{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:34:41Z","timestamp":1785429281732,"version":"3.56.0"},"reference-count":39,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:00:00Z","timestamp":1778284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["y, grant number RGP2\/461\/46"],"award-info":[{"award-number":["y, grant number RGP2\/461\/46"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]},{"award":["y, grant number RGP2\/461\/46"],"award-info":[{"award-number":["y, grant number RGP2\/461\/46"]}],"id":[{"id":"https:\/\/ror.org\/052kwzs30","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The impact of Type 1 Diabetes Mellitus (T1DM) on linear growth in children remains unclear, with conflicting evidence regarding the roles of glycemic control, disease duration, and nutritional factors. This study aimed to assess growth patterns and identify factors independently associated with short stature among Saudi school-age children and adolescents with T1DM, comparing them to a healthy control group. Methods: A retrospective cross-sectional study was conducted at an endocrinology clinic, including 250 patients with T1DM aged 5\u201318 years and 267 healthy controls. After propensity score matching, 231 patients were matched to 231 controls. Data were extracted from electronic medical records using a standardized form. Anthropometric measurements were converted to Z-scores and percentiles using validated Saudi growth charts. Short stature was defined as height below the third percentile for age and gender. Univariate and multivariable logistic regression analyses were performed to identify factors associated with short stature among T1DM participants. Results: The median age of the 250 T1DM participants was 13.0 [10.0\u201315.0] years, with a slight male predominance (58.0%). Of them, 6 (2.4%) children were tall, 30 (12.0% were short), and 214 (85.6%) were normal. A significantly higher proportion of short stature was observed in the T1DM group compared with the control group (6.1% vs. 1.7%; p = 0.016). Among T1DM participants, the proportion of short stature increased progressively with diabetes duration: 3.0% in new-onset disease, 14.9% in intermediate duration (2\u20135 years), and 25.0% in long-standing disease (&gt;5 years) (p = 0.001). Age at onset of T1DM was also significantly associated with having short stature (p = 0.036). In multivariable analysis, intermediate duration (adjusted odds ratio [aOR] = 5.72, 95% CI (1.02\u201332.1); p = 0.047) and long-standing duration (aOR = 11.03, 95% CI: (1.09\u2013111.45); p = 0.042) remained significant independent predictors of short stature. In contrast, glycemic control (HbA1c), vitamin D status, time in range, and treatment adherence were not significantly associated with short stature after adjustment. Conclusions: Children and adolescents with T1DM have significantly lower height percentiles and a higher prevalence of short stature compared to their controls. Diabetes duration is a strong, independent predictor of short stature in this population, with progressively higher risk as disease duration lengthens, regardless of glycemic control status. These findings underscore the necessity of systematic longitudinal growth monitoring, particularly in patients with disease duration exceeding five years, to enable early identification and intervention for those at highest risk of growth impairment.<\/jats:p>","DOI":"10.3390\/jcm15103629","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:17:42Z","timestamp":1778519862000},"page":"3629","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Growth Patterns and Factors Associated with Short Stature in Saudi Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8162-6288","authenticated-orcid":false,"given":"Youssef A","family":"Alqahtani","sequence":"first","affiliation":[{"name":"Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0444-5595","authenticated-orcid":false,"given":"Ayed","family":"A. Shati","sequence":"additional","affiliation":[{"name":"Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayoub Ali","family":"Alshaikh","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinh Hussein","family":"Fardan","sequence":"additional","affiliation":[{"name":"Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roaa Saad","family":"Alhuwail","sequence":"additional","affiliation":[{"name":"Asser Health Cluster, Ministry of Health, Abha 62523, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia Salem A","family":"Almosleh","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5076-030X","authenticated-orcid":false,"given":"Abeer Mohammed","family":"Alshehri","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maram Hadi A","family":"Asiri","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4921-2189","authenticated-orcid":false,"given":"Shaden Essa","family":"Hammati","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6316-8461","authenticated-orcid":false,"given":"Reema Abdullah S.","family":"Alsharif","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-706X","authenticated-orcid":false,"given":"Ramy Mohamed","family":"Ghazy","sequence":"additional","affiliation":[{"name":"Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia"},{"name":"Health and Medical Research Centre, King Khalid University, Abha 61421, Saudi Arabia"},{"name":"Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria 21526, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e075681","DOI":"10.1136\/bmj-2023-075681","article-title":"New advances in type 1 diabetes","volume":"384","author":"Subramanian","year":"2024","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/jech-2015-205710","article-title":"National surveillance for type 1, type 2 diabetes and prediabetes among children and adolescents: A population-based study (SAUDI-DM)","volume":"69","year":"2015","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_3","unstructured":"GBD 2021 Diabetes Collaborators (2023). Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: A systematic analysis for the Global Burden of Disease Study 2021. Lancet, 402, 203\u2013234."},{"key":"ref_4","first-page":"989","article-title":"Mauriac syndrome: Growth failure and type 1 diabetes mellitus","volume":"5","author":"Kim","year":"2008","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"ref_5","first-page":"100245","article-title":"Glycemic control and complications of type 1 diabetes among children in Tanzania","volume":"23","author":"Najem","year":"2021","journal-title":"J. Clin. Transl. Endocrinol."},{"key":"ref_6","first-page":"1","article-title":"The silent toll: Understanding the complications of type 2 diabetes mellitus in the male body: A narrative review article","volume":"21","author":"Ghazy","year":"2025","journal-title":"J. Men\u2019s Health"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Santi, E., Tascini, G., Toni, G., Berioli, M.G., and Esposito, S. (2019). Linear Growth in Children and Adolescents with Type 1 Diabetes Mellitus. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16193677"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Inzaghi, E., Pampanini, V., Deodati, A., and Cianfarani, S. (2022). The Effects of Nutrition on Linear Growth. Nutrients, 14.","DOI":"10.3390\/nu14091752"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"72","DOI":"10.4274\/jcrpe.v2i2.72","article-title":"Growth of children with type 1 diabetes mellitus","volume":"2","author":"Demir","year":"2010","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1464-5491.1994.tb02017.x","article-title":"Growth during childhood and final height in type 1 diabetes","volume":"11","author":"Brown","year":"1994","journal-title":"Diabet. Med."},{"key":"ref_11","first-page":"174","article-title":"Pediatric patients with type 1-diabetes: Growth and growth failure associated factors","volume":"73","author":"Keever","year":"2016","journal-title":"Bolet\u00edn M\u00e9dico Hosp. Infant. Mex. (Engl. Ed.)"},{"key":"ref_12","first-page":"57","article-title":"Hepatomegaly, dwarfism, obesity and diabetes in children: Mauriac\u2019s syndrome","volume":"67","author":"Mauriac","year":"1951","journal-title":"Vida Nueva"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF00540257","article-title":"Mauriac\u2019s syndrome revisited","volume":"142","author":"Traisman","year":"1984","journal-title":"Eur. J. Pediatr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000486698","article-title":"Growth Trajectory in Children with Type 1 Diabetes Mellitus: The Impact of Insulin Treatment and Metabolic Control","volume":"89","author":"Bizzarri","year":"2018","journal-title":"Horm. Res. Paediatr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1159\/000355116","article-title":"Residual \u03b2-cell mass influences growth of prepubertal children with type 1 diabetes","volume":"80","author":"Bizzarri","year":"2013","journal-title":"Horm. Res. Paediatr."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1210\/jcem.85.11.6996","article-title":"Growth and insulin-like growth factors (IGFs) in children with insulin-dependent diabetes mellitus at the onset of disease: Evidence for normal growth, age dependency of the IGF system alterations, and presence of a small (approximately 18-kilodalton) IGF-binding protein-3 fragment in serum","volume":"85","author":"Cianfarani","year":"2000","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1203\/00006450-199510000-00022","article-title":"Longitudinal data on growth and final height in diabetic children","volume":"38","author":"Rooman","year":"1995","journal-title":"Pediatr. Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/pedi.13452","article-title":"ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes","volume":"23","author":"Adolfsson","year":"2022","journal-title":"Pediatr. Diabetes"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"S230","DOI":"10.2337\/dc23-S014","article-title":"14. Children and Adolescents: Standards of Care in Diabetes-2023","volume":"46","author":"ElSayed","year":"2023","journal-title":"Diabetes Care"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Joy, S.S., and Al Mutairi, M. (2021). Long-Term Hyperglycemia Triggered Growth Pattern of Pediatrics with Type 1 Diabetes-A Five-Year Retrospective Follow-Up Study.","DOI":"10.37722\/ANAFS.2021103"},{"key":"ref_21","first-page":"249","article-title":"Growth status of children and adolescents with type 1 diabetes mellitus in Jeddah, Saudi Arabia: A cross-sectional study","volume":"22","author":"Aljuhani","year":"2018","journal-title":"Curr. Pediatr. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.32677\/ijch.v9i9.3635","article-title":"Prevalence of stunting and determinants of growth failure in children with Type 1 diabetes","volume":"9","author":"Bhor","year":"2022","journal-title":"Indian J. Child Health"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13052-018-0488-7","article-title":"Vitamin D in pediatric age: Consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians","volume":"44","author":"Saggese","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.2337\/dc17-1600","article-title":"International Consensus on Use of Continuous Glucose Monitoring","volume":"40","author":"Danne","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4103\/1319-3767.187608","article-title":"The LMS and Z Scale Growth Reference for Saudi School-age Children and Adolescents","volume":"22","author":"Alqurashi","year":"2016","journal-title":"Saudi J. Gastroenterol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"265","DOI":"10.5144\/0256-4947.2016.265","article-title":"Growth reference for Saudi school-age children and adolescents: LMS parameters and percentiles","volume":"36","author":"Alqurashi","year":"2016","journal-title":"Ann. Saudi Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"9111583","DOI":"10.1155\/pedi\/9111583","article-title":"Long-Term Growth Outcomes of Children with Type 1 Diabetes According to Glycemic Control and Use of Continuous Glucose Monitoring: A Retrospective Cohort Study","volume":"2026","author":"Kim","year":"2026","journal-title":"Pediatr. Diabetes"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"10.18103","DOI":"10.18103\/mra.v11i7.1.4023","article-title":"Growth status of Adolescents with Diabetic Type 1 and its associated factors","volume":"11","author":"Qadir","year":"2023","journal-title":"Med. Res. Arch."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.4103\/2230-8210.155405","article-title":"Growth disorders in type 1 diabetes: An Indian experience","volume":"19","author":"Virmani","year":"2015","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ghir.2017.04.003","article-title":"Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH\/IGF-1 axis","volume":"34","author":"Raisingani","year":"2017","journal-title":"Growth Horm. IGF Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1210\/endo-98-5-1214","article-title":"The effects of insulin and growth hormone on the release of somatomedin by the isolated rat liver","volume":"98","author":"Daughaday","year":"1976","journal-title":"Endocrinology"},{"key":"ref_32","first-page":"2139","article-title":"Insulin-like growth factor-I is related to glycemic control in children and adolescents with newly diagnosed insulin-dependent diabetes","volume":"80","author":"Dills","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1651-2227.1995.tb13718.x","article-title":"Normal stimulated growth hormone secretion but low peripheral levels of insulin-like growth factor I in prepubertal children with insulin-dependent diabetes mellitus","volume":"84","author":"Tapanainen","year":"1995","journal-title":"Acta Paediatr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-3476(82)80054-1","article-title":"Effect of intensive insulin treatment on linear growth in the young diabetic patient","volume":"101","author":"Rudolf","year":"1982","journal-title":"J. Pediatr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1046\/j.1365-2265.1996.7760786.x","article-title":"Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children","volume":"45","author":"Bereket","year":"1996","journal-title":"Clin. Endocrinol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.4103\/2230-8210.122623","article-title":"Growth status of children and adolescents with type 1 diabetes mellitus","volume":"17","author":"Khadilkar","year":"2013","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jpeds.2011.12.007","article-title":"Diabetes Patienten Verlaufsdokumentationssystem Initiative of the German Working Group for Pediatric Diabetology and the German Bundesministerium f\u00fcr Bildung und Forschung Competence Net for Diabetes Mellitus. Growth in children and adolescents with type 1 diabetes","volume":"160","author":"Bonfig","year":"2012","journal-title":"J. Pediatr."},{"key":"ref_38","first-page":"120","article-title":"Factors affecting insulin-like growth factor-1 in type 1 diabetes mellitus in children","volume":"7","author":"Rochmah","year":"2025","journal-title":"J. Med. Pharm. Chem. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.3945\/jn.110.126284","article-title":"Serum 25-hydroxyvitamin D concentrations fluctuate seasonally in young adults of diverse ancestry living in Toronto","volume":"140","author":"Gozdzik","year":"2010","journal-title":"J. Nutr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3629\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:38:46Z","timestamp":1778521126000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,9]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15103629"],"URL":"https:\/\/doi.org\/10.3390\/jcm15103629","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,9]]}}}