{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T12:13:53Z","timestamp":1780402433292,"version":"3.54.1"},"reference-count":98,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background\/Objectives: Sedation is a fundamental component of gastrointestinal endoscopy, improving patient comfort, procedural quality, and overall satisfaction. However, traditional drug-centered sedation models are increasingly challenged by rising procedural volumes, aging populations, and limited anesthesiology resources. The aim of this narrative review is to provide an integrated overview of evolving pharmacological agents, monitoring strategies, organizational models, and future directions toward personalized, technology-supported sedation pathways. Methods: A structured literature search was conducted across PubMed\/MEDLINE, Scopus, and Web of Science for studies published between January 2010 and December 2025. Relevant guidelines, randomized controlled trials, meta-analyses, and large observational studies were included. Evidence was synthesized qualitatively, emphasizing clinical applicability and real-world relevance. Results: Propofol remains the most widely used sedative agent due to its rapid onset and recovery profile, although its narrow therapeutic window and lack of antagonist limit its safety in high-risk patients. Emerging agents such as remimazolam and ciprofol demonstrate comparable efficacy with improved respiratory and hemodynamic safety profiles, particularly in elderly populations. Adjunctive strategies, including procedure-specific approaches such as spinal anesthesia, may further optimize sedation. Advanced monitoring tools, such as capnography, bispectral index, and high-flow nasal cannula, show potential in enhancing safety, especially in selected high-risk groups. Structured training programs and standardized discharge criteria are essential for ensuring quality and safety. Conclusions: Sedation in gastrointestinal endoscopy is transitioning from a standardized, drug-centered approach to a personalized, risk-adapted, and technology-supported model. Integration of novel pharmacological agents, advanced monitoring, and structured training will be key to improving patient safety, procedural efficiency, and healthcare sustainability.<\/jats:p>","DOI":"10.3390\/jcm15114281","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:25:31Z","timestamp":1780399531000},"page":"4281","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sedation in Gastrointestinal Endoscopy: From Drug-Centered Protocols to Personalized, Technology-Supported Pathways: A Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Giuliano Francesco","family":"Bonura","sequence":"first","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL di Modena, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Soriani","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL di Modena, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Gualandi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL di Modena, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8793-5890","authenticated-orcid":false,"given":"Pablo","family":"Cortegoso Valdivia","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, University Hospital of Parma, 43126 Parma, Italy"},{"name":"Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark"},{"name":"Surgical Research Unit, Odense University Hospital, 5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8457-2994","authenticated-orcid":false,"given":"Tommaso","family":"Gabbani","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL di Modena, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Parrella","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL di Modena, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2248-489X","authenticated-orcid":false,"given":"Anastasios","family":"Koulaouzidis","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Southern Denmark, 5230 Odense, Denmark"},{"name":"Surgical Research Unit, Odense University Hospital, 5000 Odense, Denmark"},{"name":"Department of Medicine, Odense University Hospital, 5700 Svendborg, Denmark"},{"name":"Department of Social Medicine and Public Health, Pomeranian Medical University, 71-210 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7854-1080","authenticated-orcid":false,"given":"Mauro","family":"Manno","sequence":"additional","affiliation":[{"name":"Gastroenterology and Digestive Endoscopy Unit, Azienda USL di Modena, 41121 Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1007\/s10620-020-06491-0","article-title":"Unsedated Colonoscopy: Impact on Quality Indicators","volume":"65","author":"Khan","year":"2020","journal-title":"Dig. 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