{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:09:18Z","timestamp":1785424158808,"version":"3.56.0"},"reference-count":25,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Glaukos Corporation","award":["2805202552389"],"award-info":[{"award-number":["2805202552389"]}]},{"award":["2805202552389"],"award-info":[{"award-number":["2805202552389"]}],"id":[{"id":"https:\/\/ror.org\/02j4hfc40","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Evaluation of real-world outcomes of standalone implantation of the third-generation trabecular micro-bypass device (iStent infinite) in eyes with mild to severe primary open-angle glaucoma (POAG). Materials: This retrospective, uncontrolled consecutive case series included eyes undergoing standalone iStent infinite implantation at a single U.S. practice. Outcomes were assessed through 12 months, including changes in intraocular pressure (IOP) and medication burden (primary), proportions achieving IOP \u2264 12\/15\/18 mmHg and medication categories (secondary), and safety. Subgroup analyses were completed based on preoperative IOP, glaucoma severity, and medication burden. Results: Fifty-one eyes (mean age 66.5 \u00b1 10.8 years) were included. Mean baseline IOP was 20.1 \u00b1 5.4 mmHg on 2.1 \u00b1 1.2 medications. At month 12, the mean IOP decreased to 16.0 \u00b1 3.6 mmHg (\u22124.1 mmHg, \u221220.4%; p &lt; 0.001), and mean medications decreased to 1.5 \u00b1 1.2 (\u221228.6%; p &lt; 0.001). The proportion of eyes achieving IOP \u2264 18\/15\/12 mmHg increased from 41.2%\/15.7%\/3.9% to 79.6%\/42.9%\/16.3%, respectively (all p &lt; 0.001). Medication-free eyes increased from 15.7% to 30.6%, while eyes requiring \u2265 3 medications decreased from 47.1% to 20.4%. Eyes with baseline IOP &gt; 18 mmHg achieved greater IOP reduction (\u221227.8%), whereas eyes with baseline IOP \u2264 18 mmHg maintained stable IOP with reduced medications. Kaplan\u2013Meier analysis demonstrated 12-month freedom from incisional reintervention of 92.2%. No intraoperative complications occurred. Transient self-resolving hyphema was observed in 3.9% of eyes. A secondary incisional surgery was performed in four eyes (7.8%); no vision-threatening complications were reported. Conclusions: Standalone iStent infinite implantation resulted in significant IOP and medication reductions with a favorable safety profile over 12 months, with outcomes aligned with preoperative treatment goals. These results suggest potential benefit as a less invasive real-world glaucoma intervention, warranting confirmation in larger prospective studies.<\/jats:p>","DOI":"10.3390\/jcm15114215","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T17:36:18Z","timestamp":1780076178000},"page":"4215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Twelve-Month Outcomes of Standalone iStent Infinite in Primary Open-Angle Glaucoma"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4122-4030","authenticated-orcid":false,"given":"Arkadiy","family":"Yadgarov","sequence":"first","affiliation":[{"name":"OMNI Eye Services, Atlanta, GA 30342, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1034-7732","authenticated-orcid":false,"given":"Dana M.","family":"Hornbeak","sequence":"additional","affiliation":[{"name":"Glaukos Corporation, 1 Glaukos Way, Aliso Viejo, CA 92656, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deana","family":"Davidova","sequence":"additional","affiliation":[{"name":"OMNI Eye Services, Atlanta, GA 30342, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global Causes of Blindness and Distance Vision Impairment 1990\u20132020: A Systematic Review and Meta-Analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob. 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