{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:44:51Z","timestamp":1791830691003,"version":"4.3.4"},"reference-count":93,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ITF Research Pharma S.L.U."},{"id":[{"id":"https:\/\/ror.org\/05xsppr58","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Iron deficiency (ID) is the most prevalent nutritional disorder worldwide, affecting diverse populations including children, women of reproductive age, older adults and patients with chronic conditions. Oral iron supplementation remains the cornerstone of treatment, together with management of the underlying causes. However, conventional ferrous and ferric salts are often associated with gastrointestinal side effects, poor adherence and limited efficacy, especially in inflammatory settings due to hepcidin-mediated absorption blockade. This review summarizes iron absorption physiology, limitations of traditional oral therapies, and the potential benefits of iron protein succinylate (IPS), a ferric complex bound to succinylated casein. IPS provides pH-dependent release and contains succinic acid, which may enhance absorption while reducing gastrointestinal adverse events. Clinical studies indicate that IPS achieves hematologic outcomes comparable or superior to standard oral salts, fewer gastrointestinal effects and better tolerability. These properties make IPS suitable for patients who do not tolerate or respond adequately to conventional therapy. Special attention is given to chronic inflammation, pregnancy, cancer, or gastrointestinal disorders, where oral iron often fails due to impaired absorption or poorer tolerance. Practical recommendations are included to optimize supplementation through dosing strategies and tailored approaches. Overall, IPS offers an effective, better-tolerated alternative to conventional oral iron therapy.<\/jats:p>","DOI":"10.3390\/jcm15103691","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:17:42Z","timestamp":1778519862000},"page":"3691","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iron Deficiency and Oral Treatments: Limitations, Pharmacokinetics, and the Role of Iron Protein Succinylate in Clinical Practice"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-6286","authenticated-orcid":false,"given":"Jos\u00e9 Antonio","family":"Garc\u00eda-Erce","sequence":"first","affiliation":[{"name":"Blood and Tissue Bank of Navarra, 31008 Navarra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-5457","authenticated-orcid":false,"given":"Santiago","family":"Garc\u00eda-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Hospital Universitario Miguel Servet, 50009 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mart\u00ednez-Franc\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hospital Cl\u00ednico Universitario Santa Luc\u00eda, 30202 Cartagena, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"ref_1","unstructured":"UNICEF, United Nations University, and World Health Organization (2001). Iron Deficiency Anaemia: Assessment, Prevention, and Control: A Guide for Programme Managers, WHO."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12937-022-00771-3","article-title":"Global Burden and Inequality of Iron Deficiency: Findings from the Global Burden of Disease Datasets 1990\u20132017","volume":"21","author":"Wang","year":"2022","journal-title":"Nutr. J."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Means, R.T. (2020). Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients, 12.","DOI":"10.3390\/nu12020447"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/S0753-3322(01)00067-1","article-title":"Iron: Deficiencies and Requirements","volume":"55","author":"Tapiero","year":"2001","journal-title":"Biomed. Pharmacother."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0140-6736(20)32594-0","article-title":"Iron Deficiency","volume":"397","author":"Pasricha","year":"2021","journal-title":"The Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Montoro-Huguet, M.A., Santolaria-Piedrafita, S., Ca\u00f1amares-Orbis, P., and Garc\u00eda-Erce, J.A. (2021). Iron Deficiency in Celiac Disease: Prevalence, Health Impact, and Clinical Management. Nutrients, 13.","DOI":"10.3390\/nu13103437"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Montoro, M., Cucala, M., Lanas, \u00c1., Villanueva, C., Herv\u00e1s, A.J., Alcedo, J., Gisbert, J.P., Aisa, \u00c1.P., Bujanda, L., and Calvet, X. (2022). Indications and Hemoglobin Thresholds for Red Blood Cell Transfusion and Iron Replacement in Adults with Gastrointestinal Bleeding: An Algorithm Proposed by Gastroenterologists and Patient Blood Management Experts. Front. Med., 9.","DOI":"10.3389\/fmed.2022.903739"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/ajh.24820","article-title":"Iron Deficiency across Chronic Inflammatory Conditions: International Expert Opinion on Definition, Diagnosis, and Management","volume":"92","author":"Cappellini","year":"2017","journal-title":"Am. J. Hematol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e548","DOI":"10.1016\/S2214-109X(18)30078-0","article-title":"Risk of Maternal Mortality in Women with Severe Anaemia during Pregnancy and Post Partum: A Multilevel Analysis","volume":"6","author":"Daru","year":"2018","journal-title":"Lancet Glob. Health"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"McCann, S., Perapoch Amad\u00f3, M., and Moore, S.E. (2020). The Role of Iron in Brain Development: A Systematic Review. Nutrients, 12.","DOI":"10.3390\/nu12072001"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5S23","DOI":"10.1016\/S0929-693X(17)24006-8","article-title":"Fer et nutrition","volume":"24","author":"Tounian","year":"2017","journal-title":"Arch. P\u00e9diatr."},{"key":"ref_12","first-page":"150","article-title":"Deficiencia de hierro en ni\u00f1os con o sin anemia: Diagn\u00f3stico diferencial y factores de riesgo","volume":"6","year":"2021","journal-title":"Polo Conoc. Rev. Cient\u00edfico\u2014Prof."},{"key":"ref_13","unstructured":"World Health Organization (2025, July 22). WHO Guideline on Use of Ferritin Concentrations to Assess Iron Status in Individuals and Populations, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK569877\/."},{"key":"ref_14","unstructured":"(2025, July 22). The Urgent Need to Implement Patient Blood Management: Policy Brief. Available online: https:\/\/www.who.int\/es\/publications\/i\/item\/9789240035744."},{"key":"ref_15","unstructured":"World Health Organization (2024). Guidance on Implementing Patient Blood Management to Improve Global Blood Health Status, World Health Organization."},{"key":"ref_16","first-page":"189","article-title":"Anaemia and the elderly: Critical review of its definition and prevalence","volume":"54","year":"2019","journal-title":"Rev. Esp. Geriatr. Gerontol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1080\/01635581.2019.1658794","article-title":"Iron Deficiency and Anemia in Cancer Patients: The Role of Iron Treatment in Anemic Cancer Patients","volume":"72","author":"Abiri","year":"2020","journal-title":"Nutr. Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Gargallo-Puyuelo, C.J., Alfambra, E., Garc\u00eda-Erce, J.A., and Gomollon, F. (2018). Iron Treatment May Be Difficult in Inflammatory Diseases: Inflammatory Bowel Disease as a Paradigm. Nutrients, 10.","DOI":"10.3390\/nu10121959"},{"key":"ref_19","first-page":"31","article-title":"Management of Iron Deficiency in Various Clinical Conditions and the Role of Intravenous Iron: Recommendations of the Spanish Erythropathology Group of the Spanish Society of Haematology and Haemotherapy","volume":"220","author":"Remacha","year":"2020","journal-title":"Rev. Clin. Esp."},{"key":"ref_20","first-page":"171","article-title":"Efficacy and Tolerability of Oral Iron Protein Succinylate in the Treatment of Iron Deficiency Anemia in Adults with Diverse Pathologies","volume":"9","year":"2021","journal-title":"Am. J. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"846824","DOI":"10.1100\/2012\/846824","article-title":"Ferrous versus Ferric Oral Iron Formulations for the Treatment of Iron Deficiency: A Clinical Overview","volume":"2012","author":"Santiago","year":"2012","journal-title":"Sci. World J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.3748\/wjg.15.4617","article-title":"An Update on Iron Physiology","volume":"15","author":"Villar","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/jcp.2010.079046","article-title":"Disorders of Iron Metabolism. Part 1: Molecular Basis of Iron Homoeostasis","volume":"64","author":"Remacha","year":"2011","journal-title":"J. Clin. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"20441","DOI":"10.1021\/acsomega.2c01833","article-title":"Iron Absorption: Factors, Limitations, and Improvement Methods","volume":"7","author":"Piskin","year":"2022","journal-title":"ACS Omega"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1039\/c0mt00043d","article-title":"Molecular Mechanism of Intestinal Iron Absorption","volume":"3","author":"Han","year":"2011","journal-title":"Metallomics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1080\/07315724.1993.10718365","article-title":"Regulation of Iron Absorption: Proteins Involved in Duodenal Mucosal Uptake and Transport","volume":"12","author":"Conrad","year":"1993","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-021-00696-z","article-title":"New Regulators of Systemic Iron Homeostasis","volume":"6","author":"Ganz","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/j.bbamcr.2012.01.014","article-title":"Hepcidin and Iron Homeostasis","volume":"1823","author":"Ganz","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Nemeth, E., and Ganz, T. (2021). Hepcidin-Ferroportin Interaction Controls Systemic Iron Homeostasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22126493"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep4.1717","article-title":"Hepcidin Signaling in Health and Disease: Ironing Out the Details","volume":"5","author":"Kowdley","year":"2021","journal-title":"Hepatol. Commun."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4425","DOI":"10.1182\/blood-2011-01-258467","article-title":"Hepcidin and Iron Regulation, 10 Years Later","volume":"117","author":"Ganz","year":"2011","journal-title":"Blood"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1606S","DOI":"10.3945\/ajcn.117.155887","article-title":"Laboratory Methodologies for Indicators of Iron Status: Strengths, Limitations, and Analytical Challenges","volume":"106","author":"Pfeiffer","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_33","first-page":"9394060","article-title":"Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions","volume":"2018","author":"Dignass","year":"2018","journal-title":"Int. J. Chronic Dis."},{"key":"ref_34","first-page":"1575","article-title":"AGA Clinical Practice Update on Management of Iron Deficiency Anemia: Expert Review","volume":"22","author":"DeLoughery","year":"2024","journal-title":"Clin. Gastroenterol. Hepatol. Off. Clin. Pract. J. Am. Gastroenterol. Assoc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1182\/asheducation-2015.1.8","article-title":"Iron Deficiency: New Insights into Diagnosis and Treatment","volume":"2015","author":"Camaschella","year":"2015","journal-title":"Hematology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1080\/10408398.2020.1787326","article-title":"Classic and Emergent Indicators for the Assessment of Human Iron Status","volume":"61","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_37","unstructured":"World Health Organization (2024). Guideline on Haemoglobin Cutoffs to Define Anaemia in Individuals and Populations, World Health Organization."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.medcli.2019.02.002","article-title":"Influence of Gender, Age and Residence Altitude on Haemoglobin Levels and the Prevalence of Anaemia","volume":"153","year":"2019","journal-title":"Med. Clin."},{"key":"ref_39","unstructured":"Ems, T., St Lucia, K., and Huecker, M.R. (2025). Biochemistry, Iron Absorption. StatPearls, StatPearls Publishing."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-2125.1991.tb05525.x","article-title":"Iron Supplements: A Common Cause of Drug Interactions","volume":"31","author":"Campbell","year":"1991","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1182\/blood-2015-05-642223","article-title":"Oral Iron Supplements Increase Hepcidin and Decrease Iron Absorption from Daily or Twice-Daily Doses in Iron-Depleted Young Women","volume":"126","author":"Moretti","year":"2015","journal-title":"Blood"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e524","DOI":"10.1016\/S2352-3026(17)30182-5","article-title":"Iron Absorption from Oral Iron Supplements given on Consecutive versus Alternate Days and as Single Morning Doses versus Twice-Daily Split Dosing in Iron-Depleted Women: Two Open-Label, Randomised Controlled Trials","volume":"4","author":"Stoffel","year":"2017","journal-title":"Lancet Haematol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Anghel, L., Dinu, C., Patra\u0219, D., Ciubar\u0103, A., and Chiscop, I. (2025). Iron Deficiency Treatment in Heart Failure-Challenges and Therapeutic Solutions. J. Clin. Med., 14.","DOI":"10.3390\/jcm14092934"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Chibanda, Y., Brookes, M., Churchill, D., and Al-Hassi, H. (2023). The Ferritin, Hepcidin and Cytokines Link in the Diagnoses of Iron Deficiency Anaemia during Pregnancy: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241713323"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Bloor, S.R., Schutte, R., and Hobson, A.R. (2025, July 14). Oral Iron Supplementation\u2014Gastrointestinal Side Effects and the Impact on the Gut Microbiota. Available online: https:\/\/www.mdpi.com\/2036-7481\/12\/2\/33.","DOI":"10.3390\/microbiolres12020033"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tolkien, Z., Stecher, L., Mander, A.P., Pereira, D.I.A., and Powell, J.J. (2015). Ferrous Sulfate Supplementation Causes Significant Gastrointestinal Side-Effects in Adults: A Systematic Review and Meta-Analysis. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0117383"},{"key":"ref_47","first-page":"2790","article-title":"Oral Iron Supplementation: New Formulations, Old Questions","volume":"109","author":"Pantopoulos","year":"2024","journal-title":"Haematologica"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Badura, K., Janc, J., W\u0105sik, J., Gnitecki, S., Skwira, S., M\u0142ynarska, E., Rysz, J., and Franczyk, B. (2024). Anemia of Chronic Kidney Disease-A Narrative Review of Its Pathophysiology, Diagnosis, and Management. Biomedicines, 12.","DOI":"10.3390\/biomedicines12061191"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jped.2023.06.002","article-title":"Hepcidin and Inflammation Associated with Iron Deficiency in Childhood Obesity\u2014A Systematic Review","volume":"100","author":"Berton","year":"2024","journal-title":"J. Pediatr. (Rio J.)"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev-nutr-061021-030404","article-title":"Iron Homeostasis During Pregnancy: Maternal, Placental, and Fetal Regulatory Mechanisms","volume":"43","author":"Sangkhae","year":"2023","journal-title":"Annu. Rev. Nutr."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Malesza, I.J., Bartkowiak-Wieczorek, J., Winkler-Galicki, J., Nowicka, A., Dzi\u0119cio\u0142owska, D., B\u0142aszczyk, M., Gajniak, P., S\u0142owi\u0144ska, K., Niepolski, L., and Walkowiak, J. (2022). The Dark Side of Iron: The Relationship between Iron, Inflammation and Gut Microbiota in Selected Diseases Associated with Iron Deficiency Anaemia\u2014A Narrative Review. Nutrients, 14.","DOI":"10.3390\/nu14173478"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"805","DOI":"10.5114\/aoms\/161802","article-title":"Iron Deficiency in Sepsis Patients Based on Reticulocyte Hemoglobin and Hepcidin Concentration: A Prospective Cohort Study","volume":"19","author":"Czempik","year":"2023","journal-title":"Arch. Med. Sci. AMS"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1080\/17474086.2017.1343140","article-title":"Position Paper on Management of Iron Deficiency in Adult Cancer Patients","volume":"10","author":"Barni","year":"2017","journal-title":"Expert Rev. Hematol."},{"key":"ref_54","unstructured":"(2025, July 23). Anemia En El Paciente Oncol\u00f3gico: Un Reto En Medicina Perioperatoria\u2014Revista Chilena de Anestesia. Available online: https:\/\/revistachilenadeanestesia.cl\/anemia-en-el-paciente-oncologico-un-reto-en-medicina-perioperatoria\/."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Zawadzki, B., Mazur, G., and Butrym, A. (2021). Iron Dysregulation and Frailty Syndrome. J. Clin. Med., 10.","DOI":"10.3390\/jcm10235596"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/ageing\/afz199","article-title":"New Horizons in Iron Deficiency Anaemia in Older Adults","volume":"49","author":"Burton","year":"2020","journal-title":"Age Ageing"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.2147\/CIA.S269379","article-title":"Iron in the General Population and Specificities in Older Adults: Metabolism, Causes and Consequences of Decrease or Overload, and Biological Assessment","volume":"15","author":"Manckoundia","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1080\/03007995.2020.1716702","article-title":"Efficacy and Tolerability of Oral Iron Protein Succinylate: A Systematic Review of Three Decades of Research","volume":"36","year":"2020","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Urso, K., Leal Mart\u00ednez-Bujanda, J., and Del Prado, J.M. (2021). Iron Protein Succinylate in the Management of Iron Deficiency Anemia: A Comparative Study with Ferrous Sulphate at Low and High Therapeutic Doses. Nutrients, 13.","DOI":"10.3390\/nu13030968"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1034\/j.1600-0773.2000.pto870302.x","article-title":"Involvement of Iron (Ferric) Reduction in the Iron Absorption Mechanism of a Trivalent Iron-Protein Complex (Iron Protein Succinylate)","volume":"87","author":"Raja","year":"2000","journal-title":"Pharmacol. Toxicol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.foodchem.2015.10.020","article-title":"Preparation of Iron Bound Succinylated Milk Protein Concentrate and Evaluation of Its Stability","volume":"196","author":"Shilpashree","year":"2016","journal-title":"Food Chem."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1177\/030006058701500608","article-title":"Treatment of Iron Deficiency Conditions in Blood Donors: Controlled Study of Iron Sulphate versus Iron Protein Succinylate","volume":"15","author":"Landucci","year":"1987","journal-title":"J. Int. Med. Res."},{"key":"ref_63","first-page":"46","article-title":"Estudio Comparativo Entre 2 Prote\u00ednas F\u00e9rricas En La Prevenci\u00f3n de La Anemia Ferrop\u00e9nica Gestacional","volume":"24","author":"Rayado","year":"1997","journal-title":"Clin. E Investig. EN Ginecol. Obstet."},{"key":"ref_64","first-page":"209","article-title":"Iron Protein Succinylate in the Treatment of Iron Deficiency: Potential Interaction with H2-Receptor Antagonists","volume":"31","author":"Bianchi","year":"1993","journal-title":"Int. J. Clin. Pharmacol."},{"key":"ref_65","first-page":"948","article-title":"Iron Derivatives of Modified Milk Protein","volume":"34","author":"Cremonesi","year":"1984","journal-title":"Arzneimittelforschung"},{"key":"ref_66","first-page":"40","article-title":"Chemical and Biological Characterization of Iron-Protein Succinylate (ITF 282)","volume":"31","author":"Cremonesi","year":"1993","journal-title":"Int. J. Clin. Pharmacol."},{"key":"ref_67","first-page":"1211","article-title":"Meta-Analysis of Efficacy and Tolerability Data on Iron Proteinsuccinylate in Patients with Iron Deficiency Anemia of Different Severity","volume":"45","author":"Sauerland","year":"1995","journal-title":"Arzneimittelforschung"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1034\/j.1600-0773.2002.910301.x","article-title":"Iron Absorption: Biochemical and Molecular Insights into the Importance of Iron Species for Intestinal Uptake","volume":"91","author":"Cremonesi","year":"2002","journal-title":"Pharmacol. Toxicol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/003693306701200503","article-title":"Succinic Acid and Iron Absorption","volume":"12","author":"Boddy","year":"1967","journal-title":"Scott. Med. J."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.0954-6820.1962.tb18684.x","article-title":"Effect of Succinic Acid on Iron Absorption","volume":"171","author":"Brise","year":"1962","journal-title":"Acta Med. Scand."},{"key":"ref_71","first-page":"4","article-title":"Loading Serum Iron Curve and Iron Absoption after the Administration of Three Different Preparations","volume":"VI","year":"1987","journal-title":"La Riv Medica Ital."},{"key":"ref_72","unstructured":"Bregani, E., Pogliani, E., and Scotti, A. (1990). Pilot Clinical Trial Legofer vs. Ferrograd\u2014Summary of Final Results, Italfarmaco Internal Report."},{"key":"ref_73","unstructured":"Pogliani, E., Scotti, A., and Acuto, G. (1990). Clinical Efficacy and Tolerability of Iron Protein Succinylate in Comparison to Slow Release Iron Sulphate in Sideropenic Anemia, Italfarmaco Internal Report."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2165\/00044011-199510040-00002","article-title":"Multicentre Double-Blind Clinical Trial of Iron Protein Succinylate in Comparison With Iron Sulfate in the Treatment of Iron Deficiency Anaemia","volume":"10","author":"Najean","year":"1995","journal-title":"Clin. Drug Investig."},{"key":"ref_75","first-page":"651","article-title":"Iron protein-succinylate in the treatment of adult iron-deficiency anemia","volume":"19","year":"2002","journal-title":"An. Med. Interna Madr. Spain"},{"key":"ref_76","unstructured":"Marcacci, B., Pierfederici, P., Signorelli, R., Tartaglia, P., and Zinelli, G. (1989). Comparative Evaluation of Iron Proteinsuccinylate Efficacy and Tolerability in the Treatment of Iron Deficiency in Obstetrical and Gynecological Patients vs. Organic and Inorganic Iron Salts, Italfarmaco Internal Report."},{"key":"ref_77","first-page":"103","article-title":"Iron Protein Succinylate in the Treatment of Iron Deficiency: Controlled, Double-Blind, Multicenter Clinical Trial on over 1000 Patients","volume":"31","author":"Liguori","year":"1993","journal-title":"Int. J. Clin. Pharmacol."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s11739-018-1993-9","article-title":"Safety and Efficacy of Sucrosomial Iron in Inflammatory Bowel Disease Patients with Iron Deficiency Anemia","volume":"14","author":"Abbati","year":"2019","journal-title":"Intern. Emerg. Med."},{"key":"ref_79","unstructured":"Danisi, M., and Frontespezi, S. (1987). Terapia Dell\u2019anemia Sideropenica: Studio Controllato Ferritina versus Ferroproteinsuccinilato. Riforma Med., 457\u2013459."},{"key":"ref_80","first-page":"597","article-title":"Indagine Clinica Sull\u2019efficacia Terapeutica e Sulla Tollerabilit\u00e0 Della Ferri-Mannitol-Albumina in Gravidanza","volume":"10","author":"Minganti","year":"1995","journal-title":"Giorn. It Ost. Gin."},{"key":"ref_81","first-page":"145","article-title":"Studio Sull\u2019assorbimento de Ferroproteinsuccinilao, Un Composto a Ase Di Ferro Coniugato Con Proteine Succinilate, in Confronto Con Gluconato Di Ferro","volume":"18","author":"Bertozzo","year":"1988","journal-title":"Basi Raz. Ter."},{"key":"ref_82","first-page":"51","article-title":"Valutazione Dell\u2019assorbimento Di Un Composto a Base Di Ferro Coniugato a Proteine Succinilate (Ferroproteinsuccinilato) in Confronto Con Ferritina Estrattiva","volume":"18","author":"Finelli","year":"1988","journal-title":"Basi Razion. Della Ter."},{"key":"ref_83","first-page":"9","article-title":"Mancata Liberazione Di Fe-Ione Nel Cavo Orale Ad Opera Di Un Nuovo Composto Di Ferro (Ferroproteinsuccinilato)","volume":"3","author":"Passariello","year":"1989","journal-title":"Ter. Mod."},{"key":"ref_84","unstructured":"Hua, L., Hou, J., Zhang, P., Zhao, C., Liu, Y., and Li, J. (1990). Ricerca Sulla Dinamica Del Metabolismo Del Medicinale ITF 282, Italfarmaco Internal Report."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1093\/ajcn\/23.6.779","article-title":"Influence of Succinic Acid on Absorption of Iron Studied by Whole-Body Monitoring","volume":"23","author":"Will","year":"1970","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_86","first-page":"389","article-title":"Assorbimiento in Rapporto Con Il Pasto Di Un Composto Di Ferro Coniugato Con Proteine Succinilate","volume":"103","author":"Deriu","year":"1988","journal-title":"Riforma Med."},{"key":"ref_87","unstructured":"WHO (2001). Iron Deficiency Anemia. Assessment, Prevention, and Control, WHO."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"40","DOI":"10.11648\/j.ijg.20210502.11","article-title":"Efficacy and Tolerability of Oral Iron Protein Succinylate in the Treatment of Iron Deficiency Anemia in Adults with Gastrointestinal Diseases","volume":"5","author":"Izquierdo","year":"2021","journal-title":"Int. J. Gastroenterol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"e376","DOI":"10.1016\/S2352-3026(25)00038-9","article-title":"Management of Iron Deficiency in Children, Adults, and Pregnant Individuals: Evidence-Based and Expert Consensus Recommendations","volume":"12","author":"Benson","year":"2025","journal-title":"Lancet Haematol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1002\/hem3.108","article-title":"Recommendations for Diagnosis, Treatment, and Prevention of Iron Deficiency and Iron Deficiency Anemia","volume":"8","author":"Iolascon","year":"2024","journal-title":"HemaSphere"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.amjmed.2008.07.012","article-title":"Individualized Treatment for Iron-Deficiency Anemia in Adults","volume":"121","author":"Alleyne","year":"2008","journal-title":"Am. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1182\/hematology.2019000034","article-title":"Management of Iron Deficiency","volume":"2019","author":"Ning","year":"2019","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"(2025, July 23). Management of Iron Deficiency | Hematology, ASH Education Program | American Society of Hematology. Available online: https:\/\/ashpublications.org\/hematology\/article\/2019\/1\/315\/422602\/Management-of-iron-deficiency.","DOI":"10.1182\/hematology.2019000034"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3691\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:42:18Z","timestamp":1788234138000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":93,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15103691"],"URL":"https:\/\/doi.org\/10.3390\/jcm15103691","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]}}}