{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:14:05Z","timestamp":1790723645560,"version":"4.1.0"},"reference-count":74,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Intensive care unit-acquired weakness (ICUAW) is a common and devastating complication in critically ill patients admitted to the intensive care unit (ICU). ICUAW is characterized by profound skeletal and respiratory muscle weakness and degeneration, as well as peripheral nerve dysfunction. The condition is further categorized into three primary diagnoses: critical illness myopathy (CIM), which affects skeletal muscles, critical illness polyneuropathy (CIP), which affects peripheral nerves, and critical illness polyneuromyopathy (CIPNM), which exhibits features of both CIM and CIP. Although the pathophysiology of ICUAW remains poorly understood, several risk factors have been identified, including female sex, advanced age, prolonged mechanical ventilation, extended ICU stay, prolonged immobilization, multiorgan failure, shock, infection, and other factors related to critical illness and its treatment. Currently, ICUAW is diagnosed after the onset of critical illness, and only once all other possible causes of generalized weakness have been excluded. The most commonly used assessments for suspected ICUAW are the Medical Research Council sum score (MRC-SS) and handgrip dynamometry. However, these tools require active patient participation and are, therefore, impractical for many ICU patients. Non-volitional testing methods, including electromyography (EMG) and nerve conduction studies, can be used to evaluate ICUAW, but these tests are invasive and require specialized training and resources. Due to the lack of effective diagnostic tools and an incomplete understanding of disease mechanisms, management of ICUAW is largely restricted to physical rehabilitation. ICUAW is associated with high morbidity and mortality, and survivors often experience long-term disability and reduced quality of life following hospital discharge. Future areas of research, including biomarker analysis and risk prediction modeling, may enable earlier diagnosis and intervention in critically ill patients. This review summarizes potential diagnostic tools, current management strategies, and short- and long-term prognosis and identifies emerging areas of research aimed at improving outcomes for critically ill patients with suspected ICUAW.<\/jats:p>","DOI":"10.3390\/jcm15103623","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T19:10:52Z","timestamp":1778267452000},"page":"3623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["ICU-Acquired Weakness: An Unsolved Clinical Problem: A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Meghan","family":"Spoeri","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Critical Care & Pain Medicine, Endeavor Health, Evanston, IL 60201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Shamberg","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care & Pain Medicine, Endeavor Health, Evanston, IL 60201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nia","family":"Moragne","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care & Pain Medicine, Endeavor Health, Evanston, IL 60201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wlodarski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neuromuscular Medicine, & Neurophysiology, Endeavor Health, Glenview, IL 60026, USA"},{"name":"Department of Neurology, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven B.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care & Pain Medicine, Endeavor Health, Evanston, IL 60201, USA"},{"name":"Department of Anesthesiology and Critical Care, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1152\/japplphysiol.00019.2021","article-title":"Pathophysiology and management of critical illness polyneuropathy and myopathy","volume":"130","author":"Cheung","year":"2021","journal-title":"J. Appl. Physiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ncl.2017.06.008","article-title":"Intensive Care Unit-Acquired Weakness","volume":"35","author":"Kramer","year":"2017","journal-title":"Neurol. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"508","DOI":"10.12688\/f1000research.17376.1","article-title":"Intensive care unit-acquired weakness: Unanswered questions and targets for future research","volume":"8","author":"Piva","year":"2019","journal-title":"F1000Research"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00134-020-05944-4","article-title":"ICU-acquired weakness","volume":"46","author":"Vanhorebeek","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.mpaic.2017.12.009","article-title":"Intensive care unit-acquired weakness","volume":"19","author":"Taylor","year":"2018","journal-title":"Anaesth. Intensive Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1097\/CCM.0000000000002763","article-title":"Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis","volume":"45","author":"Kelmenson","year":"2017","journal-title":"Crit. Care Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"P466","DOI":"10.1186\/cc13656","article-title":"Acute and long-term outcomes of ICU-acquired weakness: A cohort study and propensity matched analysis","volume":"18","author":"Hermans","year":"2014","journal-title":"Crit. Care"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1186\/s13054-023-04676-3","article-title":"Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes","volume":"27","author":"Latronico","year":"2023","journal-title":"Crit. Care"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.nmd.2018.12.005","article-title":"The clinical management of neuromuscular disorders in intensive care","volume":"29","author":"Damian","year":"2019","journal-title":"Neuromuscul. Disord."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S391","DOI":"10.1097\/CCM.0b013e3181b6f01a","article-title":"Metabolic aspects of critical illness polyneuromyopathy","volume":"37","author":"Hermans","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/CCM.0b013e31822d7c18","article-title":"Muscle atrophy and preferential loss of myosin in prolonged critically ill patients","volume":"40","author":"Derde","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1002\/jcsm.13104","article-title":"A prospective clinical study on the mechanisms underlying critical illness myopathy-A time-course approach","volume":"13","author":"Cacciani","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1164\/rccm.201411-2011ST","article-title":"An official American Thoracic Society Clinical Practice guideline: The diagnosis of intensive care unit-acquired weakness in adults","volume":"190","author":"Fan","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"R229","DOI":"10.1186\/cc13052","article-title":"Clinical predictive value of manual muscle strength testing during critical illness: An observational cohort study","volume":"17","author":"Connolly","year":"2013","journal-title":"Crit. Care"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"100301","DOI":"10.1016\/j.ijnsa.2025.100301","article-title":"Potential diagnostic tools for intensive care unit acquired weakness: A systematic review","volume":"8","author":"Xin","year":"2025","journal-title":"Int. J. Nurs. Stud. Adv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"199","DOI":"10.5935\/0103-507X.20150036","article-title":"A guided approach to diagnose severe muscle weakness in the intensive care unit","volume":"27","author":"Latronico","year":"2015","journal-title":"Rev. Bras. Ter. Intensiv."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13054-015-0780-5","article-title":"A new two-tier strength assessment approach to the diagnosis of weakness in intensive care: An observational study","volume":"19","author":"Parry","year":"2015","journal-title":"Crit. Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1097\/CCM.0000000000004467","article-title":"The Use of Physical Therapy ICU Assessments to Predict Discharge Home","volume":"48","author":"Tymkew","year":"2020","journal-title":"Crit. Care Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Petrucci, M., Gemma, S., Carbone, L., Piccioni, A., Della Polla, D.A., Simeoni, B., Franceschi, F., and Covino, M. (2025). ICU-Acquired Weakness: From Pathophysiology to Management in Critical Care. Emerg. Care Med., 2.","DOI":"10.3390\/ecm2010004"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1186\/s13054-018-2281-9","article-title":"What is the diagnostic accuracy of single nerve conduction studies and muscle ultrasound to identify critical illness polyneuromyopathy: A prospective cohort study","volume":"22","author":"Kelmenson","year":"2018","journal-title":"Crit. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/ALN.0000000000005845","article-title":"A Pilot Study Using a Portable Electromyography Device to Assess Changes in Compound Muscle Action Potential Amplitudes and Latencies in Critically Ill Intubated Patients","volume":"144","author":"Greenberg","year":"2026","journal-title":"Anesthesiology"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/mus.25732","article-title":"Compound muscle action potential duration in critical illness neuromyopathy","volume":"57","author":"Kramer","year":"2018","journal-title":"Muscle Nerve."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S1474-4422(11)70178-8","article-title":"Critical illness polyneuropathy and myopathy: A major cause of muscle weakness and paralysis","volume":"10","author":"Latronico","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/mus.21445","article-title":"Prolonged compound muscle action potential duration in critical illness myopathy","volume":"40","author":"Goodman","year":"2009","journal-title":"Muscle Nerve."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11940-022-00714-7","article-title":"Critical Illness Myopathy: Diagnostic Approach and Resulting Therapeutic Implications","volume":"24","author":"Rodriguez","year":"2022","journal-title":"Curr. Treat. Options Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.chest.2016.03.045","article-title":"ICU-Acquired Weakness","volume":"150","author":"Jolley","year":"2016","journal-title":"Chest"},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Marrero, H.D.J.G., St\u00e5lberg, E.V., Cooray, G., Kalamgi, R.C., Hedstr\u00f6m, Y., Bellander, B.M., Nennesmo, I., and Larsson, L. (2020). Neurogenic vs. Myogenic Origin of Acquired Muscle Paralysis in Intensive Care Unit (ICU) Patients: Evaluation of Different Diagnostic Methods. Diagnostics, 10.","DOI":"10.3390\/diagnostics10110966"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"154104","DOI":"10.1016\/j.jcrc.2022.154104","article-title":"The possible predictive value of muscle ultrasound in the diagnosis of ICUAW in long-term critically ill patients","volume":"71","author":"Paolo","year":"2022","journal-title":"J. Crit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s40001-024-01966-6","article-title":"Early predictive value of ultrasound measurements of rectus femoris cross-sectional area to diagnose ICU-acquired weakness in patients undergoing invasive mechanical ventilation: A prospective cohort study","volume":"29","author":"Yao","year":"2024","journal-title":"Eur. J. Med. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lei, L., He, L., Zou, T., Qui, J., Li, Y., Zhou, R., Qin, Y., and Yin, W. (2025). Predicting early diagnosis of intensive care unit-acquired weakness in septic patients using critical ultrasound and biological markers. BMC Anesthesiol., 25.","DOI":"10.1186\/s12871-025-02911-8"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"834","DOI":"10.14740\/jocmr4027","article-title":"Skeletal Muscle Index at Intensive Care Unit Admission Is a Predictor of Intensive Care Unit-Acquired Weakness in Patients With Sepsis","volume":"11","author":"Mitobe","year":"2019","journal-title":"J. Clin. Med. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4994","DOI":"10.1007\/s00330-023-09468-5","article-title":"Early shoulder-girdle MRI findings in severe COVID-19-related intensive care unit-acquired weakness: A prospective cohort study","volume":"33","author":"Daste","year":"2023","journal-title":"Eur. Radiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.hrtlng.2019.07.001","article-title":"Use of handgrip dynamometry for diagnosis and prognosis assessment of intensive care unit acquired weakness: A prospective study","volume":"48","author":"Ravetti","year":"2019","journal-title":"Heart Lung"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/SHK.0000000000002484","article-title":"Use of muscle ultrasound to detect intensive care unit-acquired weakness: A systematic review and meta-analysis","volume":"63","author":"Gu","year":"2025","journal-title":"Shock"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e22013","DOI":"10.1097\/MD.0000000000022013","article-title":"Prevalence and risk factors for intensive care unit acquired weakness: A protocol for a systematic review and meta-analysis","volume":"99","author":"Li","year":"2020","journal-title":"Medicine"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40560-024-00744-0","article-title":"Which factors are associated with acquired weakness in the ICU? An overview of systematic reviews and meta-analyses","volume":"12","author":"Seron","year":"2024","journal-title":"J. Intensive Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1007\/s00134-025-07949-3","article-title":"Altered muscle transcriptome as molecular basis of long-term muscle weakness in survivors from critical illness","volume":"51","author":"Derese","year":"2025","journal-title":"Intensive Care Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.aucc.2020.12.005","article-title":"Care and treatments related to intensive care unit-acquired muscle weakness: A cohort study","volume":"34","author":"Gallart","year":"2021","journal-title":"Aust. Crit. Care"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e31405","DOI":"10.1097\/MD.0000000000031405","article-title":"A systematic review and meta-analysis of risk factors for intensive care unit acquired weakness","volume":"101","author":"Yang","year":"2022","journal-title":"Medicine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.chest.2018.07.016","article-title":"Impact of Vasoactive Medications on ICU-Acquired Weakness in Mechanically Ventilated Patients","volume":"154","author":"Wolfe","year":"2018","journal-title":"Chest"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e70012","DOI":"10.1002\/brb3.70012","article-title":"A meta-analysis of the association between vasopressor use and intensive care unit-acquired weakness","volume":"14","author":"Yang","year":"2024","journal-title":"Brain Behav."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Yang, T., Li, Z.Q., Li, H.L., Zhou, J.X., and Chen, G.Q. (2020). Aminoglycoside use and intensive care unit-acquired weakness: A systematic review and meta-analysis. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0230181"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1097\/CCM.0000000000001839","article-title":"Neuromuscular Blocking Agents and Neuromuscular Dysfunction Acquired in Critical Illness: A Systematic Review and Meta-Analysis","volume":"44","author":"Price","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_44","first-page":"101202","article-title":"Association between neuromuscular blocking agents and the development of intensive care unit-acquired weakness (ICU-AW): A systematic review with meta-analysis and trial sequential analysis","volume":"42","author":"Bellaver","year":"2023","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1378\/chest.13-2046","article-title":"Impact of early mobilization on glycemic control and ICU-acquired weakness in critically ill patients who are mechanically ventilated","volume":"146","author":"Patel","year":"2014","journal-title":"Chest"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S2213-2600(13)70183-8","article-title":"Effect of tolerating macronutrient deficit on the development of intensive-care unit acquired weakness: A subanalysis of the EPaNIC trial","volume":"1","author":"Hermans","year":"2013","journal-title":"Lancet Respir. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJMoa1102662","article-title":"Early versus late parenteral nutrition in critically ill adults","volume":"365","author":"Casaer","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.aucc.2019.04.003","article-title":"Effects of neuromuscular electrical stimulation in critically ill patients: A systematic review and meta-analysis of randomised controlled trials","volume":"33","author":"Zayed","year":"2020","journal-title":"Aust. Crit. Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e2282","DOI":"10.1097\/CCM.0000000000006840","article-title":"Effect of Enhanced Versus Usual Mobilization Activities in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials","volume":"53","author":"Carayannopoulos","year":"2025","journal-title":"Crit. Care Med."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Liu, Y., Gong, Y., Zhang, C., Meng, P., Gai, Y., Han, X., Yuan, Z., Xing, J., and Dong, Z. (2023). Effect of neuromuscular electrical stimulation combined with early rehabilitation therapy on mechanically ventilated patients: A prospective randomized controlled study. BMC Pulm. Med., 23.","DOI":"10.1186\/s12890-023-02481-w"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1056\/NEJMoa2209083","article-title":"Early Active Mobilization during Mechanical Ventilation in the ICU","volume":"387","author":"Hodgson","year":"2022","journal-title":"N. Engl. J. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1097\/CCM.0000000000005557","article-title":"Early Neuromuscular Electrical Stimulation in Addition to Early Mobilization Improves Functional Status and Decreases Hospitalization Days of Critically Ill Patients","volume":"50","author":"Campos","year":"2022","journal-title":"Crit. Care Med."},{"key":"ref_53","first-page":"e1345","article-title":"Effect of Neuromuscular Electrical Stimulation for Older Critically Ill Patients in the ICU: A Randomized Controlled Trial","volume":"7","author":"Yokobatake","year":"2025","journal-title":"Crit. Care Explor."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/CNQ.0000000000000445","article-title":"Short-Term Outcomes of Neuromuscular Electrical Stimulation in Critically Ill Patients","volume":"46","author":"Mahran","year":"2023","journal-title":"Crit. Care Nurs. Q."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.chest.2020.03.045","article-title":"Effect of Intermittent or Continuous Feed on Muscle Wasting in Critical Illness: A Phase 2 Clinical Trial","volume":"158","author":"McNelly","year":"2020","journal-title":"Chest"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/CCM.0000000000001652","article-title":"Pharmacological Therapy for the Prevention and Treatment of Weakness After Critical Illness: A Systematic Review","volume":"44","author":"Shepherd","year":"2016","journal-title":"Crit. Care Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R213","DOI":"10.1186\/cc13028","article-title":"Early treatment with IgM-enriched intravenous immunoglobulin does not mitigate critical illness polyneuropathy and\/or myopathy in patients with multiple organ failure and SIRS\/sepsis: A prospective, randomized, placebo-controlled, double-blinded trial","volume":"17","author":"Brunner","year":"2013","journal-title":"Crit. Care"},{"key":"ref_58","first-page":"179","article-title":"Glutamine and antioxidants: Status of their use in critical illness","volume":"18","year":"2015","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1097\/CCM.0000000000005125","article-title":"ICU Survivorship-The Relationship of Delirium, Sedation, Dementia, and Acquired Weakness","volume":"49","author":"Mart","year":"2021","journal-title":"Crit. Care Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1164\/rccm.201312-2257OC","article-title":"Acute outcomes and 1-year mortality of intensive care unit-acquired weakness. A cohort study and propensity-matched analysis","volume":"190","author":"Hermans","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jcrc.2019.06.022","article-title":"Long term follow-up of quality of life and functional ability in patients with ICU acquired Weakness\u2014A post hoc analysis","volume":"53","author":"Sidiras","year":"2019","journal-title":"J. Crit. Care"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.chest.2017.08.1157","article-title":"Diaphragm Dysfunction in Critical Illness","volume":"153","author":"Supinski","year":"2018","journal-title":"Chest"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s13054-015-0937-2","article-title":"Impact of ICU-acquired weakness on post-ICU physical functioning: A follow-up study","volume":"19","author":"Wieske","year":"2015","journal-title":"Crit. Care"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Intiso, D., Centra, A.M., Bartolo, M., Gatta, M.T., Gravina, M., and Di Rienzo, F. (2022). Recovery and long term functional outcome in people with critical illness polyneuropathy and myopathy: A scoping review. BMC Neurol., 22.","DOI":"10.1186\/s12883-022-02570-z"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1186\/s13054-023-04569-5","article-title":"Guideline on multimodal rehabilitation for patients with post-intensive care syndrome","volume":"27","author":"Renner","year":"2023","journal-title":"Crit. Care"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13613-025-01500-9","article-title":"Biomarkers for intensive care unit-acquired weakness: A systematic review for prediction, diagnosis and prognosis","volume":"15","author":"Song","year":"2025","journal-title":"Ann. Intensive Care"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/thoraxjnl-2014-206225","article-title":"Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs","volume":"70","author":"Bloch","year":"2015","journal-title":"Thorax"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.1097\/CCM.0b013e3181b6ef67","article-title":"A framework for diagnosing and classifying intensive care unit-acquired weakness","volume":"37","author":"Stevens","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Picod, A., Morisson, L., de Roquetaillade, C., Sadoune, M., Mebazaa, A., Gayat, E., Davison, B.A., Cotter, G., and Chousterman, B.G. (2022). Systemic Inflammation Evaluated by Interleukin-6 or C-Reactive Protein in Critically Ill Patients: Results From the FROG-ICU Study. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.868348"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1016\/j.clinph.2021.03.016","article-title":"Critical illness polyneuropathy, myopathy and neuronal biomarkers in COVID-19 patients: A prospective study","volume":"132","author":"Frithiof","year":"2021","journal-title":"Clin. Neurophysiol."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Yang, Z., Wang, X., Chang, G., Cao, Q., Wang, F., Peng, Z., and Fan, Y. (2023). Development and validation of an intensive care unit acquired weakness prediction model: A cohort study. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1122936"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"101066","DOI":"10.1016\/j.aucc.2024.05.003","article-title":"Risk prediction models for intensive care unit-acquired weakness in critically ill patients: A systematic review","volume":"38","author":"Zhou","year":"2025","journal-title":"Aust. Crit. Care"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/s40001-025-02930-8","article-title":"Development and validation of machine learning-based risk prediction models for ICU-acquired weakness: A prospective cohort study","volume":"30","author":"Zhang","year":"2025","journal-title":"Eur. J. Med. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40635-025-00810-3","article-title":"Development and validation of a machine learning model for early prediction of intensive care unit acquired weakness","volume":"13","author":"Nakano","year":"2025","journal-title":"Intensive Care Med. 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