{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:14:30Z","timestamp":1779282870081,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Acute pancreatitis is increasingly recognized as a risk factor for disturbances in glucose metabolism and the development of diabetes mellitus (DM). However, the long-term endocrine consequences of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) remain poorly characterized. This study aimed to evaluate the association between post-ERCP pancreatitis and the risk of new-onset diabetes mellitus (NODM). Methods: This retrospective cohort study included patients who underwent ERCP between 2019 and 2024 at a tertiary referral center. New-onset diabetes mellitus was defined using laboratory data and International Classification of Diseases (ICD) diagnostic codes within one year after ERCP. Multivariable logistic regression adjusting for age, sex, hypertension, and coronary artery disease was performed. Results: A total of 2695 patients were included. Post-ERCP pancreatitis occurred in 165 patients (6.1%). New-onset diabetes developed in 9\/165 patients (5.5%) in the PEP group and in 27\/2530 patients (1.1%) in the non-PEP group. An increased incidence of new-onset diabetes was observed among patients who developed post-ERCP pancreatitis (crude OR 5.35, 95% CI 2.47\u201311.57; p &lt; 0.001). In multivariable analysis adjusting for age, sex, hypertension, and coronary artery disease, post-ERCP pancreatitis remained significantly associated with new-onset diabetes in the fully adjusted model (adjusted OR 5.33, 95% CI 2.42\u201311.77; p &lt; 0.001). The absolute risk increase was 4.39%, corresponding to a number needed to harm of 23. Conclusions: An increased incidence of new-onset diabetes was observed among patients who developed post-ERCP pancreatitis. This association remained significant after adjustment for baseline cardiovascular comorbidities. Although the absolute risk increase was modest, these findings may be clinically relevant. Because this was a retrospective study with a limited number of diabetes cases, the findings should be considered hypothesis-generating and require confirmation in prospective studies.<\/jats:p>","DOI":"10.3390\/jcm15103943","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:30:51Z","timestamp":1779280251000},"page":"3943","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Post-ERCP Pancreatitis and New-Onset Diabetes Mellitus: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9679-8042","authenticated-orcid":false,"given":"Burak Furkan","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezgi","family":"Comoglu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Etlik City Hospital, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enes Seyda","family":"\u015eahiner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeki Mesut Yalin","family":"Kilic","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ihsan","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara 06800, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1055\/a-1075-4080","article-title":"ERCP-related adverse events: European Society of Gastrointestinal Endoscopy (ESGE) Guideline","volume":"52","author":"Dumonceau","year":"2020","journal-title":"Endoscopy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0016-5107(91)70740-2","article-title":"Endoscopic sphincterotomy complications and their management: An attempt at consensus","volume":"37","author":"Cotton","year":"1991","journal-title":"Gastrointest. Endosc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.17219\/acem\/66773","article-title":"Post-ERCP pancreatitis: Pathophysiology, early identification and risk stratification","volume":"27","author":"Tryliskyy","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S2468-1253(16)30106-6","article-title":"Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer","volume":"1","author":"Hart","year":"2016","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1136\/gutjnl-2013-305062","article-title":"Newly diagnosed diabetes mellitus after acute pancreatitis: A systematic review and meta-analysis","volume":"63","author":"Das","year":"2014","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zhi, M., Zhu, X., Lugea, A., Waldron, R.T., Pandol, S.J., and Li, L. (2019). Incidence of new onset diabetes mellitus secondary to acute pancreatitis: A systematic review and meta-analysis. Front. Physiol., 10.","DOI":"10.3389\/fphys.2019.00637"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/ajg.2015.356","article-title":"Risk of diabetes mellitus after first-attack acute pancreatitis: A national population-based study","volume":"110","author":"Shen","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.2337\/dc17-0542","article-title":"Incidence, demographics, and clinical characteristics of diabetes of the exocrine pancreas (Type 3c): A retrospective cohort study","volume":"40","author":"Woodmansey","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Zahariev, O.J., Bunduc, S., Kov\u00e1cs, A., Demeter, D., Havelda, L., Budai, B.C., Veres, D.S., Hossz\u00fafalusi, N., Er\u0151ss, B.M., and Teutsch, B. (2024). Risk factors for diabetes mellitus after acute pancreatitis: A systematic review and meta-analysis. Front. Med., 10.","DOI":"10.3389\/fmed.2023.1257222"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Tu, J., Zhang, J., Ke, L., Yang, Y., Yang, Q., Lu, G., Li, B., Tong, Z., Li, W., and Li, J. (2017). Endocrine and exocrine pancreatic insufficiency after acute pancreatitis: Long-term follow-up study. BMC Gastroenterol., 17.","DOI":"10.1186\/s12876-017-0663-0"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"102027","DOI":"10.1016\/j.clinre.2022.102027","article-title":"The risk of diabetes mellitus in patients with post-ERCP pancreatitis\u2014A preliminary report","volume":"46","author":"Francis","year":"2022","journal-title":"Clin. Res. Hepatol. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejim.2012.12.017","article-title":"Diabetes mellitus secondary to pancreatic diseases (Type 3c): Are we neglecting an important disease?","volume":"24","author":"Ewald","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/gutjnl-2012-302779","article-title":"Classification of acute pancreatitis\u20142012 revision of the Atlanta classification","volume":"62","author":"Banks","year":"2013","journal-title":"Gut"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2023). Classification and diagnosis of diabetes: Standards of Medical Care in Diabetes\u20142023. Diabetes Care, 46, S19\u2013S40.","DOI":"10.2337\/dc23-S002"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Chiriac, S., Sfarti, C.V., Stanciu, C., Cojocariu, C., Zenovia, S., Nastasa, R., and Trifan, A. (2023). The relation between post-endoscopic retrograde cholangiopancreatography pancreatitis and different cannulation techniques: The experience of a high-volume center from North-Eastern Romania. Life, 13.","DOI":"10.3390\/life13061410"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gie.2023.03.023","article-title":"Incidence, severity, and mortality of post-ERCP pancreatitis: An updated systematic review and meta-analysis of 145 randomized controlled trials","volume":"98","author":"Akshintala","year":"2023","journal-title":"Gastrointest. Endosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1111\/j.1572-0241.2007.01279.x","article-title":"Incidence rates of post-ERCP complications: A systematic survey of prospective studies","volume":"102","author":"Andriulli","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0016-5107(04)02169-8","article-title":"Complications of ERCP: A prospective study","volume":"60","author":"Christensen","year":"2004","journal-title":"Gastrointest. Endosc."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ajg.2008.5","article-title":"Risk factors for ERCP-related complications: A prospective multicenter study","volume":"104","author":"Wang","year":"2009","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.47582\/jompac.1810789","article-title":"ERCP in the elderly: A comprehensive evaluation of procedural challenges and safety in a large single-center study","volume":"6","author":"Polat","year":"2025","journal-title":"J. Med. Palliat. Care"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Comoglu, M., Acehan, F., Sahiner, E.S., Kalkan, C., Comoglu, E., Y\u0131lmaz, Y., Canl\u0131, T., and Ates, I. (2024). Clinical features and prognosis of acute cholangitis in octogenarians: A prospective comparative study. Medicina, 60.","DOI":"10.3390\/medicina60111759"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.pan.2017.06.007","article-title":"Diabetes of the exocrine pancreas: American Diabetes Association-compliant lexicon","volume":"17","author":"Petrov","year":"2017","journal-title":"Pancreatology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2147\/DMSO.S99701","article-title":"Management of pancreatogenic diabetes: Challenges and solutions","volume":"9","author":"Makuc","year":"2016","journal-title":"Diabetes Metab. Syndr. Obes."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3943\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T13:00:00Z","timestamp":1779282000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3943"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,20]]},"references-count":23,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15103943"],"URL":"https:\/\/doi.org\/10.3390\/jcm15103943","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,20]]}}}