardiovascular events in patients with coronary artery disease: Insights from the Heart and Soul Study","volume":"18","author":"Grenon","year":"2013","journal-title":"Vasc. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3346\/jkms.2013.28.1.87","article-title":"Peripheral artery disease in korean patients undergoing percutaneous coronary intervention: Prevalence and association with coronary artery disease severity","volume":"28","author":"Kim","year":"2013","journal-title":"J. Korean Med. Sci."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Lisowska, A., Dubatowka, M., Chlabicz, M., Jamiolkowski, J., Kondraciuk, M., Szyszkowska, A., Knapp, M., Szpakowicz, A., Lukasiewicz, A., and Kaminski, K. (2023). Disparities in the Prevalence and Risk Factors for Carotid and Lower Extremities Atherosclerosis in a General Population-Bialystok PLUS Study. J. Clin. Med., 12.","DOI":"10.3390\/jcm12072627"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1007\/s12350-023-03343-y","article-title":"Coronary vascular dysfunction is associated with increased risk of death in patients with peripheral artery disease","volume":"30","author":"Patel","year":"2023","journal-title":"J. Nucl. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/00001573-200311000-00005","article-title":"Treatment of combined coronary and carotid artery disease","volume":"18","author":"Huh","year":"2003","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archinte.1985.00360050105017","article-title":"Coronary angiography in 506 patients with extracranial cerebrovascular disease","volume":"145","author":"Hertzer","year":"1985","journal-title":"Arch. Intern. Med."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Achim, A., P\u00e9ter, O.A., Cocoi, M., Serban, A., Mot, S., Dadarlat-Pop, A., Nemes, A., and Ruzsa, Z. (2023). Correlation between Coronary Artery Disease with Other Arterial Systems: Similar, Albeit Separate, Underlying Pathophysiologic Mechanisms. J. Cardiovasc. Dev. Dis., 10.","DOI":"10.3390\/jcdd10050210"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.jacc.2007.02.059","article-title":"Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling\u2014Molecular, cellular, and vascular behavior","volume":"49","author":"Chatzizisis","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Rampidis, G., Rafailidis, V., Kouskouras, K., Davidhi, A., Papachristodoulou, A., Samaras, A., Giannakoulas, G., Ziakas, A., Prassopoulos, P., and Karvounis, H. (2022). Relationship between Coronary Arterial Geometry and the Presence and Extend of Atherosclerotic Plaque Burden: A Review Discussing Methodology and Findings in the Era of Cardiac Computed Tomography Angiography. Diagnostics, 12.","DOI":"10.20944\/preprints202208.0295.v1"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jacc.2007.03.025","article-title":"Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial","volume":"49","author":"Bhatt","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJM200207043470112","article-title":"The value of inflammation for predicting unstable angina","volume":"347","author":"Keaney","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Lai, R., Ju, J., Lin, Q., and Xu, H. (2020). Coronary Artery Calcification Under Statin Therapy and Its Effect on Cardiovascular Outcomes: A Systematic Review and Meta-Analysis. Front. Cardiovasc. Med., 7.","DOI":"10.3389\/fcvm.2020.600497"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Ngamdu, K.S., Ghosalkar, D.S., Chung, H.E., Christensen, J.L., Lee, C., Butler, C.A., Ho, T., Chu, A., Heath, J.R., and Baig, M. (2023). Long-term statin therapy is associated with severe coronary artery calcification. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0289111"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.31083\/j.rcm2502051","article-title":"The Complex Mechanisms and the Potential Effects of Statins on Vascular Calcification: A Narrative Review","volume":"25","author":"Kadoglou","year":"2024","journal-title":"Rev. Cardiovasc. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3546\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:49:27Z","timestamp":1778147367000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/9\/3546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":42,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15093546"],"URL":"https:\/\/doi.org\/10.3390\/jcm15093546","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,6]]}}}