{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:10:37Z","timestamp":1780078237740,"version":"3.54.0"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Psoriasis (PsO) is a chronic immune-mediated disease associated with a substantial multidimensional burden extending beyond skin involvement. Sleep disturbance represents an important yet underexplored domain of patient-reported outcomes. This study aimed to investigate the relationship between PsO disease activity and sleep quality, focusing on specific sleep domains, and to evaluate whether disease severity independently predicts sleep latency and daytime dysfunction. Methods: We conducted a cross-sectional study including 136 consecutive patients with PsO from two Italian centers. Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Sleep quality was evaluated using the Pittsburgh Sleep Quality Index (PSQI), while quality of life was measured by the SF-36. Patients were stratified according to disease severity (PASI &lt; 10 vs. \u226510). Associations between disease activity and sleep domains were analyzed using univariable and multivariable ordinal regression models adjusted for demographic and clinical variables. Results: The study population had predominantly low disease activity (median PASI 2). The median global PSQI score was 5, indicating overall borderline sleep impairment. Patients with PASI \u2265 10 showed significantly worse sleep latency (p = 0.01) and greater daytime dysfunction (p = 0.02), while no significant differences were observed in global PSQI scores. In multivariable analyses, PASI \u2265 10 remained independently associated with increased sleep latency (\u03b2 = 0.95, 95% CI 0.08\u20131.82; p = 0.032) and daytime dysfunction (\u03b2 = 2.52, 95% CI 1.31\u20133.73; p &lt; 0.001), after adjustment for confounders. Conclusions: Higher PsO disease activity is independently associated with impairment in specific sleep domains, particularly sleep latency and daytime dysfunction, rather than global sleep quality. These findings highlight the importance of assessing domain-specific sleep disturbances and support the integration of sleep outcomes into a holistic, patient-centered approach to PsO management.<\/jats:p>","DOI":"10.3390\/jcm15114198","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:36:18Z","timestamp":1780076178000},"page":"4198","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease Activity-Related Sleep Dysfunction in Psoriasis: Insights from a Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1815-2304","authenticated-orcid":false,"given":"Damiano","family":"Currado","sequence":"first","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"},{"name":"Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-8873","authenticated-orcid":false,"given":"Claudio","family":"Conforti","sequence":"additional","affiliation":[{"name":"Department of Life Science, Health and Health Professions, Link University of Rome, 00165 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4199-6321","authenticated-orcid":false,"given":"Francesca","family":"Trunfio","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Marino","sequence":"additional","affiliation":[{"name":"Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo 200, 00128 Rome, Italy"},{"name":"Department of Life, Health and Environmental Sciences, University of L\u2019Aquila, via Vetoio SNC, Ed. Camillo de Meis, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vomero","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"},{"name":"Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Corberi","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Saracino","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Retrosi","sequence":"additional","affiliation":[{"name":"IDI-IRCCS, via Monti di Creta 104, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2808-1581","authenticated-orcid":false,"given":"Onorina","family":"Berardicurti","sequence":"additional","affiliation":[{"name":"Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo 200, 00128 Rome, Italy"},{"name":"Rheumatology, Department Life Sciences, Health and Health Professions, Link Campus University, 00165 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7878-4955","authenticated-orcid":false,"given":"Iris","family":"Zalaudek","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Maggiore Hospital, University of Trieste, 34127 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giacomelli","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"},{"name":"Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Navarini","sequence":"additional","affiliation":[{"name":"Rheumatology and Clinical Immunology, Department of Medicine, University of Rome Campus Biomedico, School of Medicine, 00128 Rome, Italy"},{"name":"Clinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, via Alvaro del Portillo 200, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"ii18","DOI":"10.1136\/ard.2004.033217","article-title":"Psoriasis: Epidemiology, clinical features, and quality of life","volume":"64","author":"Langley","year":"2005","journal-title":"Ann. 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