{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:14:17Z","timestamp":1779358457396,"version":"3.51.4"},"reference-count":68,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Epidemiological studies over the first decades of the 21st century have reported a decrease in cardiovascular disease (CVD) morbidity and mortality. Changes in coronary care for acute myocardial infarction (AMI) over these years, including the COVID-19 pandemic period, have been less studied in Eastern and Central Europe. The study aimed to assess changes in coronary care\u2014the time of medical assistance and treatment\u2014for AMI patients over 2000\u20132023 in urban Kaunas residents aged 25\u201364. Methods: The data source was study cases from the Kaunas Ischemic Heart Disease Registry (Registry)\u2014Kaunas city residents aged 25\u201364 years included in the Registry according to MONICA project protocol evaluation methodologies. Data were analyzed by sex and age group (25\u201354 and 55\u201364 years). Descriptive statistics (chi-square and z-score values) were used to evaluate the data; the significance level was p &lt; 0.05. A logistic regression analysis was performed to assess the odds ratios of death within 28 days across six time periods. Results: The proportion of AMI patients hospitalized up to 2 h from the onset of pain accounted for about one-fifth of all hospitalized patients in 2000\u20132016, while in 2017\u20132023, it significantly decreased. In 2017\u20132023, compared with 2000\u20132004 and 2009\u20132016, significantly fewer men who developed AMI were hospitalized within the first 2 h of emergency presentation (p &lt; 0.05). Over the whole study period, fewer women with AMI were hospitalized within the first 2 h of pain as compared to men (p &lt; 0.05). There were no significant differences in time from pain onset to hospitalization between the age groups. At the same time, from 2009 to 2012, more young AMI patients were hospitalized within the first 2 h (p &lt; 0.05). Percutaneous coronary angioplasty (PTCA) with stenting (PCI) increased 30 times from 2000\u20132004 to 2020\u20132023. PCI has been the most available treatment for men with AMI since 2009 and stayed stable from 2013 (66.0%) until 2023 (72.1%). Women with AMI tended to get less PCI, PTCA, and coronary artery bypass grafting (CABG) than men. The pre-pandemic and COVID-19 periods did not differ in the proportions of reperfusion treatment methods used in both men and women. Thrombolysis was very rare, and since 2017, it has not been used in Kaunas because PCI has become more accessible. PCI (2000\u20132016) and CABG (2009\u20132016) were more prevalent among the 25\u201354-year-old AMI patients (p &lt; 0.05). From 2017 to 2023, there were no differences between age groups in the reperfusion procedures used, nor were there differences in treatment between these groups during the pre-pandemic (2017\u20132019) and peri-COVID-19 pandemic (2020\u20132023) periods. Conclusions: In Kaunas, the treatment of patients with AMI has improved significantly over the past 20 years. The use of PCI has increased greatly, and the rate of CABG surgery stayed stable, while only every fifth patient has been admitted to the hospital in a timely manner. Men were more likely to receive PCI, and older patients were more likely to undergo CABG. Compared to the period of 2000\u20132004, the chance of dying within 28 days after AMI was significantly lower in 2017.<\/jats:p>","DOI":"10.3390\/jcm15103963","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:29:58Z","timestamp":1779355798000},"page":"3963","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes in Coronary Care for Acute Myocardial Infarction over the Past Two Decades (2000\u20132023) in Kaunas, Lithuania"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-2997","authenticated-orcid":false,"given":"Lolita","family":"Sileikiene","sequence":"first","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"},{"name":"Department of Preventive Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-457X","authenticated-orcid":false,"given":"Abdonas","family":"Tamosiunas","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karolina","family":"Marcinkeviciene","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daina","family":"Kranciukaite-Butylkiniene","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"},{"name":"Department of Family Medicine, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarunas","family":"Augustis","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"},{"name":"Department of Internal Medicine, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalia","family":"Luk\u0161ien\u0117","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"},{"name":"Department of Environment and Occupational Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolita","family":"Kirvaitiene","sequence":"additional","affiliation":[{"name":"Department of Environment and Occupational Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gintare","family":"Sakalyte","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1227-2674","authenticated-orcid":false,"given":"Ricardas","family":"Radisauskas","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"},{"name":"Department of Environment and Occupational Medicine, Faculty of Public Health, Medical Academy, Lithuanian University of Health Sciences, 50103 Kaunas, Lithuania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","unstructured":"WHO (2026, February 22). 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