{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:17:11Z","timestamp":1778858231429,"version":"3.51.4"},"reference-count":21,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: Atherosclerotic renal artery stenosis (ARAS) is increasingly prevalent among aging populations and in patients with diabetes, hyperlipidemia, aortoiliac obstructive disease, coronary artery disease, and\/or hypertension. Patients with severe ARAS are at a substantially elevated risk of cardiovascular disease, recurrent congestive heart failure, stroke, ischemic nephropathy, and chronic kidney disease. Therefore, the ARAS-TR study aims to evaluate the effect of renal artery stenting on the clinical outcomes in patients with severe ARAS and renovascular hypertension. Materials: This study was conducted as a multicenter, prospective study between July 2024 and September 2025. It encompassed 278 patients with angiographically confirmed severe ARAS who underwent renal artery stent implantation. Patients were subsequently monitored for 6 months. A paired-samples t-test was used to compare continuous variables pre- and post-intervention, while categorical variables were analyzed using the Pearson chi-square test and Fisher\u2019s exact test. Results: The mean age of the patients was 63.6 [\u00b113.4] years, and the male gender ratio was 52.5%. After renal artery stenting, systolic and diastolic blood pressures decreased significantly at the 6-month follow-up compared with the pre-procedure levels (SBP 166.99 [21.24] vs. 135.40 [15.69], p &lt; 0.001; DBP 96.28 [13.03] vs. 80.39 [11.03], p &lt; 0.001, respectively). GFR (61.23 [28.33] vs. 63.35 [26.36], p = 0.029) and creatinine (1.40 [0.93] vs. 1.29 [0.66], p = 0.004) levels improved compared to baseline. The mean number of antihypertensive drugs required for patients to remain normotensive decreased significantly (3.19 [1.04] vs. 2.48 [1.13], p &lt; 0.001) during the follow-up period. Conclusions: Percutaneous renal artery intervention appears to be a promising and safe strategy for carefully selected high-risk patients presenting with severe ARAS, renovascular hypertension, and non-atrophic kidneys. In this specific clinical context, restoring renal artery patency through percutaneous stenting was associated with improved renal function and observed reduction in the burden of antihypertensive drugs required to sustain normotension.<\/jats:p>","DOI":"10.3390\/jcm15103825","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T14:19:29Z","timestamp":1778854769000},"page":"3825","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effect of Renal Artery Stent Implantation on Clinical Outcomes in Patients with Early-Stage (Non-Atrophic Kidney) and Clinically Overt Severe Atherosclerotic Renal Artery Stenosis (ARAS-TR)"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0775-8992","authenticated-orcid":false,"given":"Mehmet","family":"K\u0131\u015f","sequence":"first","affiliation":[{"name":"Department of Cardiology, Dokuz Eylul University Faculty of Medicine, 35340 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatih","family":"Levent","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, 16330 Bursa, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Altunova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 34303 Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-1123","authenticated-orcid":false,"given":"Sad\u0131k Volkan","family":"Emren","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Izmir K\u00e2tip \u00c7elebi University Faculty of Medicine, 35620 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3895-1923","authenticated-orcid":false,"given":"Mustafa","family":"Do\u011fdu\u015f","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Izmir University of Economics Faculty of Medicine, 35330 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0230-6575","authenticated-orcid":false,"given":"Beytullah","family":"\u00c7akal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medipol University of Health Sciences, 34810 Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"\u015een\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Bak\u0131r\u00e7ay, 35665 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuncay","family":"G\u00fczel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Diyarbak\u0131r Provincial Health Directorate Gazi Ya\u015fargil Education and Research Hospital, 21070 Diyarbak\u0131r, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7671-9740","authenticated-orcid":false,"given":"\u00c7isem","family":"Oktay","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dokuz Eylul University Faculty of Medicine, 35340 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer Faruk","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, 16330 Bursa, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-5905","authenticated-orcid":false,"given":"Sezgin","family":"Atmaca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 34303 Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunus Emre","family":"Erata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, 34303 Istanbul, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8919-8444","authenticated-orcid":false,"given":"Tumarzat","family":"Ulanbekova","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Izmir K\u00e2tip \u00c7elebi University Faculty of Medicine, 35620 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Birhan","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dokuz Eylul University Faculty of Medicine, 35340 Izmir, T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1093\/eurheartj\/ehae178","article-title":"2024 ESC Guidelines for the management of elevated blood pressure and hypertension","volume":"45","author":"McEvoy","year":"2024","journal-title":"Eur. 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