{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T05:06:14Z","timestamp":1779512774809,"version":"3.53.1"},"reference-count":30,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cardiogenic shock (CS) is characterized as a state of low cardiac output that is frequently associated with multisystem organ failure. For over two decades, revascularization of the culprit lesion remained the only interventional treatment option to improve outcomes in CS following acute myocardial infarction. However, recently published data provide evidence that the use of a microaxial flow pump for mechanical circulatory support (MCS) in STEMI-related cardiogenic shock significantly reduced mortality after 180 days. Increased rates of complications such as sepsis were observed under MCS. The present study aimed to investigate the influence of sepsis on prognoses in patients with CS receiving temporary MCS with a microaxial flow pump. Methods and Results: This retrospective cohort study included 38 patients who received a microaxial flow pump for CS between 2014 and 2017. All patients were analyzed for the presence of sepsis, defined as infection and an increase in the Sequential Organ Failure Assessment (SOFA) score of \u22652 points. Analyzed clinical outcomes included all-cause mortality after 30 and 365 days and changes in renal function. A total of 38 patients were included in the final analysis. The 30-day all-cause mortality was significantly higher in the sepsis group than in the no-sepsis group (53.9% vs. 8.3%, p = 0.014). The findings were consistent for mortality at 365 days (65.4% vs. 16.7%, p = 0.008). Conclusions: These results indicate that sepsis significantly increases the risk of all-cause mortality at 30 and 365 days among patients with CS following AMI and receiving MCS via a microaxial flow pump.<\/jats:p>","DOI":"10.3390\/jcm15103989","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:02:27Z","timestamp":1779375747000},"page":"3989","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Sepsis on Clinical Outcomes During Mechanical Circulatory Support by Microaxial Flow Pump in Patients with Cardiogenic Shock Following Acute Myocardial Infarction"],"prefix":"10.3390","volume":"15","author":[{"given":"Philip","family":"D\u00fcsing","sequence":"first","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Markgraf","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baravan","family":"Al-Kassou","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Bulic","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5398-403X","authenticated-orcid":false,"given":"Thomas","family":"Beiert","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikos","family":"Werner","sequence":"additional","affiliation":[{"name":"Heart Center Trier, Medical Department III, Krankenhaus Der Barmherzigen Br\u00fcder, 54292 Trier, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Jansen","sequence":"additional","affiliation":[{"name":"Kardiologie K\u00f6ln, Gemeinschaftspraxis Kardiologie, 50676 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Nickenig","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5759-7627","authenticated-orcid":false,"given":"Andreas","family":"Zietzer","sequence":"additional","affiliation":[{"name":"Heart Center, Department of Medicine II, University Hospital Bonn, 53127 Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"ref_1","first-page":"E232","article-title":"Contemporary Management of Cardiogenic Shock: A Scientific Statement from the American Heart Association","volume":"136","author":"Katz","year":"2017","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1093\/eurheartj\/ehz363","article-title":"Management of cardiogenic shock complicating myocardial infarction: An update 2019","volume":"40","author":"Thiele","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/ejhf.1566","article-title":"Temporal trends in incidence and patient characteristics in cardiogenic shock following acute myocardial infarction from 2010 to 2017: A Danish cohort study","volume":"21","author":"Helgestad","year":"2019","journal-title":"Eur. J. Heart Fail."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1056\/NEJM199908263410901","article-title":"Early Revascularization in Acute Myocardial Infarction Complicated by Cardiogenic Shock","volume":"341","author":"Hochman","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1056\/NEJMoa2312572","article-title":"Microaxial Flow Pump or Standard Care in Infarct-Related Cardiogenic Shock","volume":"390","author":"Jensen","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/s41569-022-00796-5","article-title":"Temporary mechanical circulatory support devices: Practical considerations for all stakeholders","volume":"20","author":"Salter","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.jacc.2008.05.065","article-title":"A Randomized Clinical Trial to Evaluate the Safety and Efficacy of a Percutaneous Left Ventricular Assist Device Versus Intra-Aortic Balloon Pumping for Treatment of Cardiogenic Shock Caused by Myocardial Infarction","volume":"52","author":"Seyfarth","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ijcard.2019.05.044","article-title":"Clinical scenarios for use of transvalvular microaxial pumps in acute heart failure and cardiogenic shock\u2014A European experienced users working group opinion","volume":"291","author":"Werner","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/j.carrev.2020.05.042","article-title":"Impella Versus Extracorporeal Membrane Oxygenation for Acute Myocardial Infarction Cardiogenic Shock","volume":"21","author":"Lemor","year":"2020","journal-title":"Cardiovasc. Revasc. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Singer, M., Deutschman, C.S., Seymour, C.W., Shankar-Hari, M., Annane, D., Bauer, M., Bellomo, R., Bernard, G.R., Chiche, J.-D., and Coopersmith, C.M. (2016). The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315.","DOI":"10.1001\/jama.2016.0287"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41590-023-01660-5","article-title":"The pathophysiology of sepsis and precision-medicine-based immunotherapy","volume":"25","author":"Aschenbrenner","year":"2024","journal-title":"Nat. Immunol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Jentzer, J.C., Berg, D.D., Chonde, M.D., Dahiya, G., Elliott, A., Rampersad, P., Sinha, S.S., Truesdell, A.G., Yohannes, S., and Vallabhajosyula, S. (2025). Mixed Cardiogenic-Vasodilatory Shock. JACC Adv., 4.","DOI":"10.1016\/j.jacadv.2024.101432"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1093\/eurheartj\/ehaf340","article-title":"Sepsis-induced cardiomyopathy","volume":"46","author":"Aissaoui","year":"2025","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/CIRCULATIONAHA.118.036614","article-title":"Impella Support for Acute Myocardial Infarction Complicated by Cardiogenic Shock: Matched-Pair IABP-SHOCK II Trial 30-Day Mortality Analysis","volume":"139","author":"Schrage","year":"2019","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jtcvs.2012.01.067","article-title":"The RECOVER I: A multicenter prospective study of Impella 5.0\/LD for postcardiotomy circulatory support","volume":"145","author":"Griffith","year":"2013","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(20)30733-9","article-title":"Venoarterial extracorporeal membrane oxygenation to rescue sepsis-induced cardiogenic shock: A retrospective, multicentre, international cohort study","volume":"396","author":"Hajage","year":"2020","journal-title":"Lancet"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Naidu, S.S., Baran, D.A., Jentzer, J.C., Hollenberg, S.M., Van Diepen, S., Basir, M.B., Grines, C.L., Diercks, D.B., Hall, S., and Kapur, N.K. (2022). SCAI SHOCK Stage Classification Expert Consensus Update: A Review and Incorporation of Validation Studies. J. Soc. Cardiovasc. Angiogr. Interv., 1.","DOI":"10.1016\/j.jacc.2022.01.018"},{"key":"ref_18","unstructured":"Brunkhorst, F.M., Weigand, M., Pletz, M., Gastmeier, P., Lemmen, S.W., Meier-Hellmann, A., Ragaller, M., Weyland, A., Marx, G., and Bucher, M. (2025). S3-Leitlinie: Sepsis\u2014Pr\u00e4vention, Diagnose, Therapie und Nachsorge\u2014Update 2025, Deutsche Interdisziplin\u00e4re Vereinigung f\u00fcr Intensiv- und Notfallmedizin (DIVI). Available online: https:\/\/register.awmf.org\/de\/leitlinien\/detail\/079-001."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Seymour, C.W., Liu, V.X., Iwashyna, T.J., Brunkhorst, F.M., Rea, T.D., Scherag, A., Rubenfeld, G., Kahn, J.M., Shankar-Hari, M., and Singer, M. (2016). Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA, 315.","DOI":"10.1001\/jama.2016.0288"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1161\/CIRCULATIONAHA.110.009449","article-title":"Standardized Bleeding Definitions for Cardiovascular Clinical Trials: A Consensus Report from the Bleeding Academic Research Consortium","volume":"123","author":"Mehran","year":"2011","journal-title":"Circulation"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/CIRCULATIONAHA.122.062949","article-title":"Extracorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock: Results of the ECMO-CS Randomized Clinical Trial","volume":"147","author":"Ostadal","year":"2023","journal-title":"Circulation"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Baldetti, L., Gallone, G., Filiberti, G., Pescarmona, L., Cesari, A., Rizza, V., Roagna, E., Gurrieri, D., Peveri, B., and Nocera, L. (2024). Mixed Shock Complicating Cardiogenic Shock: Frequency, Predictors, and Clinical Outcomes. Circ. Heart Fail., 17.","DOI":"10.1161\/CIRCHEARTFAILURE.123.011404"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Ling, R.R., Ramanathan, K., Poon, W.H., Tan, C.S., Brechot, N., Brodie, D., Combes, A., and MacLaren, G. (2021). Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: A systematic review and meta-analysis with individual participant data meta-regression analysis. Crit. Care, 25.","DOI":"10.1186\/s13054-021-03668-5"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Otsuru, W., Nishihara, M., Hatakeyama, K., Iyonaga, T., Fujino, T., Sakamoto, T., Shono, Y., Abe, K., Shiose, A., and Akahoshi, T. (2025). A combination of veno-arteriovenous ECMO and Impella (VAVEcpella) as a rescue strategy for severe streptococcal toxic shock syndrome with cardiopulmonary failure: A case report. Medicine, 104.","DOI":"10.1097\/MD.0000000000043741"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1056\/NEJMoa1812379","article-title":"Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest","volume":"381","author":"Cariou","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/joic.12569","article-title":"The role of different mechanical circulatory support devices and their timing of implantation on myocardial damage and mid-term recovery in acute myocardial infarction related cardiogenic shock","volume":"31","author":"Pieri","year":"2018","journal-title":"J. Interv. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/CIRCHEARTFAILURE.112.967224","article-title":"Percutaneous Left-Ventricular Support with the Impella-2.5\u2013Assist Device in Acute Cardiogenic Shock: Results of the Impella\u2013EUROSHOCK-Registry","volume":"6","author":"Lauten","year":"2013","journal-title":"Circ. Heart Fail."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.jcin.2023.05.043","article-title":"Management of Bleeding and Hemolysis During Percutaneous Microaxial Flow Pump Support","volume":"16","author":"Gramegna","year":"2023","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/MAT.0000000000000290","article-title":"Incidence of Hemolysis in Patients with Cardiogenic Shock Treated with Impella Percutaneous Left Ventricular Assist Device","volume":"62","author":"Badiye","year":"2016","journal-title":"ASAIO J."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Patsalis, N., Kreutz, J., Chatzis, G., Syntila, S., Choukeir, M., Schieffer, B., and Markus, B. (2024). Early risk predictors of acute kidney injury and short-term survival during Impella support in cardiogenic shock. Sci. Rep., 14.","DOI":"10.1038\/s41598-024-68376-w"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3989\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T04:23:34Z","timestamp":1779510214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/10\/3989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,21]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2026,5]]}},"alternative-id":["jcm15103989"],"URL":"https:\/\/doi.org\/10.3390\/jcm15103989","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,21]]}}}