{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:08:39Z","timestamp":1793034519454,"version":"4.5.0"},"reference-count":44,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Perioperative antibiotic prophylaxis (PAP) is effective for infection prevention in implant-related surgery, with infections being the most feared complications. A total of 15% of all antibiotics in hospitals are used for surgical prophylaxis but less than 50% of them are used according to the guidelines. International guidelines recommend only a single preoperative dose for all surgical procedures. We have developed and implemented new recommendations for PAP duration in primary hip and knee arthroplasty at the University Department for Orthopaedic Surgery. Methods: The development and implementation of new recommendations regarding PAP duration were performed via the following steps: pre-interventional analysis; identification of barriers and facilitators using the Flottorp framework; analyzing the data and preparation of a tailored implementation strategy based on an educational group meeting with the development of new consented to recommendations; and dissemination; followed by postinterventional analysis of PAP duration compliance 6 months later. Results: Before the intervention, 70% of PAP was used inappropriately (longer than 24 h). The major recognized barriers were fear of prosthetic joint infection (PJI) and a lack of concern regarding global antimicrobial resistance problems. Major facilitators were a low local PJI incidence rate (0.28%), etiology of PJI and existing local experience with a single-dose regime. After implementation of new recommendations regarding the duration of PAP, the postinterventional analysis showed that 80% of PAP was used according to the new recommendations, with a significant reduction in prolonged PAP use (from 70% to 12%), leading to an important decline in antimicrobial consumption. Conclusions: Our study showed that a tailored strategy in the development and implementation of new recommendations is complex and time consuming, although necessary for successful clinical practice change.<\/jats:p>","DOI":"10.3390\/jcm15103718","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:04:36Z","timestamp":1778601876000},"page":"3718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Development and Implementation of New Recommendations for Perioperative Antibiotic Prophylaxis Duration in Elective Primary Hip and Knee Replacement Surgeries"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3198-3647","authenticated-orcid":false,"given":"Nina","family":"Gori\u0161ek Miksi\u0107","sequence":"first","affiliation":[{"name":"Department for Infectious Diseases and Febrile Conditions, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zmago","family":"Krajnc","sequence":"additional","affiliation":[{"name":"Department for Orthopaedic Surgery, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Novak","sequence":"additional","affiliation":[{"name":"Department for Orthopaedic Surgery, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1902-8447","authenticated-orcid":false,"given":"Samo Karel","family":"Fokter","sequence":"additional","affiliation":[{"name":"Department for Orthopaedic Surgery, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Naran\u0111a","sequence":"additional","affiliation":[{"name":"Department for Orthopaedic Surgery, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Moli\u010dnik","sequence":"additional","affiliation":[{"name":"Medical Faculty Ljubljana, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrej","family":"Moli\u010dnik","sequence":"additional","affiliation":[{"name":"Department for Orthopaedic Surgery, University Clinical Centre Maribor, Ljubljanska 5, 2000 Maribor, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.arth.2020.12.005","article-title":"Projected Economic Burden of Periprosthetic Joint Infection of the Hip and Knee in the United States","volume":"36","author":"Premkumar","year":"2021","journal-title":"J. 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