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Obesity is a common comorbidity in OSA, but its relationship with symptom subtypes remains unclear. This study aimed to evaluate the association between OSA symptom subtypes and obesity in a clinical cohort. Methods: This observational study analyzed data from the Santiago Obstructive Sleep Apnea (SantOSA) prospective clinical cohort, including adults with OSA confirmed by home sleep apnea testing. Symptom subtypes were identified using latent class analysis. Associations between obesity and symptom subtypes were evaluated using multivariable regression models adjusted for age, sex, tobacco use, RDI, T90%, TST, hypertension, and diabetes. Statistical significance was set at p &lt; 0.05. Results: A total of 1167 patients were included (943 men). Latent class analysis identified three symptom subtypes: non-sleepy, disturbed sleep, and excessive daytime sleepiness. Among obese patients, 30.7%, 50.0%, and 19.3% were classified into these subtypes, respectively. Obesity prevalence was 50.2%, and compared with non-obese OSA patients, obese patients showed a higher prevalence of severe OSA (46.1% vs. 26.9%), hypertension (54.4% vs. 34.9%), and diabetes (37.2% vs. 19.4%), as well as higher ESS scores and higher RDI and T90% values (all p &lt; 0.01). In adjusted analyses, obesity remained independently associated with the excessive daytime sleepiness subtype after controlling for age, sex, tobacco use, RDI, T90%, TST, and comorbidities. Conclusions: Obesity is highly prevalent in OSA and is associated with specific symptom-defined phenotypes, particularly excessive daytime sleepiness and disturbed sleep. These findings support the relevance of considering symptom profiles alongside traditional severity metrics.<\/jats:p>","DOI":"10.3390\/jcm15103969","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:29:58Z","timestamp":1779355798000},"page":"3969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Sleep Apnea Symptoms Subtypes and Obesity"],"prefix":"10.3390","volume":"15","author":[{"given":"Mario","family":"Henr\u00edquez-Beltr\u00e1n","sequence":"first","affiliation":[{"name":"N\u00facleo de Investigaci\u00f3n en Ciencias de la Salud, Universidad Adventista de Chile, Chill\u00e1n 3780000, Chile"},{"name":"Department of Respiratory Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Translational Research in Respiratory Medicine, Hospital Universitari Arnau de Vilanova-Santa Maria, Biomedical Research Institute of Lleida (IRBLleida), 25198 Lleida, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8613-0802","authenticated-orcid":false,"given":"Daniel","family":"Solomons","sequence":"additional","affiliation":[{"name":"Escuela de Kinesiolog\u00eda, Facultad de Ciencias de la Salud, Universidad Cat\u00f3lica Silva Henr\u00edquez, Santiago 8320000, Chile"},{"name":"Instituto de Matem\u00e1tica, F\u00edsica y Estad\u00edstica, Universidad de Las Am\u00e9ricas, Sede La Florida, Av. Walker Mart\u00ednez 1360, Santiago 8240000, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda F.","family":"Troncoso","sequence":"additional","affiliation":[{"name":"CIBERES, Pulmonology IIS Fundaci\u00f3n Jim\u00e9nez D\u00edaz Madrid, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat S\u00e1nchez","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Grupo de Estudio Trastornos Respiratorios del Sue\u00f1o, Cl\u00ednica Las Condes, Santiago 7591047, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Jorquera","sequence":"additional","affiliation":[{"name":"Grupo de Estudio Trastornos Respiratorios del Sue\u00f1o, Cl\u00ednica Las Condes, Santiago 7591047, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0069-3420","authenticated-orcid":false,"given":"Gonzalo","family":"Labarca","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, School of Medicine, Pontificia Universidad Cat\u00f3lica de Chile, Santiago 8330024, Chile"},{"name":"Department of Respiratory, Allergy and Sleep Medicine, Mayo Clinic, Jacksonville, FL 32224, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S2213-2600(19)30198-5","article-title":"Estimation of the global prevalence and burden of obstructive sleep apnoea: A literature-based analysis","volume":"7","author":"Benjafield","year":"2019","journal-title":"Lancet Respir. 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