{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:13:37Z","timestamp":1778562817251,"version":"3.51.4"},"reference-count":56,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Neurological diseases are increasing worldwide, but the biological processes underlying these diseases remain poorly understood, and existing treatments have been ineffective at arresting disease progression. Emerging data indicate that dysbiosis of the microbiota\u2013gut\u2013brain axis and malnutrition are comorbid factors in neurological dysfunction. Methods: An extended search strategy was developed using a multifaceted approach across various databases to identify eligible studies published between January 2010 and February 2026. Results: Results showed uniform relationships among neurological conditions, loss of microbial richness, loss of short-chain fatty acid-producing bacteria, neuroinflammation, and nutritional susceptibility. The review also identifies methodological trends in microbiome profiling and nutritional assessment and suggests an integrative framework of symptom-linked microbial imbalance, malnutrition, and inflammatory processes. Conclusions: Although dietary modulation and microbiome-targeted interventions appear promising, the evidence is mostly correlational. Longitudinal and interventional studies should be well-designed to elucidate causal mechanisms and to provide effective clinical strategies.<\/jats:p>","DOI":"10.3390\/jcm15093547","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T09:03:37Z","timestamp":1778144617000},"page":"3547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Scoping Review of Gut Dysbiosis and Malnutrition in Neurological Disorders: Implications, Indications, and Promising Therapeutic Approaches"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7647-2421","authenticated-orcid":false,"given":"Thana\u2019","family":"Aljaraedah","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, Al al-Bayt University, Mafraq 25113, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2682-8612","authenticated-orcid":false,"given":"Sameeha","family":"Al-Thnaibat","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Health, Faculty of Allied Medical Sciences, Middle East University, Amman 11831, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abd Al-Rhman","family":"Nawasreh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7565-9000","authenticated-orcid":false,"given":"Wesal","family":"Alraei","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, Al al-Bayt University, Mafraq 25113, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4100-1643","authenticated-orcid":false,"given":"Esra\u2019a","family":"Al-Trad","sequence":"additional","affiliation":[{"name":"Department of Medical Analysis, Faculty of Applied Medical Sciences, Al al-Bayt University, Mafraq 25113, Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Geisler, C., Pankoke, J., Schlicht, K., Knappe, C., Rohmann, N., Hartmann, K., Settgast, U., T\u00fcrk, K., Seoudy, A.K., and Franke, A. 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