{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:09:09Z","timestamp":1779196149936,"version":"3.51.4"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Statins have anti-inflammatory properties beyond their lipid-lowering effects, but their impact on skin and soft tissue infections (SSTIs) remains unclear. This study evaluated whether statins improve clinical outcomes in patients hospitalised with SSTIs. Methods: Adults aged \u226518 years hospitalised with SSTIs at a tertiary hospital in Australia between 1 June 2021 and 31 December 2021 were identified using the International Classification of Diseases 10th Revision Australian Modification (ICD-10-AM) codes. Patients were categorised into two groups based on statin use at admission. Multivariable regression models assessed differences in clinical outcomes including length of hospital stay (LOS), septic shock, Medical Emergency Response Team (MET) calls, intensive care unit (ICU) admission, mortality and 30-day readmissions, adjusting for age, sex, Charlson Comorbidity Index and C-reactive protein levels. Results: Of 387 admissions, complete data were available for 381 patients. The mean (standard deviation [SD]) age was 58.5 years (21.9 years), and 55.9% were male. Statins were used by 110 patients (28.9%) at admission. Statin users were older, had more comorbidities, and were more likely to have positive culture results than statin non-users (p &lt; 0.05). Median (interquartile range [IQR]) LOS was significantly longer for statin users compared to non-users (4 [2, 7] versus 3 [2, 5] days, p &lt; 0.05). However, after adjusted analysis, LOS was not significantly different between the two groups (adjusted incidence risk ratio [aIRR] 1.08; 95% confidence interval [CI] 0.97\u20131.20, p = 0.134). Other clinical outcomes were also similar between the two groups. Conclusions: This study found that statin use at admission was not associated with statistically significant differences in clinical outcomes among patients hospitalised with SSTIs.<\/jats:p>","DOI":"10.3390\/jcm15103755","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:26:37Z","timestamp":1778689597000},"page":"3755","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Statin Therapy on Clinical Outcomes of Patients Hospitalised with Skin and Soft Tissue Infections"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5525-2183","authenticated-orcid":false,"given":"Ying Chuin","family":"Wee","sequence":"first","affiliation":[{"name":"Department of Acute and General Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Udul","family":"Hewage","sequence":"additional","affiliation":[{"name":"Department of Acute and General Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Horwood","sequence":"additional","affiliation":[{"name":"Clinical Improvement Unit, Flinders Medical Centre, Bedford Park, SA 5042, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7716-2599","authenticated-orcid":false,"given":"Yogesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Acute and General Medicine, Flinders Medical Centre, Bedford Park, SA 5042, Australia"},{"name":"College of Medicine & Public Health, Flinders University, Bedford Park, SA 5042, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ray, G.T., Suaya, J.A., and Baxter, R. (2013). Incidence, microbiology, and patient characteristics of skin and soft-tissue infections in a U.S. population: A retrospective population-based study. BMC Infect. Dis., 13.","DOI":"10.1186\/1471-2334-13-252"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Suaya, J.A., Mera, R.M., Cassidy, A., O\u2019hAra, P., Amrine-Madsen, H., Burstin, S., and Miller, L.G. (2014). Incidence and cost of hospitalizations associated with Staphylococcus aureus skin and soft tissue infections in the United States from 2001 through 2009. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-296"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Tun, K., Shurko, J.F., Ryan, L., and Lee, G.C. (2018). Age-based health and economic burden of skin and soft tissue infections in the United States, 2000 and 2012. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0206893"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Morgan, B., Lancaster, R., Boyagoda, B., Ananda, R., Attwood, L.O., Jacka, D., and Woolley, I. (2024). The burden of skin and soft tissue, bone and joint infections in an Australian cohort of people who inject drugs. BMC Infect. Dis., 24.","DOI":"10.1186\/s12879-024-09143-0"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1093\/cid\/ciu296","article-title":"Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases Society of America","volume":"59","author":"Stevens","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1038\/s41577-018-0094-3","article-title":"Statins: A viable candidate for host-directed therapy against infectious diseases","volume":"19","author":"Parihar","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2796.2012.02554.x","article-title":"Treatment with anti-inflammatory drugs in community-acquired pneumonia","volume":"272","author":"Meijvis","year":"2012","journal-title":"J. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12016-020-08791-9","article-title":"Anti-inflammatory Action of Statins in Cardiovascular Disease: The Role of Inflammasome and Toll-Like Receptor Pathways","volume":"60","author":"Koushki","year":"2021","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"ref_9","first-page":"Oc09","article-title":"The Effect of Statins Use on the Risk and Outcome of Acute Bacterial Infections in Adult Patients","volume":"9","author":"Nassaji","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1161\/01.CIR.0000138932.17956.F1","article-title":"Prior statin therapy is associated with a decreased rate of severe sepsis","volume":"110","author":"Almog","year":"2004","journal-title":"Circulation"},{"key":"ref_11","first-page":"2685","article-title":"The effect of statins on mortality among patients with infection: Umbrella review of meta-analyses","volume":"25","author":"Ghayda","year":"2021","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1086\/323334","article-title":"The effect of statins on mortality in patients with bacteremia","volume":"33","author":"Liappis","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s00592-017-0990-1","article-title":"Effect of statins on hospitalization risk of bacterial infections in patients with or without diabetes","volume":"54","author":"Policardo","year":"2017","journal-title":"Acta Diabetol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1001\/archinternmed.2009.286","article-title":"Statins for the prevention and treatment of infections: A systematic review and meta-analysis","volume":"169","author":"Tleyjeh","year":"2009","journal-title":"Arch. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1111\/bcp.14077","article-title":"A sequence symmetry analysis of the interrelationships between statins, diabetes and skin infections","volume":"85","author":"Ko","year":"2019","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Hamilton, E.J., Martin, N., Makepeace, A., Sillars, B.A., Davis, W.A., and Davis, T.M. (2013). Incidence and predictors of hospitalization for bacterial infection in community-based patients with type 2 diabetes: The fremantle diabetes study. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0060502"},{"key":"ref_17","unstructured":"Independent Health and Aged Care Pricing Authority (IHACPA) (2022, March 30). The International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM) Chronicle, Available online: https:\/\/www.aihw.gov.au\/about-us\/international-collaboration\/australian-collaborating-centre-for-who\/international-classifications-in-australia."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/MLR.0000000000000471","article-title":"The Best Use of the Charlson Comorbidity Index with Electronic Health Care Database to Predict Mortality","volume":"54","author":"Bannay","year":"2016","journal-title":"Med. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"eRW0351","DOI":"10.31744\/einstein_journal\/2023RW0351","article-title":"Effects of statin therapy in hospitalized adult COVID-19 patients: A systematic review and meta-analysis of randomized controlled trials","volume":"21","author":"Xavier","year":"2023","journal-title":"Einstein"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1164\/rccm.201209-1718OC","article-title":"A multicenter randomized trial of atorvastatin therapy in intensive care patients with severe sepsis","volume":"187","author":"Kruger","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"R231","DOI":"10.1186\/cc11895","article-title":"Randomized double-blind placebo-controlled trial of 40 mg\/day of atorvastatin in reducing the severity of sepsis in ward patients (ASEPSIS Trial)","volume":"16","author":"Patel","year":"2012","journal-title":"Crit. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/cid\/ciw174","article-title":"Statin Use and Hospital Length of Stay Among Adults Hospitalized with Community-acquired Pneumonia","volume":"62","author":"Havers","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"ref_23","first-page":"356","article-title":"Role of Statins in Clinical Outcomes of Patients Hospitalised with Community Acquired Pneumonia","volume":"12","author":"Sharma","year":"2022","journal-title":"Intern. Med. Open Access"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"R71","DOI":"10.1186\/cc13828","article-title":"Effect of statin therapy on mortality from infection and sepsis: A meta-analysis of randomized and observational studies","volume":"18","author":"Wan","year":"2014","journal-title":"Crit. Care"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1001\/jama.2013.280031","article-title":"Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: A randomized clinical trial","volume":"310","author":"Papazian","year":"2013","journal-title":"JAMA"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bjid.2016.12.008","article-title":"Effects of statins on the development of sepsis and organ dysfunction in hospitalized older patients in China","volume":"21","author":"Gui","year":"2017","journal-title":"Braz. J. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jinf.2011.05.013","article-title":"Impact of diabetes and poor glycaemic control on risk of bacteraemia with haemolytic streptococci groups A, B, and G","volume":"63","author":"Thomsen","year":"2011","journal-title":"J. Infect."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4414\/smw.2008.12228","article-title":"The role of diabetes mellitus in patients with bloodstream infections","volume":"138","author":"Stoeckle","year":"2008","journal-title":"Swiss Med. Wkly."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Smit, J., Adelborg, K., Thomsen, R.W., S\u00f8gaard, M., and Sch\u00f8nheyder, H.C. (2016). Chronic heart failure and mortality in patients with community-acquired Staphylococcus aureus bacteremia: A population-based cohort study. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1570-7"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s15010-024-02265-2","article-title":"Chronic kidney disease and risk of bloodstream infections and sepsis: A 17-year follow-up of the population-based Tr\u00f8ndelag Health Study in Norway","volume":"52","author":"Liyanarachi","year":"2024","journal-title":"Infection"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/jama.286.1.64","article-title":"Effect of statin therapy on C-reactive protein levels: The pravastatin inflammation\/CRP evaluation (PRINCE): A randomized trial and cohort study","volume":"286","author":"Albert","year":"2001","journal-title":"JAMA"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1093\/cvr\/cvae034","article-title":"Effect of lipid-lowering therapies on C-reactive protein levels: A comprehensive meta-analysis of randomized controlled trials","volume":"120","author":"Xie","year":"2024","journal-title":"Cardiovasc. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.amjmed.2008.06.030","article-title":"Prior statin use is associated with improved outcomes in community-acquired pneumonia","volume":"121","author":"Chalmers","year":"2008","journal-title":"Am. J. Med."},{"key":"ref_34","first-page":"e18273","article-title":"The Effect of Statin Therapy on Inflammatory Biomarkers: A Systematic Review","volume":"13","author":"Proute","year":"2021","journal-title":"Cureus"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3755\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T12:26:32Z","timestamp":1779193592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15103755"],"URL":"https:\/\/doi.org\/10.3390\/jcm15103755","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,13]]}}}