{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:46:42Z","timestamp":1782910002321,"version":"3.54.5"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:00:00Z","timestamp":1780099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Infectious keratitis is a vision-threatening disease. Its prevalence and specific pathogens vary by geographic location. This study characterizes risk profiles, clinical manifestations, and treatment outcomes for various pathogens in the Rostock area. Results: The study included 65 patients (38 viral, 14 bacterial, seven fungal, six parasitic) with a minimum follow-up of three months. The cohort had a mean age of 59 \u00b1 19 years, with 49% female and 51% male participants. All groups showed significant improvement in visual acuity (viral \u22120.3 logMAR, p = 0.011; parasitic \u22120.8 logMAR, p = 0.043; fungal \u22120.9 logMAR, p = 0.018; Wilcoxon). Only the bacterial group did not reach statistical significance (\u22120.3 logMAR, p = 0.169; Wilcoxon). Final visual acuity did not differ significantly between medical and surgical treatments. Conclusions: No treatment modality (medical vs. surgical) showed superiority regarding visual outcome across pathogen groups. Early diagnosis and prompt therapy initiation are essential to improve visual prognosis and reduce complications.<\/jats:p>","DOI":"10.3390\/jcm15114249","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:25:31Z","timestamp":1780399531000},"page":"4249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Infectious Keratitis: A Retrospective Analysis of a Tertiary Care Center"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9842-0370","authenticated-orcid":false,"given":"Jana","family":"Schaetzel","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taos","family":"Batal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Walckling","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fuchsluger","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Medical Center Rostock, 18057 Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/ceo.14113","article-title":"Infectious keratitis: A review","volume":"50","author":"Khoo","year":"2022","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"854","DOI":"10.2471\/BLT.19.232660","article-title":"Infectious corneal ulceration: A proposal for neglected tropical disease status","volume":"97","author":"Ung","year":"2019","journal-title":"Bull. World Health Organ."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1038\/s41433-020-01339-3","article-title":"Infectious keratitis: An update on epidemiology, causative microorganisms, risk factors, and antimicrobial resistance","volume":"35","author":"Ting","year":"2021","journal-title":"Eye"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hoffman, J.J., Burton, M.J., and Leck, A. (2021). Mycotic Keratitis-A Global Threat from the Filamentous Fungi. J. Fungi, 7.","DOI":"10.3390\/jof7040273"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/opo.12752","article-title":"Acanthamoeba keratitis: A review of biology, pathophysiology and epidemiology","volume":"41","author":"Lira","year":"2021","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10792-019-01226-1","article-title":"Atypical herpes simplex keratitis: Frequency, clinical presentations and treatment results","volume":"40","author":"Erdem","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lee, J.W., Somerville, T., Kaye, S.B., and Romano, V. (2021). Staphylococcus aureus Keratitis: Incidence, Pathophysiology, Risk Factors and Novel Strategies for Treatment. J. Clin. Med., 10.","DOI":"10.3390\/jcm10040758"},{"key":"ref_8","first-page":"506","article-title":"Herpes simplex keratitis revisited","volume":"84","year":"2021","journal-title":"Arq. Bras. Oftalmol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"108647","DOI":"10.1016\/j.exer.2021.108647","article-title":"Foundational concepts in the biology of bacterial keratitis","volume":"209","author":"Ung","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1038\/s41433-020-01153-x","article-title":"Update on Herpes simplex keratitis management","volume":"34","author":"Sibley","year":"2020","journal-title":"Eye"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Herpetic Eye Disease Study Group (1998). Acyclovir for the prevention of recurrent herpes simplex virus eye disease. N. Engl. J. Med., 339, 300\u2013306.","DOI":"10.1056\/NEJM199807303390503"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1055\/a-1147-9019","article-title":"Cham\u00e4leonartige Hornhautver\u00e4nderungen: Akantham\u00f6benkeratitis","volume":"237","author":"Fries","year":"2020","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1055\/s-0035-1545994","article-title":"Bakterielle Keratitis","volume":"232","author":"Rachwalik","year":"2015","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s10792-021-01873-3","article-title":"Update on the management of fungal keratitis","volume":"41","author":"Sha","year":"2021","journal-title":"Int. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.4103\/ijo.IJO_2509_21","article-title":"Toxic non-inflammatory fungal keratitis","volume":"70","author":"Subudhi","year":"2022","journal-title":"Indian J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1444-0938.2006.00069.x","article-title":"Rethinking contact lens associated keratitis","volume":"89","author":"Efron","year":"2006","journal-title":"Clin. Exp. Optom."},{"key":"ref_17","unstructured":"Statistisches Bundesamt (Destatis) (2023, February 07). Genesis-Online, Datenlizenz-by-2-0. Available online: https:\/\/www.destatis.de\/DE\/Themen\/Gesellschaft-Umwelt\/Bevoelkerung\/Sterbefaelle-Lebenserwartung\/sterbetafel.html."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1007\/s10792-020-01539-6","article-title":"Ocular surgery after herpes simplex and herpes zoster keratitis","volume":"40","author":"Kanclerz","year":"2020","journal-title":"Int. Ophthalmol."},{"key":"ref_19","first-page":"989","article-title":"Auspr\u00e4gung und Therapie der Herpeskeratitis an der Universit\u00e4ts-Augenklinik des Saarlandes","volume":"238","author":"Lepper","year":"2021","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00347-014-3225-7","article-title":"Das Deutsche Akantham\u00f6benkeratitis-Register: Erste Ergebnisse einer multizentrischen Erhebung","volume":"112","author":"Daas","year":"2015","journal-title":"Ophthalmologe"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41433-019-0589-6","article-title":"Acanthamoeba keratitis in Australia: Demographics, associated factors, presentation and outcomes: A 15-year case review","volume":"34","author":"Keay","year":"2020","journal-title":"Eye"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41598-020-80222-3","article-title":"Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years","volume":"11","author":"List","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3126\/nepjoph.v12i1.24769","article-title":"Acanthamoeba keratitis: A 4-year review from a tertiary care hospital in North India","volume":"12","author":"Megha","year":"2020","journal-title":"Nepal. J. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102834","DOI":"10.1016\/j.amsu.2021.102834","article-title":"Acanthamoeba keratitis in contact lens wearers in a tertiary center of Tunisia, North Africa","volume":"70","author":"Nadia","year":"2021","journal-title":"Ann. Med. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.2147\/OPTH.S301903","article-title":"Acanthamoeba Keratitis in Egypt: Characteristics and Treatment Outcomes","volume":"15","author":"Nasef","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"108365","DOI":"10.1016\/j.exer.2020.108365","article-title":"The biology of Acanthamoeba keratitis","volume":"202","author":"Niederkorn","year":"2021","journal-title":"Exp. Eye Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.pt.2006.02.004","article-title":"The pathophysiology of Acanthamoeba keratitis","volume":"22","author":"Clarke","year":"2006","journal-title":"Trends Parasitol."},{"key":"ref_28","first-page":"358","article-title":"Bakterielle und mykotische Keratitis: Eine retrospektive Analyse an einer Schweizer Universit\u00e4tsklinik","volume":"236","author":"Bograd","year":"2019","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00417-019-04434-8","article-title":"Effectiveness of 16S ribosomal DNA real-time PCR and sequencing for diagnosing bacterial keratitis","volume":"258","author":"Shimizu","year":"2020","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jamaophthalmol.2014.292","article-title":"Early addition of topical corticosteroids in the treatment of bacterial keratitis","volume":"132","author":"Ray","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1167\/iovs.14-13980","article-title":"Visual outcomes in treated bacterial keratitis: Four years of prospective follow-up","volume":"55","author":"McClintic","year":"2014","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"myac047","DOI":"10.1093\/mmy\/myac047","article-title":"Clinical and microbiological analysis of fungal keratitis in Toronto, Canada: A 20-year study","volume":"60","author":"Trinh","year":"2022","journal-title":"Med. Mycol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/aos.14910","article-title":"Update on fungal keratitis in France: A case-control study","volume":"100","author":"Olivier","year":"2022","journal-title":"Acta Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.4274\/tjo.galenos.2021.09515","article-title":"Clinical and Mycological Features of Fungal Keratitis: A Retrospective Single-Center Study (2012\u20132018)","volume":"52","author":"Harbiyeli","year":"2022","journal-title":"Turk. J. Ophthalmol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/myc.13009","article-title":"The clinical and microbiological features and outcomes of fungal keratitis over 9 years in Sydney, Australia","volume":"63","author":"Watson","year":"2020","journal-title":"Mycoses"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"343","DOI":"10.26444\/aaem\/109414","article-title":"A single-centre retrospective observational study of fungal keratitis in Poland with a review of findings in Europe","volume":"27","author":"Nowik","year":"2020","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1097\/ICO.0000000000000129","article-title":"Clinical features of ocular herpetic infection in an Italian referral center","volume":"33","author":"Miserocchi","year":"2014","journal-title":"Cornea"},{"key":"ref_38","first-page":"669","article-title":"Contact Lens-Associated Keratitis\u2014An Often Underestimated Risk","volume":"119","author":"Maier","year":"2022","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bjophthalmol-2020-316730","article-title":"PCR and culture for diagnosis of Acanthamoeba keratitis","volume":"105","author":"Yera","year":"2021","journal-title":"Br. J. Ophthalmol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Hsiao, C.-H., Kang, E.Y.-C., Yeh, L.-K., Ma, D.H.K., Chen, H.-C., Hung, K.-H., and Huang, Y.-C. (2022). Staphylococcus aureus Keratitis in Taiwan: Genotyping, Antibiotic Susceptibility, and Clinical Features. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms231911703"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jtos.2022.03.002","article-title":"The use of in vivo confocal microscopy in fungal keratitis\u2014Progress and challenges","volume":"24","author":"Bakken","year":"2022","journal-title":"Ocul. Surf."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s40123-022-00592-x","article-title":"Nonsurgical Management of Severe Viral Keratitis with Hypopyon and Retrocorneal Plaques: A Case Series","volume":"12","author":"Yang","year":"2023","journal-title":"Ophthalmol. Ther."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1136\/bjophthalmol-2013-304660","article-title":"Topical antibiotics for the management of bacterial keratitis: An evidence-based review of high quality randomised controlled trials","volume":"98","author":"McDonald","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.ophtha.2013.12.041","article-title":"Visual recovery in treated bacterial keratitis","volume":"121","author":"Srinivasan","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00003226-200101000-00001","article-title":"Herpes simplex virus epidemiology and ocular importance","volume":"20","author":"Liesegang","year":"2001","journal-title":"Cornea"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/11\/4249\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:59:54Z","timestamp":1782907194000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/11\/4249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,30]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["jcm15114249"],"URL":"https:\/\/doi.org\/10.3390\/jcm15114249","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,30]]}}}